Publications by authors named "Takao Iwawaki"

97 Publications

Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain.

Arch Toxicol 2021 Jan 16. Epub 2021 Jan 16.

Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8530, Japan.

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January 2021

Role of IRE1α in podocyte proteostasis and mitochondrial health.

Cell Death Discov 2020 Nov 19;6(1):128. Epub 2020 Nov 19.

Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, QC, Canada.

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November 2020

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.

Cell Death Differ 2020 Nov 20. Epub 2020 Nov 20.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

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November 2020

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.

PLoS Biol 2020 06 10;18(6):e3000687. Epub 2020 Jun 10.

The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, California, United States of America.

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June 2020

IRE1α Promotes Zika Virus Infection via XBP1.

Viruses 2020 03 3;12(3). Epub 2020 Mar 3.

Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

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March 2020

Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescenceafter Cre/loxP-mediated recombination.

Exp Anim 2020 Aug 1;69(3):306-318. Epub 2020 Mar 1.

Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan.

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August 2020

MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.

EMBO J 2019 08 13;38(15):e100999. Epub 2019 Jun 13.

Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

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August 2019

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin.

J Dermatol Sci 2019 Aug 12;95(2):62-69. Epub 2019 Jul 12.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan. Electronic address:

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August 2019

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1.

Cell Rep 2019 07;28(3):746-758.e4

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan. Electronic address:

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July 2019

ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin.

Front Immunol 2019 4;10:1249. Epub 2019 Jun 4.

College of Pharmacy, and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon-si, South Korea.

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October 2020

Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients.

Front Immunol 2019 22;10:506. Epub 2019 Mar 22.

Division of Microbiology and Molecular Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

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September 2020

IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8 T Cell Priming.

Front Immunol 2018 4;9:3050. Epub 2019 Jan 4.

Program of Immunology, Laboratory of Immunology and Cellular Stress, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile.

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October 2019

Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of .

Front Cell Infect Microbiol 2018 20;8:103. Epub 2018 Apr 20.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Plant Sciences, Jilin University, Changchun, China.

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April 2019

IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.

J Cell Biol 2018 04 5;217(4):1287-1301. Epub 2018 Mar 5.

Graduate School of Biological Sciences and Institute for Research Initiatives, Nara Institute of Science and Technology, Ikoma, Japan

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April 2018