Publications by authors named "T L Chelidze"

9 Publications

Simultaneous determination of cyclodol and diprazin by thin layer chromatography and high performance liquid chromatography.

Georgian Med News 2009 Nov(176):66-71

Tbilisi State Medical University, Department Pharmaceutical and Toxicological Chemistry.

Ciklodol (trihexyphenidil)--the central and peripheral m-cholinoblocker is currently used with other antipsychotic drugs such as phenotiazines and tricycle antidepressants. For the purpose of simultaneous determination of ciklodol and diprazine, were selected two methods of analysis: Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography (HPLC). During development of TLC method was studied the 10 visualizing system and 24 mobile systems. For individual or simultaneous determination of ciklodol and diprazine were recommended the following solvents' systems: 1. Toluene-acetone-ethanole-25%NH(4)OH (45:45: 7.5:2.5), 2. Hexane-ethyl acetate (15:5), 3. Chloroform-heptene-25%NH(4)OH (16:3:3), 4. Ethylacetate-hexane (10:10), 5. Acetonitrile-metanol (10:10) and 6.Heptene-chloroform-ethanol-25% NH(4)OH (5:10:3:1). As visualizing systems were chosen: Iodine vapors, blacklight (UV254) and reagent of FNP. Reagent of FNP gives colored spot just with diprazine and it is also could be used for separation of both objects in simultaneous analysis. Developed HPLC method of simultaneous determination of ciklodol and diprazine: like mobile phase is recommended: Acetonitril- 0.05M KH(2)PO4 (55:45) (v/v) +H(3)PO(4) (pH3.5), column EC250 x 4.6mm, with solid phase Nucleosil, flow rate 1ml/min, sample volume 40 microl. In given conditions, the retention time of ciklodol is 6.005min and diprazine 7.227min. Developed method of simultaneous determination and separation of ciklodol and diprazine in respective mixtures could be successfully applied as in the pharmaceutical, as well in the chemical-toxicological laboratories.
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November 2009

Electromagnetic signature of prefracture criticality in heterogeneous media.

Phys Rev Lett 2004 Feb 12;92(6):065702. Epub 2004 Feb 12.

Solid State Section, Physics Department, University of Athens, Athens, Greece.

Fractal statistical analysis under the critical point (CP) hypothesis is applied to electromagnetic (EM) signals emitted before failure. A new approach to the analysis of a possible EM fractal pattern evolution toward CP is suggested. The analysis reveals characteristic signs of approaching the CP: the emergence of memory effects; the increase of the spatial correlation; the decrease of the antipersistence behavior; the appearance of persistence properties in the tail of the precursors, a loss of multifractality, and, finally, the divergence of the energy release rate. These critical features are compatible with the percolation theory of fracture process.
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http://dx.doi.org/10.1103/PhysRevLett.92.065702DOI Listing
February 2004

[Letter: Mechanism of alpha-dispersion of blood dielectric permeability].

Authors:
T L Chelidze

Biofizika 1974 Nov-Dec;19(6):1100-1

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April 1975
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