Takao Iwawaki

Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain.

Authors:

Hideki Hiraoka Ryosuke Nomura Nobumasa Takasugi Ryoko Akai Takao Iwawaki Yoshito Kumagai Masatake Fujimura Takashi Uehara

Arch Toxicol 2021 Jan 16. Epub 2021 Jan 16.

Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8530, Japan.

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January 2021

Role of IRE1α in podocyte proteostasis and mitochondrial health.

Authors:

José R Navarro-Betancourt Joan Papillon Julie Guillemette Takao Iwawaki Chen-Fang Chung Andrey V Cybulsky

Cell Death Discov 2020 Nov 19;6(1):128. Epub 2020 Nov 19.

Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, QC, Canada.

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November 2020

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.

Authors:

Caroline C Duwaerts Kevin Siao Russell K Soon Chris Her Takao Iwawaki Kenji Kohno Aras N Mattis Jacquelyn J Maher

Cell Death Differ 2020 Nov 20. Epub 2020 Nov 20.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

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November 2020

Corrigendum to: The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.

Authors:

Dimitra Athanasiou Dalila Bevilacqua Monica Aguila Caroline McCulley Naheed Kanuga Takao Iwawaki J Paul Chapple Michael E Cheetham

Hum Mol Genet 2020 Nov;29(19):3338-3339

UCL Institute of Ophthalmology, London EC1V 9EL, UK.

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November 2020

Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions.

Nat Cell Biol 2020 10 21;22(10):1162-1169. Epub 2020 Sep 21.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

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October 2020

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.

Authors:

Alyssa Batista Jeffrey J Rodvold Su Xian Stephen C Searles Alyssa Lew Takao Iwawaki Gonzalo Almanza T Cameron Waller Jonathan Lin Kristen Jepsen Hannah Carter Maurizio Zanetti

PLoS Biol 2020 06 10;18(6):e3000687. Epub 2020 Jun 10.

The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, California, United States of America.

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June 2020

Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia-reperfusion injury.

Authors:

Yuta Inoue Akihiko Uchiyama Akiko Sekiguchi Sahori Yamazaki Chisako Fujiwara Yoko Yokoyama Sachiko Ogino Ryoko Torii Mari Hosoi Ryoko Akai Takao Iwawaki Osamu Ishikawa Sei-Ichiro Motegi

Wound Repair Regen 2020 Sep 12;28(5):600-608. Epub 2020 May 12.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

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September 2020

AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity.

Authors:

Monica Aguilà James Bellingham Dimitra Athanasiou Dalila Bevilacqua Yanai Duran Ryea Maswood David A Parfitt Takao Iwawaki Giannis Spyrou Alexander J Smith Robin R Ali Michael E Cheetham

Hum Mol Genet 2020 May;29(8):1310-1318

UCL Institute of Ophthalmology, London EC1V 9EL, UK.

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May 2020

IRE1α Promotes Zika Virus Infection via XBP1.

Authors:

Elena P Kolpikova Ana R Tronco Andreas B den Hartigh Konner J Jackson Takao Iwawaki Susan L Fink

Viruses 2020 03 3;12(3). Epub 2020 Mar 3.

Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

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March 2020

Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescenceafter Cre/loxP-mediated recombination.

Authors:

Ryoko Akai Michiko Saito Kenji Kohno Takao Iwawaki

Exp Anim 2020 Aug 1;69(3):306-318. Epub 2020 Mar 1.

Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan.

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August 2020

Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model.

Authors:

Sahori Yamazaki Akiko Sekiguchi Akihiko Uchiyama Chisako Fujiwara Yuta Inoue Yoko Yokoyama Sachiko Ogino Ryoko Torii Mari Hosoi Ryoko Akai Takao Iwawaki Osamu Ishikawa Sei-Ichiro Motegi

Sci Rep 2020 Jan 28;10(1):1349. Epub 2020 Jan 28.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

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January 2020

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD.

Blood 2019 11;134(19):1670-1682

Division of Blood and Marrow Transplantation, Department of Pediatrics.

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November 2019

Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress.

Authors:

Akiko Sekiguchi Sei-Ichiro Motegi Chisako Fujiwara Sahori Yamazaki Yuta Inoue Akihiko Uchiyama Ryoko Akai Takao Iwawaki Osamu Ishikawa

J Dermatol Sci 2019 Oct 16;96(1):8-17. Epub 2019 Aug 16.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

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October 2019

MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.

Authors:

Keisuke Takeda Shun Nagashima Isshin Shiiba Aoi Uda Takeshi Tokuyama Naoki Ito Toshifumi Fukuda Nobuko Matsushita Satoshi Ishido Takao Iwawaki Takashi Uehara Ryoko Inatome Shigeru Yanagi

EMBO J 2019 08 13;38(15):e100999. Epub 2019 Jun 13.

Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

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August 2019

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin.

Authors:

Hideharu Nakamura Akiko Sekiguchi Youichi Ogawa Tatsuyoshi Kawamura Ryoko Akai Takao Iwawaki Takaya Makiguchi Satoshi Yokoo Osamu Ishikawa Sei-Ichiro Motegi

J Dermatol Sci 2019 Aug 12;95(2):62-69. Epub 2019 Jul 12.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan. Electronic address:

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August 2019

IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.

Science 2019 07;365(6450)

Weill Cornell Graduate School of Medical Sciences, Cornell University. New York, NY 10065, USA.

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July 2019

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1.

Authors:

Takafumi Suzuki Aki Muramatsu Ryota Saito Tatsuro Iso Takahiro Shibata Keiko Kuwata Shin-Ichi Kawaguchi Takao Iwawaki Saki Adachi Hiromi Suda Masanobu Morita Koji Uchida Liam Baird Masayuki Yamamoto

Cell Rep 2019 07;28(3):746-758.e4

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan. Electronic address:

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July 2019

ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin.

Authors:

Mee-Sun Kim Eun-Je Yi Young-In Kim So Hee Kim Yi-Sook Jung Seong-Ryeol Kim Takao Iwawaki Hyun-Jeong Ko Sun-Young Chang

Front Immunol 2019 4;10:1249. Epub 2019 Jun 4.

College of Pharmacy, and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon-si, South Korea.

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October 2020

Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients.

Authors:

Eirini Apostolou Petros Moustardas Takao Iwawaki Athanasios G Tzioufas Giannis Spyrou

Front Immunol 2019 22;10:506. Epub 2019 Mar 22.

Division of Microbiology and Molecular Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

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September 2020

Correction: IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.

Authors:

Yuichi Tsuchiya Michiko Saito Hiroshi Kadokura Jun-Ichi Miyazaki Fumi Tashiro Yusuke Imagawa Takao Iwawaki Kenji Kohno

J Cell Biol 2019 May 29;218(5):1764. Epub 2019 Mar 29.

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May 2019

Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.

Authors:

Lu Liu Meiling Zhao Xi Jin Gina Ney Kevin B Yang Fanglue Peng Jin Cao Takao Iwawaki Juan Del Valle Xi Chen Qing Li

Nat Cell Biol 2019 03 18;21(3):328-337. Epub 2019 Feb 18.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

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March 2019

IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8 T Cell Priming.

Authors:

Bernardita Medel Cristobal Costoya Dominique Fernandez Cristian Pereda Alvaro Lladser Daniela Sauma Rodrigo Pacheco Takao Iwawaki Flavio Salazar-Onfray Fabiola Osorio

Front Immunol 2018 4;9:3050. Epub 2019 Jan 4.

Program of Immunology, Laboratory of Immunology and Cellular Stress, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile.

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October 2019