Publications by authors named "Tae Heung Kang"

65Publications

Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment.

Nat Commun 2020 02 28;11(1):1137. Epub 2020 Feb 28.

Department of Pathology, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41467-020-14821-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048819PMC
February 2020

Brown Adipocyte and Splenocyte Co-Culture Maintains Regulatory T Cell Subset in Intermittent Hypobaric Conditions.

Tissue Eng Regen Med 2019 10 19;16(5):539-548. Epub 2019 Aug 19.

2Department of Plastic and Reconstructive Surgery, School of Medicine, Konkuk University, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030 Republic of Korea.

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http://dx.doi.org/10.1007/s13770-019-00205-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778593PMC
October 2019

TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy.

J Immunother Cancer 2019 10 16;7(1):260. Epub 2019 Oct 16.

Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/s40425-019-0738-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794732PMC
October 2019

Lyophilizable and Multifaceted Toll-like Receptor 7/8 Agonist-Loaded Nanoemulsion for the Reprogramming of Tumor Microenvironments and Enhanced Cancer Immunotherapy.

ACS Nano 2019 11 11;13(11):12671-12686. Epub 2019 Oct 11.

SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, School of Chemical Engineering , Sungkyunkwan University (SKKU) , 2066 Seobu-ro , Jangan-gu, Suwon , Gyeonggi-do 16419 , Republic of Korea.

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http://dx.doi.org/10.1021/acsnano.9b04207DOI Listing
November 2019

Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence.

Nat Commun 2019 08 20;10(1):3745. Epub 2019 Aug 20.

Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.

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http://dx.doi.org/10.1038/s41467-019-11730-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702226PMC
August 2019

Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis.

Int Immunopharmacol 2019 Aug 4;73:482-490. Epub 2019 Jun 4.

Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine, Konkuk University, Chungju 380-701, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2019.05.051DOI Listing
August 2019

Endoplasmic reticulum stress enhances the antigen-specific T cell immune responses and therapeutic antitumor effects generated by therapeutic HPV vaccines.

J Biomed Sci 2019 May 27;26(1):41. Epub 2019 May 27.

Department of Pathology, Johns Hopkins Medical Institutes, 1550 Orleans Street, Cancer Research Building II, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1186/s12929-019-0536-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535840PMC
May 2019

Repositioning of the antipsychotic drug TFP for sepsis treatment.

J Mol Med (Berl) 2019 05 8;97(5):647-658. Epub 2019 Mar 8.

Department of Immunology, School of Medicine, KonKuk University, 268, Chungwondaero, Chungju, 27478, South Korea.

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http://dx.doi.org/10.1007/s00109-019-01762-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488556PMC
May 2019

A novel TLR4 binding protein, 40S ribosomal protein S3, has potential utility as an adjuvant in a dendritic cell-based vaccine.

J Immunother Cancer 2019 02 28;7(1):60. Epub 2019 Feb 28.

Department of Immunology, KU Open Innovation Center, School of Medicine, Konkuk University, 268, Chungwondaero, Chungju, 274798, South Korea.

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http://dx.doi.org/10.1186/s40425-019-0539-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394096PMC
February 2019

An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model.

Cancer Immunol Res 2019 02 4;7(2):219-229. Epub 2018 Dec 4.

Aging Research Institute, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0317DOI Listing
February 2019

Elevated expression of pancreatic adenocarcinoma upregulated factor (PAUF) is associated with poor prognosis and chemoresistance in epithelial ovarian cancer.

Sci Rep 2018 08 15;8(1):12161. Epub 2018 Aug 15.

Experimental Pathology Laboratory, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41598-018-30582-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093878PMC
August 2018

Tamarixetin Exhibits Anti-inflammatory Activity and Prevents Bacterial Sepsis by Increasing IL-10 Production.

J Nat Prod 2018 06 31;81(6):1435-1443. Epub 2018 May 31.

Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine , Konkuk University , Chungju , 380-701 , South Korea.

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http://dx.doi.org/10.1021/acs.jnatprod.8b00155DOI Listing
June 2018

Non-genetic engineering of cytotoxic T cells to target IL-4 receptor enhances tumor homing and therapeutic efficacy against melanoma.

Biomaterials 2018 03 8;159:161-173. Epub 2018 Jan 8.

Department of Biochemistry and Cell Biology, Department of Biomedical Science, CMRI, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183001
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http://dx.doi.org/10.1016/j.biomaterials.2018.01.013DOI Listing
March 2018

Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity.

Biomaterials 2017 06 26;130:56-66. Epub 2017 Mar 26.

SKKU Advanced Institute of Nanotechnology (SAINT) and School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.03.034DOI Listing
June 2017

Neoagarooligosaccharides prevent septic shock by modulating A20-and cyclooxygenase-2-mediated interleukin-10 secretion in a septic-shock mouse model.

Biochem Biophys Res Commun 2017 May 28;486(4):998-1004. Epub 2017 Mar 28.

Department of Immunology, Laboratory of Dendritic Cell Differentiation and Regulation, School of Medicine, Konkuk University, Chungju 380-701, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.03.152DOI Listing
May 2017

Toll-like receptor 3-induced immune response by poly(d,l-lactide-co-glycolide) nanoparticles for dendritic cell-based cancer immunotherapy.

Int J Nanomedicine 2016;11:5729-5742. Epub 2016 Nov 2.

Department of Immunology, School of Medicine, Konkuk University, Chungwondaero, Chungju-Si, Chungcheongbuk-Do.

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http://dx.doi.org/10.2147/IJN.S109001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098754PMC
February 2017

Annexin A5 increases survival in murine sepsis model by inhibiting HMGB1-mediated pro-inflammation and coagulation.

Mol Med 2016 Sep 6;22:424-436. Epub 2016 Jul 6.

Department of Immunology, KU open innovation center and School of Medicine, Konkuk University, Chungju 380-701, South Korea.

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http://dx.doi.org/10.2119/molmed.2016.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072405PMC
September 2016

Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-γ-induced Indoleamine 2,3-Dioxygenase Expression.

J Biol Chem 2015 May 26;290(19):12394-402. Epub 2015 Mar 26.

the Department of Immunology, Laboratory of Dendritic Cell Differentiation and Regulation, Konkuk University School of Medicine, Chungju 380-701, South Korea

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http://dx.doi.org/10.1074/jbc.M114.628578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424368PMC
May 2015

MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer.

BMC Cancer 2014 Dec 15;14:957. Epub 2014 Dec 15.

Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-Dong, Gangnam-Gu, Seoul 135-720, Korea.

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http://dx.doi.org/10.1186/1471-2407-14-957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301905PMC
December 2014

GM-CSF-loaded chitosan hydrogel as an immunoadjuvant enhances antigen-specific immune responses with reduced toxicity.

BMC Immunol 2014 Oct 18;15:48. Epub 2014 Oct 18.

Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University, Gojan-1 Dong, Ansan-Si 425-707, Gyeonggi-Do, South Korea.

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http://dx.doi.org/10.1186/s12865-014-0048-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201920PMC
October 2014

Apoptosis Inhibitor 5 Increases Metastasis via Erk-mediated MMP expression.

BMB Rep 2015 Jun;48(6):330-5

Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University, Ansan 425-707; Department of Biochemistry, Korea University College of Medicine, Seoul 136-705, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578619PMC
http://dx.doi.org/10.5483/bmbrep.2015.48.6.139DOI Listing
June 2015

Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects.

PLoS One 2014 29;9(7):e103562. Epub 2014 Jul 29.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103562PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114790PMC
November 2015

Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X.

J Immunol 2014 Aug 2;193(3):1233-45. Epub 2014 Jul 2.

Department of Immunology, Laboratory of Dendritic Cell Differentiation and Regulation, School of Medicine, Konkuk University, Chungju 380-701, South Korea;

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http://dx.doi.org/10.4049/jimmunol.1400656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105239PMC
August 2014

API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.

Cancer Res 2014 Jul 25;74(13):3556-66. Epub 2014 Apr 25.

Authors' Affiliations: Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University; Global Research Lab, Division of Brain Korea 21 Program for Biomedical Science and Department of Biochemistry, Korea University College of Medicine, Seoul;

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http://cancerres.aacrjournals.org/content/early/2014/04/25/0
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http://cancerres.aacrjournals.org/content/early/2014/06/12/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-3225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394897PMC
July 2014

The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4.

BMB Rep 2014 Feb;47(2):115-20

Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, School of Medicine, Konkuk University, Chungju 380-701, Korea; Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan 626-770, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163902PMC
http://dx.doi.org/10.5483/bmbrep.2014.47.2.277DOI Listing
February 2014

Control of spontaneous ovarian tumors by CD8+ T cells through NKG2D-targeted delivery of antigenic peptide.

Cell Biosci 2013 Dec 20;3(1):48. Epub 2013 Dec 20.

Department of Pathology, School of Medicine, Johns Hopkins University, Bldg, CRBII Rm, 309, 1550 Orleans Street, Baltimore, Maryland 21231, USA.

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http://cellandbioscience.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/2045-3701-3-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903078PMC
December 2013

Nanoparticle-based vaccine delivery for cancer immunotherapy.

Immune Netw 2013 Oct 26;13(5):177-83. Epub 2013 Oct 26.

Department of Immunology, School of Medicine, Konkuk University, Chungju 380-701, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.4110/in.2013.13.
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http://dx.doi.org/10.4110/in.2013.13.5.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817298PMC
October 2013

Intratumoral injection of therapeutic HPV vaccinia vaccine following cisplatin enhances HPV-specific antitumor effects.

Cancer Immunol Immunother 2013 Jul 25;62(7):1175-85. Epub 2013 Apr 25.

Department of Pathology, Johns Hopkins Medical Institutions, CRB II Room 309, 1550 Orleans Street, Baltimore, MD 21231, USA.

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http://link.springer.com/content/pdf/10.1007/s00262-013-1421
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http://link.springer.com/10.1007/s00262-013-1421-y
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http://dx.doi.org/10.1007/s00262-013-1421-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690484PMC
July 2013

Innovative DNA vaccine to break immune tolerance against tumor self-antigen.

Hum Gene Ther 2013 Feb 30;24(2):181-8. Epub 2013 Jan 30.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1089/hum.2012.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581028PMC
February 2013

Ovarian cancer gene therapy using HPV-16 pseudovirion carrying the HSV-tk gene.

PLoS One 2012 17;7(7):e40983. Epub 2012 Jul 17.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398866PMC
January 2013

Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype.

Cancer Res 2012 Apr 14;72(7):1717-27. Epub 2012 Feb 14.

Divison of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul, South Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319841PMC
April 2012

LAH4 enhances CD8+ T cell immunity of protein/peptide-based vaccines.

Vaccine 2012 Jan 24;30(4):784-93. Epub 2011 Nov 24.

Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.vaccine.2011.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253925PMC
January 2012

Enhancement of protein vaccine potency by in vivo electroporation mediated intramuscular injection.

Vaccine 2011 Jan 4;29(5):1082-9. Epub 2010 Dec 4.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0264410X1001707
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http://dx.doi.org/10.1016/j.vaccine.2010.11.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026065PMC
January 2011

Enhancement of DC vaccine potency by activating the PI3K/AKT pathway with a small interfering RNA targeting PTEN.

Immunol Lett 2010 Nov 19;134(1):47-54. Epub 2010 Aug 19.

Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul, South Korea.

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http://dx.doi.org/10.1016/j.imlet.2010.08.008DOI Listing
November 2010

Enhancement of DNA vaccine potency by antigen linkage to IFN-γ-inducible protein-10.

Int J Cancer 2011 Feb;128(3):702-14

Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul, South Korea.

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http://dx.doi.org/10.1002/ijc.25391DOI Listing
February 2011

Combined administration with DNA encoding vesicular stomatitis virus G protein enhances DNA vaccine potency.

J Virol 2010 Mar 16;84(5):2331-9. Epub 2009 Dec 16.

Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01954-09
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http://dx.doi.org/10.1128/JVI.01954-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820938PMC
March 2010

Modification of dendritic cells with interferon-gamma-inducible protein-10 gene to enhance vaccine potency.

J Gene Med 2009 Oct;11(10):889-98

Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul, South Korea.

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http://dx.doi.org/10.1002/jgm.1371DOI Listing
October 2009

Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8(+) T cell-mediated cell death.

Immunol Lett 2009 Jan 9;122(1):58-67. Epub 2009 Jan 9.

Laboratory Of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.imlet.2008.12.006DOI Listing
January 2009

Activation of Akt as a mechanism for tumor immune evasion.

Mol Ther 2009 Mar 23;17(3):439-47. Epub 2008 Dec 23.

Divison of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul, South Korea.

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http://dx.doi.org/10.1038/mt.2008.255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835083PMC
March 2009

Oral administration of high molecular mass poly-gamma-glutamate induces NK cell-mediated antitumor immunity.

J Immunol 2007 Jul;179(2):775-80

Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University, Gyeonggi-Do, Korea.

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http://dx.doi.org/10.4049/jimmunol.179.2.775DOI Listing
July 2007

Chemotherapy enhances CD8(+) T cell-mediated antitumor immunity induced by vaccination with vaccinia virus.

Mol Ther 2007 Aug 5;15(8):1558-63. Epub 2007 Jun 5.

Bioactive Molecules Delivery and Control Research Team, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, South Korea.

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http://dx.doi.org/10.1038/sj.mt.6300221DOI Listing
August 2007

Enhancement of dendritic cell-based vaccine potency by targeting antigen to endosomal/lysosomal compartments.

Immunol Lett 2006 Aug 22;106(2):126-34. Epub 2006 May 22.

Laboratory of Infection and Immunology, Graduate School of Medicine, Korea University, 516 Gojan-1 Dong, Ansan-Si, Gyeonggi-Do 425-707, South Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S016524780600130
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http://dx.doi.org/10.1016/j.imlet.2006.05.004DOI Listing
August 2006

Purification of a constitutive chitosanase produced by Bacillus sp. MET 1299 with cloning and expression of the gene.

FEMS Microbiol Lett 2004 Nov;240(1):31-9

Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA.

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http://femsle.oxfordjournals.org/content/femsle/240/1/31.ful
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http://femsle.oxfordjournals.org/cgi/doi/10.1016/j.femsle.20
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http://dx.doi.org/10.1016/j.femsle.2004.09.006DOI Listing
November 2004