Publications by authors named "T Brian Marcoux"

7 Publications

Adverse childhood experiences and trauma informed care: treating the whole patient with a more complete osteopathic approach.

Authors:
T Brian Marcoux

J Osteopath Med 2021 Jul 22;121(9):763-769. Epub 2021 Jul 22.

Division of Child & Adolescent Psychiatry, The Johns Hopkins Hospital, 1800 Orleans St, Baltimore, MD 21287-0010, USA.

In 1998, a seminal study identified a strong connection between participants' exposures to adverse childhood experiences (ACEs) and the development of risk factors for serious health conditions later in life. More than two decades later, leaders in both policy and health care professions now appreciate the impact of social determinants of health, including the enormous societal costs incurred by deleterious experiences, and recognize that treating illness begins with prevention in early childhood. The trauma informed care (TIC) model offers a treatment approach that lends consideration to the traumatic experiences that impact a given patient and allows for more complete treatment by their physician. Delivering care under the TIC model encourages trauma identification, early intervention, system level awareness and policy change, and avoiding retraumatization in the therapeutic setting. Various programs across the country seek to employ these methods at the community, state, and federal level. Several programs aimed at introducing medical students to these principles have contributed to an incorporation of TIC within the physician pipeline. In this Commentary, the author proposes an expansion of the with a fifth principle-considering the implications of a patient's past formative experiences, their present life circumstances, and their future prospects-as a vehicle for instilling TIC principles ubiquitously throughout osteopathic medical training to develop physicians who treat the person more completely and are better equipped to manage this public health crisis.
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http://dx.doi.org/10.1515/jom-2020-0322DOI Listing
July 2021

A public online resource to track COVID-19 misinfodemic.

Soc Netw Anal Min 2021 5;11(1):45. Epub 2021 May 5.

University of Arkansas At Little Rock, Little Rock, USA.

The COVID-19 pandemic has seen the rise of many unique online narratives through social media and other sources. They can range from theories about the origin of the virus, to misinformation regarding personal health measures. Such narratives have a direct impact on public health and safety. In an effort to inform the general public and with support of the Arkansas Attorney General's office our team sought to keep track of narratives for research purposes and provide near-real-time public documentation via a website with two main goals. The first is to track every unique narrative as curated by our analysts. This allows individuals to fact-check the information they consume. The second goal is to relay recommendations to the State Attorney General on how to detect such misinformation and avoid fraud and scams seeking to profit from this online fear and chaos. This paper showcases our website as well as some research findings from the data we collected. More broadly, this effort showcases a unique collaboration between scientists and policy makers to stem the flow of misinformation during a major public health crisis.
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http://dx.doi.org/10.1007/s13278-021-00748-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098788PMC
May 2021

Energetics and behavior of coral reef fishes during oscillatory swimming in a simulated wave surge.

J Exp Biol 2019 02 27;222(Pt 4). Epub 2019 Feb 27.

Department of Natural Sciences, Hawaii Pacific University, 1 Aloha Tower Drive, Honolulu, HI 96813, USA

Oxygen consumption rates were measured for coral reef fishes during swimming in a bidirectional, oscillatory pattern to simulate station-holding in wave-induced, shallow-water flows. For all species examined, increases in wave intensity, as simulated by increases in frequency and amplitude of oscillation, yielded increased metabolic rates and net costs of swimming (NCOS; swimming metabolic rate minus standard metabolic rate). Comparing species with different swimming modes, the caudal fin swimming spp. (Kuhliidae) and simultaneous pectoral-caudal fin swimming (Pomacentridae) turned around to face the direction of swimming most of the time, whereas the median-paired fin (MPF) swimmers, the pectoral fin swimming (Acanthuridae) and dorsal-anal fin swimming (Balistidae), more frequently swam in reverse for one half of the oscillation to avoid turning. Contrary to expectations, the body-caudal fin (BCF) swimming spp. had the lowest overall NCOS in the oscillatory swimming regime compared with the MPF swimmers. However, when examining the effect of increasing frequency of oscillation at similar average velocities, spp. showed a 24% increase in NCOS with a 50% increase in direction changes and accelerations. The two strict MPF swimmers had lower increases on average, suggestive of reduced added costs with increasing frequency of direction changes with this swimming mode. Further studies are needed on the costs of unsteady swimming to determine whether these differences can explain the observed prevalence of fishes using the MPF pectoral fin swimming mode in reef habitats exposed to high, wave-surge-induced water flows.
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http://dx.doi.org/10.1242/jeb.191791DOI Listing
February 2019

Inexpensive production of near-native engineered stromas.

J Tissue Eng Regen Med 2017 05 26;11(5):1377-1389. Epub 2015 May 26.

LOEX/CMDGT, Université Laval, Quebec, Canada.

Although the self-assembly approach is an efficient method for the production of engineered physiological and pathological tissues, avoiding the use of exogenous materials, it nevertheless remains expensive and requires dexterity, which are features incompatible with large-scale production. We propose a modification to this technique to make easier the production of mesenchymal compartment, to reduce the cost and to improve the histological quality of the self-assembled tissues. The stroma produced by this novel approach allowed epithelial cell differentiation, resulting in a pseudostratified epithelium that shared several features with native tissues. The incorporation of endothelial cells in the reconstructed mesenchyme formed a three-dimensional capillary-like network, positive for CD31 and von Willebrand factor and surrounded by NG2 positive cells. It could limit self-contraction of the resulting tissue by recruiting α-Smooth Muscle Actin positive cells. With this new technique, which is relatively inexpensive and easy to use in a research laboratory set-up, near-native stromas can now be produced with minimal handling time. Copyright © 2015 John Wiley & Sons, Ltd.
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http://dx.doi.org/10.1002/term.2036DOI Listing
May 2017

Lysophosphatidic acid enhances collagen deposition and matrix thickening in engineered tissue.

J Tissue Eng Regen Med 2015 Nov 18;9(11):E65-75. Epub 2013 Feb 18.

Centre LOEX de l'Université Laval, Génie tissulaire et régénération: LOEX du Centre de recherche FRQS du Centre hospitalier affilié universitaire de Québec, Département de Chirurgie, Faculté de Médecine, Université Laval, Québec, QC, Canada.

The time needed to produce engineered tissue is critical. A self-assembly approach provided excellent results regarding biological functions and cell differentiation because it closely respected the microenvironment of cells. Nevertheless, the technique was time consuming for producing tissue equivalents with enough extracellular matrix to allow manipulations. Unlike L-arginine supplementation that only increased accumulation of collagen in cell culture supernatant in our model, addition of lysophosphatidic acid, a natural bioactive lipid, did not modify the amount of accumulated collagen in the cell culture supernatant; however, it enhanced the matrix deposition rate without inducing fibroblast hyperproliferation and tissue fibrosis.
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http://dx.doi.org/10.1002/term.1711DOI Listing
November 2015
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