Publications by authors named "Tabatabaee Aliye"

3 Publications

  • Page 1 of 1

Bacterial Profile and Antimicrobial Resistance Patterns of Infected Diabetic Foot Ulcers in Iran: A Systematic Review and Meta-Analysis of Cross-Sectional Studies.

Int J Low Extrem Wounds 2021 Apr 28:15347346211002715. Epub 2021 Apr 28.

Isfahan Endocrine and Metabolism Research Center, 48455Isfahan University of Medical Sciences, Isfahan, Iran.

Since infectious foot ulcers represent one of the major causes of lower-limb amputation, it calls for an appropriate action for early detection and sufficient treatment of diabetic foot infection (DFI). The present study aimed at investigating the bacterial epidemiology and antimicrobial resistance (AMR) patterns of DFIs in Iran. We have conducted a systematic search in PubMed, Embase, Web of Science, Scopus, Google Scholar, and Scientific Information Database to identify all articles reporting the proportion of different kinds of bacteria isolated from Iranian DFI samples. Quality was assessed using Joanna Briggs Institute tool. A pooled estimate of proportion with a corresponding 95% confidence interval (95% CI) was calculated using the random effect method. Fifteen studies were eligible, of which 1970 bacterial isolates were obtained from 1316 patients. The most predominant isolates recovered from DFIs was with a pooled proportion of 24.29% (95% CI: 20.25%, 28.57%) from which 55% (95% CI: 38%, 72%) were methicillin-resistant (MRSA). Among Gram-negative strains, had the highest proportion (17.19%; 95% CI: 13.96%, 20.68%) followed by , 7.54% (95% CI: 4.56%, 11.14%). The highest pooled estimates of resistance against cotrimoxazole and ciprofloxacin were found in 66% (95% CI: 48%, 82%) and isolates 68% (95% CI: 51%, 84%), respectively. Our study revealed that AMR is at a high level in Iran and clinicians should be aware of bacterial resistance patterns to prescribe appropriate antibiotic regimens.
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April 2021

Synergistic Effects of Lauryl Gallate and Tamoxifen on Human Breast Cancer Cell.

Iran J Public Health 2020 Jul;49(7):1324-1329

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: Tamoxifen (TAM) is widely used for adjuvant therapy in breast cancer patients. Tamoxifen therapy may lead to serious side effects. Anti-apoptotic substances in combination with chemotherapy drugs can result in additive or synergistic effects. Lauryl gallate (LG), a Gallic acid derivative, has been proven to inhibit tumor growth, without affecting normal cells. This study aimed to investigate the synergistic effect of TAM and LG in breast cancer cell line (MCF-7).

Methods: In this experimental study, performed in ShahreKord University of Medical Science, Iran in 2017, the MCF-7 cells were treated by final concentrations of 10 μM TAM alone, and in combination with 200 μM of LG. We also used EX-527, as SIRT-1 inhibitor to examine the role of SIRT1 in cell apoptosis. and gene expression were measured by real-time PCR method, and cell apoptosis was investigated by flow cytometry.

Results: Tamoxifen alone and in combination with LG decreased expression 2.64±0.75 and 6.38±1.9 fold, respectively, after 48 h (<0.05). expression was increased 1.67±0.22 and 2.47±0.34 - fold by TAM alone and in combination with LG, respectively (<0.05). TAM alone and in combination with LG increased the percentage of apoptotic cells 15.79±2.81 and 60.67±6.23 percent, respectively after 48 h (<0.001).

Conclusion: The combination of LG and TAM is more effective for induction of apoptosis of breast cancer cells, compared to individual use of each. Thus, our data pave the way for new therapeutic options for suppressing breast cancer growth.
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July 2020

A roundup of the simplest mobile phone uses in diabetes management.

Diabetes Res Clin Pract 2019 Dec 26;158:107895. Epub 2019 Oct 26.

Clinical Biochemistry, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

With the increasing use of mobile phones, mHealth has grown to be a very promising subject. However, mHealth programs haven't been widespread in many countries, especially in developing countries. Health-related phone applications, and in particular diabetes-related mobile apps, are gaining more popularity by the day. Yet, there are still some concerns about the safety and effectiveness of these apps. In this short commentary, we will discuss the simple uses of mobile phones and how they can contribute to the communication between patients and health professional providers.
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December 2019