Thomas Klimkait

Thomas Klimkait

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Thomas Klimkait

Publications by authors named "Thomas Klimkait"

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Safety and tolerance of lymph node biopsies from chronic HIV-1 volunteers in rural Tanzania.

BMC Res Notes 2019 Sep 6;12(1):561. Epub 2019 Sep 6.

Department of Medical Parasitology and Infection Biology, Clinical Immunology, Swiss Tropical and Public Health Institute, Socinstr. 57, 4002, Basel, Switzerland.

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http://dx.doi.org/10.1186/s13104-019-4600-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729032PMC
September 2019

Performance Evaluation of a Genotypic Tropism Test Using HIV-1 CRF01_AE Isolates in Japan.

Jpn J Infect Dis 2018 Jul 27;71(4):264-266. Epub 2018 Apr 27.

Molecular Virology, Department Biomedicine - Petersplatz, University of Basel.

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http://dx.doi.org/10.7883/yoken.JJID.2017.482DOI Listing
July 2018

The Treatment Cascade in Children With Unsuppressed Viral Load-A Reality Check in Rural Lesotho, Southern Africa.

J Acquir Immune Defic Syndr 2018 03;77(3):250-256

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/QAI.0000000000001597DOI Listing
March 2018

Phenotypic co-receptor tropism and Maraviroc sensitivity in HIV-1 subtype C from East Africa.

Sci Rep 2018 02 5;8(1):2363. Epub 2018 Feb 5.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-018-20814-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799384PMC
February 2018

Specificity of two HIV screening tests detecting simultaneously HIV-1 p24 antigen and antibodies to HIV-1 and -2.

J Virol Methods 2017 11 8;249:143-146. Epub 2017 Sep 8.

Division of Clinical Microbiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2017.09.005DOI Listing
November 2017

Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression.

J Antimicrob Chemother 2017 07;72(7):2069-2074

ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1093/jac/dkx095DOI Listing
July 2017

Therapeutic Immune Recovery and Reduction of CXCR4-Tropic HIV-1.

Clin Infect Dis 2017 Feb 12;64(3):295-300. Epub 2016 Nov 12.

Molecular Virology, Department of Biomedicine-Petersplatz, University of Basel,

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https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/
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http://dx.doi.org/10.1093/cid/ciw737DOI Listing
February 2017

MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing.

J Virol Methods 2017 02 17;240:7-13. Epub 2016 Nov 17.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2016.11.008DOI Listing
February 2017

Development of HIV drug resistance and therapeutic failure in children and adolescents in rural Tanzania: an emerging public health concern.

AIDS 2017 01;31(1):61-70

aSwiss Tropical and Public Health Institute (Swiss TPH) bUniversity of Basel, Basel, Switzerland cIfakara Health Institute, Ifakara, United Republic of Tanzania dDivision of infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel, Basel eDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern fMolecular Virology, Department Biomedicine Petersplatz, University of Basel, Basel, Switzerland gISGlobal, Barcelona Centre for Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1097/QAD.0000000000001273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131685PMC
January 2017

Algorithm evolution for drug resistance prediction: comparison of systems for HIV-1 genotyping.

Antivir Ther 2015 24;20(6):661-5. Epub 2015 Feb 24.

Molecular Virology, Department of Biomedicine - Petersplatz, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.3851/IMP2947DOI Listing
September 2016

Large-scale inference of conjunctive Bayesian networks.

Bioinformatics 2016 09;32(17):i727-i735

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland SIB Swiss Institute of Bioinformatics, Basel, Switzerland.

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http://dx.doi.org/10.1093/bioinformatics/btw459DOI Listing
September 2016

Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.

J Infect Dis 2016 08 29;214(3):399-402. Epub 2016 Apr 29.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Institute of Medical Virology, University of Zurich.

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http://dx.doi.org/10.1093/infdis/jiw165DOI Listing
August 2016

Should viral load thresholds be lowered?: Revisiting the WHO definition for virologic failure in patients on antiretroviral therapy in resource-limited settings.

Medicine (Baltimore) 2016 Jul;95(28):e3985

aMedical Services and Diagnostic, Clinical Research Unit, Swiss Tropical and Public Health Institute bUniversity of Basel cMolecular Virology, Department Biomedicine-Petersplatz, University of Basel, Basel, Switzerland dSolidarMed, Swiss Organization for Health in Africa, Maseru, Lesotho eSolidarMed, Swiss Organization for Health in Africa, Luzern, Switzerland fFaculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1097/MD.0000000000003985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956783PMC
July 2016

Performance of Risk Charts to Guide Targeted HIV Viral Load Monitoring of ART: Applying the Method on the Data From a Multicenter Study in Rural Lesotho.

J Acquir Immune Defic Syndr 2016 May;72(1):e22-5

*Faculty of Medicine, University of Geneva, Geneva, Switzerland †Molecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland ‡SolidarMed, Luzern, Switzerland §Medical Services and Diagnostics, Swiss Tropical and Public Health Institute, Basel, Switzerland ‖University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/QAI.0000000000000961DOI Listing
May 2016

Still Far From 90-90-90: Virologic Outcomes of Children on Antiretroviral Therapy in Nurse-led Clinics in Rural Lesotho.

Pediatr Infect Dis J 2016 Jan;35(1):78-80

From the *SolidarMed, Swiss Organization for Health in Africa, Maseru, Lesotho; †Faculty of Medicine, University of Geneva, Geneva, Switzerland; ‡Laboratory Services, Seboche Hospital, Butha-Buthe, Lesotho; §Molecular Virology, Department of Biomedicine - Petersplatz, University of Basel, Basel, Switzerland; ¶SolidarMed, Swiss Organization for Health in Africa, Lucerne, Switzerland; ‖Clinical Research Unit, Swiss Tropical and Public Health Institute; and **University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/INF.0000000000000929DOI Listing
January 2016

A Case Series of Acquired Drug Resistance-Associated Mutations in Human Immunodeficiency Virus-Infected Children: An Emerging Public Health Concern in Rural Africa.

Open Forum Infect Dis 2016 Jan 17;3(1):ofv199. Epub 2015 Dec 17.

Swiss Tropical and Public Health Institute, Basel; University of Basel; Ifakara Health Institute, United Republic of Tanzania; ISGLOBAL, Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, Spain.

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http://dx.doi.org/10.1093/ofid/ofv199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722282PMC
January 2016

Assessing efficacy of different nucleos(t)ide backbones in NNRTI-containing regimens in the Swiss HIV Cohort Study.

J Antimicrob Chemother 2015 Dec 11;70(12):3323-31. Epub 2015 Sep 11.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland Institute of Medical Virology, University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1093/jac/dkv257DOI Listing
December 2015

Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings?

Trop Med Int Health 2015 Jul 2;20(7):914-8. Epub 2015 Apr 2.

Molecular Virology, Department Biomedicine - Petersplatz, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1111/tmi.12509DOI Listing
July 2015

Identification of anti-HIV active dicaffeoylquinic- and tricaffeoylquinic acids in Helichrysum populifolium by NMR-based metabolomic guided fractionation.

Fitoterapia 2015 Jun 1;103:155-64. Epub 2015 Apr 1.

Department of Plant Science, University of Pretoria, Pretoria, Gauteng 0002, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2015.03.024DOI Listing
June 2015

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds.

PLoS Pathog 2015 Mar 23;11(3):e1004722. Epub 2015 Mar 23.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1004722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370492PMC
March 2015

A diagnostic HIV-1 tropism system based on sequence relatedness.

J Clin Microbiol 2015 Feb 10;53(2):597-610. Epub 2014 Dec 10.

Molecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland

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http://dx.doi.org/10.1128/JCM.02762-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298515PMC
February 2015

Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients.

AIDS 2014 Sep;28(15):2231-9

aDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich bInstitute of Medical Virology, Swiss National Center for Retroviruses, University of Zurich, Zurich cLaboratory of Virology and AIDS Center, University Hospital Geneva, Geneva dDepartment of Biomedicine, Haus Petersplatz, University of Basel, Basel eDivision of Immunology, University Hospital Lausanne, Lausanne fDepartment of Infectious Diseases, Bern University Hospital and University of Bern, Bern gDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel hDivision of Infectious Diseases, Cantonal Hospital St. Gallen, St. Gallen iInfectious Diseases Service, University Hospital Lausanne, Lausanne jDivision of Infectious Diseases, Geneva University Hospitals, Geneva kDivision of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland. *Karin J. Metzner, Alexandra U. Scherrer and Viktor Von Wyl contributed equally to this work.

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http://dx.doi.org/10.1097/QAD.0000000000000397DOI Listing
September 2014

Preserved antigen-specific immune response in patients with multiple sclerosis responding to IFNβ-therapy.

PLoS One 2013 5;8(11):e78532. Epub 2013 Nov 5.

Immunobiology Laboratory, Department of Biomedicine and Medical Outpatient Department, University Hospital Basel, Basel, Switzerland ; Department of Neurology and Clinical Neuroimmunology Laboratory/Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078532PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818403PMC
August 2014

Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV.

Int J Epidemiol 2014 Jun 22;43(3):887-96. Epub 2014 Jan 22.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland, Laboratory of Virology, University Hospital Geneva, Geneva, Switzerland, Division of Immunology and Allergy, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland, Department Biomedicine, University of Basel, Basel, Switzerland, Division of Infectious Diseases, Geneva University Hospital, Geneva, Division of Immunology, University Hospital Lausanne, Lausanne, Switzerland, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Division of Infectious Diseases, Cantonal Hospital St Gallen, St Gallen, Switzerland and Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.

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http://dx.doi.org/10.1093/ije/dyt276DOI Listing
June 2014

Development of a simple microarray for genotyping HIV-1 drug resistance mutations in the reverse transcriptase gene in rural Tanzania.

Trop Med Int Health 2014 Jun 21;19(6):664-671. Epub 2014 Mar 21.

Swiss Tropical and Public Health Institute, University of Basel, Switzerland.

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http://dx.doi.org/10.1111/tmi.12289DOI Listing
June 2014

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.

Elife 2013 Oct 29;2:e01123. Epub 2013 Oct 29.

School of Life Sciences , École Polytechnique Fédérale de Lausanne , Lausanne , Switzerland ; Institute of Microbiology , University Hospital and University of Lausanne , Lausanne , Switzerland ; Research Group of Theoretical Biology and Evolutionary Ecology , Eötvös Loránd University and the Hungarian Academy of Sciences , Budapest , Hungary ; Swiss Institute of Bioinformatics , Lausanne , Switzerland.

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http://dx.doi.org/10.7554/eLife.01123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807812PMC
October 2013

Bioassay-guided investigation of the Tanzanian plant Pyrenacantha kaurabassana for potential anti-HIV-active compounds.

J Nat Prod 2012 Oct 24;75(10):1712-6. Epub 2012 Sep 24.

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand , P.O. Wits 2050, Johannesburg, South Africa.

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http://dx.doi.org/10.1021/np300255rDOI Listing
October 2012

Ethnopharmacology in overdrive: the remarkable anti-HIV activity of Artemisia annua.

J Ethnopharmacol 2012 Jun 24;141(3):854-9. Epub 2012 Mar 24.

Natural Products Laboratory, Institute of Biology, Leiden University, PO Box 9502, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jep.2012.03.024DOI Listing
June 2012

The XTrack system: application and advantage.

Authors:
Thomas Klimkait

Intervirology 2012 24;55(2):118-22. Epub 2012 Jan 24.

Institut für Virologie, Universität Basel, Basel, Schweiz.

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http://dx.doi.org/10.1159/000332003DOI Listing
May 2012

Estimating the basic reproductive number from viral sequence data.

Mol Biol Evol 2012 Jan 2;29(1):347-57. Epub 2011 Sep 2.

Institute of Integrative Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1093/molbev/msr217DOI Listing
January 2012

Incidence of HIV-1 drug resistance among antiretroviral treatment-naive individuals starting modern therapy combinations.

Clin Infect Dis 2012 Jan 4;54(1):131-40. Epub 2011 Nov 4.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland.

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http://dx.doi.org/10.1093/cid/cir728DOI Listing
January 2012

Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients.

Ann Neurol 2011 Feb;69(2):408-13

Department of Neurology, Clinical Neuroimmunology Laboratory, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1002/ana.22352DOI Listing
February 2011