Publications

Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus.
Antimicrob Agents Chemother 2017 Jun 24;61(6). Epub 2017 May 24.
Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan


The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.
Proc Natl Acad Sci U S A 2016 Dec 21;113(49):14097-14102. Epub 2016 Nov 21.
Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan;


PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Proc Natl Acad Sci U S A 2016 Apr 21;113(14):3844-9. Epub 2016 Mar 21.
Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan;

Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.
Cancer Prev Res (Phila) 2016 Mar 17;9(3):253-63. Epub 2016 Feb 17.
Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan. AMED-CREST, AMED, Japan Agency for Medical Research and Development, Tokyo, Japan.

Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis.
Proc Natl Acad Sci U S A 2015 Dec 23;112(49):15136-41. Epub 2015 Nov 23.
Department of Dermatology, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8655, Japan;

Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.
Proc Natl Acad Sci U S A 2015 Oct 29;112(41):12770-5. Epub 2015 Sep 29.
Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan; Department of Immunology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-033, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Meguro-ku, Tokyo 153-8505, Japan;


Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
Cell 2014 Dec;159(7):1563-77
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute. Electronic address:


Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.
Proc Natl Acad Sci U S A 2013 Dec 3;110(51):20699-704. Epub 2013 Dec 3.
Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan.


Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction.
Proc Natl Acad Sci U S A 2012 Dec 3;109(51):21016-21. Epub 2012 Dec 3.
Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan.

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.
Nat Immunol 2012 May 20;13(7):659-66. Epub 2012 May 20.
Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan.

Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth.
Biochem Biophys Res Commun 2011 Jul 12;411(1):7-13. Epub 2011 Jun 12.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.


Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
J Exp Med 2010 Nov 8;207(12):2675-87. Epub 2010 Nov 8.
Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo 060-8638, Japan.



A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.
Proc Natl Acad Sci U S A 2009 Oct 1;106(42):17870-5. Epub 2009 Oct 1.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.
Proc Natl Acad Sci U S A 2009 Jul 17;106(30):12448-52. Epub 2009 Jul 17.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Critical role for constitutive type I interferon signaling in the prevention of cellular transformation.
Cancer Sci 2009 Mar 14;100(3):449-56. Epub 2008 Dec 14.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.


A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.
Proc Natl Acad Sci U S A 2008 Dec 11;105(51):20446-51. Epub 2008 Dec 11.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells.
Nat Immunol 2008 Jan 2;9(1):34-41. Epub 2007 Dec 2.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Nature 2007 Jul 8;448(7152):501-5. Epub 2007 Jul 8.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.
Proc Natl Acad Sci U S A 2006 Oct 3;103(41):15136-41. Epub 2006 Oct 3.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.


IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.
J Immunol 2004 Dec;173(12):7416-25
Max F. Perutz Laboratories, University Department at the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Austria.

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Proc Natl Acad Sci U S A 2004 Oct 18;101(43):15416-21. Epub 2004 Oct 18.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Type I interferon production enhances susceptibility to Listeria monocytogenes infection.
J Exp Med 2004 Aug 9;200(4):437-45. Epub 2004 Aug 9.
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8-240 Factor Bldg., 10833 Le Conte Ave., 90095, USA.

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
Nature 2004 Apr;428(6984):758-63
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.


Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Proc Natl Acad Sci U S A 2003 Sep 5;100(19):10872-7. Epub 2003 Sep 5.
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan.

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.
Nature 2003 Jul;424(6948):516-23
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.



Requirement of the IFN-alpha/beta-induced CXCR3 chemokine signalling for CD8+ T cell activation.
Genes Cells 2002 Mar;7(3):309-20
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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