Publications by authors named "Taha Merghoub"

100Publications

Innate immune checkpoints for cancer immunotherapy: expanding the scope of non T cell targets.

Ann Transl Med 2020 Aug;8(16):1031

Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.21037/atm-20-1816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475486PMC
August 2020

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.

Nat Commun 2020 08 11;11(1):4011. Epub 2020 Aug 11.

Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41467-020-17750-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419300PMC
August 2020

Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism.

Arch Biochem Biophys 2020 09 15;690:108479. Epub 2020 Jul 15.

Cell and Molecular Biology Laboratory (LBCM), Team Cytokines and Nitric oxide Synthase: Immunity and Pathogeny, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), Bab Ezzouar, Algiers, Algeria. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2020.108479DOI Listing
September 2020

In vitro assays for effector T cell functions and activity of immunomodulatory antibodies.

Methods Enzymol 2020 22;631:43-59. Epub 2019 Oct 22.

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Weill Cornell Medicine, New York, NY, United States.

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http://dx.doi.org/10.1016/bs.mie.2019.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362725PMC
October 2019

One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade.

Hepatobiliary Surg Nutr 2019 Jun;8(3):289-294

Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.21037/hbsn.2019.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561888PMC
June 2019

Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect.

Front Immunol 2019 2;10:604. Epub 2019 Apr 2.

Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00604
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http://dx.doi.org/10.3389/fimmu.2019.00604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454083PMC
July 2020

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.

Cell Rep 2019 04;27(3):806-819.e5

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193039
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http://dx.doi.org/10.1016/j.celrep.2019.03.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719696PMC
April 2019

Correction to: Strategies for Predicting Response to Checkpoint Inhibitors.

Curr Hematol Malig Rep 2019 Feb;14(1):62

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://link.springer.com/10.1007/s11899-018-0488-0
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http://dx.doi.org/10.1007/s11899-018-0488-0DOI Listing
February 2019

Strategies for Predicting Response to Checkpoint Inhibitors.

Curr Hematol Malig Rep 2018 10;13(5):383-395

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://link.springer.com/10.1007/s11899-018-0471-9
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http://dx.doi.org/10.1007/s11899-018-0471-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719799PMC
October 2018

Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus.

Oncotarget 2018 Jun 19;9(47):28702-28716. Epub 2018 Jun 19.

Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.25614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033351PMC
June 2018

Non-conventional Inhibitory CD4Foxp3PD-1 T Cells as a Biomarker of Immune Checkpoint Blockade Activity.

Cancer Cell 2018 06;33(6):1017-1032.e7

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648657PMC
June 2018

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.

N Engl J Med 2018 May 16;378(21):1976-1986. Epub 2018 Apr 16.

From the Bloomberg-Kimmel Institute for Cancer Immunotherapy and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (P.M.F., K.N.S., V.A., T.R.C., M.Z., S.C.Y., S.B., R.J.B., J.N., K.A.M., F.V., H.G., J.Z., J.X.C., H.Y.C., J.-W.S., R.B.S., J.W., E.G., H.W., G.L.R., J.M.T., V.E.V., S.L.T., J.R.B., D.M.P.); Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine (J.E.C., M.D.H., D.R.J., M.J.V., N.R., Z.O., V.R., J.D.W., T.M.) and the Ludwig Collaborative (J.D.W., T.M.) - all in New York; the Parker Institute for Cancer Immunotherapy, San Francisco (J.D.W., T.M.); and Swim Across America Laboratory, Charlotte, NC (J.D.W., T.M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1716078
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http://dx.doi.org/10.1056/NEJMoa1716078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223617PMC
May 2018

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.

Cancer Cell 2018 05 12;33(5):843-852.e4. Epub 2018 Apr 12.

Department of Medicine, Memorial Sloan Kettering Cancer Center, 885 2(nd) Avenue, New York, NY 10017, USA; Weill Cornell School of Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183012
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http://dx.doi.org/10.1016/j.ccell.2018.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953836PMC
May 2018

Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.

Cancer Cell 2018 04;33(4):581-598

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896787PMC
April 2018

PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.

J Clin Invest 2018 04 5;128(4):1413-1428. Epub 2018 Mar 5.

Department of Medicine, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, USA.

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http://dx.doi.org/10.1172/JCI98047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873884PMC
April 2018

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Mol Ther 2018 04 31;26(4):1008-1019. Epub 2018 Jan 31.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079372PMC
April 2018

Immune-Active Microenvironment in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Rationale for Immune Checkpoint Blockade.

J Natl Cancer Inst 2018 07;110(7):787-790

Department of Medicine, Gynecologic Medical Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1093/jnci/djx277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037122PMC
July 2018

Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.

J Clin Oncol 2018 03 16;36(7):633-641. Epub 2018 Jan 16.

Hira Rizvi, Francisco Sanchez-Vega, Konnor La, Walid Chatila, Philip Jonsson, Darragh Halpenny, Andrew Plodkowski, Niamh Long, Jennifer L. Sauter, Natasha Rekhtman, Travis Hollmann, Ronglai Shen, Ai Ni, Kathryn C. Arbour, Taha Merghoub, Jedd Wolchok, Jamie E. Chaft, Mark G. Kris, Charles M. Rudin, Nicholas D. Socci, Michael F. Berger, Barry S. Taylor, Ahmet Zehir, David B. Solit, Maria E. Arcila, Marc Ladanyi, Gregory J. Riely, Nikolaus Schultz, and Matthew D. Hellmann, Memorial Sloan Kettering Cancer Center; Taha Merghoub, Jedd Wolchok, Alexandra Snyder, Jamie E. Chaft, Mark G. Kris, Charles M. Rudin, Gregory J. Riely, and Matthew D. Hellmann, Weill Cornell Medical College, New York, NY; Kurt A. Schalper, Yale School of Medicine, New Haven, CT; Justin F. Gainor, Massachusetts General Hospital, Boston, MA; and Alexandra Snyder, Adaptive Biotechnologies, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2017.75.3384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075848PMC
March 2018

Antiangiogenic therapy and immune checkpoint blockade go hand in hand.

Ann Transl Med 2017 Dec;5(24):497

Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, NY, USA.

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http://dx.doi.org/10.21037/atm.2017.10.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750272PMC
December 2017

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment.

Sci Signal 2017 Aug 29;10(494). Epub 2017 Aug 29.

Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scisignal.aak9702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851440PMC
August 2017

In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide.

Sci Immunol 2016 Jul 23;1(1):aaf6925. Epub 2016 Jun 23.

Division of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/sciimmunol.aaf6925DOI Listing
July 2016

Loss-of-Function Alterations Are Associated With Intrinsic Resistance to BRAF Inhibitors in Metastatic Melanoma.

JCO Precis Oncol 2017 23;1. Epub 2017 Jun 23.

, , , , , , , , , , , and , Memorial Sloan Kettering Cancer Center, New York, NY; , , and , Vanderbilt University Medical Center; and and , Vanderbilt-Ingram Cancer Center, Nashville, TN.

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http://dx.doi.org/10.1200/PO.16.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446400PMC
June 2017

Curbing Tregs' (Lack of) Enthusiasm.

Cell 2017 06;169(6):981-982

Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Ludwig Institute for Cancer Research, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, New York, NY 10065, USA; Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.05.027DOI Listing
June 2017

Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma.

J Invest Dermatol 2017 05 28;137(5):1135-1143. Epub 2017 Jan 28.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392423PMC
May 2017

Interfering with Helios-induced regulatory T cell stability as a strategy for cancer immunotherapy.

Transl Cancer Res 2016 Nov;5(Suppl 6):S1116-S1118

Ludwig Collaborative and Swim Across America Laboratory & Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.21037/tcr.2016.11.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785040PMC
November 2016

Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.

Oncoimmunology 2016 Jul 25;5(7):e1151595. Epub 2016 Apr 25.

Swim Across America/Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center , New York, NY, USA.

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http://dx.doi.org/10.1080/2162402X.2016.1151595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006914PMC
July 2016

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors.

EBioMedicine 2016 Apr 13;6:50-58. Epub 2016 Feb 13.

Swim Across America/Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; Weill Cornell Medical College, New York, NY 10065, United States; Graduate School of Medical Sciences of Cornell University, New York, NY 10065, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856741PMC
April 2016

Protein Expression Analysis of Melanocyte Differentiation Antigen TRP-2.

Am J Dermatopathol 2016 Mar;38(3):201-7

*Department of Immunology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY; †Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY; ‡Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai Hospital, New York, NY; and §Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/DAD.0000000000000362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844230PMC
March 2016

Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.

Immunity 2016 Jan;44(1):179-193

Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996670PMC
January 2016

Genetics and immunology: reinvigorated.

Oncoimmunology 2015 Oct 14;4(10):e1029705. Epub 2015 Apr 14.

Human Oncology and Pathogenesis Program; Memorial Sloan-Kettering Cancer Center ; New York, NY USA.

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http://dx.doi.org/10.1080/2162402X.2015.1029705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589040PMC
October 2015

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner.

Cell Rep 2015 Oct 24;13(2):412-24. Epub 2015 Sep 24.

Swim Across America/Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Programs, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013825PMC
October 2015

Alphavirus-based vaccines in melanoma: rationale and potential improvements in immunotherapeutic combinations.

Immunotherapy 2015 27;7(9):981-97. Epub 2015 Aug 27.

Ludwig Collaborative & Swim Across America Laboratory, New York, NY, USA.

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http://dx.doi.org/10.2217/imt.15.64DOI Listing
August 2016

The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy.

Adv Cancer Res 2015 9;128:1-68. Epub 2015 Jun 9.

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2015.04.010DOI Listing
April 2016

A Retrospective Evaluation of Vemurafenib as Treatment for BRAF-Mutant Melanoma Brain Metastases.

Oncologist 2015 Jul 8;20(7):789-97. Epub 2015 May 8.

Departments of Medicine and Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Department of Medicine, Weill Cornell Medical College, New York, New York, USA; Human Oncology and Pathogenesis Program, Memorial Hospital Research Laboratories, New York, New York, USA; Immunology and Molecular and Pharmacology and Chemistry Programs, Sloan Kettering Institute, New York, New York, USA.

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http://dx.doi.org/10.1634/theoncologist.2014-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492223PMC
July 2015

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.

Science 2015 Apr 12;348(6230):124-8. Epub 2015 Mar 12.

Weill Cornell Medical College, New York, NY, 10065, USA. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aaa1348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993154PMC
April 2015

Genetic basis for clinical response to CTLA-4 blockade in melanoma.

N Engl J Med 2014 Dec 19;371(23):2189-2199. Epub 2014 Nov 19.

Department of Medicine (A.S., T.M., M.A.P., J.D.W.), Human Oncology and Pathogenesis Program (A.S., V.M., A.D., L.A.W., K.K., T.A.C.), Swim across America-Ludwig Collaborative Research Laboratory (T.M., Y.L., C.E., C.L., J.D.W.), Department of Radiation Oncology (T.A.C.), Department of Pathology (T.J.H.), and Immunology Program, Ludwig Center for Cancer Immunotherapy (J.Y., P.W., T.S.H., J.D.W.), Memorial Sloan Kettering Cancer Center; Weill Cornell Medical College (A.S., M.A.P., J.D.W., T.A.C.); and Department of Mathematics, Columbia University (C.B.) - all in New York; the Department of Molecular and Medical Pharmacology (J.M.Z., A.R.) and the Department of Medicine, Division of Hematology-Oncology, Jonsson Comprehensive Cancer Center (A.R.), University of California, Los Angeles, Los Angeles; and Bristol-Myers Squibb, Princeton, NJ (C.T.H., L.W.).

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http://dx.doi.org/10.1056/NEJMoa1406498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315319PMC
December 2014

Immunotherapy and the belly of the beast.

J Exp Med 2014 Nov;211(12):2327-8

Memorial Sloan Kettering Cancer Center

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http://dx.doi.org/10.1084/jem.21112insight3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235645PMC
November 2014

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.

PLoS Pathog 2014 Apr 17;10(4):e1003989. Epub 2014 Apr 17.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America; Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990710PMC
April 2014

The importance of animal models in tumor immunity and immunotherapy.

Curr Opin Genet Dev 2014 Feb 29;24:46-51. Epub 2013 Dec 29.

Ludwig Collaborative Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2013.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241684PMC
February 2014

Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies.

Cancer Discov 2014 May 3;4(5):538-45. Epub 2014 Mar 3.

1Human Oncology and Pathogenesis Program, 2Leukemia Service, 3Gastrointestinal Oncology Service, 4Melanoma and Immunotherapeutics Service, Department of Medicine, 5Molecular Diagnostics Service, Department of Pathology, 6Department of Radiology, 7Center for Molecular Oncology, 8Ludwig Center for Cancer Immunotherapy, and 9Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center; and 10Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850735PMC
May 2014

Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation.

Cell 2014 Feb;156(5):986-1001

Laboratory of Systems Cancer Biology, Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.038DOI Listing
February 2014

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.

Cancer Res 2014 Apr 27;74(8):2340-50. Epub 2014 Feb 27.

Authors' Affiliations: Louis V. Gerstner, Jr. Graduate School of Biomedical Science; Human Oncology and Pathogenesis Program; Departments of Pediatrics, Pathology, and Medicine; Programs in Molecular Pharmacology and Chemistry; Computational Biology; Ludwig Collaborative Lab, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles; Departments of Epidemiology and Biostatistics and Medicine, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005042PMC
April 2014

Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.

Blood 2014 Apr 20;123(14):2172-80. Epub 2014 Feb 20.

Ludwig Collaborative Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY;

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http://dx.doi.org/10.1182/blood-2013-12-544742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975257PMC
April 2014

GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability.

Cancer Immunol Res 2013 Nov;1(5):320-31

Swim Across America & Ludwig Collaborative Lab Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY ; Weill Cornell Medical College, Memorial Sloan-Kettering Cancer Center, New York, NY ; Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885345PMC
November 2013