Publications by authors named "T Andrew Black"

402 Publications

Self-Care and Gratitude.

Rehabil Nurs 2021 May-Jun 01;46(3):123-124

Clinical Assistant Professors College of Nursing, University of Massachusetts Amherst, Amherst, MA, USA.

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http://dx.doi.org/10.1097/RNJ.0000000000000322DOI Listing
April 2021

Prevalence and Predictors of Per- and Polyfluoroalkyl Substances (PFAS) Serum Levels among Members of a Suburban US Volunteer Fire Department.

Int J Environ Res Public Health 2021 Apr 2;18(7). Epub 2021 Apr 2.

Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.

Background: Per-and polyfluoroalkyl substances (PFAS), are ubiquitous pollutants associated with adverse health outcomes. High PFAS levels have been demonstrated among career firefighters; less is known about PFAS levels among volunteer firefighters who comprise two-thirds of US firefighters.

Methods: Volunteer fire department members completed a survey and provided blood samples. We calculated geometric means and 95% CIs for PFAS reported by the National Health and Nutrition Examination Survey (NHANES). We compared PFAS distribution and levels among non-Hispanic white adult male study participants to those in the 2015-2016 and 2017-2018 NHANES cycles. We assessed associations between PFAS serum levels and years of firefighting controlling demographics and occupation using linear regression.

Results: Participant's average age was 46.6 years (sd. 17.1). Perfluorododecanoic acid (PFDoA) was detected in almost half study but <3% of NHANES participants; serum levels of PFDoA, perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were elevated among participants compared with NHANES. Serum levels of both PFDA and PFDoA were positively associated with years of firefighting.

Conclusions: Volunteer firefighters may have a different serum profile and levels of PFAS than the general population. Future work in this area should include volunteer firefighters from other geographic locations and assess sources of PFAS exposure.
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http://dx.doi.org/10.3390/ijerph18073730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038206PMC
April 2021

Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.

J Med Chem 2021 Apr 7. Epub 2021 Apr 7.

Department of Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.

We apply the magic methyl effect to improve the potency/efficacy of GAT211, the prototypic 2-phenylindole-based cannabinoid type-1 receptor (CB1R) agonist-positive allosteric modulator (ago-PAM). Introducing a methyl group at the α-position of nitro group generated two diastereomers, the greater potency and efficacy of , (±)- vs , (±)- constitutes the first demonstration of diastereoselective CB1R-allosteric modulator interaction. Of the (±)- enantiomers, (-)-(,)- evidenced improved potency over GAT211 as a CB1R ago-PAM, whereas (+)-(,)- was a CB1R allosteric agonist biased toward G protein- vs β-arrestin1/2-dependent signaling. (-)-(,)- and (+)-(,)- were devoid of undesirable side effects (triad test), and (+)-(,)- reduced intraocular pressure with an unprecedentedly long duration of action in a murine glaucoma model. (-)-(,)- docked into both a CB1R extracellular PAM and intracellular allosteric-agonist site(s), whereas (+)-(,)- preferentially engaged only the latter. Exploiting G-protein biased CB1R-allosteric modulation can offer safer therapeutic candidates for glaucoma and, potentially, other diseases.
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http://dx.doi.org/10.1021/acs.jmedchem.1c00040DOI Listing
April 2021

Utility of MyHEARTSMAP in Youth Presenting to the Emergency Room with Mental Health Concerns.

J Pediatr 2021 Apr 2. Epub 2021 Apr 2.

Department of Pediatrics, University of British Columbia, Vancouver, British Columbia. Electronic address:

Objectives: To evaluate the utility of a digital psychological self-assessment tool, MyHEARTSMAP, in youth presenting to the pediatric emergency department (ED) with a mental health concern.

Study Design: We conducted a prospective cohort study in two tertiary care pediatric EDs from December 2017-October 2019. Youth 10-17 years old triaged for a mental health concern were screened and enrolled to complete MyHEARTSMAP on a mobile device. A clinician blinded to the MyHEARTSMAP assessment conducted their own assessment which was used as the reference standard. Utility was quantified as the sensitivity and specificity of MyHEARTSMAP in detecting psychiatric, social, youth health, and functional concerns.

Results: Among 379 eligible youth, 351 were approached and 233 (66.4%) families were enrolled. Sensitivity for youth MyHEARTSMAP self-assessments ranged from 87.4% in the youth health domain to 99.5% in the psychiatric domain for identifying any concern, and 33.3% in the social domain to 74.6% in the psychiatric domain for severe concerns. Specificity ranged from 66.7% in the psychiatric domain to 98.2% in the youth health domain for no or only mild concerns.

Conclusion: Youth and guardian MyHEARTSMAP assessments are sensitive for detecting psychosocial concerns requiring follow-up beyond pediatric ED evaluation. Specificity for no or only mild concerns was high in the non-psychiatric domains.
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http://dx.doi.org/10.1016/j.jpeds.2021.03.062DOI Listing
April 2021

Are outer-membrane targets the solution for MDR Gram-negative bacteria?

Drug Discov Today 2021 Mar 31. Epub 2021 Mar 31.

Infectious Diseases and Vaccines Basic Research, Merck & Co., Inc, 770 Sumneytown Pike, West Point, PA 19486, USA. Electronic address:

The outer membrane (OM) of Gram-negative bacteria confers a significant barrier to many antibacterial agents targeting periplasmic and cytosolic functions. 'Synergist' approaches to disrupt the OM have been hampered by poor specificity and accompanying toxicities. The OM contains proteins required for optimal growth and pathogenesis, including lipopolysaccharide (LPS) and capsular polysaccharide (CPS) transport, porins for uptake of macromolecules, and transporters for essential elements (such as iron). Does the external proximity of these proteins offer an enhanced potential to identify effective therapies? Here, we review recent experiences in exploiting Gram-negative OM proteins (OMPs) to address the calamity of exploding antimicrobial resistance. Teaser: Multidrug-resistant (MDR) Gram-negative bacteria are a growing crisis. Few new antimicrobial chemotypes or targets have been identified after decades of screening. Are OMP targets a solution to MDR Gram-negative bacteria?
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http://dx.doi.org/10.1016/j.drudis.2021.03.027DOI Listing
March 2021