Publications

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
Biochem Biophys Res Commun 2017 Jun 5;488(1):159-164. Epub 2017 May 5.
Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.
Development 2017 Feb 19;144(3):385-399. Epub 2016 Dec 19.
Laboratory of Neural Differentiation, Graduate School of Brain Science, Doshisha University, Kyoto 6190225, Japan

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
Cell Rep 2017 Feb;18(9):2228-2242
The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:





Crystal structure of the anion exchanger domain of human erythrocyte band 3.
Science 2015 Nov;350(6261):680-4
Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Human Receptor Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. JST, Research Acceleration Program, Membrane Protein Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. Department of Cell Biology, Kyoto University Faculty of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. Division of Molecular Biosciences, Membrane Protein Crystallography group, Imperial College London, London SW7 2AZ, UK. Membrane Protein Laboratory, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Chilton, Oxfordshire OX11 0DE, UK. Research Complex at Harwell Rutherford, Appleton Laboratory, Harwell Oxford, Didcot, Oxfordshire OX11 0FA, UK. Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.

Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.
J Biochem 2015 Oct 21;158(4):331-8. Epub 2015 May 21.
Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0321, Japan; and

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
Biochem Biophys Res Commun 2015 Oct 18;465(4):725-31. Epub 2015 Aug 18.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:



Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.
J Immunol 2015 May 8;194(10):4963-73. Epub 2015 Apr 8.
Hungarian Academy of Sciences-Eötvös Loránd University "Lendület" Complement Research Group, Department of Immunology, Eötvös Loránd University, 1117 Budapest, Hungary; Junior Research Group for Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, 07745 Jena, Germany;



Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Nat Med 2015 Jan 8;21(1):19-26. Epub 2014 Dec 8.
1] Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan. [2] Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan.


Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.
Clin Transl Med 2014 Dec 22;3(1):61. Epub 2014 Nov 22.
First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan ; Clinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC D13, 221 84 Lund, Sweden ; Center of Excellence in Biological and Medical mass spectrometry (CEBMMS), 221 84 Lund, Sweden.

Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.
Mol Pharmacol 2014 Sep 23;86(3):252-62. Epub 2014 Jun 23.
Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, Illinois (M.P., A.V.K., T.Ko.); Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia (T. Ka.); and Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan (N.S., T.H., T.Ko.).

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis.
Sci Signal 2014 Sep 16;7(343):ra88. Epub 2014 Sep 16.
Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

Immunostaining of oxidized DJ-1 in human and mouse brains.
J Neuropathol Exp Neurol 2014 Jul;73(7):714-28
From the Systems Life Sciences (YS, KH, YM, NN) and Neuropathology (TM, YI), Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University, Kyotanabe, Kyoto; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology (HH, SM); Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo (OK-A, HI, TH); and Institute of Immunology Co Ltd (OK-A), Tokyo; Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka (YY, EN); and Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo (KT-N, HA), Japan.




A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.
Dev Cell 2013 Dec;27(5):516-29
Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:



Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.
Arterioscler Thromb Vasc Biol 2013 Apr 24;33(4):805-13. Epub 2013 Jan 24.
Department of Medicine, Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott, M/C868, E403 MSB, Chicago, IL 60612, USA.

Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.
J Biol Chem 2012 Nov 12;287(48):40256-65. Epub 2012 Oct 12.
Department of Cancer Biology, Division of Oncology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Tokyo 108-8639, Japan.


The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps.
Mol Cell Proteomics 2012 Jun 25;11(6):M111.015073. Epub 2012 Jan 25.
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

Creation and biochemical analysis of a broad-specific claudin binder.
Biomaterials 2012 Apr 7;33(12):3464-74. Epub 2012 Feb 7.
Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody.
Nature 2012 Jan 29;482(7384):237-40. Epub 2012 Jan 29.
Iwata Human Receptor Crystallography Project, ERATO, Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner.
Biochem Biophys Res Commun 2011 Dec 6;415(4):709-13. Epub 2011 Nov 6.
Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.
J Immunol Methods 2011 Jun 3;369(1-2):108-14. Epub 2011 May 3.
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.


Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis.
Pathol Int 2011 May 17;61(5):290-7. Epub 2011 Mar 17.
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Chuou-ku, Niigata, Japan.

The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma.
Histopathology 2011 Feb 23;58(3):467-76. Epub 2011 Feb 23.
Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Hospital, Niigata, Japan.

Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.
Neurosci Lett 2010 Oct 11;483(3):201-5. Epub 2010 Aug 11.
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan.



Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
J Biol Chem 2009 Oct 14;284(41):27838-47. Epub 2009 Aug 14.
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

A wave of nascent transcription on activated human genes.
Proc Natl Acad Sci U S A 2009 Oct 13;106(43):18357-61. Epub 2009 Oct 13.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
J Biol Chem 2009 Aug 24;284(33):22195-205. Epub 2009 Jun 24.
Graduate School of Pharmaceutical Sciences, Osaka University, Department of Molecular Pharmaceutical Science, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.



Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95.
J Cell Biol 2009 Jul;186(1):147-60
Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.

COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
Pathol Int 2009 Mar;59(3):152-60
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.
J Biol Chem 2009 Feb 23;284(9):5592-601. Epub 2008 Dec 23.
Department of Structural Analysis, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells.
Biochem Biophys Res Commun 2009 Jan 18;378(2):279-84. Epub 2008 Nov 18.
Research Laboratories, Chugai Pharmaceutical Co. Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.

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