Takashi Miyauchi

Takashi Miyauchi

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Takashi Miyauchi

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Endothelin and the heart in health and diseases.

Peptides 2019 01 21;111:77-88. Epub 2018 Oct 21.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183018
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http://dx.doi.org/10.1016/j.peptides.2018.10.002DOI Listing
January 2019

Splenic volume in severe sepsis is associated with disease severity and pneumococcal infection.

Acute Med Surg 2016 10 3;3(4):339-344. Epub 2016 May 3.

Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital Ube Yamaguchi Japan.

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http://dx.doi.org/10.1002/ams2.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667317PMC
October 2016

Antagonists to endothelin receptor type B promote apoptosis in human pulmonary arterial smooth muscle cells.

Life Sci 2016 Aug 26;159:116-120. Epub 2016 Mar 26.

Division of Cardiovascular Medicine, Department of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2016.03.044DOI Listing
August 2016

Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study.

J Intensive Care 2016 29;4:33. Epub 2016 Apr 29.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505 Japan ; Acute and General Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi Japan.

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http://dx.doi.org/10.1186/s40560-016-0156-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850650PMC
May 2016

Extent of pleural effusion on chest radiograph is associated with failure of high-flow nasal cannula oxygen therapy.

J Crit Care 2016 Apr 11;32:165-9. Epub 2015 Dec 11.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Yamaguchi, Japan; Acute and General Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

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http://dx.doi.org/10.1016/j.jcrc.2015.12.001DOI Listing
April 2016

Effects of mechanical chest compression device with a load-distributing band on post-resuscitation injuries identified by post-mortem computed tomography.

Resuscitation 2015 Nov 31;96:226-31. Epub 2015 Aug 31.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Yamaguchi, Japan; Acute and General Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

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http://dx.doi.org/10.1016/j.resuscitation.2015.08.013DOI Listing
November 2015

Predictive Factors for Hospitalization of Patients with Heat Illness in Yamaguchi, Japan.

Int J Environ Res Public Health 2015 Sep 18;12(9):11770-80. Epub 2015 Sep 18.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.

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http://www.mdpi.com/1660-4601/12/9/11770
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http://dx.doi.org/10.3390/ijerph120911770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586706PMC
September 2015

Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice.

Life Sci 2014 Nov 18;118(2):288-96. Epub 2014 Jan 18.

Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.01.007DOI Listing
November 2014

Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model.

Life Sci 2014 Nov 16;118(2):364-9. Epub 2014 Feb 16.

Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.02.008DOI Listing
November 2014

Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1: intravital microscopic observation and (31)P-MR spectroscopic studies.

Life Sci 2014 Nov 5;118(2):248-54. Epub 2014 Mar 5.

Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Life Science Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.02.024DOI Listing
November 2014

Fish oil constituent eicosapentaenoic acid inhibits endothelin-induced cardiomyocyte hypertrophy via PPAR-α.

Life Sci 2014 Nov 2;118(2):173-8. Epub 2014 May 2.

Department of Cardiovascular Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba; Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2014.04.025DOI Listing
November 2014

Effects of uninterrupted chest compressions on the rescuer's physical condition.

Am J Emerg Med 2014 Aug 12;32(8):909-12. Epub 2014 May 12.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Yamaguchi 755-8505, Japan; Department of Stress and Bio-response Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.

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http://dx.doi.org/10.1016/j.ajem.2014.05.008DOI Listing
August 2014

Effects of selective endothelin (ET)-A receptor antagonist versus dual ET-A/B receptor antagonist on hearts of streptozotocin-treated diabetic rats.

Life Sci 2014 Aug 20;111(1-2):6-11. Epub 2014 Jun 20.

Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2014.06.008DOI Listing
August 2014

Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women.

Life Sci 2014 Jul 11;108(1):30-3. Epub 2014 May 11.

Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2014.05.003DOI Listing
July 2014

Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy.

Life Sci 2014 May 21;102(2):98-104. Epub 2014 Mar 21.

Division of Cardiovascular Medicine, Department of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Division of Life Science Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.03.018DOI Listing
May 2014

Diabetes and obesity are significant risk factors for morning hypertension: from Ibaraki Hypertension Assessment Trial (I-HAT).

Life Sci 2014 May 13;104(1-2):32-7. Epub 2014 Apr 13.

Graduate School of Comprehensive Human Science, University of Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.03.029DOI Listing
May 2014

Evidence for the therapeutic efficacy of either mild hypothermia or oxygen radical scavengers after repetitive mild traumatic brain injury.

J Neurotrauma 2014 Apr 7;31(8):773-81. Epub 2014 Feb 7.

1 Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center , Richmond, Virginia.

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http://dx.doi.org/10.1089/neu.2013.3181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967419PMC
April 2014

Clinical value of plasma pentraxin 3 levels for predicting cardiac troponin elevation after percutaneous coronary intervention.

Life Sci 2014 Jan 12;95(1):40-4. Epub 2013 Dec 12.

Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.lfs.2013.11.021DOI Listing
January 2014

Therapeutic targeting of the axonal and microvascular change associated with repetitive mild traumatic brain injury.

J Neurotrauma 2013 Oct 27;30(19):1664-71. Epub 2013 Aug 27.

1 Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center , Richmond, Virginia.

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http://dx.doi.org/10.1089/neu.2013.2995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787368PMC
October 2013

Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.

FEBS Lett 2012 Dec 15;586(24):4357-61. Epub 2012 Nov 15.

Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.febslet.2012.10.050DOI Listing
December 2012

Endothelin and endothelin receptors in the renal and cardiovascular systems.

Life Sci 2012 Oct 28;91(13-14):490-500. Epub 2012 Mar 28.

Kobe Pharmaceutical University, Clinical Pharmacy, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00243205120014
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http://dx.doi.org/10.1016/j.lfs.2012.03.026DOI Listing
October 2012

Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymerase II.

Life Sci 2012 Oct 30;91(13-14):572-7. Epub 2012 Apr 30.

Department of Cardiovascular Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2012.04.034DOI Listing
October 2012

The First Tomoh Masaki Award (2011).

Life Sci 2012 Oct 2;91(13-14):466-9. Epub 2012 Aug 2.

Molecular Internal Medicine, University of Zurich, 8057 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.lfs.2012.07.017DOI Listing
October 2012

Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease.

Life Sci 2012 Oct 21;91(13-14):729-32. Epub 2012 Aug 21.

Life Science Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.lfs.2012.08.008DOI Listing
October 2012

Global end-diastolic volume, serum osmolarity, and albumin are risk factors for increased extravascular lung water.

J Crit Care 2011 Apr 24;26(2):224.e9-13. Epub 2010 Sep 24.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 755-8505, Japan.

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http://dx.doi.org/10.1016/j.jcrc.2010.07.011DOI Listing
April 2011

Comparison of the predictability of neurological outcome by serum procalcitonin and glial fibrillary acidic protein in postcardiac-arrest patients.

Neurocrit Care 2010 Apr;12(2):252-7

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, Japan.

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http://dx.doi.org/10.1007/s12028-009-9318-5DOI Listing
April 2010

Increase in plasma glucagon, a factor in hyperglycemia, is related to neurological outcome in postcardiac-arrest patients.

Resuscitation 2010 Feb 16;81(2):187-92. Epub 2009 Dec 16.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S03009572090059
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http://dx.doi.org/10.1016/j.resuscitation.2009.11.012DOI Listing
February 2010

Moderate hypothermia suppresses jugular venous superoxide anion radical, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats.

Brain Res 2010 Jan 18;1311:197-205. Epub 2009 Nov 18.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1, Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.

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http://dx.doi.org/10.1016/j.brainres.2009.11.028DOI Listing
January 2010

Successful treatment with hydrocortisone for heat stroke with critical illness-related corticosteroid insufficiency: transitional changes in serum cytokine and cortisol concentrations.

J Anesth 2009 15;23(2):266-9. Epub 2009 May 15.

Advanced Medical Emergency And Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minami-Kogushi, Ube, 755-8505, Japan.

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http://link.springer.com/10.1007/s00540-008-0725-0
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http://dx.doi.org/10.1007/s00540-008-0725-0DOI Listing
December 2009

Serum macrophage migration inhibitory factor reflects adrenal function in the hypothalamo-pituitary-adrenal axis of septic patients: an observational study.

BMC Infect Dis 2009 Dec 21;9:209. Epub 2009 Dec 21.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.

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http://dx.doi.org/10.1186/1471-2334-9-209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807431PMC
December 2009

Reduction in alpha-adrenergic receptor-mediated vascular tone contributes to improved arterial compliance with endurance training.

Int J Cardiol 2009 Jul 7;135(3):346-52. Epub 2008 Jul 7.

Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.ijcard.2008.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745711PMC
July 2009

Serum glial fibrillary acidic protein as a predictive biomarker of neurological outcome after cardiac arrest.

Resuscitation 2009 Jul 2;80(7):790-4. Epub 2009 May 2.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Minamikogushi, Ube, Japan.

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http://dx.doi.org/10.1016/j.resuscitation.2009.04.003DOI Listing
July 2009

The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations.

Am J Physiol Heart Circ Physiol 2008 Jul 2;295(1):H136-44. Epub 2008 May 2.

Institute of Clinical Medicine, Univ. of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1152/ajpheart.01417.2006DOI Listing
July 2008

Systemic arterial compliance, systemic vascular resistance, and effective arterial elastance during exercise in endurance-trained men.

Am J Physiol Regul Integr Comp Physiol 2008 Jul 7;295(1):R228-35. Epub 2008 May 7.

Health and Sports Management Major, Faculty of Health and Welfare Human Services, St. Catherine University, Matsuyama, Ehime, Japan.

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http://dx.doi.org/10.1152/ajpregu.00009.2008DOI Listing
July 2008

Estrogen receptor-alpha genotype affects exercise-related reduction of arterial stiffness.

Med Sci Sports Exerc 2008 Feb;40(2):252-7

Department of Music, Sapporo Otani University, Sapporo, Hokkaido, Japan.

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http://dx.doi.org/10.1249/mss.0b013e31815c04cfDOI Listing
February 2008

Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats.

J Appl Physiol (1985) 2008 Jan 1;104(1):67-74. Epub 2007 Nov 1.

Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1152/japplphysiol.00558.2007DOI Listing
January 2008

Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat.

Eur J Pharmacol 2007 Nov 21;574(2-3):158-71. Epub 2007 Jul 21.

Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2007.07.023DOI Listing
November 2007

Systemic alpha-adrenergic and nitric oxide inhibition on basal limb blood flow: effects of endurance training in middle-aged and older adults.

Am J Physiol Heart Circ Physiol 2007 Sep 11;293(3):H1466-72. Epub 2007 May 11.

Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan.

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http://dx.doi.org/10.1152/ajpheart.00273.2007DOI Listing
September 2007

Relationship between arterial stiffness and athletic training programs in young adult men.

Am J Hypertens 2007 Sep;20(9):967-73

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.amjhyper.2007.05.001DOI Listing
September 2007

Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy.

Am J Physiol Heart Circ Physiol 2007 Jul 16;293(1):H474-81. Epub 2007 Mar 16.

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1152/ajpheart.00922.2006DOI Listing
July 2007

Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans.

Hypertens Res 2007 May;30(5):411-5

Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.

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http://dx.doi.org/10.1291/hypres.30.411DOI Listing
May 2007

Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts.

Am J Physiol Endocrinol Metab 2007 Apr 5;292(4):E1030-40. Epub 2006 Dec 5.

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1152/ajpendo.00517.2006DOI Listing
April 2007

Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men.

Am J Physiol Heart Circ Physiol 2007 Feb 22;292(2):H786-91. Epub 2006 Sep 22.

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.

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http://dx.doi.org/10.1152/ajpheart.00678.2006DOI Listing
February 2007

Postexercise heart rate recovery accelerates in strength-trained athletes.

Med Sci Sports Exerc 2007 Feb;39(2):365-70

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1249/01.mss.0000241647.13220.4cDOI Listing
February 2007

Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts.

Am J Physiol Heart Circ Physiol 2006 Sep 14;291(3):H1290-8. Epub 2006 Apr 14.

Institute of Health and Sport Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1152/ajpheart.00820.2005DOI Listing
September 2006

Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat.

Peptides 2006 Sep 24;27(9):2258-70. Epub 2006 May 24.

Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300-0394, Japan.

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http://dx.doi.org/10.1016/j.peptides.2006.03.025DOI Listing
September 2006

Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-beta 1 and phosphorylated JNK.

Am J Physiol Heart Circ Physiol 2006 Aug 24;291(2):H835-45. Epub 2006 Feb 24.

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://ajpheart.physiology.org/content/ajpheart/291/2/H835.f
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http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.0136
Publisher Site
http://dx.doi.org/10.1152/ajpheart.01365.2005DOI Listing
August 2006

Down-regulated VEGF expression in the diabetic heart is normalized by an endothelin ETA receptor antagonist.

Eur J Pharmacol 2006 Aug;542(1-3):184-5

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2006.04.041DOI Listing
August 2006

Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise.

J Appl Physiol (1985) 2006 Jul 16;101(1):151-63. Epub 2006 Feb 16.

Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1152/japplphysiol.00392.2005DOI Listing
July 2006

[Endothelin].

Nihon Rinsho 2006 Jul;64 Suppl 5:112-6

Graduate School of Comprehensive Human Sciences, University of Tsukuba.

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July 2006

Effects of athletic strength and endurance exercise training in young humans on plasma endothelin-1 concentration and arterial distensibility.

Exp Biol Med (Maywood) 2006 Jun;231(6):789-93

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.

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June 2006

Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac hypertrophy.

Exp Biol Med (Maywood) 2006 Jun;231(6):871-5

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.

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June 2006

Effect of eicosapentaenoic acid on the different endothelin system components in endothelin-1-induced hypertrophied cardiomyocytes.

Exp Biol Med (Maywood) 2006 Jun;231(6):888-92

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Differential effects of selective endothelin type a receptor antagonist on the gene expression of vascular endothelial growth factor and its receptors in streptozotocin-induced diabetic heart.

Exp Biol Med (Maywood) 2006 Jun;231(6):902-6

Department of Cardiovascular Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Reversal of elevated cardiac expression of TGFbeta1 and endothelin-1 in OLETF diabetic rats by long-acting calcium antagonist.

Exp Biol Med (Maywood) 2006 Jun;231(6):907-12

Department of Cardiovascular Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

EPA effect on NOS gene expression and on NO level in endothelin-1-induced hypertrophied cardiomyocytes.

Exp Biol Med (Maywood) 2006 Jun;231(6):913-8

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Endothelin antagonism suppresses plasma and cardiac endothelin-1 levels in SHRSPs at the typical hypertensive stage.

Exp Biol Med (Maywood) 2006 Jun;231(6):919-24

Department of Cardiovascular Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Effects of a selective endothelin a receptor antagonist on the expressions of iNOS and eNOS in the heart of early streptozotocin-induced diabetic rats.

Exp Biol Med (Maywood) 2006 Jun;231(6):925-31

Department of Internal Medicine, Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Changes in important apoptosis-related molecules in the endothelin-1-induced hypertrophied cardiomyocytes: effect of the pretreatment with eicosapentaenoic Acid.

Exp Biol Med (Maywood) 2006 Jun;231(6):932-6

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Alterations in gene expressions encoding preproET-1 and NOS in pulmonary tissue in endotoxemic rats.

Exp Biol Med (Maywood) 2006 Jun;231(6):992-6

Department of Cardiovascular Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats.

Exp Biol Med (Maywood) 2006 Jun;231(6):1034-9

Department of Cardiovascular Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Weight loss reduces plasma endothelin-1 concentration in obese men.

Exp Biol Med (Maywood) 2006 Jun;231(6):1044-7

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.

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June 2006

Alterations of gene expressions of preproET-1 and ET receptors in brains of endotoxemic Sprague-Dawley rats.

Exp Biol Med (Maywood) 2006 Jun;231(6):1058-63

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

A model of retinal ischemia-reperfusion injury in rats by subconjunctival injection of endothelin-1.

Exp Biol Med (Maywood) 2006 Jun;231(6):1085-9

Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.

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June 2006

Effect of endothelin dual receptor antagonist on VEGF levels in streptozotocin-induced diabetic rat retina.

Exp Biol Med (Maywood) 2006 Jun;231(6):1090-4

Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.

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June 2006

Altered expression of endothelin, vascular endothelial growth factor, and its receptor in hepatic tissue in endotoxemic rat.

Exp Biol Med (Maywood) 2006 Jun;231(6):1182-6

Department of Cardiovascular Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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June 2006

Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo.

J Pharmacol Sci 2006 Jun 10;101(2):151-8. Epub 2006 Jun 10.

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, Tsukaba, Ibaraki, Japan.

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http://dx.doi.org/10.1254/jphs.fp0050980DOI Listing
June 2006

Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats.

Am J Physiol Heart Circ Physiol 2006 May 30;290(5):H2146-54. Epub 2005 Dec 30.

Department of Cardiovascular Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1152/ajpheart.01142.2005DOI Listing
May 2006

Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects.

Hypertension 2006 May 27;47(5):928-36. Epub 2006 Mar 27.

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.

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http://dx.doi.org/10.1161/01.HYP.0000217520.44176.73DOI Listing
May 2006

An endothelin type A receptor antagonist reverses upregulated VEGF and ICAM-1 levels in streptozotocin-induced diabetic rat retina.

Curr Eye Res 2006 Jan;31(1):79-89

Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1080/02713680500478923DOI Listing
January 2006

2,4,6-Trinitrotoluene inhibits endothelial nitric oxide synthase activity and elevates blood pressure in rats.

Arch Toxicol 2005 Dec 16;79(12):705-10. Epub 2005 Jul 16.

Doctoral Programs in Medicine Sciences, Graduate School of Comprehensive Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1007/s00204-005-0003-yDOI Listing
December 2005

Aortic stiffness and aerobic exercise: mechanistic insight from microarray analyses.

Med Sci Sports Exerc 2005 Oct;37(10):1710-6

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1249/01.mss.0000175052.37087.f8DOI Listing
October 2005

Moderate regular exercise increases basal production of nitric oxide in elderly women.

Hypertens Res 2004 Dec;27(12):947-53

Center for Tsukuba Advanced Research Alliance (TARA), Institute of Health and Sport Sciences, University of Tsukuba, Japan.

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http://dx.doi.org/10.1291/hypres.27.947DOI Listing
December 2004

The peroxisome proliferator-activated receptor alpha activator fenofibrate inhibits endothelin-1-induced cardiac fibroblast proliferation.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S279-82

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166274.24797.0eDOI Listing
November 2004

Exercise-induced tissue-specific change in gene expression of endothelin-1.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S336-40

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166268.94302.caDOI Listing
November 2004

Activation of peroxisome proliferator-activated receptor-alpha decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S358-61

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166303.33313.01DOI Listing
November 2004

Effects of endothelin-1 eyedrops on the retina in rats.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S421-5

Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166286.85785.a1DOI Listing
November 2004

Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S443-6

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166319.91623.b0DOI Listing
November 2004

Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S447-50

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166317.84000.2eDOI Listing
November 2004

The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type II diabetic rat model.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S49-53

Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166213.04674.c2DOI Listing
November 2004

Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S59-63

Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166223.57970.5fDOI Listing
November 2004

Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S64-7

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166212.04674.8bDOI Listing
November 2004

Emergence of clinical applications of endothelin system inhibitors.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:xiii-xiv

Department of Pharmacology, Institute of Basic Medical Sciences,University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. kgoto@ md.tsukuba.ac.jp

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November 2004