SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33596513 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 17 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1878-7487 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 78 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Jan [Day] => 21 ) ) [Title] => Journal of forensic and legal medicine [ISOAbbreviation] => J Forensic Leg Med ) [ArticleTitle] => Acute abdominal disease with nonspecific symptoms in the elderly: A case series. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 102089 ) [ELocationID] => Array ( [0] => S1752-928X(20)30196-7 [1] => 10.1016/j.jflm.2020.102089 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Acute stomach disease in elderly patients often lacks characteristic clinical manifestations. Presentations may differ from those in younger patients and are often complicated by concomitant diseases, delayed presentation, and misdiagnosis. Incorrect diagnosis and treatment can lead to medical-related death claims. We investigated eight cases of elderly fatality due to acute abdominal diseases in forensic autopsy cases. Although most fatalities were unwitnessed, possibly due to the characteristics of elderly individuals, recent social backgrounds, and involvement with health care, some cases of possible misdiagnosis suggested that physicians should carefully consider atypical clinical manifestations and the characteristics of elderly individuals when the managing abdominal symptoms, particularly in primary health care. Our investigation of these forensic autopsy cases indicated the particular importance of peritoneal adhesions as an unexpected cause of acute abdomen in the elderly due to strangulation ileus, even among those with no history of abdominal surgery or trauma. Diagnosis of acute stomach symptoms can be difficult in elderly patients. Pathophysiological examination and autopsy analyses can thus contribute to early-stage diagnosis and prevention of acute stomach symptoms in elderly patient populations. [CopyrightInformation] => Copyright © 2020. Published by Elsevier Ltd. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Kei [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: ikeda.kei@med.osaka-cu.ac.jp. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, C/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: ikeda.tomoya@med.osaka-cu.ac.jp. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, C/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: tani.naoto@med.osaka-cu.ac.jp. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shida [ForeName] => Alissa [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: shida.alissa@med.osaka-cu.ac.jp. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Aoki [ForeName] => Yayoi [Initials] => Y [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: aoki.yayoi@med.osaka-cu.ac.jp. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Morioka [ForeName] => Fumiya [Initials] => F [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: f.morioka@med.osaka-cu.ac.jp. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, C/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: takaki@med.osaka-cu.ac.jp. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 01 [Day] => 21 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => J Forensic Leg Med [NlmUniqueID] => 101300022 [ISSNLinking] => 1752-928X ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Acute abdominal disease [1] => Asymptomatic [2] => Elderly [3] => Forensic [4] => Medical-related death [5] => Trauma ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2019 [Month] => 11 [Day] => 08 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 10 [Day] => 22 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 11 [Day] => 14 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 17 [Hour] => 20 [Minute] => 6 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 18 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 18 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33596513 [1] => S1752-928X(20)30196-7 [2] => 10.1016/j.jflm.2020.102089 ) ) ) ) [1] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Process [Owner] => NLM ) [PMID] => 33532907 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 23 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1749-0774 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 34 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Mar ) ) [Title] => Human cell [ISOAbbreviation] => Hum Cell ) [ArticleTitle] => Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 400-418 ) [ELocationID] => 10.1007/s13577-020-00481-0 [Abstract] => SimpleXMLElement Object ( [AbstractText] => This study aimed to investigate the changes associated with acute systemic hypoxia in the endocrine system, particularly in pancreatic tissues. The investigation was based on macroscopic, pathohistological, biochemical, and molecular biological findings in cell lines and human cadavers. The results showed that cases of death due to asphyxia more frequently showed severe subcapsular/interstitial hemorrhage versus the other causes of death. Histological examination showed that asphyxia cases were associated with severe morphological changes. Although measured insulin levels in the asphyxia were higher compared to other causes of death, no differences were noted for the glucagon and amylase levels with regard to the cause of death. Increased blood insulin levels were not associated with macro- and micromorphological changes, and did not show any association with glucose or cortisol levels. The experiment conducted under hypoxic conditions in cultured cells demonstrated that insulin mRNA expression and insulin protein levels peaked at 10 min after hypoxia exposure. However, there were no changes in either the amylase mRNA or protein levels. Corticosterone level peaked at 120 min after exposure to hypoxic conditions. Overall, acute systemic hypoxic conditions can directly affect the mechanisms involved in pancreatic insulin secretion. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Morioka [ForeName] => Fumiya [Initials] => F [Identifier] => http://orcid.org/0000-0002-1280-8643 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. fmorioka@med.osaka-cu.ac.jp. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. ) [1] => SimpleXMLElement Object ( 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Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. ) [1] => SimpleXMLElement Object ( [Affiliation] => Forensic Autopsy Section, Medico-Legal Consultation and Postmortem Investigation Support Center (MLCPI-SC), Osaka, Japan. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 02 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Japan [MedlineTA] => Hum Cell [NlmUniqueID] => 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Effects of intermittent hypoxia on pulmonary vascular and systemic diseases. Int J Environ Res Public Health. 2019;16:3101. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 6747246 ) ) [1] => SimpleXMLElement Object ( [Citation] => Prisby RD. Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone. J Endocrinol. 2017;235:R77–100. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 28814440 [1] => 5611884 ) ) ) [2] => SimpleXMLElement Object ( [Citation] => Xing J, Ying Y, Mao C, et al. Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota. Nat Commun. 2018;9:2020. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 29789585 [1] => 5964076 ) ) ) [3] => SimpleXMLElement Object ( [Citation] => Fisher DA. Endocrinology of fatal development. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, editors. Williams textbook of endocrinology, 11th ed. Philadelphia, PA: Saunders; 2007. p. 755–82. ) [4] => SimpleXMLElement Object ( [Citation] => Fink G, Pfaff DW, Levine JE, editors. Handbook of Neuroendocrinology. 1st ed. Cambridge (MA): Academic Press; 2011. ) [5] => SimpleXMLElement Object ( [Citation] => Tani N, Ikeda T, Shida A, Aoki Y, Oritani S, Ishikawa T. Postmortem water contents of major organs with regard to the cause of death. J Forensic Leg Med. 2019;65:48–54. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 31103923 ) ) [6] => SimpleXMLElement Object ( [Citation] => Zeng Y, Lv Y, Tao L, et al. G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers. Oncotarget. 2016;7:74526–36. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 27793029 [1] => 5342684 ) ) ) [7] => SimpleXMLElement Object ( [Citation] => Tani N, Ishikawa M, Watanabe M, Ikeda T, Ishikawa T. Thyroid-related hormones as potential markers of hypoxia/ischemia. Hum Cell. 2020;33:545–58. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32146707 [1] => 7324426 ) ) ) [8] => SimpleXMLElement Object ( [Citation] => Tani N, Ikeda T, Watanabe M, Toyomura J, Ohyama A, Ishikawa T. Prolactin selectively transported to cerebrospinal fluid from blood under hypoxic/ischemic conditions. PLoS ONE. 2018;13:e0198673. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 29949606 [1] => 6021042 ) ) ) [9] => SimpleXMLElement Object ( [Citation] => Michiue T, Ishikawa T, Kawamoto O, et al. Postmortem serum levels of amylase and gamma glutamyl transferase (GGT) as markers of systemic tissue damage in forensic autopsy. Leg Med (Tokyo). 2013;15:79–84. ) [10] => SimpleXMLElement Object ( [Citation] => Zhu BL, Ishikawa T, Michiue T, et al. Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 1. Analysis with special regard to traumatic causes of death. Leg Med (Tokyo). 2006;8:86–93. ) [11] => SimpleXMLElement Object ( [Citation] => Greco AV, Crucitti F, Ghirlanda G, et al. Insulin and glucagon concentrations in portal and peripheral veins in patients with hepatic cirrhosis. Diabetologia. 1979;17:23–8. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 467851 ) ) [12] => SimpleXMLElement Object ( [Citation] => Maneva-Radicheva L, Amatya C, Parker C, et al. Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. PLoS ONE. 2014;9:e107213. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 25259810 [1] => 4178025 ) ) ) [13] => SimpleXMLElement Object ( [Citation] => Feng F, Hu P, Chen L, et al. Display of human proinsulin on the Bacillus subtilis spore surface for oral administration. Curr Microbiol. 2013;67:1–8. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23380802 ) ) [14] => SimpleXMLElement Object ( [Citation] => Zheng H, Fu J, Xue P, et al. CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion. Antioxid Redox Signal. 2015;22:819–31. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 25556857 [1] => 4367236 ) ) ) [15] => SimpleXMLElement Object ( [Citation] => Vierra NC, Dickerson MT, Jordan KL, et al. TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. Mol Metab. 2018;9:84–97. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 29402588 [1] => 5870147 ) ) ) [16] => SimpleXMLElement Object ( [Citation] => Palmiere C, Sabatasso S, Torrent C, Rey F, Werner D, Bardy D. Post-mortem determination of insulin using chemiluminescence enzyme immunoassay: preliminary results. Drug Test Anal. 2015;7:797–803. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25641775 ) ) [17] => SimpleXMLElement Object ( [Citation] => Zhang X, Sun M, Zheng A, Cao D, Bi Y, Sun J. Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration. Eur J Pharm Sci. 2012;45:632–8. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22248882 ) ) [18] => SimpleXMLElement Object ( [Citation] => Bugelli V, Campobasso CP, Angelino A, Focardi M, Pinchi V. CLEIA of humor vitreous in a case of suicidal insulin overdose. Leg Med (Tokyo). 2019;40:22–5. ) [19] => SimpleXMLElement Object ( [Citation] => Tong F, Wu R, Huang W, et al. Forensic aspects of homicides by insulin overdose. Forensic Sci Int. 2017;278:9–15. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28686962 ) ) [20] => SimpleXMLElement Object ( [Citation] => Murata M, Adachi H, Nakade T, Oshima S. Glucagon secretion determined by the RIA method is lower in patients with low left ventricular ejection fraction: the new glass study. Diabetes Res Clin Pract. 2018;144:260–9. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30213772 ) ) [21] => SimpleXMLElement Object ( [Citation] => Ohneda A, Kobayashi T, Nihei J, Iwasa S, Kondo K. Measurement of glucagon in human plasma by enzyme immunoassay. J Immunoassay. 1983;4:339–49. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 6365976 ) ) [22] => SimpleXMLElement Object ( [Citation] => Hellman B, Salehi A, Gylfe E, Dansk H, Grapengiesser E. Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets. Endocrinology. 2009;150:5334–40. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19819962 ) ) [23] => SimpleXMLElement Object ( [Citation] => Morishita Y, Iinuma Y, Nakashima N, Majima K, Mizuguchi K, Kawamura Y. Total and pancreatic amylase measured with 2-chloro-4-nitrophenyl-4-O-beta-D-galactopyranosylmaltoside. Clin Chem. 2000;46:928–33. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10894835 ) ) [24] => SimpleXMLElement Object ( [Citation] => Lutz RA, Flückige J. Kinetic determination of glucose with the GEMSAEC (ENI) centrifugal analyzer by the glucose dehydrogenase reaction, and comparison with two commonly used procedures. Clin Chem. 1975;21:1372–7. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1157301 ) ) [25] => SimpleXMLElement Object ( [Citation] => Deeg R, Kraemer W, Ziegenhorn J. Kinetic determination of serum glucose by use of the hexokinase/glucose-6-phosphate dehydrogenase method. J Clin Chem Clin Biochem. 1980;18:49–52. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7359090 ) ) [26] => SimpleXMLElement Object ( [Citation] => Marks V, Lloyd K. Preservation of blood samples for glucose analysis by glucose-oxidase. Clin Chim Acta. 1963;8:326. ) [27] => SimpleXMLElement Object ( [Citation] => Benjamin EM. Self-monitoring of blood glucose: the basics. Clin Diabetes. 2002;20:45–7. ) [28] => SimpleXMLElement Object ( [Citation] => Weykamp C, John WG, Mosca A. A review of the challenge in measuring hemoglobin A1c. J Diabetes Sci Technol. 2009;3:439–45. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 20144280 [1] => 2769874 ) ) ) [29] => SimpleXMLElement Object ( [Citation] => Higgs P, Costa M, Freke A, Papasouliotis K. Measurement of thyroxine and cortisol in canine and feline blood samples using two immunoassay analysers. J Small Anim Pract. 2014;55:153–9. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24438095 ) ) [30] => SimpleXMLElement Object ( [Citation] => Irvine KL, Burt K, Hill AJ, Shaw S, Papasouliotis K. Initial analytic quality assessment and method comparison of an immunoassay for adrenocorticotropic hormone measurement in equine samples. Vet Clin Pathol. 2016;45:154–63. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26756538 ) ) [31] => SimpleXMLElement Object ( [Citation] => McClenaghan NH, Barnett CR, O’Harte FP, Swanston-Flatt SK, Ah-Sing E, Flatt PR. Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion. J Endocrinol. 1996;148:409–17. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8778219 ) ) [32] => SimpleXMLElement Object ( [Citation] => Rosewicz S, Riecken EO, Wiedenmann B. The amphicrine pancreatic cell line AR42J: a model system for combined studies on exocrine and endocrine secretion. Clin Investig. 1992;70:205–9. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1355676 ) ) [33] => SimpleXMLElement Object ( [Citation] => Dupuy G, Hilaire G, Aubry C. Rapid determination of alpha-amylase activity by use of a new chromogenic substrate. Clin Chem. 1987;33:524–8. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3103953 ) ) [34] => SimpleXMLElement Object ( [Citation] => Costa ET, Forti FL, Rocha KM, Moraes MS, Armelin HA. Molecular mechanisms of cell cycle control in the mouse Y1 adrenal cell line. Endocr Res. 2004;30:503–9. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15666780 ) ) [35] => SimpleXMLElement Object ( [Citation] => Yasumura Y, Buonassisi V, Sato G. Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype. Cancer Res. 1966;26:529–35. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 5930699 ) ) [36] => SimpleXMLElement Object ( [Citation] => Goymann W, Geue D, Schwabl I, et al. Testosterone and corticosterone during the breeding cycle of equatorial and European stonechats (Saxicola torquata axillaris and S. t. rubicola). Horm Behav. 2006;50:779–85. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16934809 ) ) [37] => SimpleXMLElement Object ( [Citation] => Vázquez-Palacios G, Retana-Márquez S, Bonilla-Jaime H, Velázquez-Moctezuma J. Further definition of the effect of corticosterone on the sleep-wake pattern in the male rat. Pharmacol Biochem Behav. 2001;70:305–10. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11701201 ) ) [38] => SimpleXMLElement Object ( [Citation] => Yamamoto N, Oyaizu T, Enomoto M, et al. VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration. Sci Rep. 2020;10:2744. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32066777 [1] => 7026099 ) ) ) [39] => SimpleXMLElement Object ( [Citation] => Kang HS, Kwon HY, Kim IK, et al. Intermittent hypoxia exacerbates tumor progression in a mouse model of lung cancer. Sci Rep. 2020;10:1854. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32024881 [1] => 7002457 ) ) ) [40] => SimpleXMLElement Object ( [Citation] => Sui Y, Zhang W, Tang T, et al. Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice. Stem Cell Res Ther. 2020;11:86. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32102690 [1] => 7045450 ) ) ) [41] => SimpleXMLElement Object ( [Citation] => Tani N, Ikeda T, Aoki Y, Shida A, Oritani S, Ishikawa T. Pathophysiological significance of clock genes BMAL1 and PER2 as erythropoietin-controlling factors in acute blood hemorrhage. Hum Cell. 2019;32:275–84. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30941700 ) ) [42] => SimpleXMLElement Object ( [Citation] => Tanaka F, Tominaga K, Fujikawa Y, et al. Concentration of glial cell line-derived neurotrophic factor positively correlates with symptoms in functional dyspepsia. Dig Dis Sci. 2016;61:3478–85. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27718082 ) ) [43] => SimpleXMLElement Object ( [Citation] => Bloch K, Vennäng J, Lazard D, Vardi P. Different susceptibility of rat pancreatic alpha and beta cells to hypoxia. Histochem Cell Biol. 2012;137:801–10. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22310982 ) ) [44] => SimpleXMLElement Object ( [Citation] => Eguchi R, Naitou H, Kunimasa K, et al. Proteomic analysis of hypoxia-induced tube breakdown of an in vitro capillary model composed of HUVECs: potential role of p38-regulated reduction of HSP27. Proteomics. 2008;8:2897–906. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18655027 ) ) [45] => SimpleXMLElement Object ( [Citation] => Kaur C, Sivakumar V, Foulds ES. Early response of neurons and glial cells to hypoxia in the retina. Invest Ophthalmol Vis Sci. 2006;47:1126–41. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16505051 ) ) [46] => SimpleXMLElement Object ( [Citation] => Olshaker JS. Near drowning. Emerg Med Clin North Am. 1992;10:339–50. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1559473 ) ) [47] => SimpleXMLElement Object ( [Citation] => Zhu BL, Ishida K, Quan L, et al. Pulmonary immunohistochemistry and serum levels of a surfactant-associated protein A in fatal drowning. Leg Med (Tokyo). 2002;4:1–6. ) [48] => SimpleXMLElement Object ( [Citation] => Sawaguchi A, Funao T. Changes in blood glucose and related hormones in experimental asphyxia. Kitasato Med. 1976;6:238–44. ) [49] => SimpleXMLElement Object ( [Citation] => Shida A, Ikeda T, Tani N, et al. Cortisol levels after cold exposure are independent of adrenocorticotropic hormone stimulation. PLoS ONE. 2020;15:e0218910. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32069307 [1] => 7028257 ) ) ) [50] => SimpleXMLElement Object ( [Citation] => Weiss M, Steiner DF, Philipson LH, et al. Insulin biosynthesis, secretion, structure, and structure-activity relationships. Endotext. 2000–2014; https://pubmed.ncbi.nlm.nih.gov/25905258/ ) [51] => SimpleXMLElement Object ( [Citation] => Maeda H, Ishikawa T, Michiue T. Forensic biochemistry for functional investigation of death: concept and practical application. Leg Med (Tokyo). 2011;13:55–67. ) ) ) ) ) [2] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [IndexingMethod] => Curated [Owner] => NLM ) [PMID] => 33076672 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 07 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 14 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 0371-1854 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Print ) [Volume] => 65 [Issue] => 3 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Season] => Summer ) ) [Title] => Soudni lekarstvi [ISOAbbreviation] => Soud Lek ) [ArticleTitle] => Analysis of fatal industrial accidents in forensic postmortem investigations in South Osaka. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 56-60 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Předkládaná studie zkoumala aktuální stav a příčiny smrtelných pracovních úrazů ze zdravotně-sociálního hlediska. Retrospektivně jsme hodnotili případy smrtelných pracovních úrazů mezi lety 2007 a 2016 v Ósace, která je druhým nejlidnatějším městem v Japonsku, z forenzních posmrtných dat 1689 zemřelých. Z těchto případů jsme analyzovali celkem 57 smrtelných průmyslových nehod. Oběťmi byli typicky muži v relativně pokročilém věku pracující generace, téměř polovina případů (přesněji 28) byli muži mezi 50 a 70 lety života. Nejčastějším typem nehody byl pád z výše (24 případů) a nejčastějším místem, kde k nehodám docházelo, bylo staveniště (28 případů). Většina nehod (29 případů) se odehrála na pracovišti s malým pracovním týmem. V 60 % případů oběť na sobě neměla ochranou helmu a ve 34 případech (60 %) byla nehoda připisována vlastní nedbalosti. Nehody se nejčastěji stávaly v úterý. Nejběžnější doba, kdy k nehodám docházelo, byla kolem 10. a 11. hodiny dopolední a kolem 1. a 2. hodiny odpolední. V přibližně 60 % případů žaludeční obsah zahrnoval i zbytky potravy, což naznačuje, že k nehodám typicky docházelo po jídle. V předkládané studii jsme zjistili, že pracovní nehody, z nichž nejčastější byl pád z výše, vykazují tendenci se vyskytovat na pracovišti s malým pracovním týmem. Pouze pár obětí mělo na sobě ochranou helmu. Tato zjištění naznačují, že na pracovištích by měly být důkladně zaváděny systémy monitorování a řízení bezpečnosti a že pracovníci by měli před i po jídle dbát zvýšené opatrnosti. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Naoto [ForeName] => Tani [Initials] => T ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tomoya [ForeName] => Ikeda [Initials] => I ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shigeki [ForeName] => Oritani [Initials] => O ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Fumiya [ForeName] => Morioka [Initials] => M ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kei [ForeName] => Ikeda [Initials] => I ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Alissa [ForeName] => Shida [Initials] => S ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Yayoi [ForeName] => Aoki [Initials] => A ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Takaki [ForeName] => Ishikawa [Initials] => I ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [VernacularTitle] => Analýza fatálních industriálních nehod v soudnělékařském zkoumání v oblasti jižní Osaky. ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Czech Republic [MedlineTA] => Soud Lek [NlmUniqueID] => 9601665 [ISSNLinking] => 0371-1854 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Accidents, Occupational ) [1] => SimpleXMLElement Object ( [DescriptorName] => Autopsy ) [2] => SimpleXMLElement Object ( [DescriptorName] => Industry ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => construction site [1] => factory [2] => forensic [3] => industrial accidents [4] => sociomedical perspective ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 10 [Day] => 20 [Hour] => 5 [Minute] => 38 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 10 [Day] => 21 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 12 [Day] => 15 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33076672 [1] => 123973 ) ) ) ) [3] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Process [Owner] => NLM ) [PMID] => 33012316 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 10 [Day] => 05 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1878-7487 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 74 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Aug ) ) [Title] => Journal of forensic and legal medicine [ISOAbbreviation] => J Forensic Leg Med ) [ArticleTitle] => Inferior mesenteric artery laceration associated with blunt abdominal trauma with Casper's sign in a physically abused child: An autopsy case and literature review. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 102001 ) [ELocationID] => Array ( [0] => S1752-928X(20)30108-6 [1] => 10.1016/j.jflm.2020.102001 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => There have been few studies of the death of children secondary to child abuse-related abdominal compression, and the detailed pathophysiology of such deaths is therefore unknown. The autopsy findings of a 3-year-old boy who died of hemorrhagic shock due to non-accidental severe blunt abdominal trauma were compared to those of children who died of other non-accidental abdominal injuries. Old and acute subcutaneous hemorrhages, abrasions, and scars were present all over the subject's body. No superficial injuries were found on the ventral midline, but a minor hemorrhage was found in the subcutaneous fat tissue, as well as in the rectus abdominis muscle. The intraperitoneal space contained 450 mL of blood, including coagulated blood. There was a tear in the transverse mesocolon and a crush injury in the small bowel mesentery. The inferior mesenteric artery was transected 0.5 cm from the aortic root. The transverse colon was necrotic, with hemorrhages in the mucosa. Since various organs were ischemic, the cause of death was determined to be blood loss from the inferior mesenteric artery injuries. Blunt abdominal trauma in children usually causes organ damage and intestinal injury, but because it is caused on the posterior surface of the mesentery, vascular injury should also be considered, and an autopsy should be performed. In the case of child abuse-related deaths, damage to the skin surface may not always be present; therefore, imaging tests, histopathological examinations, and biochemical tests should be performed with a focus on the gross anatomy to determine the cause of death and pathology. [CopyrightInformation] => Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Kei [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: ikeda.kei@med.osaka-cu.ac.jp. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: ikeda.tomoya@med.osaka-cu.ac.jp. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: tani.naoto@med.osaka-cu.ac.jp. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shida [ForeName] => Alissa [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: shida.alissa@med.osaka-cu.ac.jp. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Aoki [ForeName] => Yayoi [Initials] => Y [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: aoki.yayoi@med.osaka-cu.ac.jp. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Morioka [ForeName] => Fumiya [Initials] => F [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: f.morioka@med.osaka-cu.ac.jp. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address: takaki@med.osaka-cu.ac.jp. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 07 [Day] => 19 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => J Forensic Leg Med [NlmUniqueID] => 101300022 [ISSNLinking] => 1752-928X ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Autopsy [1] => Blunt abdominal trauma [2] => Child abuse [3] => Non-accidental injury [4] => Pathology [5] => Vascular injury ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 03 [Day] => 10 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 06 [Day] => 09 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 06 [Day] => 11 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 10 [Day] => 5 [Hour] => 5 [Minute] => 29 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 10 [Day] => 6 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 10 [Day] => 6 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33012316 [1] => S1752-928X(20)30108-6 [2] => 10.1016/j.jflm.2020.102001 ) ) ) ) [4] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 32146707 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 09 [Day] => 02 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 10 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1749-0774 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 33 [Issue] => 3 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Jul ) ) [Title] => Human cell [ISOAbbreviation] => Hum Cell ) [ArticleTitle] => Thyroid-related hormones as potential markers of hypoxia/ischemia. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 545-558 ) [ELocationID] => 10.1007/s13577-020-00341-x [Abstract] => SimpleXMLElement Object ( [AbstractText] => This study aimed to investigate the usefulness of the thyroid-related hormones as markers of acute systemic hypoxia/ischemia to identify deaths caused by asphyxiation due to neck compression in human autopsy cases. The following deaths from pathophysiological conditions were examined: mechanical asphyxia and acute/subacute blunt head injury; acute/subacute non-head blunt injury; sharp instrument injury as the hemorrhagic shock condition; drowning as alveolar injury; burn; and death due to cardiac dysfunction. Blood samples were collected from the left and right cardiac chambers and iliac veins, and serum triiodothyronine (T3), thyroxine (T4), thyroglobulin (Tg), and thyroid-stimulating hormone (TSH) levels were measured using electrochemiluminescence immunoassays. Two types of thyroid cell lines were used to confirm independent thyroid function under the condition of hypoxia (3% O). The human thyroid carcinoma cell line (HOTHC) cell line derived from human anaplastic thyroid carcinoma and the UD-PTC (sample of the second resection papillary thyroid carcinoma) cell line derived from human thyroid papillary adenoma, which forms Tg retention follicles, were used to examine the secretion levels of T3, T4, and Tg hormones. The results showed a strong correlation between T3 and T4 levels in all blood sampling sites, while the TSH and Tg levels were not correlated with the other markers. Serum T3 and T4 levels were higher in cases of mechanical asphyxia and acute/subacute blunt head injury, representing hypoxic and ischemic conditions of the brain as compared to those in other causes of death. In the thyroid gland cell line, T4, T3, and Tg levels were stimulated after exposure to hypoxia for 10-30 min. These findings suggest that systemic advanced hypoxia/ischemia may cause a rapid and TSH-independent release of T3 and T4 thyroid hormones in autopsy cases. These findings demonstrate that increased thyroid-related hormone (T3 and T4) levels in the pathophysiological field may indicate systemic hypoxia/ischemia. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. tani.naoto@med.osaka-cu.ac.jp. ) [1] => SimpleXMLElement Object ( [Affiliation] => Forensic Autopsy Section, Medico-Legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. tani.naoto@med.osaka-cu.ac.jp. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Mayumi [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Center of Endocrinology, Diabetes and Arteriosclerosis, Nippon Medical School Musashikosugi Hospital, Kosugi-cho 1-396, Nakahara-ku, Kawasaki, 211-8533, Japan. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Watanabe [ForeName] => Miho [Initials] => M [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. ) [1] => SimpleXMLElement Object ( [Affiliation] => Laboratory of Clinical Regenerative Medicine, Laboratory of Advanced Research, Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, D326 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. ) ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. ) [1] => SimpleXMLElement Object ( [Affiliation] => Forensic Autopsy Section, Medico-Legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. ) ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. ) [1] => SimpleXMLElement Object ( [Affiliation] => Forensic Autopsy Section, Medico-Legal Consultation and Postmortem Investigation Support Center, c/o Department of 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Knight’s forensic pathology. 3rd ed. London: Hodder Arnold; 2004. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10.1201/b13642 ) ) [1] => SimpleXMLElement Object ( [Citation] => Safar P, Paradis NA. Asphyxial cardiac arrest. In: Paradis NA, Halperin HR, Nowak RM, editors. Cardiac arrest: the science and practice of resuscitation medicine. Baltimore: Williams & Wilkins; 1999. p. 702–726. ) [2] => SimpleXMLElement Object ( [Citation] => Chen JH, Michiue T, Ishikawa T, Maeda H. Difference in molecular pathology of natriuretic peptides in the myocardium between acute asphyxial and cardiac deaths. Leg Med (Tokyo). 2012;14:177–82. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10.1016/j.legalmed.2012.01.015 ) ) [3] => SimpleXMLElement Object ( [Citation] => Maeda H, Zhu BL, Ishikawa T, Michiue T. Forensic molecular pathology of violent deaths. Forensic Sci Int. 2010;203:83–92. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 20719442 [1] => 10.1016/j.forsciint.2010.07.024 ) ) ) [4] => SimpleXMLElement Object ( [Citation] => Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H. Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection. Int J Legal Med. 2013;127:881–9. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 23702882 [1] => 10.1007/s00414-013-0868-x ) ) ) [5] => SimpleXMLElement Object ( [Citation] => Tamaki K, Katsumata Y. Enzyme-linked immunoabsorbent assay for plasma thyroglobulin following compression of the neck. Forensic Sci Int. 1990;44:193–201. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 2318474 [1] => 10.1016/0379-0738(90)90250-3 ) ) ) [6] => SimpleXMLElement Object ( [Citation] => Senol E, Demirel B, Akar T, Gülbahar O, Bakar C, Bukan N. The analysis of hormones and enzymes extracted from endocrine glands of the neck region in deaths due to hanging. Am J Forensic Med Pathol. 2008;29:49–544. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 19749617 [1] => 10.1097/PAF.0b013e31815b4c80 ) ) ) [7] => SimpleXMLElement Object ( [Citation] => Dressler J, Mueller E. High thyroglobulin (Tg) concentrations in fatal traumatic brain injuries. Am J Forensic Med Pathol. 2006;27:280–2. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 16936513 [1] => 10.1097/01.paf.0000221049.43363.99 ) ) ) [8] => SimpleXMLElement Object ( [Citation] => Guyton AC. Thyroid metabolic hormones. In: Guyton AC, Hall JE, editors. Text book of medical physiology. Philadelphia: Elsevier; 2016. p. 907–918. ) [9] => SimpleXMLElement Object ( [Citation] => Al-Hashem F, Alkhateeb M, Al-Ani B, Sakr H, Khalil M. Exhaustive exercise and vitamins C and E modulate thyroid hormone levels at low and high altitudes. Excli J. 2012;11:487–94. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 27540343 [1] => 4983714 ) ) ) [10] => SimpleXMLElement Object ( [Citation] => Basu M, Pal K, Malhotra AS, Prasad R, Sawhney RC. Free and total thyroid hormones in humans at extreme altitude. Int J Biometeorol. 1995;39:17–211. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 7558406 [1] => 10.1007/BF01320888 ) ) ) [11] => SimpleXMLElement Object ( [Citation] => Avivi A, Nevo E, Cohen K, et al. They live in the land down under: thyroid function and basal metabolic rate in the blind mole rat. Spalax Endocr Res. 2014;39:79–84. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24066698 ) ) [12] => SimpleXMLElement Object ( [Citation] => Brooks WW, Cicogna AC, Conrad CH, Robinson KG, Sen S, Bing OH. Thyroid state and tolerance of mammalian myocardium to hypoxia. J Exp Zool A Ecol Genet Physiol. 2009;311:399–407. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 19415714 [1] => 10.1002/jez.537 ) ) ) [13] => SimpleXMLElement Object ( [Citation] => Ishiwata I, Ono I, Kiguchi K, Ishiwata C, Soma M, Ishikawa H. Establishment and characterization of human thyroid carcinoma cell line (HOTHC) producing colony stimulating factor. Hum Cell. 2005;18:163–9. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 17022149 [1] => 10.1111/j.1749-0774.2005.tb00007.x ) ) ) [14] => SimpleXMLElement Object ( [Citation] => Ishikawa M, Tachibana T, Hashimoto H, et al. Functional analysis of three novel cell lines derived from human papillary thyroid carcinomas with three different clinical courses. Hum Cell. 2014;27:111–20. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 24567186 [1] => 10.1007/s13577-014-0088-9 ) ) ) [15] => SimpleXMLElement Object ( [Citation] => Zhu BL, Ishikawa T, Michiue T, et al. Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 1. Analysis with special regard to traumatic causes of death. Leg Med (Tokyo). 2006;8:86–93. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 16338155 [1] => 10.1016/j.legalmed.2005.10.004 ) ) ) [16] => SimpleXMLElement Object ( [Citation] => Kazerouni F, Amirrasouli H. Performance characteristics of three automated immunoassays for thyroid hormones. Caspian J Intern Med. 2012;3:400–4. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 24358433 [1] => 3861902 ) ) ) [17] => SimpleXMLElement Object ( [Citation] => Sánchez-Carbayo M, Mauri M, Alfayate R, Miralles C, Soria F. Analytical and clinical evaluation of TSH and thyroid hormones by electrochemiluminescent immunoassays. Clin Biochem. 1999;32:395–403. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 10667473 [1] => 10.1016/S0009-9120(99)00032-6 ) ) ) [18] => SimpleXMLElement Object ( [Citation] => Maeda H, Fukita K, Oritani S, Nagai K, Zhu BL. Evaluation of post-mortem oxymetry in fire victims. Forensic Sci Int. 1996;81:201–9. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 8837496 [1] => 10.1016/S0379-0738(96)01952-4 ) ) ) [19] => SimpleXMLElement Object ( [Citation] => Maeda H, Fukita K, Oritani S, Ishida K, Zhu BL. Evaluation of post-mortem oxymetry with reference to the causes of death. Forensic Sci Int. 1997;87:201–10. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 9248039 [1] => 10.1016/S0379-0738(97)00050-9 ) ) ) [20] => SimpleXMLElement Object ( [Citation] => Maeda H, Zhu BL, Ishikawa T, et al. Evaluation of post-mortem ethanol concentrations in pericardial fluid and bone marrow aspirate. Forensic Sci Int. 2006;161:141–3. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 16842951 [1] => 10.1016/j.forsciint.2006.01.016 ) ) ) [21] => SimpleXMLElement Object ( [Citation] => Tominaga M, Michiue T, Ishikawa T, Inamori-Kawamoto O, Oritani S, Maeda H. Evaluation of postmortem drug concentrations in cerebrospinal fluid compared with blood and pericardial fluid. Forensic Sci Int. 2015;254:118–25. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 26218406 [1] => 10.1016/j.forsciint.2015.07.005 ) ) ) [22] => SimpleXMLElement Object ( [Citation] => Akanbi KA, Brodie AE, Suryawan A, Hu CY. Effect of age on the differentiation of porcine adipose stromal-vascular cells in culture. J Anim Sci. 1994;72:2828–35. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 7730175 [1] => 10.2527/1994.72112828x ) ) ) [23] => SimpleXMLElement Object ( [Citation] => Ishikawa T, Zhu BL, Maeda H. Effects of therapeutic agents on cellular respiration as an indication of metabolic activity. Hum Exp Toxicol. 2006;25:135–40. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 16634332 [1] => 10.1191/0960327106ht610oa ) ) ) [24] => SimpleXMLElement Object ( [Citation] => Stacpoole SR, Bilican B, Webber DJ, et al. Derivation of neural precursor cells from humans ES cells at 3 % O is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Cell Death Differ. 2011;18:1016–23. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 21274009 [1] => 3091847 [2] => 10.1038/cdd.2010.171 ) ) ) [25] => SimpleXMLElement Object ( [Citation] => Feril LB Jr, Tsuda Y, Kondo T, et al. Ultrasound-induced killing of monocytic U 937 cells enhanced by 2,2’-azobis (2-amidinopropane) dihydrochloride. Cancer Sci. 2004;95:181–5. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 14965370 [1] => 10.1111/j.1349-7006.2004.tb03201.x ) ) ) [26] => SimpleXMLElement Object ( [Citation] => Hansen C, Christensen P, Stryhn H, Hedeboe AM, Rode M, Boe-Hansen G. Validation of the FACS Count AF system for determination of sperm concentration in boar semen. Reprod Dom Anim. 2002;37:330–4. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10.1046/j.1439-0531.2002.00367.x ) ) [27] => SimpleXMLElement Object ( [Citation] => Takahashi H, Ishikawa H, Tanaka A. Regenerative medicine for Parkinson’s disease using differentiated nerve cells derived from human buccal fat pad stem cells. Hum Cell. 2017;30:60–71. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 28210976 [1] => 10.1007/s13577-017-0160-3 ) ) ) [28] => SimpleXMLElement Object ( [Citation] => Ishiwata I, Sudo T, Kiguchi K, Ishikawa H. Tumor angiogenesis factors produced cancer cells. Hum Cell. 1999;12:37–46. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10457904 ) ) [29] => SimpleXMLElement Object ( [Citation] => Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983;148:839–43. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 6878708 [1] => 10.1148/radiology.148.3.6878708 ) ) ) [30] => SimpleXMLElement Object ( [Citation] => Ruokonen E, Ilkka L, Niskanen M, Takala J. Procalcitonin and neopterin as indicators of infection in critically ill patients. Acta Anaesthesiol Scand. 2002;46:398–404. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 11952440 [1] => 10.1034/j.1399-6576.2002.460412.x ) ) ) [31] => SimpleXMLElement Object ( [Citation] => Miyazato T, Ishikawa T, Michiue T, Maeda H. Molecular pathology of pulmonary surfactants and cytokines in drowning compared with other asphyxiation and fatal hypothermia. Int J Legal Med. 2012;126:581–7. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 22552475 [1] => 10.1007/s00414-012-0698-2 ) ) ) [32] => SimpleXMLElement Object ( [Citation] => Tamaki K, Sato K, Katsumata Y. Enzyme-linked immunosorbent assay for determination of plasma thyroglobulin and its application to post-mortem diagnosis of mechanical asphyxia. Forensic Sci Int. 1987;33:259–65. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 3583176 [1] => 10.1016/0379-0738(87)90107-1 ) ) ) [33] => SimpleXMLElement Object ( [Citation] => Müller E, Erfurt C, Franke WG. Thyroglobulin content of the blood in cases of hanging. Z Rechtsmed. 1990;103:361–7. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 2356663 [1] => 10.1007/BF01263041 ) ) ) [34] => SimpleXMLElement Object ( [Citation] => Katsumata Y, Sato K, Oya M, Yada S. Detection of thyroglobulin in blood stains as an aid in the diagnosis of mechanical asphyxia. J Forensic Sci. 1984;29:299–302. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 6699597 ) ) [35] => SimpleXMLElement Object ( [Citation] => Katsumata Y, Suzuki O, Oya M, Yada S. Plasma thyroglobulin as an indicator of mechanical asphyxia-comparison of plasma thyroglobulin levels by radioimmunoassay and the results of precipitation-electrophoresis. Med Sci Law. 1980;20:84–8. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 7392853 [1] => 10.1177/002580248002000203 ) ) ) [36] => SimpleXMLElement Object ( [Citation] => Li DR, Ishikawa T, Quan L, et al. Morphological analysis of astrocytes in the hippocampus in mechanical asphyxiation. Leg Med (Tokyo). 2010;12:63–7. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10.1016/j.legalmed.2009.11.005 ) ) [37] => SimpleXMLElement Object ( [Citation] => Shen Y, Wang Z, Li F, Sun L. Morphological characteristics of eosinophilic neuronal death after transient unilateral forebrain ischemia in Mongolian gerbils. Neuropathology. 2016;36:227–36. [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 26607557 [1] => 10.1111/neup.12264 ) ) ) [38] => SimpleXMLElement Object ( [Citation] => Tani N, Ikeda T, Watanabe M, Toyomura J, Ohyama A, Ishikawa T. Prolactin selectively transported to cerebrospinal fluid from blood under hypoxic/ischemic conditions. PLoS ONE. 2018;13:e0198673. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => e0218910 ) [ELocationID] => 10.1371/journal.pone.0218910 [Abstract] => SimpleXMLElement Object ( [AbstractText] => We previously showed that postmortem serum levels of adrenocorticotropic hormone (ACTH) were significantly higher in cases of hypothermia (cold exposure) than other causes of death. This study examined how the human hypothalamic-pituitary-adrenal axis, and specifically cortisol, responds to hypothermia. Human samples: Autopsies on 205 subjects (147 men and 58 women; age 15-98 years, median 60 years) were performed within 3 days of death. Cause of death was classified as either hypothermia (cold exposure, n = 14) or non-cold exposure (controls; n = 191). Cortisol levels were determined in blood samples obtained from the left and right cardiac chambers and common iliac veins using a chemiluminescent enzyme immunoassay. Adrenal gland tissues samples were stained for cortisol using a rabbit anti-human polyclonal antibody. Cell culture: AtT20, a mouse ACTH secretory cell line, and Y-1, a corticosterone secretory cell line derived from a mouse adrenal tumor, were analyzed in mono-and co-culture, and times courses of ACTH (in AtT20) and corticosterone (in Y-1) secretion were assessed after low temperature exposure mimicking hypothermia and compared with data for samples collected postmortem for other cases of death. However, no correlation between ACTH concentration and cortisol levels was observed in hypothermia cases. Immunohistologic analyses of samples from hypothermia cases showed that cortisol staining was localized primarily to the nucleus rather than the cytoplasm of cells in the zona fasciculata of the adrenal gland. During both mono-culture and co-culture, AtT20 cells secreted high levels of ACTH after 10-15 minutes of cold exposure, whereas corticosterone secretion by Y-1 cells increased slowly during the first 15-20 minutes of cold exposure. Similar to autopsy results, no correlation was detected between ACTH levels and corticosterone secretion, either in mono-culture or co-culture experiments. 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[Year] => 2020 [Month] => 2 [Day] => 19 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 4 [Day] => 21 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => epublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32069307 [1] => 10.1371/journal.pone.0218910 [2] => PONE-D-19-16479 [3] => PMC7028257 ) ) [ReferenceList] => SimpleXMLElement Object ( [Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2014 Jul;128(4):607-14 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24557588 ) ) [1] => SimpleXMLElement Object ( [Citation] => Forensic Sci. 1976 Sep-Oct;8(2):155-64 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 976901 ) ) [2] => SimpleXMLElement Object ( [Citation] => Endocrinology. 1977 Feb;100(2):406-19 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12932 ) ) [3] => SimpleXMLElement Object ( [Citation] => Arch Pathol Lab Med. 2006 Sep;130(9):1297-304 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16948514 ) ) [4] => SimpleXMLElement Object ( [Citation] => Forensic Sci Med Pathol. 2016 Jun;12(2):163-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27017494 ) ) [5] => SimpleXMLElement Object ( [Citation] => J Biol Chem. 1976 Jul 10;251(13):4115-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 180015 ) ) [6] => SimpleXMLElement Object ( [Citation] => Endocrinology. 2019 Feb 1;160(2):276-291 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30535142 ) ) [7] => SimpleXMLElement Object ( [Citation] => Med Sci Law. 1964 Jan;4:44-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 14106767 ) ) [8] => SimpleXMLElement Object ( [Citation] => J Forensic Leg Med. 2016 Aug;42:51-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27239954 ) ) [9] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2013 Jun 10;229(1-3):60-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23683909 ) ) [10] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2008 Aug 6;179(2-3):147-51 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18554831 ) ) [11] => SimpleXMLElement Object ( [Citation] => J Small Anim Pract. 2014 Mar;55(3):153-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24438095 ) ) [12] => SimpleXMLElement Object ( [Citation] => Horm Res Paediatr. 2018;89(4):212-223 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29719288 ) ) [13] => SimpleXMLElement Object ( [Citation] => Cancer Res. 1966 Mar;26(3):529-35 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 5930699 ) ) [14] => SimpleXMLElement Object ( [Citation] => Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1213-22 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17190905 ) ) [15] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 1999 Dec;1(4):204-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12935470 ) ) [16] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2011 Jan;125(1):11-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19760428 ) ) [17] => SimpleXMLElement Object ( [Citation] => J Bone Miner Metab. 2006;24(6):439-46 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17072735 ) ) [18] => SimpleXMLElement Object ( [Citation] => J Virol. 1997 Jan;71(1):95-101 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8985327 ) ) [19] => SimpleXMLElement Object ( [Citation] => J Forensic Sci. 2014 Jul;59(4):983-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24712835 ) ) [20] => SimpleXMLElement Object ( [Citation] => PLoS One. 2012;7(1):e30069 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22253884 ) ) [21] => SimpleXMLElement Object ( [Citation] => Clin Chem Lab Med. 2018 Oct 25;56(11):1819-1827 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29715177 ) ) [22] => SimpleXMLElement Object ( [Citation] => J Trauma. 1987 Sep;27(9):1019-24 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3656464 ) ) [23] => SimpleXMLElement Object ( [Citation] => Cancer Res. 1978 Nov;38(11 Pt 1):3673-80 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 581273 ) ) [24] => SimpleXMLElement Object ( [Citation] => Am J Vet Res. 2001 Apr;62(4):561-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11327464 ) ) [25] => SimpleXMLElement Object ( [Citation] => Mol Cell Endocrinol. 2015 Jun 15;408:235-40 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25462585 ) ) [26] => SimpleXMLElement Object ( [Citation] => J Clin Endocrinol Metab. 1972 Mar;34(3):460-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 4622132 ) ) [27] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2013 Mar 10;226(1-3):54-61 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23313602 ) ) [28] => SimpleXMLElement Object ( [Citation] => Biochem J. 2019 Mar 12;476(5):827-842 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30787050 ) ) [29] => SimpleXMLElement Object ( [Citation] => Forensic Sci Med Pathol. 2010 Jun;6(2):106-15 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20151230 ) ) [30] => SimpleXMLElement Object ( [Citation] => Pathology. 2008 Jan;40(1):46-51 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18038315 ) ) [31] => SimpleXMLElement Object ( [Citation] => Endocr Res. 2004 Nov;30(4):503-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15666780 ) ) [32] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2014 Nov;16(6):321-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25048514 ) ) [33] => SimpleXMLElement Object ( [Citation] => Vet Clin Pathol. 2016 Mar;45(1):154-63 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26756538 ) ) [34] => SimpleXMLElement Object ( [Citation] => J Mol Neurosci. 2017 Jun;62(2):163-180 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28462458 ) ) [35] => SimpleXMLElement Object ( [Citation] => J Steroid Biochem Mol Biol. 1992 Dec;43(8):973-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22217842 ) ) [36] => SimpleXMLElement Object ( [Citation] => Int J Med Microbiol. 2018 Oct;308(7):829-839 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30049648 ) ) [37] => SimpleXMLElement Object ( [Citation] => Ann Emerg Med. 1987 Sep;16(9):1042-55 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3631669 ) ) [38] => SimpleXMLElement Object ( [Citation] => Am J Pathol. 1957 Nov-Dec;33(6):1075-97 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 13478658 ) ) [39] => SimpleXMLElement Object ( [Citation] => J Clin Endocrinol Metab. 1970 Mar;30(3):393-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 5412546 ) ) [40] => SimpleXMLElement Object ( [Citation] => MMWR Morb Mortal Wkly Rep. 2015 Feb 20;64(6):141-3 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25695318 ) ) [41] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2016 May;130(3):765-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26384507 ) ) [42] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2004 Jul;6(3):157-63 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15231284 ) ) [43] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2012 Sep;126(5):747-56 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22752749 ) ) [44] => SimpleXMLElement Object ( [Citation] => Proc Soc Exp Biol Med. 1953 Oct;84(1):253-4 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 13121002 ) ) [45] => SimpleXMLElement Object ( [Citation] => Z Rechtsmed. 1980;86(1):59-69 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7467877 ) ) [46] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2016 Sep;22:23-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27591535 ) ) [47] => SimpleXMLElement Object ( [Citation] => FEMS Microbiol Lett. 2018 Dec 1;365(24): [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30476042 ) ) [48] => SimpleXMLElement Object ( [Citation] => J Immunol Methods. 1992 Jun 24;150(1-2):5-21 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1613258 ) ) [49] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2015 Nov;17(6):451-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26593989 ) ) [50] => SimpleXMLElement Object ( [Citation] => QJM. 2002 Dec;95(12):775-85 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12454320 ) ) [51] => SimpleXMLElement Object ( [Citation] => Clin Exp Immunol. 2005 May;140(2):241-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15807847 ) ) [52] => SimpleXMLElement Object ( [Citation] => J Biol Chem. 1996 Apr 26;271(17):10023-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8626556 ) ) [53] => SimpleXMLElement Object ( [Citation] => Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R137-42 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16902183 ) ) [54] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2009 Apr;11 Suppl 1:S228-30 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19369110 ) ) [55] => SimpleXMLElement Object ( [Citation] => J Vis Exp. 2016 May 06;(111): [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27213495 ) ) [56] => SimpleXMLElement Object ( [Citation] => Life Sci. 1987 Jun 1;40(22):2161-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 2884543 ) ) [57] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2014 Nov;16(6):344-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25155919 ) ) [58] => SimpleXMLElement Object ( [Citation] => J Biochem. 1987 Nov;102(5):1101-12 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3481365 ) ) [59] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2013 May 10;228(1-3):52-60 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23597740 ) ) [60] => SimpleXMLElement Object ( [Citation] => Intern Med. 2008;47(24):2157-64 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19075542 ) ) [61] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2013 Mar;127(2):267-76 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22773274 ) ) [62] => SimpleXMLElement Object ( [Citation] => J Biol Chem. 1999 Jan 15;274(3):1432-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9880517 ) ) [63] => SimpleXMLElement Object ( [Citation] => Acta Physiol Scand. 1988 Apr;132(4):543-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3227893 ) ) [64] => SimpleXMLElement Object ( [Citation] => Endocrine. 2017 Dec;58(3):503-512 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28405879 ) ) [65] => SimpleXMLElement Object ( [Citation] => Beitr Gerichtl Med. 1979;37:159-66 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 518480 ) ) [66] => SimpleXMLElement Object ( [Citation] => J Appl Physiol. 1974 Feb;36(2):183-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 4811377 ) ) [67] => SimpleXMLElement Object ( [Citation] => J Clin Endocrinol Metab. 2014 Mar;99(3):E518-27 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24423296 ) ) [68] => SimpleXMLElement Object ( [Citation] => J Forensic Sci. 2019 Mar;64(2):443-445 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30080942 ) ) [69] => SimpleXMLElement Object ( [Citation] => Am J Pathol. 1957 Jul-Aug;33(4):631-51 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 13444454 ) ) [70] => SimpleXMLElement Object ( [Citation] => Mol Cell Endocrinol. 1982 Sep;28(1):27-35 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7128920 ) ) [71] => SimpleXMLElement Object ( [Citation] => J Clin Endocrinol Metab. 1992 Sep;75(3):750-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1517364 ) ) [72] => SimpleXMLElement Object ( [Citation] => Clin Sci (Lond). 1980 Jul;59(1):19-27 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7471642 ) ) [73] => SimpleXMLElement Object ( [Citation] => J Immunol Methods. 1992 Jun 24;150(1-2):23-32 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1613256 ) ) [74] => SimpleXMLElement Object ( [Citation] => Chest. 2001 Dec;120(6):1998-2003 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11742934 ) ) [75] => SimpleXMLElement Object ( [Citation] => Gan. 1978 Aug;69(4):525-31 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 213336 ) ) [76] => SimpleXMLElement Object ( [Citation] => Hum Cell. 2011 Jun;24(2):74-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21547353 ) ) [77] => SimpleXMLElement Object ( [Citation] => Proc Natl Acad Sci U S A. 1962 Jul 15;48:1184-90 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 13874682 ) ) [78] => SimpleXMLElement Object ( [Citation] => Proc Soc Exp Biol Med. 1957 Jun;95(2):304-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 13441719 ) ) [79] => SimpleXMLElement Object ( [Citation] => PLoS One. 2018 Jun 27;13(6):e0198673 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29949606 ) ) ) ) ) ) [6] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 31789819 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 02 [Day] => 19 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 22 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1533-404X [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 41 [Issue] => 1 [PubDate] => 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 67-69 ) [ELocationID] => 10.1097/PAF.0000000000000521 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The patient was a 5-year-old boy who was found in a state of cardiorespiratory arrest in the tub of a washing machine without water with the door closed. The autopsy findings included severe facial congestion and petechiae of the facial skin and palpebral conjunctiva. Several organs exhibited congestion. Hemorrhagic spots were seen on the serous membranes of various organs, with particularly marked hemorrhagic spots seen on the lungs. The heart contained fluid blood without soft clots. There were no findings indicative of marked trauma, intoxication, or hyperthermia. The examination results suggested that asphyxia had occurred in this case. However, there were no findings indicative of cervical compression, oronasal obstruction, or the presence of a foreign body in the respiratory tract. Image analysis showed the child could make postural changes inside the washing machine tub. Consequently, impaired thoracic movement and postural asphyxia were considered unlikely to have occurred. The results of blood gas analysis showed no evidence of marked hypercapnia. 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Barotrauma in a washing machine. Injury. 1992;23:339–340. ) [1] => SimpleXMLElement Object ( [Citation] => Osculati A, Visonà SD, Re L, et al. Death of a seven-month-old child in a washing machine: a case report. Int J Leg Med. 2017;131:719–722. ) [2] => SimpleXMLElement Object ( [Citation] => Langman VA, Ellifrit N, Sime D, et al. Testing refrigeration trucks for the emergency evacuation of companion animals. J Appl Anim Welf Sci. 2015;18:398–403. ) [3] => SimpleXMLElement Object ( [Citation] => Kettner M, Ramsthaler F, Juhnke C, et al. A fatal case of CO2 intoxication in a fermentation tank. J Forensic Sci. 2013;58:556–558. ) [4] => SimpleXMLElement Object ( [Citation] => Williams HI. Carbon dioxide poisoning: report of eight cases, with two deaths. Br Med J. 1958;2:1012–1014. ) [5] => SimpleXMLElement Object ( [Citation] => Sato H, Tanaka T, Kasai K, et al. Autopsy case of drowning caused by accidental carbon dioxide intoxication in a hold tank. J UOEH. 2009;31:353–358. ) [6] => SimpleXMLElement Object ( [Citation] => Dedouit F, Tournel G, Robert AB, et al. An apple a day does not always keep the doctor away. J Forensic Sci. 2008;53:1434–1436. ) [7] => SimpleXMLElement Object ( [Citation] => Chmieliauskas S, Mundinas E, Fomin D, et al. Sudden deaths from positional asphyxia: a case report. Medicine (Baltimore). 2018;97:e11041. ) [8] => SimpleXMLElement Object ( [Citation] => deJong JL, Adams T. Entrapment in small, enclosed spaces: a case report and points to consider regarding the mechanism of death. J Forensic Sci. 2001;46:708–713. ) [9] => SimpleXMLElement Object ( [Citation] => Michiue T, Sakurai T, Ishikawa T, et al. Quantitative analysis of pulmonary pathophysiology using postmortem computed tomography with regard to the cause of death. Forensic Sci Int. 2012;220:232–238. ) [10] => SimpleXMLElement Object ( [Citation] => Tominaga M, Michiue T, Ishikawa T, et al. Postmortem analyses of drugs in pericardial fluid and bone marrow aspirate. J Anal Toxicol. 2013;37:423–429. ) [11] => SimpleXMLElement Object ( [Citation] => Tominaga M, Michiue T, Maeda H. Evaluation of the on-site immunoassay drug-screening device triage-TOX in routine forensic autopsy. Leg Med (Tokyo). 2015;17:499–502. ) [12] => SimpleXMLElement Object ( [Citation] => Yamaguchi T. Resting metabolism and daily energy intake and expenditure in preschool children. J Nutr Sci Vitaminol (Tokyo). 1993;46:287–297. ) [13] => SimpleXMLElement Object ( [Citation] => Ohya I, Iwasa M, Komoriya H. A fatal case of suffocation in a big plastic container; on the estimation of the survival time. Res Pract Forens Med. 1984;27:125–131. ) ) ) ) ) [7] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Process [Owner] => NLM ) [PMID] => 31514489 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 06 [Day] => 24 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1308-5735 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 12 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 06 [Day] => 03 ) ) [Title] => Journal of clinical research in pediatric endocrinology [ISOAbbreviation] => J Clin Res Pediatr Endocrinol ) [ArticleTitle] => Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic Ketoacidosis [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 160-167 ) [ELocationID] => 10.4274/jcrpe.galenos.2019.2019.0076 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => To determine the time relationships of soluble receptor for glycation end-products (sRAGE), [a decoy of the advanced glycation end-products (AGE)-RAGE axis] and D-lactate, (a metabolite of methylglyoxal) in the inflammatory response to diabetic ketoacidosis (DKA). [1] => Sixteen children and adolescents with type 1 diabetes (T1D) had blood samples obtained, 6-12 hours into treatment, at three weeks and three months post start of treatment. sRAGE and D-lactate concentrations at three months were considered baseline. Expression of RAGE was investigated in the myocardium of a newly diagnosed and untreated young person with fatal T1D/DKA. [2] => sRAGE 6-12 hours after the start of treatment was 39% lower than the values at two weeks (p=0.0036) and at three months (p=0.0023) post treatment. D-lactate was higher during treatment than at three weeks (p=0.04) and at three months (p=0.035). [3] => sRAGE concentration was decreased during treatment, compared to concentrations at two weeks and three months after treatment. The increased D-lactate during treatment was in keeping with the known increase in dicarbonyls at this time. 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=> SimpleXMLElement Object ( [Citation] => Endocr J. 2011;58(12):1045-53 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22033476 ) ) [3] => SimpleXMLElement Object ( [Citation] => Atherosclerosis. 2015 Jan;238(1):33-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25437887 ) ) [4] => SimpleXMLElement Object ( [Citation] => Diabetes Metab. 2008 Sep;34(4 Pt 1):392-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18701333 ) ) [5] => SimpleXMLElement Object ( [Citation] => Exp Mol Pathol. 2014 Feb;96(1):71-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24246157 ) ) [6] => SimpleXMLElement Object ( [Citation] => Lancet. 2018 Aug 11;392(10146):477-486 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30129464 ) ) [7] => SimpleXMLElement Object ( [Citation] => J Diabetes Complications. 1998 Nov-Dec;12(6):314-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9877465 ) ) [8] => SimpleXMLElement Object ( [Citation] => Exp Mol Pathol. 2006 Jun;80(3):283-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16494864 ) ) [9] => SimpleXMLElement Object ( [Citation] => Neuroimmunomodulation. 2014;21(5):226-33 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24603633 ) ) [10] => SimpleXMLElement Object ( [Citation] => Clin Immunol. 2005 Jul;116(1):11-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15925827 ) ) [11] => SimpleXMLElement Object ( [Citation] => Diabetes Care. 2015 Oct;38(10):1876-82 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26283737 ) ) [12] => SimpleXMLElement Object ( [Citation] => Pediatr Diabetes. 2006 Apr;7(2):75-80 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16629712 ) ) [13] => SimpleXMLElement Object ( [Citation] => Diabetes Care. 2015 Apr;38(4):665-70 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25573878 ) ) [14] => SimpleXMLElement Object ( [Citation] => Oxid Med Cell Longev. 2017;2017:1625130 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29098058 ) ) [15] => SimpleXMLElement Object ( [Citation] => Clin Immunol. 2003 Sep;108(3):175-81 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 14499240 ) ) [16] => SimpleXMLElement Object ( [Citation] => PLoS One. 2016 Jul 19;11(7):e0159175 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27434539 ) ) [17] => SimpleXMLElement Object ( [Citation] => Diabetes Metab. 2006 Apr;32(2):176-80 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16735968 ) ) [18] => SimpleXMLElement Object ( [Citation] => Clin Biochem. 2003 Jun;36(4):269-73 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12810155 ) ) [19] => SimpleXMLElement Object ( [Citation] => Mol Med. 2007 Nov-Dec;13(11-12):625-35 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17932553 ) ) [20] => SimpleXMLElement Object ( [Citation] => AJNR Am J Neuroradiol. 1988 Jul-Aug;9(4):733-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3135717 ) ) [21] => SimpleXMLElement Object ( [Citation] => J Diabetes Complications. 2002 Jul-Aug;16(4):294-300 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12126788 ) ) [22] => SimpleXMLElement Object ( [Citation] => Autoimmunity. 2016;49(3):188-96 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26911924 ) ) [23] => SimpleXMLElement Object ( [Citation] => Nephrol Dial Transplant. 1996;11 Suppl 5:13-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9044300 ) ) [24] => SimpleXMLElement Object ( [Citation] => Diab Vasc Dis Res. 2012 Oct;9(4):309-14 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22337892 ) ) [25] => SimpleXMLElement Object ( [Citation] => PLoS Biol. 2015 Jul 16;13(7):e1002202 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26181372 ) ) [26] => SimpleXMLElement Object ( [Citation] => Brain Res. 2008 Oct 31;1238:154-62 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18775683 ) ) [27] => SimpleXMLElement Object ( [Citation] => Pediatr Diabetes. 2007 Feb;8(1):28-43 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17341289 ) ) [28] => SimpleXMLElement Object ( [Citation] => Diab Vasc Dis Res. 2015 Mar;12(2):139-45 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25616705 ) ) [29] => SimpleXMLElement Object ( [Citation] => J Endocrinol Invest. 2000 Dec;23(11):732-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11194706 ) ) [30] => SimpleXMLElement Object ( [Citation] => Mol Med. 2007 Mar-Apr;13(3-4):185-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17592553 ) ) [31] => SimpleXMLElement Object ( [Citation] => Am J Physiol Endocrinol Metab. 2014 May 1;306(9):E1077-84 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24619879 ) ) [32] => SimpleXMLElement Object ( [Citation] => Cell Mol Biol (Noisy-le-grand). 1998 Nov;44(7):1139-45 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9846896 ) ) [33] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2016 Sep;22:23-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27591535 ) ) [34] => SimpleXMLElement Object ( [Citation] => Pediatr Diabetes. 2007 Jun;8(3):142-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17550424 ) ) [35] => SimpleXMLElement Object ( [Citation] => Int J Angiol. 2011 Mar;20(1):49-54 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22532771 ) ) [36] => SimpleXMLElement Object ( [Citation] => Circ J. 2014;78(5):1197-205 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24599045 ) ) [37] => SimpleXMLElement Object ( [Citation] => J Biol Chem. 2017 Dec 15;292(50):20437-20448 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29051224 ) ) [38] => SimpleXMLElement Object ( [Citation] => Mol Cell Biochem. 2010 Aug;341(1-2):135-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20339904 ) ) [39] => SimpleXMLElement Object ( [Citation] => Biochem J. 1995 Feb 1;305 ( Pt 3):999-1003 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7848303 ) ) [40] => SimpleXMLElement Object ( [Citation] => Diabetes. 2010 Jan;59(1):249-55 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19833897 ) ) [41] => SimpleXMLElement Object ( [Citation] => Nutr Metab (Lond). 2012 Feb 01;9(1):6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22296683 ) ) [42] => SimpleXMLElement Object ( [Citation] => PLoS One. 2013 Aug 27;8(8):e71905 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24013901 ) ) [43] => SimpleXMLElement Object ( [Citation] => Microcirculation. 2013 Aug;20(6):534-43 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23441883 ) ) [44] => SimpleXMLElement Object ( [Citation] => Int J Mol Sci. 2015 Aug 25;16(9):20100-17 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26307981 ) ) ) ) ) ) [8] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 781-791 ) [ELocationID] => 10.1111/ped.13901 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Respiratory syncytial virus (RSV) infection can be fatal in infants <1 year after birth. Morphological findings associated with infant death, however, are insufficient, and screening procedures are problematic. The aim of the present study was to establish a postmortem diagnosis of RSV pathogenicity. [1] => Serial forensic autopsies of 55 infants who suddenly died ≤1 year after birth due to viral pneumonia (n = 18), bacterial pneumonia (n = 12), or other diseases and trauma (n = 25) were assessed. Causes of viral pneumonia determined on immunochemical screening and histological staining of airway effusions consisted of RSV (n = 8) and other viruses (n = 10). [2] => Bronchial epithelial and inflammatory cells in the interstitium around bronchioles and alveoli were immunopositive for RSV. Bronchial epithelium was more frequently positive for RSV (5/8, 62.5%) than for bacterial pneumonia and other causes of death (7/47, 14.9%); and intra-alveolar sites were also more frequently positive for RSV pneumonia (3/8, 37.5%) than for bacterial pneumonia and other causes of death (4/47, 8.5%). Screening immunoassays and immunohistochemical staining for RSV can serve as an index of RSV infection when serum antibody titers, viral identification and polymerase chain reaction (PCR) are not informative. Peribronchiolar interstitial RSV positivity was similar between RSV pneumonia (7/8, 87.5%) and other causes of death (34/47, 72.3%). [3] => RSV was the cause of death in only eight infants because RSV infection was difficult to diagnose. Therefore, more deaths associated with RSV need to be investigated. 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Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289: 179-86. ) [1] => SimpleXMLElement Object ( [Citation] => Black CP. Systematic review of the biology and medical management of respiratory syncytial virus infection. Respir. Care 2003; 48: 209-33. ) [2] => SimpleXMLElement Object ( [Citation] => Resch B, Kurath S, Manzoni P. Epidemiology of respiratory syncytial virus infection in preterm infants. Open Microbiol. J. 2011; 5: 135-43. ) [3] => SimpleXMLElement Object ( [Citation] => Dawson-Caswell M, Muncie HL. Respiratory syncytial virus infection in children. Am. Fam. Physician 2011; 83: 141-6. ) [4] => SimpleXMLElement Object ( [Citation] => Sigurs N. Epidemiologic and clinical evidence of a respiratory syncytial virus-reactive airway disease link. Am. J. Respir. Crit. Care Med. 2001; 163: S2-6. ) [5] => SimpleXMLElement Object ( [Citation] => Leung AKC, Kellner JD, Davies HD. Respiratory syncytial virus bronchiolitis. J. Natl Med. Assoc. 2005; 97: 1708-13. ) [6] => SimpleXMLElement Object ( [Citation] => Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2095-128. ) [7] => SimpleXMLElement Object ( [Citation] => Mori M, Kawashima H, Nakamura H, et al. Nationwide survey of severe respiratory syncytial virus infection in children who do not meet indications for palivizumab in Japan. J. Infect. Chemother. 2011; 17: 254-63. ) [8] => SimpleXMLElement Object ( [Citation] => Aujard Y, Fauroux B. Risk factors for severe respiratory syncytial virus infection in infants. Respir. Med. 2002; S9-14. ) [9] => SimpleXMLElement Object ( [Citation] => Welliver RC. Detection, pathogenesis, and therapy of respiratory syncytial virus infections. Clin. Microbiol. Rev. 1988; 1: 27-39. ) [10] => SimpleXMLElement Object ( [Citation] => Falsey AR, Formica MA, Walsh EE. Diagnosis of respiratory syncytial virus infection: Comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness. J. Clin. Microbiol. 2002; 40: 817-20. ) [11] => SimpleXMLElement Object ( [Citation] => Liao RS, Tomalty LL, Majury A, Zoutman DE. Comparison of viral isolation and multiplex real-time reverse transcription-PCR for confirmation of respiratory syncytial virus and influenza virus detection by antigen immunoassays. J. Clin. Microbiol. 2009; 47: 527-32. ) [12] => SimpleXMLElement Object ( [Citation] => García J, García-Barreno B, Vivo A, Melero JA. Cytoplasmic inclusions of respiratory syncytial virus-infected cells: Formation of inclusion bodies in transfected cells that coexpress the nucleoprotein, the phosphoprotein, and the 22K protein. Virology 1993; 195: 243-7. ) [13] => SimpleXMLElement Object ( [Citation] => Robbins SL, Cotran RS, Kumar V. The lung. In: Kobzik L, Frederick SJ (eds). Robbins and Contran Pathologic Basis of Disease, 5th edn. Elsevier Saunders, Philadelphia, 1994; 673-734. ) [14] => SimpleXMLElement Object ( [Citation] => Hasleton P. Viral infections. In: Hasleton P, Flieder D (eds). Spencer's Pathology of the Lung, 5th edn. McGraw-Hill Professional, New York, 1996; 139-77. ) [15] => SimpleXMLElement Object ( [Citation] => Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS. The histopathology of fatal untreated human respiratory syncytial virus infection. Mod. Pathol. 2007; 20: 108-19. ) [16] => SimpleXMLElement Object ( [Citation] => Murdoch DR, O'Brien KL, Scott JAG, et al. Breathing new life into pneumonia diagnostics. J. Clin. Microbiol. 2009; 47: 3405-8. ) [17] => SimpleXMLElement Object ( [Citation] => Saukko P, Knight B. Sudden death in infancy. In: Saukko P, Knight B (eds). Knight's Forensic Pathology, 3rd edn. Hodder Arnold, London, 2004; 451-60. ) [18] => SimpleXMLElement Object ( [Citation] => Byard RW. Pediatric forensic pathology: The practice, the prose, and the problems. Forensic Sci. Med. Pathol. 2006; 2: 135-6. ) [19] => SimpleXMLElement Object ( [Citation] => Aherne W. The pathology of sudden unexpected death in childhood. J. Forensic Sci. Soc. 1972; 12: 585-6. ) [20] => SimpleXMLElement Object ( [Citation] => Bruhn FW, Mokrohisky ST, McIntosh K. Apnea associated with respiratory syncytial virus infection in young infants. J. Pediatr. 1977; 90: 382-6. ) [21] => SimpleXMLElement Object ( [Citation] => Abreu E, Silva FA, Brezinova V, et al. Sleep apnoea in acute bronchiolitis. Arch. Dis. Child. 1982; 57: 467-72. ) [22] => SimpleXMLElement Object ( [Citation] => Anas N, Boettrich C, Hall CB, et al. The association of apnea and respiratory syncytial virus infection in infants. J. Pediatr. 1982; 101: 65-8. ) [23] => SimpleXMLElement Object ( [Citation] => Colditz PB, Henry RL, DeSilva LM. Apnoea and bronchiolitis due to respiratory syncytial virus. Aust. Paediatr. J. 1982; 18: 53-4. ) [24] => SimpleXMLElement Object ( [Citation] => Lindgren C. Respiratory syncytial virus and the sudden infant death syndrome. Acta Paediatr. Suppl. 1993; 389: 67-9. ) [25] => SimpleXMLElement Object ( [Citation] => Southall DP, Stebbens VA, Alexander JR, et al. Cardiorespiratory patterns occurring in infants during and after recovery from respiratory tract infection. Pediatrics 1986; 78: 37-43. ) [26] => SimpleXMLElement Object ( [Citation] => Ng PC, Cheng SH, Chui KM, et al. Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants. Arch. Dis. Child. Fetal Neonatal Ed. 1997; 77: F221-7. ) [27] => SimpleXMLElement Object ( [Citation] => Bustamante-Calvillo ME, Velázquez FR, Cabrera-Munõz L, et al. Molecular detection of respiratory syncytial virus in postmortem lung tissue samples from Mexican children deceased with pneumonia. Pediatr. Infect. Dis. J. 2001; 20: 495-501. ) [28] => SimpleXMLElement Object ( [Citation] => Scott DJ, Gardner PS, McQuillin J, Stanton AN, Downham MA. Respiratory viruses and cot death. Br. Med. J. 1978; 2: 12-3. ) [29] => SimpleXMLElement Object ( [Citation] => Williams AL, Uren EC, Bretherton L. Respiratory viruses and sudden infant death. Br. Med. J. (Clin Res Ed) 1984; 288: 1491-3. ) [30] => SimpleXMLElement Object ( [Citation] => Weber MA, Hartley JC, Ashworth MT, Malone M, Sebire NJ. Virological investigations in sudden unexpected deaths in infancy (SUDI). Forensic Sci. Med. Pathol. 2010; 6: 261-7. ) [31] => SimpleXMLElement Object ( [Citation] => Kawashima H, Hiroaki I, Hasegawa Y, et al. Life-threatening extrapulmonary manifestations associated with respiratory syncytial virus infection in Japan. J. Tokyo Med. Univ. 2008; 66: 549-52. ) [32] => SimpleXMLElement Object ( [Citation] => Ito H, Osamura T, Nakajima F, et al. Survey of severe respiratory syncytial virus infection in Kyoto Prefecture from 2003 to 2007. Pediatr. Int. 2010; 52: 273-8. ) [33] => SimpleXMLElement Object ( [Citation] => Price JF. Acute and long-term effects of viral bronchiolitis in infancy. Lung 1990; 168: 414-21. ) [34] => SimpleXMLElement Object ( [Citation] => Puchkov GF, Min'kovich BM. Respiratory syncytial infection in a child complicated by interstitial myocarditis with fatal outcome. Arkh. Patol. 1972;34:70-3. ) [35] => SimpleXMLElement Object ( [Citation] => Eisenhut M. Extrapulmonary manifestations of severe respiratory syncytial virus infection: A systematic review. Crit. Care 2006; 10: R107. ) [36] => SimpleXMLElement Object ( [Citation] => Ikeda T, Tani N, Michiue T, Ishikawa T. Forensic Biochemistry. In: Ishikawa T (ed). Forensic Medicine and Human Cell Reserch. Springer Nature Singapore Pte Ltd, Singapore, 2019; 13-27. ) [37] => SimpleXMLElement Object ( [Citation] => Kardar G, Oraei M, Shahsavani M, et al. Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children. Iran J Public Health 2012; 41: 59-63. ) [38] => SimpleXMLElement Object ( [Citation] => Narula G, Khodaiji S, Bableshwar A, et al. Age-related reference intervals for immunoglobulin levels and lymphocyte subsets in Indian children. Indian J Pathol Microbiol 2017; 3: 360-364. ) ) ) ) ) [9] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 31103923 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 06 [Day] => 24 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 06 [Day] => 24 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1878-7487 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 65 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => Jul ) ) [Title] => Journal of forensic and legal medicine [ISOAbbreviation] => J Forensic Leg Med ) [ArticleTitle] => Postmortem water contents of major organs with regard to the cause of death. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 48-54 ) [ELocationID] => Array ( [0] => S1752-928X(18)30399-8 [1] => 10.1016/j.jflm.2019.05.003 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => The water contents of individual organs are maintained in a narrow range, but altered in morbidity owing to a disturbance of water equilibrium. The present study investigated the tissue water contents of major organs with regard to the cause of death in serial autopsy cases within 3 days postmortem (n = 329; 223 males, 106 females; age range, 1-100 years). Individual tissue water contents differed markedly across organs, but no significant postmortem or survival-period dependence, gender-related difference, or age dependence was observed. However, the lung water contents were higher in drowning cases, especially in saltwater cases (p < 0.05), and in strangulation among the acute mechanical asphyxiation cases. The brain water contents were higher in hypothermia cases (cold exposure) and tended to be higher in hyperthermia cases (heatstroke). The kidney water contents were higher in drowning and acute cardiac cases than in fatal intoxication and fire fatality cases, but tended to be higher in fresh- and bathwater drowning cases than in saltwater cases (p > 0.05). The spleen water contents were higher in bathwater drowning than in saltwater and freshwater cases, but did not differ among other the causes of death. These findings suggest that the postmortem tissue water content of individual organs, especially the lungs and/or kidney, depends on the cause of death and particularly contributes to differentiation between saltwater and freshwater drowning, respectively. This work therefore provides insight into the investigation of varied tissue water imbalances during the death process. In conclusion, we recommend the measurement of tissue water content because it is easy to perform and appears to be useful for evaluating the pathophysiology of systemic circulatory failure. [CopyrightInformation] => Copyright © 2019. Published by Elsevier Ltd. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585, Osaka, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585, Osaka, Japan. 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Aoki [ForeName] => Yayoi [Initials] => Y [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585, Osaka, Japan. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Oritani [ForeName] => Shigeki [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585, Osaka, Japan. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585, Osaka, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, 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medicine [ISOAbbreviation] => Int J Legal Med ) [ArticleTitle] => Evaluation of the distribution of nicotine intravenous injection: an adult autopsy case report with a review of literature. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 243-249 ) [ELocationID] => 10.1007/s00414-019-02035-y [Abstract] => SimpleXMLElement Object ( [AbstractText] => We reported the first comprehensive autopsy case of death due to intravenous injection of nicotine. We examined the distribution of nicotine in the body tissues and fluid and exposed the pathophysiology of nicotine poisoning. A 19-year-old woman was rushed to the hospital in cardiorespiratory arrest and was confirmed dead upon arrival. Liquid nicotine, hydrogen peroxide water, and a syringe were found in the hotel room where she stayed. On autopsy, nicotine concentration was the highest (15,023 μg/mg) in the tissue around the injection mark on the right upper arm. Among the body fluids, the intraperitoneal fluid had the highest, whereas the pericardial fluid had the lowest (0.736 μg/mL) nicotine concentration. Among the organs, the brain had the highest (11.637 μg/mg), whereas the fat tissue had the lowest (1.307 μg/mg) nicotine concentration. The concentration of cotinine, which is the metabolite of nicotine, was the highest in the tissue around the injection mark on the right arm (5.495 μg/mg) and was almost the same among the other body fluids and organs. The respective concentrations of nicotine and cotinine were 1.529 μg/mL and 0.019 μg/mL in the left heart blood and 3.157 μg/mL and 0.002 μg/mL in right heart blood. In this case, the nicotine concentrations in blood reached the lethal level. The distributions of nicotine and cotinine, as indicated by the intravenous injection, were related to the distribution of organs that metabolize nicotine and the distribution of nicotinic acetylcholine receptors. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Aoki [ForeName] => Yayoi [Initials] => Y [Identifier] => http://orcid.org/0000-0002-8378-0174 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. aoki.yayoi@med.osaka-cu.ac.jp. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical 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Oct;15(2):193-222 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9396010 ) ) [5] => SimpleXMLElement Object ( [Citation] => Neuropsychopharmacology. 2000 May;22(5):451-65 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10731620 ) ) [6] => SimpleXMLElement Object ( [Citation] => Pharmacol Rev. 2005 Mar;57(1):79-115 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15734728 ) ) [7] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2007 May;9(3):115-22 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17197225 ) ) [8] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2011 Oct 10;212(1-3):96-101 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21664082 ) ) [9] => SimpleXMLElement Object ( [Citation] => J Surg Res. 2016 Jan;200(1):298-307 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26316444 ) ) [10] => SimpleXMLElement Object ( [Citation] => Chem Res Toxicol. 1992 Sep-Oct;5(5):639-46 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1446003 ) ) [11] => SimpleXMLElement Object ( [Citation] => Forensic Sci Med Pathol. 2018 Dec;14(4):424-431 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30056625 ) ) [12] => SimpleXMLElement Object ( [Citation] => Hum Cell. 2017 Apr;30(2):106-116 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27838883 ) ) [13] => SimpleXMLElement Object ( [Citation] => Shock. 2013 Nov;40(5):358-65 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24088989 ) ) [14] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2002 Jan 24;125(1):59-66 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11852203 ) ) [15] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2008 Aug 6;179(2-3):135-43 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18541395 ) ) [16] => SimpleXMLElement Object ( [Citation] => J Leukoc Biol. 2016 Nov;100(5):1105-1112 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27312847 ) ) [17] => SimpleXMLElement Object ( [Citation] => CJEM. 2015 Nov;17(6):699-703 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25892642 ) ) [18] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2001 Jan 15;115(3):183-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11074173 ) ) [19] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2011 Sep;13(5):226-32 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21683643 ) ) [20] => SimpleXMLElement Object ( [Citation] => Free Radic Biol Med. 1989;6(5):479-84 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 2744580 ) ) [21] => SimpleXMLElement Object ( [Citation] => Pediatrics. 2010 May;125(5):896-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20403932 ) ) [22] => SimpleXMLElement Object ( [Citation] => Lancet. 1996 Jan 20;347(8995):200-1 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8544577 ) ) [23] => SimpleXMLElement Object ( [Citation] => Intern Emerg Med. 2007 Oct;2(3):210-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17909702 ) ) [24] => SimpleXMLElement Object ( [Citation] => Psychiatry Investig. 2014 Apr;11(2):173-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24843373 ) ) [25] => SimpleXMLElement Object ( [Citation] => Clin Toxicol (Phila). 2015 Nov;53(9):914-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26457570 ) ) [26] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2002 Dec 4;130(2-3):160-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12477638 ) ) [27] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2010 Feb 25;195(1-3):e19-22 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19954906 ) ) [28] => SimpleXMLElement Object ( [Citation] => Hum Exp Toxicol. 2010 May;29(5):427-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20068013 ) ) [29] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2015 Nov;17(6):535-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26594005 ) ) [30] => SimpleXMLElement Object ( [Citation] => Korean J Pediatr. 2016 Dec;59(12):490-493 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28194215 ) ) [31] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2010 Jun 15;199(1-3):e9-13 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20202767 ) ) [32] => SimpleXMLElement Object ( [Citation] => J Med Toxicol. 2014 Jun;10(2):202-4 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24500565 ) ) [33] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2013 May 10;228(1-3):52-60 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23597740 ) ) [34] => SimpleXMLElement Object ( [Citation] => Environ Sci Pollut Res Int. 2017 Jul;24(20):16605-16616 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28474259 ) ) [35] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2007 Jan;121(1):28-35 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16741745 ) ) [36] => SimpleXMLElement Object ( [Citation] => NIDA Res Monogr. 1990;99:12-29 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 2267009 ) ) [37] => SimpleXMLElement Object ( [Citation] => Annu Rev Pharmacol Toxicol. 1996;36:597-613 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8725403 ) ) [38] => SimpleXMLElement Object ( [Citation] => J Renin Angiotensin Aldosterone Syst. 2016 May 11;17(2):1470320316647239 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27169890 ) ) [39] => SimpleXMLElement Object ( [Citation] => Croat Med J. 2014 Apr;55(2):103-14 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24778096 ) ) [40] => SimpleXMLElement Object ( [Citation] => Clin Pharmacol Ther. 1982 Dec;32(6):758-64 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7140139 ) ) [41] => SimpleXMLElement Object ( [Citation] => Handb Exp Pharmacol. 2009;(192):29-60 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19184645 ) ) [42] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2001 Nov 1;122(2-3):107-23 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11672964 ) ) [43] => SimpleXMLElement Object ( [Citation] => Prev Med. 2017 Mar;96:94-100 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28034733 ) ) [44] => SimpleXMLElement Object ( [Citation] => Toxicol In Vitro. 1994 Feb;8(1):47-54 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20692888 ) ) ) ) ) ) [11] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 30941700 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 10 [Day] => 18 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 09 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1749-0774 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 32 [Issue] => 3 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => Jul ) ) [Title] => Human cell [ISOAbbreviation] => Hum Cell ) [ArticleTitle] => Pathophysiological significance of clock genes BMAL1 and PER2 as erythropoietin-controlling factors in acute blood hemorrhage. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 275-284 ) [ELocationID] => 10.1007/s13577-019-00248-2 [Abstract] => SimpleXMLElement Object ( [AbstractText] => This study aimed to characterize the pathophysiology, including possible correlations, of clock gene expression and erythropoietin (EPO) production in the acute stage of blood hemorrhage. Specimens of human cortical tissues (right and left kidneys) and cardiac blood were collected at autopsy from 52 cases following mortality due to acute-stage blood hemorrhage following sharp instrument injury. BMAL1 and PER2 mRNA levels were determined by reverse transcription-polymerase chain reaction; BMAL1 and PER2 protein levels were assessed using immunohistochemistry; BMAL1 protein levels were quantitatively measured by western blotting; and serum EPO levels were measured by chemiluminescent enzyme immunoassay. Separately, a rat model of hemorrhagic conditions was generated and used to confirm the results obtained with autopsy-derived specimens. A positive correlation was observed between BMAL1 protein and serum EPO levels, but not between BMAL1 mRNA levels and serum EPO levels. We also noted that Per2 mRNA expression became elevated in humans who survived for > 3 h after acute hemorrhagic events, with subsequent decreases in serum EPO levels. The rat model showed that even short (30-min) intervals of blood loss yielded increases in both Bmal1 mRNA and serum EPO levels; longer (60-min) intervals resulted in increases in Per2 mRNA expression along with decreases in serum EPO. Thus, the acute-stage human hemorrhage cases and the rat hemorrhage model yielded similar tendencies for clock gene expression and EPO secretion. In conclusion, our results indicated that clock genes are involved in the regulation of EPO production during the early stages of hypoxia/ischemia resulting from the acute hemorrhagic events. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [Identifier] => http://orcid.org/0000-0002-4981-0456 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-Machi 1-4-3, Abeno, Osaka, 545-8585, Japan. tani.naoto@med.osaka-cu.ac.jp. ) [1] => SimpleXMLElement Object ( [Affiliation] => Forensic Autopsy Section, Medico-Legal Consultation and Postmortem Investigation Support Center (MLCPI-SC), Osaka, Japan. tani.naoto@med.osaka-cu.ac.jp. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) 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[ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12606578 ) ) [2] => SimpleXMLElement Object ( [Citation] => Histol Histopathol. 2014 Jun;29(6):767-75 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24368520 ) ) [3] => SimpleXMLElement Object ( [Citation] => Oncologist. 1996;1(5):337-339 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10388012 ) ) [4] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2002 Jan 24;125(1):59-66 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11852203 ) ) [5] => SimpleXMLElement Object ( [Citation] => J Biol Rhythms. 2015 Dec;30(6):470-86 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26527094 ) ) [6] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2010 Jul 15;200(1-3):117-22 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20430543 ) ) [7] => SimpleXMLElement Object ( [Citation] => Kidney Int. 2010 Oct;78(7):640-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20664559 ) ) [8] => SimpleXMLElement Object ( [Citation] => PLoS One. 2009;4(3):e4882 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19287494 ) ) [9] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2015 Oct;255:118-22 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26372538 ) ) [10] => SimpleXMLElement Object ( [Citation] => Exp Physiol. 2016 Aug 1;101(8):1025-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27474264 ) ) [11] => SimpleXMLElement Object ( [Citation] => Cell Metab. 2017 Jan 10;25(1):73-85 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27773697 ) ) [12] => SimpleXMLElement Object ( [Citation] => Pflugers Arch. 2018 Feb;470(2):227-239 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29302752 ) ) [13] => SimpleXMLElement Object ( [Citation] => PLoS One. 2013 Aug 20;8(8):e71493 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23977055 ) ) [14] => SimpleXMLElement Object ( [Citation] => Immunity. 2014 Feb 20;40(2):178-86 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24560196 ) ) [15] => SimpleXMLElement Object ( [Citation] => Neural Regen Res. 2012 Oct 5;7(28):2221-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25538743 ) ) [16] => SimpleXMLElement Object ( [Citation] => N Engl J Med. 2018 Jan 25;378(4):370-379 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29365303 ) ) [17] => SimpleXMLElement Object ( [Citation] => J Nephropathol. 2017 Mar;6(2):69-73 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28491856 ) ) [18] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2011 Jan;125(1):11-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19760428 ) ) [19] => SimpleXMLElement Object ( [Citation] => Methods Enzymol. 2007;435:157-77 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17998054 ) ) [20] => SimpleXMLElement Object ( [Citation] => Mol Cell. 2017 Oct 5;68(1):198-209.e6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28985504 ) ) [21] => SimpleXMLElement Object ( [Citation] => Elife. 2015 Aug 29;4: [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26319354 ) ) [22] => SimpleXMLElement Object ( [Citation] => J Am Soc Nephrol. 2011 Apr;22(4):598-604 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21436284 ) ) [23] => SimpleXMLElement Object ( [Citation] => PLoS One. 2012;7(1):e30124 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22253904 ) ) [24] => SimpleXMLElement Object ( [Citation] => Curr Hypertens Rep. 2018 May 5;20(5):43 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29730779 ) ) [25] => SimpleXMLElement Object ( [Citation] => Tumour Biol. 2014 Jan;35(1):1-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23943393 ) ) [26] => SimpleXMLElement Object ( [Citation] => J Med Biochem. 2017 Apr 22;36(2):145-152 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28680358 ) ) [27] => SimpleXMLElement Object ( [Citation] => Molecules. 2017 Feb 14;22(2): [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28216581 ) ) [28] => SimpleXMLElement Object ( [Citation] => Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):831-843 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30266651 ) ) [29] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2012 Nov;126(6):943-52 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23010907 ) ) ) ) ) ) [12] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 30794821 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 02 [Day] => 13 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 02 [Day] => 13 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 71-76 ) [ELocationID] => Array ( [0] => S0304-3940(19)30121-1 [1] => 10.1016/j.neulet.2019.02.029 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Monoamine oxidase A (MAOA) plays important roles in the metabolism of catecholamines and modulates adrenergic, noradrenergic, and dopaminergic signaling. A polymorphic promoter variable number tandem repeat (VNTR) locus (MAOA-uVNTR) is located approximately 1.2 kb upstream from MAOA exon 1. Functional studies revealed that MAOA-uVNTR affects gene expression. In the present study, we examined the frequencies of MAOA-uVNTR alleles in Japanese autopsy cases, in which amphetamines or psychotropic drugs were not detected. In total, 87 males and 35 females were evaluated and investigated for the possible effect of MAOA-uVNTR polymorphisms on cerebrospinal fluid (CSF) catecholamine concentrations. In males, there was no significant association between MAOA-uVNTR polymorphisms and CSF adrenaline (Adr), noradrenaline (Nad), or dopamine (DA) levels. In contrast, females who were homozygous for the 3-repeat allele (i.e., 3/3 genotype carriers) had higher CSF levels of Adr (p =  0.024) and DA (p =  0.035) than individuals who were heterozygous or homozygous for the 4-repeat allele (3/4 and 4/4, respectively). We found no significant association between MAOA-uVNTR polymorphisms and CSF Nad levels in females. Thus, the results of the present study indicated that MAOA-uVNTR polymorphism influences CSF Adr and DA levels in females. [CopyrightInformation] => Copyright © 2019 Elsevier B.V. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Matsusue [ForeName] => Aya [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address: miyoshi@fukuoka-u.ac.jp. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kubo [ForeName] => Shin-Ichi [Initials] => SI [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Maeda [ForeName] => Toshiki [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Preventive Medicine and Public Health,Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kashiwagi [ForeName] => Masayuki [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hara [ForeName] => Kenji [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Waters [ForeName] => Brian [Initials] => B [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Takayama [ForeName] => Mio [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikematsu [ForeName] => Natsuki [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2019 [Month] => 02 [Day] => 19 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Ireland [MedlineTA] => Neurosci Lett [NlmUniqueID] => 7600130 [ISSNLinking] => 0304-3940 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Catecholamines ) [1] => SimpleXMLElement Object ( [RegistryNumber] => EC 1.4.3.4 [NameOfSubstance] => Monoamine Oxidase ) [2] => SimpleXMLElement Object ( [RegistryNumber] => EC 1.4.3.4. [NameOfSubstance] => monoamine oxidase A, human ) ) ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Adolescent ) [1] => SimpleXMLElement Object ( [DescriptorName] => Adult ) [2] => SimpleXMLElement Object ( [DescriptorName] => Aged ) [3] => SimpleXMLElement Object ( [DescriptorName] => Aged, 80 and over ) [4] => SimpleXMLElement Object ( [DescriptorName] => Alleles ) [5] => SimpleXMLElement Object ( [DescriptorName] => Autopsy ) [6] => SimpleXMLElement Object ( [DescriptorName] => Catecholamines [QualifierName] => cerebrospinal fluid ) [7] => SimpleXMLElement Object ( [DescriptorName] => Child ) [8] => SimpleXMLElement Object ( [DescriptorName] => Female ) [9] => SimpleXMLElement Object ( [DescriptorName] => Forensic Sciences ) [10] => SimpleXMLElement Object ( [DescriptorName] => Genotype ) [11] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [12] => SimpleXMLElement Object ( [DescriptorName] => Male ) [13] => SimpleXMLElement Object ( [DescriptorName] => Middle Aged ) [14] => SimpleXMLElement Object ( [DescriptorName] => Minisatellite Repeats ) [15] => SimpleXMLElement Object ( [DescriptorName] => Monoamine Oxidase [QualifierName] => genetics ) [16] => SimpleXMLElement Object ( [DescriptorName] => Polymorphism, Genetic ) [17] => SimpleXMLElement Object ( [DescriptorName] => Promoter Regions, Genetic ) [18] => SimpleXMLElement Object ( [DescriptorName] => Young Adult ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Autopsy case [1] => Catecholamine [2] => Monoamine oxidase A [3] => Variable number tandem repeat ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2018 [Month] => 12 [Day] => 12 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2019 [Month] => 02 [Day] => 13 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2019 [Month] => 02 [Day] => 18 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2019 [Month] => 2 [Day] => 23 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 2 [Day] => 14 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2019 [Month] => 2 [Day] => 23 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 30794821 [1] => S0304-3940(19)30121-1 [2] => 10.1016/j.neulet.2019.02.029 ) ) ) ) [13] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => PubMed-not-MEDLINE [Owner] => NLM ) [PMID] => 30595699 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 10 [Day] => 01 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic-eCollection ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1687-9627 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Print ) [Volume] => 2018 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 ) ) [Title] => Case reports in medicine [ISOAbbreviation] => Case Rep Med ) [ArticleTitle] => Toxicological and Biochemical Analyses of an Autopsy Case Involving Oral Overdose of Multiple Antidiabetic and Antihypertensive Drugs. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 5864658 ) [ELocationID] => 10.1155/2018/5864658 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Oral antidiabetics can cause fatal hypoglycemia; although they can be chemically identified and quantified, biochemical investigations are important for assessing the biological consequences of an overdose. Such cases of overdose involving oral antidiabetics may involve other drugs for treating lifestyle-related diseases, particularly antihypertensives. Here, we report a toxicological and biochemical investigation of drugs and biochemical profiles in a fatal overdose involving multiple oral antidiabetics and antihypertensives. A 55-year-old woman died about 2 days after the ingestion of around 110 tablets of antidiabetics and antihypertensives that had been prescribed for her husband. A forensic autopsy and histological analysis demonstrated no evident pathology as the cause of death. A toxicological analysis suggested hypoglycemia and an overdose of antihypertensives as well as the retention of antidiabetics and diuretics in the pericardial fluid. A relatively low pericardial amlodipine concentration was observed, which may have been the result of its long half-life (slower distribution and reduction rate) and/or possible affinity with the myocardium. In addition, a biochemical analysis indicated hypoglycemia, without increased serum insulin and C-peptide, but with increased glucagon levels, as the possible influence of glibenclamide overdose. These observations suggest the usefulness of a combination of toxicological and biochemical analyses in postmortem investigations involving a fatal overdose of such drugs. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [Identifier] => 0000-0003-3262-3141 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) [1] => SimpleXMLElement Object ( [Affiliation] => Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, C/o Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) 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Object ( [Citation] => Med Sci Law. 1999 Oct;39(4):354-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10581918 ) ) [1] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2001 Nov 1;122(2-3):107-23 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11672964 ) ) [2] => SimpleXMLElement Object ( [Citation] => Drugs. 2005;65(3):385-411 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15669880 ) ) [3] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2005 Oct 4;153(1):67-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15935584 ) ) [4] => SimpleXMLElement Object ( [Citation] => J Mass Spectrom. 2005 Nov;40(11):1462-71 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16255063 ) ) [5] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2006 Sep 12;161(2-3):216-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16872774 ) ) [6] => SimpleXMLElement Object ( [Citation] => Basic Clin Pharmacol Toxicol. 2006 Sep;99(3):209-12 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16930293 ) ) [7] => SimpleXMLElement Object ( [Citation] => Br J Clin Pharmacol. 2007 Jun;63(6):732-40 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17223855 ) ) [8] => SimpleXMLElement Object ( [Citation] => Diabetes Care. 2007 Feb;30(2):389-94 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17259518 ) ) [9] => SimpleXMLElement Object ( [Citation] => Diabetes Care. 2009 Jan;32(1):193-203 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18945920 ) ) [10] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2009 Nov 20;192(1-3):78-82 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19729257 ) ) [11] => SimpleXMLElement Object ( [Citation] => Diabetes Care. 2009 Dec;32(12):2275-80 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19729529 ) ) [12] => SimpleXMLElement Object ( [Citation] => Diabetes Care. 2011 Jan;34(1):50-2 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20929999 ) ) [13] => SimpleXMLElement Object ( [Citation] => Anal Bioanal Chem. 2011 Apr;400(1):33-41 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21327875 ) ) [14] => SimpleXMLElement Object ( [Citation] => Clin Chem Lab Med. 2011 Aug;49(8):1265-70 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21663468 ) ) [15] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2012 Mar;126(2):187-98 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21947676 ) ) [16] => SimpleXMLElement Object ( [Citation] => Indian J Crit Care Med. 2011 Jul;15(3):182-4 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22013313 ) ) [17] => SimpleXMLElement Object ( [Citation] => J Manag Care Pharm. 2011 Nov;17(9):664-71 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22050391 ) ) [18] => SimpleXMLElement Object ( [Citation] => BMJ Case Rep. 2011 Sep 04;2011:null [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22679190 ) ) [19] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2012 Nov 30;223(1-3):119-24 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22940189 ) ) [20] => SimpleXMLElement Object ( [Citation] => Clin Toxicol (Phila). 2013 Jun;51(5):444-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23544622 ) ) [21] => SimpleXMLElement Object ( [Citation] => Indian J Crit Care Med. 2012 Oct;16(4):204-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23559727 ) ) [22] => SimpleXMLElement Object ( [Citation] => Vasc Health Risk Manag. 2013;9:155-63 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23637538 ) ) [23] => SimpleXMLElement Object ( [Citation] => J Anal Toxicol. 2013 Sep;37(7):423-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23852608 ) ) [24] => SimpleXMLElement Object ( [Citation] => Proc (Bayl Univ Med Cent). 2013 Oct;26(4):410-1 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24082424 ) ) [25] => SimpleXMLElement Object ( [Citation] => Hosp Pharm. 2013 Nov;48(10):848-54 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24421438 ) ) [26] => SimpleXMLElement Object ( [Citation] => Indian J Crit Care Med. 2013 Nov;17(6):375-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24501491 ) ) [27] => SimpleXMLElement Object ( [Citation] => Case Rep Cardiol. 2013;2013:842606 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24826296 ) ) [28] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2015 May;17(3):172-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25637163 ) ) [29] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2015 Sep;254:118-25 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26218406 ) ) [30] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2015 Nov;17(6):475-82 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26593993 ) ) [31] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2015 Nov;17(6):535-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26594005 ) ) [32] => SimpleXMLElement Object ( [Citation] => Hum Cell. 2017 Apr;30(2):106-116 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27838883 ) ) [33] => SimpleXMLElement Object ( [Citation] => Br J Clin Pharmacol. 1986 Jul;22(1):21-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 2943308 ) ) [34] => SimpleXMLElement Object ( [Citation] => Int J Endocrinol Metab. 2017 Dec 20;16(1):e62591 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29805453 ) ) [35] => SimpleXMLElement Object ( [Citation] => J Physiol. 1978 Apr;277:367-77 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 650542 ) ) [36] => SimpleXMLElement Object ( [Citation] => N Engl J Med. 1995 Apr 27;332(17):1144-52 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7700289 ) ) [37] => SimpleXMLElement Object ( [Citation] => Clin Pharmacokinet. 1996 Aug;31(2):111-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8853933 ) ) [38] => SimpleXMLElement Object ( [Citation] => Ann Pharmacother. 1997 Jul-Aug;31(7-8):853-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9220044 ) ) [39] => SimpleXMLElement Object ( [Citation] => Arch Intern Med. 1997 Aug 11-25;157(15):1681-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9250229 ) ) [40] => SimpleXMLElement Object ( [Citation] => JAMA. 1997 Nov 26;278(20):1663-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9388085 ) ) [41] => SimpleXMLElement Object ( [Citation] => Am J Emerg Med. 1998 Sep;16(5):527-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9725975 ) ) ) ) ) ) [14] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 30390281 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 04 [Day] => 17 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 03 [Day] => 09 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1556-2891 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 15 [Issue] => 1 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 03 ) ) [Title] => Forensic science, medicine, and pathology [ISOAbbreviation] => Forensic Sci Med Pathol ) [ArticleTitle] => Effects of postmortem positional changes on conjunctival petechiae. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 13-22 ) [ELocationID] => 10.1007/s12024-018-0032-5 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The present study aimed to determine whether postmortem period, physical constitution, cause of death, and cardiopulmonary resuscitation are associated with positional changes in the postmortem appearance of conjunctival petechiae. We retrospectively investigated serial forensic autopsies from 6 h to 6 days postmortem (n = 442; male, 303; female, 139; median age, 62 years; range, 0-100 years). The causes of death were sharp instrument injury, blunt force trauma, fire, intoxication, asphyxia, drowning, hypothermia, hyperthermia, acute heart failure, and natural causes. Of these, 28 (male, n = 18; female, n = 10) were aged ≤5 years. Palpebral conjunctival petechiae were initially assessed at autopsy in supine bodies, then reassessed in prone bodies after 30 min. Among 414 bodies, 291 (70.2%) and 123 (29.7%) who were aged between 6 and 100 years, and 18 (64.2%) and 10 (35.7%) aged <5 years at the time of death, were discovered in the supine and prone positions, respectively. The amounts of petechiae increased within 1.5 days postmortem, but not in those discovered in the prone position. The rates at which petechiae increased were higher in supine overweight bodies (BMI ≥ 25.0) and in those who were discovered supine and had died of asphyxia or drowning (37.5%). Cardiopulmonary resuscitation for bodies discovered in the supine and prone positions did not statistically affect the occurrence of petechiae. Several postmortem factors can cause hypostatic blood redistribution that manifests as increased amounts of petechiae in the palpebral conjunctivae. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [Identifier] => 0000-0003-3262-3141 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. ikeda.tomoya@med.osaka-cu.ac.jp. ) [1] => SimpleXMLElement Object ( [Affiliation] => Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. ikeda.tomoya@med.osaka-cu.ac.jp. ) ) ) [1] => SimpleXMLElement Object ( 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[Citation] => J Vasc Surg. 2010 Sep;52(3):664-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20576394 ) ) [3] => SimpleXMLElement Object ( [Citation] => Am J Forensic Med Pathol. 1988 Mar;9(1):35-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3354520 ) ) [4] => SimpleXMLElement Object ( [Citation] => J Forensic Sci. 2000 Nov;45(6):1274-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11110181 ) ) [5] => SimpleXMLElement Object ( [Citation] => Am J Forensic Med Pathol. 1988 Mar;9(1):32-4 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3354519 ) ) [6] => SimpleXMLElement Object ( [Citation] => Eur J Vasc Endovasc Surg. 2008 Jun;35(6):739-44 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18313335 ) ) [7] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2012 Nov 30;223(1-3):e53-5 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22981961 ) ) [8] => SimpleXMLElement Object ( [Citation] => Z Rechtsmed. 1975 Dec 30;77(1):47-60 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1220425 ) ) [9] => SimpleXMLElement Object ( [Citation] => J Appl Physiol (1985). 1993 Mar;74(3):1374-80 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8482680 ) ) [10] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2005 May 10;149(2-3):133-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15749353 ) ) [11] => SimpleXMLElement Object ( [Citation] => J Forensic Leg Med. 2010 Feb;17(2):87-91 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20129428 ) ) [12] => SimpleXMLElement Object ( [Citation] => J Physiol. 1975 Nov;252(3):817-32 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1206576 ) ) [13] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2001 Apr 1;117(3):191-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11248449 ) ) [14] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 1983 Nov-Dec;23(2-3):109-16 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 79-90 ) [ELocationID] => 10.2147/SAR.S163491 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => The aim of this study was to investigate the occurrence of deaths due to psychotropic drugs in south Osaka during a 10-year period and discuss societal factors from a medical viewpoint. [1] => Psychotropic drug-related deaths were retrospectively investigated based on the forensic postmortem data of 1,746 decedents in 2005-2014, and we excluded cases in which stimulant drugs were detected. Of these, 133 cases (7.6%) were found to be psychotropic drug-related deaths and were analyzed. [2] => Psychotropic drug-related deaths occurred in 78 males (59%; age range, 14-95 years) and 55 females (41%; 20-84 years). The direct cause of death was acute drug intoxication in many cases, and of these, acute combined drug intoxication due to the use of multiple drugs accounted for 76% of the deaths. Most of these victims were found to have gastrointestinal and cardiovascular diseases. Cases of psychotropic drug-related deaths had especially poor medical conditions. In addition, tests were positive for blood alcohol in 23% of the cases. [3] => The descriptive results revealed several factors that may be related to psychotropic drug-related deaths. 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[Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2010 Jul 15;200(1-3):136-40 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20434283 ) ) [1] => SimpleXMLElement Object ( [Citation] => East Mediterr Health J. 2017 May 01;23(3):168-172 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28493263 ) ) [2] => SimpleXMLElement Object ( [Citation] => Ann N Y Acad Sci. 2011 Jan;1216:62-72 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21272011 ) ) [3] => SimpleXMLElement Object ( [Citation] => BMC Psychiatry. 2007 Nov 07;7:64 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17986359 ) ) [4] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2000 Sep 11;113(1-3):443-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10978660 ) ) [5] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2006 Sep 12;161(2-3):141-3 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16842951 ) ) [6] => SimpleXMLElement Object ( [Citation] => Pharmacopsychiatry. 2017 Mar;50(2):69-73 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27595297 ) ) [7] => SimpleXMLElement Object ( [Citation] => J Toxicol Sci. 2016;41(6):765-773 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27853105 ) ) [8] => SimpleXMLElement Object ( [Citation] => Int J Environ Res Public Health. 2015 Mar 03;12(3):2781-92 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25741639 ) ) [9] => SimpleXMLElement Object ( [Citation] => Eur J Clin Pharmacol. 2016 Jun;72(6):731-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26896941 ) ) [10] => SimpleXMLElement Object ( [Citation] => Cochrane Database Syst Rev. 2013 Sep 13;(9):CD008297 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24030739 ) ) [11] => SimpleXMLElement Object ( [Citation] => Bull Narc. 1987;39(2):11-27 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3329548 ) ) [12] => SimpleXMLElement Object ( [Citation] => Curr Psychiatry Rep. 2012 Aug;14(4):376-90 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22707017 ) ) [13] => SimpleXMLElement Object ( [Citation] => BMC Health Serv Res. 2013 May 10;13:173 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23663281 ) ) [14] => SimpleXMLElement Object ( [Citation] => Psychiatry Res. 2016 May 30;239:301-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27046394 ) ) [15] => SimpleXMLElement Object ( [Citation] => Drug Alcohol Rev. 2010 Jan;29(1):21-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20078678 ) ) [16] => SimpleXMLElement Object ( [Citation] => Acute Med Surg. 2015 Mar 15;2(4):237-243 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29123730 ) ) [17] => SimpleXMLElement Object ( [Citation] => J Affect Disord. 2016 Jun;197:81-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26971125 ) ) [18] => SimpleXMLElement Object ( [Citation] => BMC Infect Dis. 2011 Jan 21;11:22 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21255421 ) ) [19] => SimpleXMLElement Object ( [Citation] => Psychiatr Serv. 2014 Oct;65(10):1201-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24933361 ) ) [20] => SimpleXMLElement Object ( [Citation] => Hepat Mon. 2016 Dec 03;16(12):e41564 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28123443 ) ) [21] => SimpleXMLElement Object ( [Citation] => BMC Psychiatry. 2018 Jan 10;18(1):6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29320999 ) ) [22] => SimpleXMLElement Object ( [Citation] => Asia Pac Psychiatry. 2017 Dec;9(4):null [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28220613 ) ) [23] => SimpleXMLElement Object ( [Citation] => Soc Psychiatry Psychiatr Epidemiol. 2009 Sep;44(9):777-83 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19190833 ) ) [24] => SimpleXMLElement Object ( [Citation] => Hepatol Res. 2011 Aug;41(8):731-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21707885 ) ) [25] => SimpleXMLElement Object ( [Citation] => Psychiatry Clin Neurosci. 2015 Apr;69(4):220-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25112197 ) ) [26] => SimpleXMLElement Object ( [Citation] => Resuscitation. 2014 Jan;85(1):59-64 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24036196 ) ) [27] => SimpleXMLElement Object ( [Citation] => Drug Alcohol Depend. 2003 Oct 24;72(1):67-74 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 14563544 ) ) [28] => SimpleXMLElement Object ( [Citation] => World J Gastrointest Pharmacol Ther. 2017 Feb 6;8(1):26-38 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28217372 ) ) [29] => SimpleXMLElement Object ( [Citation] => Am J Addict. 2017 Jun;26(4):388-394 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28456010 ) ) [30] => SimpleXMLElement Object ( [Citation] => Seishin Shinkeigaku Zasshi. 2011;113(12):1184-98 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22352004 ) ) [31] => SimpleXMLElement Object ( [Citation] => BMJ Open. 2013 Apr 03;3(4):null [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23558729 ) ) [32] => SimpleXMLElement Object ( [Citation] => PLoS One. 2015 Dec 03;10(12):e0144069 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26633033 ) ) [33] => SimpleXMLElement Object ( [Citation] => Dan Med J. 2016 Mar;63(3):null [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26931193 ) ) [34] => SimpleXMLElement Object ( [Citation] => J Anal Toxicol. 2016 Jun;40(5):367-73 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27185819 ) ) [35] => SimpleXMLElement Object ( [Citation] => Subst Use Misuse. 2004 Jan;39(1):1-23 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15002942 ) ) [36] => SimpleXMLElement Object ( [Citation] => J Forensic Sci. 2016 May;61(3):735-42 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27122413 ) ) [37] => SimpleXMLElement Object ( [Citation] => Psychiatry Clin Neurosci. 2012 Jun;66(4):292-302 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22624734 ) ) [38] => SimpleXMLElement Object ( [Citation] => Nihon Shinkei Seishin Yakurigaku Zasshi. 1999 Oct;19(4):209-13 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10637830 ) ) ) ) ) ) [16] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 30255208 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 04 [Day] => 03 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 05 [Day] => 08 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1437-1596 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 133 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => Mar ) ) [Title] => International journal of legal medicine [ISOAbbreviation] => Int J Legal Med ) [ArticleTitle] => Time since death nomographs implementing the nomogram, body weight adjusted correction factors, metric and imperial measurements. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 491-499 ) [ELocationID] => 10.1007/s00414-018-1928-z [Abstract] => SimpleXMLElement Object ( [AbstractText] => The concept of nomography was developed around 1880 as a means to compute formulas graphically. Regular use has decreased over time in most fields, mainly owing to progress in electronic computation devices. In forensic pathology, nomography is still used in the so-called "nomogram method" for the estimation of time since death. It is the graphical representation of the formula by Marshall and Hoare with the parameters of Henssge. Here, two nomograms exist (for ambient temperatures below and above 23 °C, no imperial measurements). Rounding for body weight input and result reading introduces errors. In addition, correction factors, applied to body weight, allow to adapt for certain conditions on the crime scene and are essential to the method. They are not directly integrated into the nomograms but must be applied in advance. A formula, scaling correction factors for different body weights, was later added by Henssge, along with a simplified table for case work. In this publication, we present newly designed time since death nomographs as representations of Henssge's parameters with the addition of both metric and imperial measurements, integration of weight adjusted scaling of correction factors, and a geometrically consistent framework for body weight and result reading, which eliminates some rounding steps and reduces the overall rounding-related estimation errors. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Potente [ForeName] => Stefan [Initials] => S [Identifier] => http://orcid.org/0000-0002-7196-5964 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan. stefan.potente@uks.eu. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine of Frankfurt 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Furthermore, an inverted culture method was used as an in vitro model of the blood-CSF barrier using epithelial cells of the human choroid plexus (HIBCPP cell line) and SDR-P-1D5 or MSH-P3 (PRL-secreting cell line derived from miniature swine hypophysis) under normoxic or hypoxic (5% oxygen) conditions, and as an index of cell activity, we used Vascular Endothelial Growth Factor (VEGF). [2] => Serum PRL levels were not significantly different between hypoxia/ischemia cases and other causes of death. However, PRL levels in CSF were three times higher in cases of hypoxia/ischemia than in those of the other causes of death. In the cultured cell under the hypoxia condition, PRL and VEGF showed a high concentration at 10 min. We established a brain-CSF barrier model to clarify the mechanism of PRL transport to CSF from blood, the PRL concentrations from blood to CSF increased under hypoxic conditions from 5 min. 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[ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17698391 ) ) [1] => SimpleXMLElement Object ( [Citation] => Indian J Endocrinol Metab. 2017 Jan-Feb;21(1):80-84 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28217503 ) ) [2] => SimpleXMLElement Object ( [Citation] => Endocrinology. 1987 May;120(5):1846-50 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 3569115 ) ) [3] => SimpleXMLElement Object ( [Citation] => J Hum Reprod Sci. 2013 Jul;6(3):168-75 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24347930 ) ) [4] => SimpleXMLElement Object ( [Citation] => Life Sci. 1983 Apr 18;32(16):1857-63 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 6300590 ) ) [5] => SimpleXMLElement Object ( [Citation] => Crit Pathw Cardiol. 2016 Dec;15(4):174-178 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27846011 ) ) [6] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2008 Aug 6;179(2-3):147-51 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18554831 ) ) [7] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2006 Sep 12;161(2-3):141-3 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16842951 ) ) [8] => SimpleXMLElement Object ( [Citation] => Lab Invest. 2003 Nov;83(11):1627-36 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 14615416 ) ) [9] => SimpleXMLElement Object ( [Citation] => PLoS One. 2017 Sep 26;12(9):e0184339 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28950026 ) ) [10] => SimpleXMLElement Object ( [Citation] => J Anim Sci Biotechnol. 2014 Jan 21;5(1):9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24444333 ) ) [11] => SimpleXMLElement Object ( [Citation] => Transl Psychiatry. 2016 Apr 19;6:e785 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27093067 ) ) [12] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2015 Sep;254:118-25 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26218406 ) ) [13] => SimpleXMLElement Object ( [Citation] => Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1685-92 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20926759 ) ) [14] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2009 Apr;11 Suppl 1:S228-30 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19369110 ) ) [15] => SimpleXMLElement Object ( [Citation] => Brain Behav Immun. 2012 Feb;26(2):201-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21820505 ) ) [16] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 1997 Jun 23;87(3):201-10 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 9248039 ) ) [17] => SimpleXMLElement Object ( [Citation] => Horm Metab Res. 1989 Aug;21(8):453-4 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 2793067 ) ) [18] => SimpleXMLElement Object ( [Citation] => PLoS One. 2017 Feb 6;12(2):e0171492 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28166273 ) ) [19] => SimpleXMLElement Object ( [Citation] => Endocrine. 2012 Feb;41(1):19-30 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22169962 ) ) [20] => SimpleXMLElement Object ( [Citation] => FASEB J. 2016 Feb;30(2):1002-10 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 26567005 ) ) [21] => SimpleXMLElement Object ( [Citation] => Endocrine. 2017 Aug;57(2):199-213 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28634745 ) ) [22] => SimpleXMLElement Object ( [Citation] => PLoS One. 2012;7(1):e30069 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22253884 ) ) [23] => SimpleXMLElement Object ( [Citation] => Neurosci Lett. 2000 Feb 4;279(3):137-40 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10688048 ) ) [24] => SimpleXMLElement Object ( [Citation] => J Vis Exp. 2016 May 06;(111): [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27213495 ) ) [25] => SimpleXMLElement Object ( [Citation] => Hum Cell. 2011 Jun;24(2):74-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21547353 ) ) [26] => SimpleXMLElement Object ( [Citation] => Int J Legal Med. 2011 Jan;125(1):11-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19760428 ) ) [27] => SimpleXMLElement Object ( [Citation] => Science. 2003 Jan 3;299(5603):117-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12511652 ) ) [28] => SimpleXMLElement Object ( [Citation] => Eur J Endocrinol. 1999 Oct;141(4):387-95 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10526254 ) ) [29] => SimpleXMLElement Object ( [Citation] => Front Endocrinol (Lausanne). 2016 Mar 30;7:25 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27065946 ) ) [30] => SimpleXMLElement Object ( [Citation] => Horm Behav. 2008 Jan;53(1):112-23 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 17963758 ) ) [31] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 2000 Sep 11;113(1-3):193-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10978624 ) ) [32] => SimpleXMLElement Object ( [Citation] => Hum Cell. 2005 Mar;18(1):67-72 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 16130902 ) ) [33] => SimpleXMLElement Object ( [Citation] => Leg Med (Tokyo). 2009 Apr;11 Suppl 1:S290-3 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19269212 ) ) [34] => SimpleXMLElement Object ( [Citation] => Life Sci. 2018 Jan 15;193:9-19 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29196053 ) ) [35] => SimpleXMLElement Object ( [Citation] => PLoS Biol. 2013;11(4):e1001542 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23630454 ) ) [36] => SimpleXMLElement Object ( [Citation] => Indian J Endocrinol Metab. 2017 Jul-Aug;21(4):545-550 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28670538 ) ) [37] => SimpleXMLElement Object ( [Citation] => Curr Pharm Biotechnol. 2016;17(14):1213-1221 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27604355 ) ) [38] => SimpleXMLElement Object ( [Citation] => Prz Menopauzalny. 2017 Mar;16(1):1-7 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28546800 ) ) [39] => SimpleXMLElement Object ( [Citation] => BMC Pediatr. 2017 Mar 28;17(1):90 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28351378 ) ) [40] => SimpleXMLElement Object ( [Citation] => Forensic Sci Int. 1996 Aug 15;81(2-3):201-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 8837496 ) ) [41] => SimpleXMLElement Object ( [Citation] => Adv Exp Med Biol. 2015;846:83-95 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25472535 ) ) [42] => SimpleXMLElement Object ( [Citation] => Endocrinology. 1989 Aug;125(2):964-70 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 2752987 ) ) [43] => SimpleXMLElement Object ( [Citation] => Ann Transl Med. 2017 May;5(10):206 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28603721 ) ) ) ) ) ) [18] => SimpleXMLElement Object 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 33-39 ) [ELocationID] => Array ( [0] => S0379-0738(18)30263-9 [1] => 10.1016/j.forsciint.2018.05.018 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Methamphetamine (MA) is an illicit stimulant that affects the central nervous system. Cytochrome P450 2D6 (CYP2D6) plays an important role in MA metabolism. Numerous allelic variants confer substantial variation in CYP2D6 activity among individuals. In the present study, we examined the frequencies of CYP2D6 alleles, including CYP2D6*1, *2, *4, *5, *10, *14A, *14B, *18, and *36, and multiplication, in 82 forensic autopsy cases of MA abusers and 567 autopsy cases in which MA was not detected (controls). Ultrarapid metabolizer (UM), extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM) phenotypes were predicted from CYP2D6 genotypes. Of MA abusers, 64 subjects were predicted to be EM, 17 were IM, and 1 was UM. No MA abuser had the predicted PM phenotype. No significant differences in CYP2D6 phenotype frequencies were found between MA abusers and controls. MA and amphetamine (AMP) concentrations were measured in the right heart blood, left heart blood, peripheral external iliac blood, urine, pericardial fluid, and bone marrow of MA abusers. MA concentrations in urine and bone marrow were significantly higher in IM than in EM. AMP concentration was not associated with CYP2D6 phenotype in any body fluid. These results suggest that the MA concentration in body fluids is influenced by CYP2D6 phenotypes in the Japanese population. [CopyrightInformation] => Copyright © 2018 Elsevier B.V. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Matsusue [ForeName] => Aya [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address: miyoshi@fukuoka-u.ac.jp. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikeda [ForeName] => Tomoya [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tani [ForeName] => Naoto [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Waters [ForeName] => Brian [Initials] => B [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hara [ForeName] => Kenji [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kashiwagi [ForeName] => Masayuki [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Takayama [ForeName] => Mio [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ikematsu [ForeName] => Natsuki [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kubo [ForeName] => Shin-Ichi [Initials] => SI [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2018 [Month] => 05 [Day] => 18 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Ireland [MedlineTA] => Forensic Sci Int [NlmUniqueID] => 7902034 [ISSNLinking] => 0379-0738 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Narcotics ) [1] => SimpleXMLElement Object ( [RegistryNumber] => 44RAL3456C [NameOfSubstance] => Methamphetamine ) [2] => SimpleXMLElement Object ( [RegistryNumber] => EC 1.14.14.1 [NameOfSubstance] => Cytochrome P-450 CYP2D6 ) ) ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Adolescent ) [1] => SimpleXMLElement Object ( [DescriptorName] => Adult ) [2] => 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SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2018 [Month] => 05 [Day] => 10 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2018 [Month] => 5 [Day] => 31 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2018 [Month] => 8 [Day] => 8 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2018 [Month] => 5 [Day] => 30 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 29843110 [1] => S0379-0738(18)30263-9 [2] => 10.1016/j.forsciint.2018.05.018 ) ) ) ) [19] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 29705644 [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 11 [Day] => 20 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1873-4162 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 33 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 [Month] => Apr [Day] => 24 ) ) [Title] => Legal medicine (Tokyo, Japan) [ISOAbbreviation] => Leg Med (Tokyo) ) [ArticleTitle] => Japaneseplex: A forensic SNP assay for identification of Japanese people using Japanese-specific alleles. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 17-22 ) [ELocationID] => Array ( [0] => S1344-6223(17)30226-2 [1] => 10.1016/j.legalmed.2018.04.008 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => It is sometimes necessary to determine whether a forensic biological sample came from a Japanese person. In this study, we developed a 60-locus SNP assay designed for the differentiation of Japanese people from other East Asians using entirely and nearly Japanese-specific alleles. This multiplex assay consisted of 6 independent PCR reactions followed by single nucleotide extension. The average number and standard deviation of Japanese-specific alleles possessed by an individual were 0.81 ± 0.93 in 108 Koreans from Seoul, 8.87 ± 2.89 in 103 Japanese from Tottori, 17.20 ± 3.80 in 88 Japanese from Okinawa, and 0 in 220 Han Chinese from Wuxi and Changsha. The Koreans had 0-4 Japanese-specific alleles per individual, whereas the Japanese had 4-26 Japanese-specific alleles. Almost all Japanese were distinguished from the Koreans and other people by the factorial correspondence and principal component analyses. The Snipper program was also useful to estimate the degree of Japaneseness. The method described here was successfully applied to the differentiation of Japanese from non-Japanese people in forensic cases. This Japanese-specific SNP assay was named Japaneseplex. [CopyrightInformation] => Copyright © 2018 Elsevier B.V. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Yuasa [ForeName] => Isao [Initials] => I [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan. Electronic address: yuasai@med.tottori-u.ac.jp. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Akane [ForeName] => Atsushi [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Kansai Medical University, Hirakata, Japan. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Yamamoto [ForeName] => Toshimichi [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine and Bioethics, Nagoya University School of Medicine, Nagoya, Japan. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Matsusue [ForeName] => Aya [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Fukuoka University School of Medicine, Fukuoka, Japan. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Endoh [ForeName] => Minoru [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Nakagawa [ForeName] => Mayumi [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Pathobiological Science and Technology, Faculty of Medicine, Tottori University, Yonago, Japan. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Umetsu [ForeName] => Kazuo [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Forensic Medicine, Yamagata University School of Medicine, Yamagata, Japan. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ishikawa [ForeName] => Takaki [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Iino [ForeName] => Morio [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2018 [Month] => 04 [Day] => 24 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Ireland [MedlineTA] => Leg Med (Tokyo) [NlmUniqueID] => 100889186 [ISSNLinking] => 1344-6223 ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Biogeographical ancestry [1] => Japanese-specific [2] => Japaneseplex [3] => SNaPshot [4] => Single nucleotide polymorphism ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2017 [Month] => 06 [Day] => 19 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2018 [Month] => 02 [Day] => 15 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2018 [Month] => 04 [Day] => 23 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2018 [Month] => 5 [Day] => 1 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2018 [Month] => 5 [Day] => 1 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2018 [Month] => 4 [Day] => 30 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 29705644 [1] => S1344-6223(17)30226-2 [2] => 10.1016/j.legalmed.2018.04.008 ) ) ) ) ) ) Takaki Ishikawa | PubFacts

Publications by authors named "Takaki Ishikawa"

170Publications

Acute abdominal disease with nonspecific symptoms in the elderly: A case series.

J Forensic Leg Med 2021 Jan 21;78:102089. Epub 2021 Jan 21.

Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, C/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address:

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January 2021

Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia.

Hum Cell 2021 Mar 2;34(2):400-418. Epub 2021 Feb 2.

Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan.

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March 2021

Inferior mesenteric artery laceration associated with blunt abdominal trauma with Casper's sign in a physically abused child: An autopsy case and literature review.

J Forensic Leg Med 2020 Aug 19;74:102001. Epub 2020 Jul 19.

Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan. Electronic address:

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August 2020

Thyroid-related hormones as potential markers of hypoxia/ischemia.

Hum Cell 2020 Jul 7;33(3):545-558. Epub 2020 Mar 7.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan.

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July 2020

Cortisol levels after cold exposure are independent of adrenocorticotropic hormone stimulation.

PLoS One 2020 18;15(2):e0218910. Epub 2020 Feb 18.

Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan.

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April 2020

Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic Ketoacidosis

J Clin Res Pediatr Endocrinol 2020 06 13;12(2):160-167. Epub 2019 Sep 13.

Drexel University College of Medicine, Department of Microbiology and Immunology, Pennsylvania, USA

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June 2020

Immunohistochemical detection of respiratory syncytial virus at autopsy.

Pediatr Int 2019 Aug 23;61(8):781-791. Epub 2019 Aug 23.

Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan.

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August 2019

Postmortem water contents of major organs with regard to the cause of death.

J Forensic Leg Med 2019 Jul 11;65:48-54. Epub 2019 May 11.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585, Osaka, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585, Osaka, Japan.

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July 2019

Evaluation of the distribution of nicotine intravenous injection: an adult autopsy case report with a review of literature.

Int J Legal Med 2020 Jan 7;134(1):243-249. Epub 2019 Apr 7.

Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka, 545-8585, Japan.

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January 2020

Pathophysiological significance of clock genes BMAL1 and PER2 as erythropoietin-controlling factors in acute blood hemorrhage.

Hum Cell 2019 Jul 2;32(3):275-284. Epub 2019 Apr 2.

Department of Legal Medicine, Osaka City University Medical School, Asahi-Machi 1-4-3, Abeno, Osaka, 545-8585, Japan.

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July 2019

Toxicological and Biochemical Analyses of an Autopsy Case Involving Oral Overdose of Multiple Antidiabetic and Antihypertensive Drugs.

Case Rep Med 2018 25;2018:5864658. Epub 2018 Nov 25.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan.

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November 2018

Effects of postmortem positional changes on conjunctival petechiae.

Forensic Sci Med Pathol 2019 03 3;15(1):13-22. Epub 2018 Nov 3.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan.

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March 2019

Analysis of psychotropic drug-related deaths in south Osaka.

Subst Abuse Rehabil 2018 24;9:79-90. Epub 2018 Sep 24.

Department of Legal Medicine, Osaka City University Medical School, Abeno, Osaka, Japan,

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September 2018

Time since death nomographs implementing the nomogram, body weight adjusted correction factors, metric and imperial measurements.

Int J Legal Med 2019 Mar 25;133(2):491-499. Epub 2018 Sep 25.

Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka, 545-8585, Japan.

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March 2019

Prolactin selectively transported to cerebrospinal fluid from blood under hypoxic/ischemic conditions.

PLoS One 2018 27;13(6):e0198673. Epub 2018 Jun 27.

Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan.

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December 2018

Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases.

Forensic Sci Int 2018 Aug 18;289:33-39. Epub 2018 May 18.

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan.

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August 2018

Japaneseplex: A forensic SNP assay for identification of Japanese people using Japanese-specific alleles.

Leg Med (Tokyo) 2018 Apr 24;33:17-22. Epub 2018 Apr 24.

Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.

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April 2018