Publications by authors named "T Alianova"

5 Publications

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[INFLUENCE OF COMBINED ERADICATION AND PROKINETIC THERAPY ON CLINICAL MANIFESTATIONS, PSYCHOLOGICAL STATUS AND QUALITY OF LIFE OF PATIENTS WITH FUNCTIONAL DYSPEPSIA - POSTPRANDIAL DISTRESS SYNDROME: RANDOMIZED PROSPECTIVE STUDY].

Georgian Med News 2021 Mar(312):61-67

1Bogomolets National Medical University, Kyiv; Ukraine.

Functional dyspepsia - postprandial distress-syndrome (FD-PDS) is one of the most common reasons for seeking medical attention of general practitioners, internists and gastroenterologists worldwide. Standard approaches to the treatment of patients with postprandial distress syndrome are only effective in small amount of cases. Aim of the study - comparative assessment of the effectiveness of combined eradication and prokinetic therapy and eradication therapy only in the treatment of FD-PDS by studying their effect on the clinical manifestations of the disease, patients' psychological status and quality of life. This was a randomized prospective study among patients with FD-PDS in the presence of Helicobater pylori invasion. Participants from group 1 - 65 patients - received eradication therapy and prokinetic itoprid hydrochloride 50 mg three times a day; participants in group 2 - 61 patients - received only eradication therapy for 14 days. Helicobacter pylori was evaluated using a rapid one-step immunochromatographic test to detect stool antigen, or using PCR for Helicobacter pylori DNA, or using a histological method. To assess the severity of dyspeptic and concomitant gastroenterological symptoms, a 7-point Likert scale was used; to assess the severity of anxiety and depression in dynamics - Hospital Anxiety and Depression Scale (HADS); to assess the quality of life indicators - the SF-36 questionnaire. The duration of the study was 30 days. Combined eradication and prokinetic therapy, in comparison with eradication therapy only, is more effective in the treatment of FD-PDS. The additional use of itopride hydrochloride contributes to a more effective decrease in the severity and a longer elimination of symptoms of the disease (p˂0.05), helps to reduce the level of depression (p=0.002) and improve the quality of life indicators on the scales of physical functioning (p=0.032), role-physical functioning (p=0.039), bodily pain (p=0.0001), general health (p = 0.041), vitality (p=0.0001), social functioning (p=0.048).
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March 2021

RISK FACTORS AND COMORBIDITY IN DIFFERENT TYPES OF FUNCTIONAL DYSPEPSIA: RETROSPECTIVE COHORT ANALYSIS.

Georgian Med News 2020 Oct(307):104-108

3Azerbaijan Medical University, Baku, Azerbaijan.

There is a significant data about overlap of functional dyspepsia (FD) and irritable bowel syndrome (IBS), however mostly the data is based on the previous diagnostic criteria and do not include other pathologies. In the previous researches there were no differential statistical analysis performed for different types of FD - postprandial distress syndrome (PDS) and epigastric pain syndrome (EBS). Aim of the study - to assess potential risk factors and the prevalence of comorbid conditions associated with FD and to compare their frequency with the same in the group with no dyspeptic complaints and in patients with different types of FD - PDS and EPS. This study was conducted as a retrospective database analysis of the patients with newly set diagnosis of FD and control group. For all the cases the information on demographic (working status, family status) and lifestyle characteristics (body mass index, smoking status, and alcohol consumption), and comorbidities were collected from the medical files. We statistically analyzed the presence of risk factors, comorbidity and its frequency in the patients with FD and compared the results with control group and in the groups with different types of FD according to the generally accepted standards. This study included 158 patients with PDS, 87 patients with EBS, and 90 volunteers with no dyspeptic complaints. Smoking, alcohol consumption, and family status were not associated with the risk of FD. The presence of sleep disorders and being unemployed increased the risk of FD. The comparison of the results of the patients with different types of FD demonstrated that there were no statistical difference in risk factors for the PDS and EPS. Gastroesophageal reflux disease (GERD), IBS, chronic gastritis and / or duodenitis, anxiety, and depression occur more frequently in the group of patients with FD. No association between autoimmune thyroiditis (AIT), arterial hypertension and ischemic heart disease (IHD) was evaluated. There was no statistical difference for the frequency of GERD, chronic gastritis and / or duodenitis, anxiety, AIT, arterial hypertension, and IHD in the patients with different types of FD. However, it was evaluated that IBS and depression occur more frequently in the group of patients with PDS, than in the patients with EPS.
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October 2020

Peculiarities of psychological status in patients with functional dyspepsia: postprandial distress syndrome

Wiad Lek 2019 Oct;72(10):1872-1877

Bogomolets National Medical University, Kyiv, Ukraine

Introduction: Among all causes of epigastric pain or burning, early satiety, bothersome fullness, the most common one is functional dyspepsia (FD). Analysis of psychological peculiarities of patients with FD becomes one of the key problems. The aim: To compare the level of anxiety, depression, and social functioning of patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EBS), and healthy volunteers.

Material And Methods: This cross-sectional study was conducted in adult patients with FD (58 patients with PDS and 37 patients with EPS) and healthy volunteers (30 persons). Patients’ social functioning was assessed with the 36-Item Short Form Health Survey (SF-36). Anxiety and depression levels were measured with the Hospital Anxiety and Depression Scale (HADS).

Results: Patients with PDS showed significantly lower rates of physical functioning (p=0.0002), role physical (p=0.003), bodily pain (p=0.0001), general health (p=0.0001), vitality (p=0.0001), and social functioning (p=0.0003), in comparison with healthy volunteers. This group also showed significantly lower rates of general health (p=0.041), and social functioning (p=0.048), as compared to patients with EPS. FD led to an increase in anxiety levels regardless of the type of disease as compared with healthy volunteers (p=0.024). Patients with PDS had elevated depression levels compared to patients with EPS (p=0.023) and healthy volunteers (p=0.001).

Conclusions: Each type of FD has a certain impact on the social functioning, anxiety and depression levels. Patients with PDS manifested significant differences in the psychological state as compared to patients with EPS, and healthy volunteers.
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October 2019

MORPHOLOGICAL PECULIARITIES OF CHRONIC GASTRITIS IN PATIENTS WITH FUNCTIONAL DYSPEPSIA.

Georgian Med News 2019 Apr(289):102-107

2Gastro center of the Clinic "Oberig", Kyiv, Ukraine.

Functional dyspepsia (FD) is the most common cause of chronic epigastric pain and abdominal fullness. Helicobacter pylori-associated gastritis is one of the pathophysiological factors of FD, however the peculiarities of it are still unknown. Aim of the study - to compare the morphological changes in biopsy specimens of gastroduodenal area in patients with different types of functional dyspepsia. This study was conducted as a cross-sectional study in adult subjects with FD. Biopsy specimens were taken from the stomach as per the Houston-updated gastric biopsy sampling protocol. To measure gastritis grade we used OLGA and OLGIM staging systems. Analysis was performed by pathologist who was blinded to the clinical diagnosis of the patients. We compare the degree of inflammation, activity of gastritis, presence and degree of atrophy, metaplasia and dysplasia in patients with different types of FD. This study included 33 subjects with postprandial distress syndrome (PDS) and 28 subjects with epigastric pain syndrome (EPS) according to Rome IV criteria. The level of gastric body and antral inflammation, activity degree, and metaplasia were detected at the same frequency in both groups (p>0.05). The grade of antral atrophy was significantly higher in patients with PDS (p=0,002) with no difference in the gastric body.
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April 2019

Clinical Case Report of Familial Benign Pancreatic Hyperenzymemia.

Pancreas 2018 07;47(6):e35-e36

Department of Internal Medicine Donetsk National Medical University Lyman, Ukraine Unit of Internal Medicine, Infectious Diseases, and Dermatovenereology Institute of Postgraduate Education of Bogomolets National Medical University Kyiv, Ukraine Department of Internal Medicine Donetsk National Medical University Lyman, Ukraine Unit of Internal Medicine, Infectious Diseases, and Dermatovenereology Institute of Postgraduate Education of Bogomolets National Medical University Kyiv, Ukraine.

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http://dx.doi.org/10.1097/MPA.0000000000001078DOI Listing
July 2018