Dr. Taher Darreh-Shori, PhD - Karolinska Institutet - Associate Professor

Dr. Taher Darreh-Shori

PhD

Karolinska Institutet

Associate Professor

Stockholm, Stockholm | Sweden

Main Specialties: Pharmacology

Additional Specialties: Pharmacology & Enzymology

Dr. Taher Darreh-Shori, PhD - Karolinska Institutet - Associate Professor

Dr. Taher Darreh-Shori

PhD

Introduction

Primary Affiliation: Karolinska Institutet - Stockholm, Stockholm , Sweden

Specialties:

Additional Specialties:

Publications

19Publications

437Reads

-Profile Views

188PubMed Central Citations

Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway.

PLoS One 2013 19;8(6):e65936. Epub 2013 Jun 19.

Division of Alzheimer Neurobiology Center, Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Huddinge, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065936PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686815PMC
October 2017
11 Reads
17 Citations
3.234 Impact Factor

Understanding the beneficial and detrimental effects of donepezil and rivastigmine to improve their therapeutic value.

J Alzheimers Dis 2015 ;44(4):1039-62

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Huddinge, Sweden.

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http://dx.doi.org/10.3233/JAD-142268DOI Listing
November 2015
1 Read
2 Citations
4.151 Impact Factor

Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor.

J Alzheimers Dis 2015 ;43(3):1059-72

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Department of Geriatrics, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-141068DOI Listing
August 2015
65 Reads
10 Citations
4.151 Impact Factor

Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.

J Alzheimers Dis 2014 ;39(2):423-40

Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institute, Stockholm, Sweden Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-130845DOI Listing
October 2014
24 Reads
3 Citations
4.151 Impact Factor

High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.

Alzheimers Dement 2014 Sep 24;10(5):530-540.e1. Epub 2013 Aug 24.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Neurobiology Center, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2013.03.010DOI Listing
September 2014
27 Reads
4 Citations
12.410 Impact Factor

Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation.

J Cell Mol Med 2014 Sep 11;18(9):1874-88. Epub 2014 Aug 11.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Stockholm, Sweden.

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http://dx.doi.org/10.1111/jcmm.12343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196662PMC
September 2014
19 Reads
7 Citations

Unbiased expression mapping identifies a link between the complement and cholinergic systems in the rat central nervous system.

J Immunol 2014 Feb 18;192(3):1138-53. Epub 2013 Dec 18.

Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden;

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http://dx.doi.org/10.4049/jimmunol.1301233DOI Listing
February 2014
38 Reads
5 Citations
4.922 Impact Factor

Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease.

Neurobiol Aging 2013 Nov 4;34(11):2465-81. Epub 2013 Jun 4.

Division of Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.027DOI Listing
November 2013
19 Reads
8 Citations
5.013 Impact Factor

A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease.

Prim Care Companion CNS Disord 2013 7;15(2). Epub 2013 Mar 7.

Alzheimer Neurobiology Center, Karolinska Institute, Stockholm, Sweden (Drs Nordberg and Darreh-Shori); Wolfson Centre for Age-Related Diseases, King's College, London, United Kingdom (Dr Ballard); Kingshill Research Centre, Victoria Hospital, Swindon, United Kingdom (Dr Bullock); and Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (Dr Somogyi).

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http://dx.doi.org/10.4088/PCC.12r01412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733526PMC
August 2013
61 Reads
12 Citations

Biomarkers in Alzheimer's disease and lewy body disorders with dementia.

Int J Alzheimers Dis 2013 9;2013:473181. Epub 2013 Jan 9.

Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwer Str. 14, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1155/2013/473181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556405PMC
February 2013
4 Reads

Apolipoprotein ε4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease.

J Alzheimers Dis 2012 ;28(2):443-58

Division of Alzheimer Neurobiology Center, Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JAD-2011-111088DOI Listing
May 2012
40 Reads
9 Citations
4.151 Impact Factor

Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo.

Neurobiol Aging 2011 Dec 9;32(12):2320.e15-32. Epub 2010 Jun 9.

Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.04.028DOI Listing
December 2011
35 Reads
19 Citations
5.013 Impact Factor

The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase.

Neurobiol Aging 2011 Jul 26;32(7):1236-48. Epub 2009 Aug 26.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.07.015DOI Listing
July 2011
5 Reads
14 Citations
5.013 Impact Factor

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease.

Brain 2011 Jan 13;134(Pt 1):301-17. Epub 2010 Dec 13.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awq349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009843PMC
January 2011
8 Reads
35 Citations
9.200 Impact Factor

Safety and tolerability of transdermal and oral rivastigmine in Alzheimer's disease and Parkinson's disease dementia.

Expert Opin Drug Saf 2010 Jan;9(1):167-76

Karolinska University Hospital, Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Novum, 4th Floor, Room 4F23:10, 141 86, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1517/14740330903439717DOI Listing
January 2010
16 Reads
4 Citations
2.911 Impact Factor

Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment.

Pharmacogenet Genomics 2009 Aug;19(8):635-46

Alzheimer's Disease Center, Center of Excellence on Brain Aging, NYU Langone Medical Center, Orangeburg, New York, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32832f8c17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114757PMC
August 2009
19 Reads
5 Citations
3.481 Impact Factor

Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients.

Curr Alzheimer Res 2009 Feb;6(1):4-14

Karolinska Institute, Division of Alzheimer Neurobiology, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046577PMC
http://dx.doi.org/10.2174/156720509787313961DOI Listing
February 2009
14 Reads
8 Citations
3.890 Impact Factor

Changes in brain 11C-nicotine binding sites in patients with mild Alzheimer's disease following rivastigmine treatment as assessed by PET.

Psychopharmacology (Berl) 2007 May 20;191(4):1005-14. Epub 2007 Feb 20.

Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, Novum Floor-5, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00213-007-0725-zDOI Listing
May 2007
6 Reads
13 Citations
3.880 Impact Factor

Top co-authors

Agneta Nordberg
Agneta Nordberg

Karolinska Institutet

11
Swetha Vijayaraghavan
Swetha Vijayaraghavan

Karolinska Institutet

5
Ove Almkvist
Ove Almkvist

Karolinska Institutet

4
Shahin Aeinehband
Shahin Aeinehband

Department of Clinical Neuroscience

3
Fredrik Piehl
Fredrik Piehl

Karolinska Institutet

3
Roger Lane
Roger Lane

University of Hull

3
Hilkka Soininen
Hilkka Soininen

Institute of Clinical Medicine

3
Niels Andreasen
Niels Andreasen

Karolinska Institute

3
Kaj Blennow
Kaj Blennow

Institute of Neuroscience and Physiology

3