Publications


Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.
PLoS One 2017 17;12(4):e0175632. Epub 2017 Apr 17.
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.



Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis.
Sci Signal 2014 Sep 16;7(343):ra88. Epub 2014 Sep 16.
Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Nat Commun 2014 Jul 29;5:4552. Epub 2014 Jul 29.
1] Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science Technology Agency, 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan.



Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.
Arterioscler Thromb Vasc Biol 2014 Apr 13;34(4):790-800. Epub 2014 Feb 13.
From the Department of Molecular Genetics (E.H., T.K., K.M., H.H., M.E., M. Tabata, H.T., Z.T., O.T., K.T., Y.O.), Department of Cardiovascular Medicine (E.H., H.O., K.K.), and Department of Cell Pathology (M. Takeya), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Division of Geriatric Medicine, Department of Internal Medicine (Y.A., N.H.) and Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine (K.H., T.S.), Keio University School of Medicine, Tokyo, Japan; Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (Y.D., T.N., Y.K.); Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan (H.H.); Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan (T.M.); and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan (Y.O.).

A major role for RCAN1 in atherosclerosis progression.
EMBO Mol Med 2013 Dec 15;5(12):1901-17. Epub 2013 Oct 15.
Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.


Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T₂ correction: phantom and clinical study with histologic assessment.
Radiol Phys Technol 2013 Jan 7;6(1):219-25. Epub 2012 Dec 7.
School of Radiological Technology, Gunma Prefectural College of Health Sciences, 323-1 Kamioki, Maebashi, Gunma 371-0052, Japan.




Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis.
Proc Natl Acad Sci U S A 2011 Dec 5;108(51):20725-9. Epub 2011 Dec 5.
Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Bunkyo-ku, Yushima, Tokyo 113-8519, Japan.


Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter.
Mol Cell Biol 2011 Jun 4;31(11):2196-209. Epub 2011 Apr 4.
Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.



Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.
Blood 2009 Dec 12;114(27):5557-66. Epub 2009 Oct 12.
The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

A wave of nascent transcription on activated human genes.
Proc Natl Acad Sci U S A 2009 Oct 13;106(43):18357-61. Epub 2009 Oct 13.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.


Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.
J Biol Chem 2009 Feb 23;284(9):5592-601. Epub 2008 Dec 23.
Department of Structural Analysis, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo.
Blood 2008 Sep 2;112(6):2336-9. Epub 2008 Jun 2.
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.
Nat Cell Biol 2008 May 20;10(5):513-26. Epub 2008 Apr 20.
Department of Structural Analysis, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.


A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.
Circ Res 2007 Jun 10;100(12):1712-22. Epub 2007 May 10.
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.
Free Radic Biol Med 2007 Jan 20;42(2):260-9. Epub 2006 Oct 20.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (LSBM), University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo 153-8904, Japan.

Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression.
Arterioscler Thromb Vasc Biol 2006 Dec 28;26(12):2652-9. Epub 2006 Sep 28.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo, 153-8904, Japan.

A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression.
J Biol Chem 2006 Nov 15;281(46):35544-53. Epub 2006 Sep 15.
Center for Vascular Biology Research, Department of Medicine, the Division of Molecular, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.
Proc Natl Acad Sci U S A 2006 Nov 6;103(46):17278-83. Epub 2006 Nov 6.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Meguro, Tokyo 153-8904, Japan.

Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell.
FASEB J 2005 Nov 19;19(13):1914-6. Epub 2005 Sep 19.
The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215, USA.


Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.
J Biol Chem 2004 May 10;279(20):20626-35. Epub 2004 Mar 10.
Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.

Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade.
Physiol Genomics 2003 Nov 11;15(3):199-208. Epub 2003 Nov 11.
Department of Hepato-Biliary-Pancreatic and Transplantation Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

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