Takao Hamakubo

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Takao Hamakubo

Publications by authors named "Takao Hamakubo"

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100Publications

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Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody.

J Biochem 2018 Jul;164(1):65-76

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan.

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July 2018

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.

Mol Cell Biol 2018 Jun 4. Epub 2018 Jun 4.

Department of Diabetes and Metabolic Diseases Department of Molecular Sciences on Diabetes Graduate School of Medicine, Translational Systems Biology and Medicine Initiative (TSBMI) Research Center for Advanced Science and Technology the University of Tokyo, Tokyo, Japan; Department of Home Economics, Otsuma Women's University, Tokyo, Japan

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June 2018

Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17.

Monoclon Antib Immunodiagn Immunother 2018 Feb;37(1):1-11

1 Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo , Tokyo, Japan .

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February 2018

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells.

Stem Cell Reports 2018 Jan 14;10(1):272-286. Epub 2017 Dec 14.

Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan. Electronic address:

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January 2018

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.

Sci Rep 2017 Oct 2;7(1):12494. Epub 2017 Oct 2.

Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.

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October 2017

Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen.

J Biochem 2017 Sep;162(3):203-210

Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Japan.

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September 2017

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

Biochem Biophys Res Commun 2017 06 5;488(1):159-164. Epub 2017 May 5.

Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

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June 2017

Visualization of ligand-induced G-protein activation in chemotaxing cells.

FASEB J 2017 03 23;31(3):910-919. Epub 2016 Nov 23.

Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan; and

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March 2017

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

Cell Rep 2017 02;18(9):2228-2242

The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

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February 2017

Optical inactivation of synaptic AMPA receptors erases fear memory.

Nat Biotechnol 2017 Jan 5;35(1):38-47. Epub 2016 Dec 5.

Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, Japan.

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January 2017

The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs.

Front Immunol 2016 7;7:344. Epub 2016 Sep 7.

Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology , The University of Tokyo, Tokyo , Japan.

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September 2016

Kinetic exclusion assay of monoclonal antibody affinity to the membrane protein Roundabout 1 displayed on baculovirus.

Anal Biochem 2016 07 16;504:41-9. Epub 2016 Apr 16.

Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan. Electronic address:

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July 2016

Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 In Vitro.

Microcirculation 2016 Apr;23(3):240-7

Department of Haematology, Manchester Royal Infirmary, Liverpool, UK.

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April 2016

Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4.

Biochem Biophys Res Commun 2016 Jan 20;469(4):797-802. Epub 2015 Dec 20.

Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan. Electronic address:

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January 2016

Crystal structure of the anion exchanger domain of human erythrocyte band 3.

Science 2015 Nov;350(6261):680-4

Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Human Receptor Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. JST, Research Acceleration Program, Membrane Protein Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. Department of Cell Biology, Kyoto University Faculty of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. Division of Molecular Biosciences, Membrane Protein Crystallography group, Imperial College London, London SW7 2AZ, UK. Membrane Protein Laboratory, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Chilton, Oxfordshire OX11 0DE, UK. Research Complex at Harwell Rutherford, Appleton Laboratory, Harwell Oxford, Didcot, Oxfordshire OX11 0FA, UK. Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.

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November 2015

Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.

J Biochem 2015 Oct 21;158(4):331-8. Epub 2015 May 21.

Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0321, Japan; and

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October 2015

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.

Biochem Biophys Res Commun 2015 Oct 18;465(4):725-31. Epub 2015 Aug 18.

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

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October 2015

MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells.

Stem Cell Reports 2015 Sep 23;5(3):365-77. Epub 2015 Jul 23.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-Ku, Tokyo 160-8582, Japan. Electronic address:

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September 2015

Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.

J Immunol 2015 May 8;194(10):4963-73. Epub 2015 Apr 8.

Hungarian Academy of Sciences-Eötvös Loránd University "Lendület" Complement Research Group, Department of Immunology, Eötvös Loránd University, 1117 Budapest, Hungary; Junior Research Group for Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, 07745 Jena, Germany;

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May 2015

Differential expression of pentraxin 3 in neutrophils.

Exp Mol Pathol 2015 Feb 20;98(1):33-40. Epub 2014 Nov 20.

Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address:

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February 2015

Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.

Nat Med 2015 Jan 8;21(1):19-26. Epub 2014 Dec 8.

1] Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan. [2] Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan.

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January 2015

Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.

Clin Transl Med 2014 Dec 22;3(1):61. Epub 2014 Nov 22.

First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan ; Clinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC D13, 221 84 Lund, Sweden ; Center of Excellence in Biological and Medical mass spectrometry (CEBMMS), 221 84 Lund, Sweden.

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December 2014

Generation of antibodies against membrane proteins.

Biochim Biophys Acta 2014 Nov 15;1844(11):1920-1924. Epub 2014 Aug 15.

Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.

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November 2014

Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.

Mol Pharmacol 2014 Sep 23;86(3):252-62. Epub 2014 Jun 23.

Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, Illinois (M.P., A.V.K., T.Ko.); Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia (T. Ka.); and Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan (N.S., T.H., T.Ko.).

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September 2014

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis.

Sci Signal 2014 Sep 16;7(343):ra88. Epub 2014 Sep 16.

Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

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September 2014

Laboratory-size three-dimensional x-ray microscope with Wolter type I mirror optics and an electron-impact water window x-ray source.

Rev Sci Instrum 2014 Sep;85(9):093701

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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September 2014

Immunostaining of oxidized DJ-1 in human and mouse brains.

J Neuropathol Exp Neurol 2014 Jul;73(7):714-28

From the Systems Life Sciences (YS, KH, YM, NN) and Neuropathology (TM, YI), Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University, Kyotanabe, Kyoto; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology (HH, SM); Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo (OK-A, HI, TH); and Institute of Immunology Co Ltd (OK-A), Tokyo; Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka (YY, EN); and Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo (KT-N, HA), Japan.

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July 2014

A baculoviral display system to assay viral entry.

Biol Pharm Bull 2013 ;36(11):1867-9

Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University.

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June 2014

Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex.

Anal Bioanal Chem 2014 May 21;406(12):2957-64. Epub 2014 Mar 21.

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Meguro-ku, Tokyo, 153-8904, Japan.

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May 2014

Identification and characterization of the X-dimer of human P-cadherin: implications for homophilic cell adhesion.

Biochemistry 2014 Mar 10;53(11):1742-52. Epub 2014 Mar 10.

Department of Chemistry & Biotechnology, The University of Tokyo , Tokyo 108-8639, Japan.

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March 2014

A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.

Dev Cell 2013 Dec;27(5):516-29

Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

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December 2013

Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.

Cell Signal 2013 Nov 29;25(11):2085-92. Epub 2013 Jun 29.

Department of Pharmacology, University of Illinois at Chicago, 835 S. Wolcott Avenue Room E403 (m/c 868), Chicago, IL 60612, USA.

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November 2013

Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.

J Biol Chem 2013 Nov 7;288(46):33292-302. Epub 2013 Oct 7.

From the Department of Quantitative Biology and Medicine and.

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November 2013

A novel monoclonal antibody against the C-terminal region of aquaporin-4.

Monoclon Antib Immunodiagn Immunother 2013 Aug;32(4):270-6

Department of Pharmacology, School of Medicine, Keio University, Shinjyuku-ku, Tokyo, Japan.

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August 2013

Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.

Arterioscler Thromb Vasc Biol 2013 Apr 24;33(4):805-13. Epub 2013 Jan 24.

Department of Medicine, Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott, M/C868, E403 MSB, Chicago, IL 60612, USA.

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April 2013

Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin.

Protein Sci 2013 Feb 4;22(2):213-21. Epub 2013 Jan 4.

Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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February 2013

Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.

J Biol Chem 2013 Jan 27;288(2):1009-21. Epub 2012 Nov 27.

Department of Molecular Biology and Medicine, The University of Tokyo, Tokyo 153-8904, Japan.

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January 2013

Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps.

Front Immunol 2012 13;3:378. Epub 2012 Dec 13.

Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo Tokyo, Japan.

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December 2012

Functional reconstitution of olfactory receptor complex on baculovirus.

Chem Senses 2012 Nov 5;37(9):837-47. Epub 2012 Sep 5.

Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Tokyo 153-8904, Japan.

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November 2012

Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.

J Biol Chem 2012 Nov 12;287(48):40256-65. Epub 2012 Oct 12.

Department of Cancer Biology, Division of Oncology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Tokyo 108-8639, Japan.

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November 2012

Evaluation of the asparagine synthetase level in leukemia cells by monoclonal antibodies.

Hybridoma (Larchmt) 2012 Oct;31(5):325-32

Department of Molecular Biology and Medicine, The University of Tokyo, Meguro, Tokyo, Japan.

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October 2012

Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin.

Mol Biosyst 2012 Aug 7;8(8):2050-3. Epub 2012 Jun 7.

Department of Medical Genome Sciences, The University of Tokyo, Tokyo 108-8639, Japan.

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August 2012

Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1.

Biosci Biotechnol Biochem 2012 ;76(3):486-94

Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo, Japan.

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July 2012

The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps.

Mol Cell Proteomics 2012 Jun 25;11(6):M111.015073. Epub 2012 Jan 25.

Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

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June 2012

Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione.

PLoS One 2011 21;6(11):e27883. Epub 2011 Nov 21.

Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University, Tatara, Kyotanabe, Kyoto, Japan.

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April 2012

Creation and biochemical analysis of a broad-specific claudin binder.

Biomaterials 2012 Apr 7;33(12):3464-74. Epub 2012 Feb 7.

Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

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April 2012

The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice.

Biomaterials 2012 Jan 7;33(1):317-24. Epub 2011 Oct 7.

Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

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January 2012

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody.

Nature 2012 Jan 29;482(7384):237-40. Epub 2012 Jan 29.

Iwata Human Receptor Crystallography Project, ERATO, Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

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January 2012

Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner.

Biochem Biophys Res Commun 2011 Dec 6;415(4):709-13. Epub 2011 Nov 6.

Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

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December 2011

Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.

Eur J Cell Biol 2011 Aug 21;90(8):657-64. Epub 2011 Apr 21.

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

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August 2011

Mutated C-terminal fragments of Clostridium perfringens enterotoxin have increased affinity to claudin-4 and reversibly modulate tight junctions in vitro.

Biochem Biophys Res Commun 2011 Jul 6;410(3):466-70. Epub 2011 Jun 6.

Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

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July 2011

A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.

J Immunol Methods 2011 Jun 3;369(1-2):108-14. Epub 2011 May 3.

Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.

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June 2011

Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis.

Pathol Int 2011 May 17;61(5):290-7. Epub 2011 Mar 17.

Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Chuou-ku, Niigata, Japan.

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May 2011

Visual observation of avidin-biotin affinity by fluorescent G4.5 poly(amidoamine) dendrimer.

Colloids Surf B Biointerfaces 2011 Mar 2;83(1):58-60. Epub 2010 Nov 2.

Graduate School of Science and Technology, Keio University, Hiyoshi, Yokohama 223-8522, Japan.

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March 2011

A novel screening system for claudin binder using baculoviral display.

PLoS One 2011 Feb 14;6(2):e16611. Epub 2011 Feb 14.

Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.

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February 2011

The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma.

Histopathology 2011 Feb 23;58(3):467-76. Epub 2011 Feb 23.

Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Hospital, Niigata, Japan.

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February 2011

Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.

Neurosci Lett 2010 Oct 11;483(3):201-5. Epub 2010 Aug 11.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan.

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October 2010

Mucosal vaccination using claudin-4-targeting.

Biomaterials 2010 Jul;31(20):5463-71

Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

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July 2010

Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

FEBS Lett 2010 Jul 13;584(13):2909-15. Epub 2010 May 13.

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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July 2010

A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide.

Biochem Pharmacol 2010 May 21;79(10):1437-44. Epub 2010 Jan 21.

Department of Biopharmaceuticals Research, Biopharma Center, Asubio Pharma Co., Ltd., Gunma, Japan.

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May 2010

Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3.

Blood 2010 Mar 23;115(12):2520-32. Epub 2009 Nov 23.

Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

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March 2010

Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells.

Biochem Biophys Res Commun 2009 Nov 11;389(3):501-5. Epub 2009 Sep 11.

Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.

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November 2009

Expression of the mouse PR domain protein Prdm8 in the developing central nervous system.

Gene Expr Patterns 2009 Oct 16;9(7):503-14. Epub 2009 Jul 16.

Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, Kyoto 606-8507, Japan.

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October 2009

A novel tumor-targeted therapy using a claudin-4-targeting molecule.

Mol Pharmacol 2009 Oct 28;76(4):918-26. Epub 2009 Jul 28.

Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

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October 2009

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

J Biol Chem 2009 Oct 14;284(41):27838-47. Epub 2009 Aug 14.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2009

Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.

J Biol Chem 2009 Aug 24;284(33):22195-205. Epub 2009 Jun 24.

Graduate School of Pharmaceutical Sciences, Osaka University, Department of Molecular Pharmaceutical Science, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

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August 2009

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95.

J Cell Biol 2009 Jul;186(1):147-60

Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.

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July 2009

COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.

Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.

Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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April 2009