Symen Ligthart

Symen Ligthart

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Symen Ligthart

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Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Authors:
Aldi T Kraja Chunyu Liu Jessica L Fetterman Mariaelisa Graff Christian Theil Have Charles Gu Lisa R Yanek Mary F Feitosa Dan E Arking Daniel I Chasman Kristin Young Symen Ligthart W David Hill Stefan Weiss Jian'an Luan Franco Giulianini Ruifang Li-Gao Fernando P Hartwig Shiow J Lin Lihua Wang Tom G Richardson Jie Yao Eliana P Fernandez Mohsen Ghanbari Mary K Wojczynski Wen-Jane Lee Maria Argos Sebastian M Armasu Ruteja A Barve Kathleen A Ryan Ping An Thomas J Baranski Suzette J Bielinski Donald W Bowden Ulrich Broeckel Kaare Christensen Audrey Y Chu Janie Corley Simon R Cox Andre G Uitterlinden Fernando Rivadeneira Cheryl D Cropp E Warwick Daw Diana van Heemst Lisa de Las Fuentes He Gao Ioanna Tzoulaki Tarunveer S Ahluwalia Renée de Mutsert Leslie S Emery A Mesut Erzurumluoglu James A Perry Mao Fu Nita G Forouhi Zhenglong Gu Yang Hai Sarah E Harris Gibran Hemani Steven C Hunt Marguerite R Irvin Anna E Jonsson Anne E Justice Nicola D Kerrison Nicholas B Larson Keng-Hung Lin Latisha D Love-Gregory Rasika A Mathias Joseph H Lee Matthias Nauck Raymond Noordam Ken K Ong James Pankow Amit Patki Alison Pattie Astrid Petersmann Qibin Qi Rasmus Ribel-Madsen Rebecca Rohde Kevin Sandow Theresia M Schnurr Tamar Sofer John M Starr Adele M Taylor Alexander Teumer Nicholas J Timpson Hugoline G de Haan Yujie Wang Peter E Weeke Christine Williams Hongsheng Wu Wei Yang Donglin Zeng Daniel R Witte Bruce S Weir Nicholas J Wareham Henrik Vestergaard Stephen T Turner Christian Torp-Pedersen Evie Stergiakouli Wayne Huey-Herng Sheu Frits R Rosendaal M Arfan Ikram Oscar H Franco Paul M Ridker Thomas T Perls Oluf Pedersen Ellen A Nohr Anne B Newman Allan Linneberg Claudia Langenberg Tuomas O Kilpeläinen Sharon L R Kardia Marit E Jørgensen Torben Jørgensen Thorkild I A Sørensen Georg Homuth Torben Hansen Mark O Goodarzi Ian J Deary Cramer Christensen Yii-Der Ida Chen Aravinda Chakravarti Ivan Brandslund Klaus Bonnelykke Kent D Taylor James G Wilson Santiago Rodriguez Gail Davies Bernardo L Horta Bharat Thyagarajan D C Rao Niels Grarup Victor G Davila-Roman Gavin Hudson Xiuqing Guo Donna K Arnett Caroline Hayward Dhananjay Vaidya Dennis O Mook-Kanamori Hemant K Tiwari Daniel Levy Ruth J F Loos Abbas Dehghan Paul Elliott Afshan N Malik Robert A Scott Diane M Becker Mariza de Andrade Michael A Province James B Meigs Jerome I Rotter Kari E North

Am J Hum Genet 2019 Jan 27;104(1):112-138. Epub 2018 Dec 27.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323610PMC
January 2019

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

Authors:
Anubha Mahajan Daniel Taliun Matthias Thurner Neil R Robertson Jason M Torres N William Rayner Anthony J Payne Valgerdur Steinthorsdottir Robert A Scott Niels Grarup James P Cook Ellen M Schmidt Matthias Wuttke Chloé Sarnowski Reedik Mägi Jana Nano Christian Gieger Stella Trompet Cécile Lecoeur Michael H Preuss Bram Peter Prins Xiuqing Guo Lawrence F Bielak Jennifer E Below Donald W Bowden John Campbell Chambers Young Jin Kim Maggie C Y Ng Lauren E Petty Xueling Sim Weihua Zhang Amanda J Bennett Jette Bork-Jensen Chad M Brummett Mickaël Canouil Kai-Uwe Ec Kardt Krista Fischer Sharon L R Kardia Florian Kronenberg Kristi Läll Ching-Ti Liu Adam E Locke Jian'an Luan Ioanna Ntalla Vibe Nylander Sebastian Schönherr Claudia Schurmann Loïc Yengo Erwin P Bottinger Ivan Brandslund Cramer Christensen George Dedoussis Jose C Florez Ian Ford Oscar H Franco Timothy M Frayling Vilmantas Giedraitis Sophie Hackinger Andrew T Hattersley Christian Herder M Arfan Ikram Martin Ingelsson Marit E Jørgensen Torben Jørgensen Jennifer Kriebel Johanna Kuusisto Symen Ligthart Cecilia M Lindgren Allan Linneberg Valeriya Lyssenko Vasiliki Mamakou Thomas Meitinger Karen L Mohlke Andrew D Morris Girish Nadkarni James S Pankow Annette Peters Naveed Sattar Alena Stančáková Konstantin Strauch Kent D Taylor Barbara Thorand Gudmar Thorleifsson Unnur Thorsteinsdottir Jaakko Tuomilehto Daniel R Witte Josée Dupuis Patricia A Peyser Eleftheria Zeggini Ruth J F Loos Philippe Froguel Erik Ingelsson Lars Lind Leif Groop Markku Laakso Francis S Collins J Wouter Jukema Colin N A Palmer Harald Grallert Andres Metspalu Abbas Dehghan Anna Köttgen Goncalo R Abecasis James B Meigs Jerome I Rotter Jonathan Marchini Oluf Pedersen Torben Hansen Claudia Langenberg Nicholas J Wareham Kari Stefansson Anna L Gloyn Andrew P Morris Michael Boehnke Mark I McCarthy

Nat Genet 2018 11 8;50(11):1505-1513. Epub 2018 Oct 8.

Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41588-018-0241-6
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http://dx.doi.org/10.1038/s41588-018-0241-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287706PMC
November 2018

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Authors:
Symen Ligthart Ahmad Vaez Urmo Võsa Maria G Stathopoulou Paul S de Vries Bram P Prins Peter J Van der Most Toshiko Tanaka Elnaz Naderi Lynda M Rose Ying Wu Robert Karlsson Maja Barbalic Honghuang Lin René Pool Gu Zhu Aurélien Macé Carlo Sidore Stella Trompet Massimo Mangino Maria Sabater-Lleal John P Kemp Ali Abbasi Tim Kacprowski Niek Verweij Albert V Smith Tao Huang Carola Marzi Mary F Feitosa Kurt K Lohman Marcus E Kleber Yuri Milaneschi Christian Mueller Mahmudul Huq Efthymia Vlachopoulou Leo-Pekka Lyytikäinen Christopher Oldmeadow Joris Deelen Markus Perola Jing Hua Zhao Bjarke Feenstra Marzyeh Amini Jari Lahti Katharina E Schraut Myriam Fornage Bhoom Suktitipat Wei-Min Chen Xiaohui Li Teresa Nutile Giovanni Malerba Jian'an Luan Tom Bak Nicholas Schork Fabiola Del Greco M Elisabeth Thiering Anubha Mahajan Riccardo E Marioni Evelin Mihailov Joel Eriksson Ayse Bilge Ozel Weihua Zhang Maria Nethander Yu-Ching Cheng Stella Aslibekyan Wei Ang Ilaria Gandin Loïc Yengo Laura Portas Charles Kooperberg Edith Hofer Kumar B Rajan Claudia Schurmann Wouter den Hollander Tarunveer S Ahluwalia Jing Zhao Harmen H M Draisma Ian Ford Nicholas Timpson Alexander Teumer Hongyan Huang Simone Wahl YongMei Liu Jie Huang Hae-Won Uh Frank Geller Peter K Joshi Lisa R Yanek Elisabetta Trabetti Benjamin Lehne Diego Vozzi Marie Verbanck Ginevra Biino Yasaman Saba Ingrid Meulenbelt Jeff R O'Connell Markku Laakso Franco Giulianini Patrik K E Magnusson Christie M Ballantyne Jouke Jan Hottenga Grant W Montgomery Fernando Rivadineira Rico Rueedi Maristella Steri Karl-Heinz Herzig David J Stott Cristina Menni Mattias Frånberg Beate St Pourcain Stephan B Felix Tune H Pers Stephan J L Bakker Peter Kraft Annette Peters Dhananjay Vaidya Graciela Delgado Johannes H Smit Vera Großmann Juha Sinisalo Ilkka Seppälä Stephen R Williams Elizabeth G Holliday Matthijs Moed Claudia Langenberg Katri Räikkönen Jingzhong Ding Harry Campbell Michele M Sale Yii-Der I Chen Alan L James Daniela Ruggiero Nicole Soranzo Catharina A Hartman Erin N Smith Gerald S Berenson Christian Fuchsberger Dena Hernandez Carla M T Tiesler Vilmantas Giedraitis David Liewald Krista Fischer Dan Mellström Anders Larsson Yunmei Wang William R Scott Matthias Lorentzon John Beilby Kathleen A Ryan Craig E Pennell Dragana Vuckovic Beverly Balkau Maria Pina Concas Reinhold Schmidt Carlos F Mendes de Leon Erwin P Bottinger Margreet Kloppenburg Lavinia Paternoster Michael Boehnke A W Musk Gonneke Willemsen David M Evans Pamela A F Madden Mika Kähönen Zoltán Kutalik Magdalena Zoledziewska Ville Karhunen Stephen B Kritchevsky Naveed Sattar Genevieve Lachance Robert Clarke Tamara B Harris Olli T Raitakari John R Attia Diana van Heemst Eero Kajantie Rossella Sorice Giovanni Gambaro Robert A Scott Andrew A Hicks Luigi Ferrucci Marie Standl Cecilia M Lindgren John M Starr Magnus Karlsson Lars Lind Jun Z Li John C Chambers Trevor A Mori Eco J C N de Geus Andrew C Heath Nicholas G Martin Juha Auvinen Brendan M Buckley Anton J M de Craen Melanie Waldenberger Konstantin Strauch Thomas Meitinger Rodney J Scott Mark McEvoy Marian Beekman Cristina Bombieri Paul M Ridker Karen L Mohlke Nancy L Pedersen Alanna C Morrison Dorret I Boomsma John B Whitfield David P Strachan Albert Hofman Peter Vollenweider Francesco Cucca Marjo-Riitta Jarvelin J Wouter Jukema Tim D Spector Anders Hamsten Tanja Zeller André G Uitterlinden Matthias Nauck Vilmundur Gudnason Lu Qi Harald Grallert Ingrid B Borecki Jerome I Rotter Winfried März Philipp S Wild Marja-Liisa Lokki Michael Boyle Veikko Salomaa Mads Melbye Johan G Eriksson James F Wilson Brenda W J H Penninx Diane M Becker Bradford B Worrall Greg Gibson Ronald M Krauss Marina Ciullo Gianluigi Zaza Nicholas J Wareham Albertine J Oldehinkel Lyle J Palmer Sarah S Murray Peter P Pramstaller Stefania Bandinelli Joachim Heinrich Erik Ingelsson Ian J Deary Reedik Mägi Liesbeth Vandenput Pim van der Harst Karl C Desch Jaspal S Kooner Claes Ohlsson Caroline Hayward Terho Lehtimäki Alan R Shuldiner Donna K Arnett Lawrence J Beilin Antonietta Robino Philippe Froguel Mario Pirastu Tine Jess Wolfgang Koenig Ruth J F Loos Denis A Evans Helena Schmidt George Davey Smith P Eline Slagboom Gudny Eiriksdottir Andrew P Morris Bruce M Psaty Russell P Tracy Ilja M Nolte Eric Boerwinkle Sophie Visvikis-Siest Alex P Reiner Myron Gross Joshua C Bis Lude Franke Oscar H Franco Emelia J Benjamin Daniel I Chasman Josée Dupuis Harold Snieder Abbas Dehghan Behrooz Z Alizadeh

Am J Hum Genet 2018 11;103(5):691-706

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183032
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http://dx.doi.org/10.1016/j.ajhg.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218410PMC
November 2018

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Authors:
Anubha Mahajan Jennifer Wessel Sara M Willems Wei Zhao Neil R Robertson Audrey Y Chu Wei Gan Hidetoshi Kitajima Daniel Taliun N William Rayner Xiuqing Guo Yingchang Lu Man Li Richard A Jensen Yao Hu Shaofeng Huo Kurt K Lohman Weihua Zhang James P Cook Bram Peter Prins Jason Flannick Niels Grarup Vassily Vladimirovich Trubetskoy Jasmina Kravic Young Jin Kim Denis V Rybin Hanieh Yaghootkar Martina Müller-Nurasyid Karina Meidtner Ruifang Li-Gao Tibor V Varga Jonathan Marten Jin Li Albert Vernon Smith Ping An Symen Ligthart Stefan Gustafsson Giovanni Malerba Ayse Demirkan Juan Fernandez Tajes Valgerdur Steinthorsdottir Matthias Wuttke Cécile Lecoeur Michael Preuss Lawrence F Bielak Marielisa Graff Heather M Highland Anne E Justice Dajiang J Liu Eirini Marouli Gina Marie Peloso Helen R Warren Saima Afaq Shoaib Afzal Emma Ahlqvist Peter Almgren Najaf Amin Lia B Bang Alain G Bertoni Cristina Bombieri Jette Bork-Jensen Ivan Brandslund Jennifer A Brody Noël P Burtt Mickaël Canouil Yii-Der Ida Chen Yoon Shin Cho Cramer Christensen Sophie V Eastwood Kai-Uwe Eckardt Krista Fischer Giovanni Gambaro Vilmantas Giedraitis Megan L Grove Hugoline G de Haan Sophie Hackinger Yang Hai Sohee Han Anne Tybjærg-Hansen Marie-France Hivert Bo Isomaa Susanne Jäger Marit E Jørgensen Torben Jørgensen Annemari Käräjämäki Bong-Jo Kim Sung Soo Kim Heikki A Koistinen Peter Kovacs Jennifer Kriebel Florian Kronenberg Kristi Läll Leslie A Lange Jung-Jin Lee Benjamin Lehne Huaixing Li Keng-Hung Lin Allan Linneberg Ching-Ti Liu Jun Liu Marie Loh Reedik Mägi Vasiliki Mamakou Roberta McKean-Cowdin Girish Nadkarni Matt Neville Sune F Nielsen Ioanna Ntalla Patricia A Peyser Wolfgang Rathmann Kenneth Rice Stephen S Rich Line Rode Olov Rolandsson Sebastian Schönherr Elizabeth Selvin Kerrin S Small Alena Stančáková Praveen Surendran Kent D Taylor Tanya M Teslovich Barbara Thorand Gudmar Thorleifsson Adrienne Tin Anke Tönjes Anette Varbo Daniel R Witte Andrew R Wood Pranav Yajnik Jie Yao Loïc Yengo Robin Young Philippe Amouyel Heiner Boeing Eric Boerwinkle Erwin P Bottinger Rajiv Chowdhury Francis S Collins George Dedoussis Abbas Dehghan Panos Deloukas Marco M Ferrario Jean Ferrières Jose C Florez Philippe Frossard Vilmundur Gudnason Tamara B Harris Susan R Heckbert Joanna M M Howson Martin Ingelsson Sekar Kathiresan Frank Kee Johanna Kuusisto Claudia Langenberg Lenore J Launer Cecilia M Lindgren Satu Männistö Thomas Meitinger Olle Melander Karen L Mohlke Marie Moitry Andrew D Morris Alison D Murray Renée de Mutsert Marju Orho-Melander Katharine R Owen Markus Perola Annette Peters Michael A Province Asif Rasheed Paul M Ridker Fernando Rivadineira Frits R Rosendaal Anders H Rosengren Veikko Salomaa Wayne H-H Sheu Rob Sladek Blair H Smith Konstantin Strauch André G Uitterlinden Rohit Varma Cristen J Willer Matthias Blüher Adam S Butterworth John Campbell Chambers Daniel I Chasman John Danesh Cornelia van Duijn Josée Dupuis Oscar H Franco Paul W Franks Philippe Froguel Harald Grallert Leif Groop Bok-Ghee Han Torben Hansen Andrew T Hattersley Caroline Hayward Erik Ingelsson Sharon L R Kardia Fredrik Karpe Jaspal Singh Kooner Anna Köttgen Kari Kuulasmaa Markku Laakso Xu Lin Lars Lind Yongmei Liu Ruth J F Loos Jonathan Marchini Andres Metspalu Dennis Mook-Kanamori Børge G Nordestgaard Colin N A Palmer James S Pankow Oluf Pedersen Bruce M Psaty Rainer Rauramaa Naveed Sattar Matthias B Schulze Nicole Soranzo Timothy D Spector Kari Stefansson Michael Stumvoll Unnur Thorsteinsdottir Tiinamaija Tuomi Jaakko Tuomilehto Nicholas J Wareham James G Wilson Eleftheria Zeggini Robert A Scott Inês Barroso Timothy M Frayling Mark O Goodarzi James B Meigs Michael Boehnke Danish Saleheen Andrew P Morris Jerome I Rotter Mark I McCarthy

Nat Genet 2018 04 9;50(4):559-571. Epub 2018 Apr 9.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41588-018-0084-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898373PMC
April 2018

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.

Am J Hum Genet 2017 Dec 30;101(6):888-902. Epub 2017 Nov 30.

Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812919PMC
December 2017

Gamma-glutamyltransferase levels, prediabetes and type 2 diabetes: a Mendelian randomization study.

Int J Epidemiol 2017 10;46(5):1400-1409

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/ije/dyx006DOI Listing
October 2017

Age at natural menopause and risk of type 2 diabetes: a prospective cohort study.

Diabetologia 2017 10 18;60(10):1951-1960. Epub 2017 Jul 18.

Department of Epidemiology, Erasmus University Medical Center, Dr. Molewaterplein 50, Office NA29-14, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1007/s00125-017-4346-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448832PMC
October 2017

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

PLoS One 2017 20;12(1):e0167742. Epub 2017 Jan 20.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249120PMC
August 2017

Circulating Levels of Interleukin 1-Receptor Antagonist and Risk of Cardiovascular Disease: Meta-Analysis of Six Population-Based Cohorts.

Arterioscler Thromb Vasc Biol 2017 06 20;37(6):1222-1227. Epub 2017 Apr 20.

From the Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany (C. Herder, M.C.-K., M.R.); German Center for Diabetes Research (DZD), München-Neuherberg, Germany (C. Herder, M.C.-K., A. Peters, M.R., B.T.); Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (T.d.l.H.G., C. Huth, A.Z., S.W., C.M., A. Peters, B.T.); German Center for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Germany (T.d.l.H.G., W.K.); Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (S.W.); Tethys Bioscience, Emeryville, CA (J.S.-K., D.P.); National Institute for Health and Welfare, Helsinki, Finland (K.K., A. Pietilä, V.S.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands (S.L., A.D., M.A.I.); Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany (B.W.C.B.); Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, United Kingdom (A.D.); National Institute for Health and Welfare, Turku, Finland (A.J.); Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Institute of Clinical Science B, Queen's University Belfast, United Kingdom (F.K.); UKCRC Centre of Excellence for Public Health (Northern Ireland), Queen's University Belfast, United Kingdom (F.K.); Dalla Lana School of Public Health, University of Toronto, Ontario, Canada (O.S.); Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany (T.Z., S.B.); German Center for Cardiovascular Research (DZHK), Partner site Hamburg, Lübeck, Kiel, Germany (T.Z., S.B.); Department of Endocrinology and Diabetology, Medical Faculty, University Hospital Düsseldorf, Germany (M.R.); Deutsches Herzzentrum München, Technische Universität München, Germany (W.K.); and Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Germany (W.K.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309307DOI Listing
June 2017

Serum magnesium and the risk of prediabetes: a population-based cohort study.

Diabetologia 2017 05 21;60(5):843-853. Epub 2017 Feb 21.

Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1007/s00125-017-4224-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518103PMC
May 2017

Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study.

Diabetes Care 2017 Mar 28;40(3):346-351. Epub 2016 Dec 28.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

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http://dx.doi.org/10.2337/dc16-1295DOI Listing
March 2017

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study.

Eur J Epidemiol 2017 03 3;32(3):217-226. Epub 2017 Mar 3.

Department of Epidemiology, Erasmus University Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10654-017-0236-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380703PMC
March 2017

Metabolic syndrome is related to polyneuropathy and impaired peripheral nerve function: a prospective population-based cohort study.

J Neurol Neurosurg Psychiatry 2016 12 21;87(12):1336-1342. Epub 2016 Sep 21.

Department of Neurology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2016-314171DOI Listing
December 2016

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.

Genome Biol 2016 12 12;17(1):255. Epub 2016 Dec 12.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13059-016-1119-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151130PMC
December 2016

Gait characteristics in older adults with diabetes and impaired fasting glucose: The Rotterdam Study.

J Diabetes Complications 2016 Jan-Feb;30(1):61-6. Epub 2015 Oct 20.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2015.10.006DOI Listing
October 2016

Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study.

BMC Med 2016 Sep 30;14(1):150. Epub 2016 Sep 30.

Department of Epidemiology, Erasmus University Medical Center, Room NA-2828, 3000CA, Rotterdam, The Netherlands.

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http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043536PMC
http://dx.doi.org/10.1186/s12916-016-0693-4DOI Listing
September 2016

Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study.

PLoS Med 2016 07 19;13(7):e1002086. Epub 2016 Jul 19.

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1371/journal.pmed.1002086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951120PMC
July 2016

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

BMC Genomics 2016 06 10;17:443. Epub 2016 Jun 10.

Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12864-016-2712-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901478PMC
June 2016

Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes.

Diabetologia 2016 May 29;59(5):998-1006. Epub 2016 Jan 29.

Department of Epidemiology, Erasmus University Medical Center, P. O. Box 2040, 3000 CA, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1007/s00125-016-3872-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826423PMC
May 2016

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.

Authors:
Bonnie R Joubert Janine F Felix Paul Yousefi Kelly M Bakulski Allan C Just Carrie Breton Sarah E Reese Christina A Markunas Rebecca C Richmond Cheng-Jian Xu Leanne K Küpers Sam S Oh Cathrine Hoyo Olena Gruzieva Cilla Söderhäll Lucas A Salas Nour Baïz Hongmei Zhang Johanna Lepeule Carlos Ruiz Symen Ligthart Tianyuan Wang Jack A Taylor Liesbeth Duijts Gemma C Sharp Soesma A Jankipersadsing Roy M Nilsen Ahmad Vaez M Daniele Fallin Donglei Hu Augusto A Litonjua Bernard F Fuemmeler Karen Huen Juha Kere Inger Kull Monica Cheng Munthe-Kaas Ulrike Gehring Mariona Bustamante Marie José Saurel-Coubizolles Bilal M Quraishi Jie Ren Jörg Tost Juan R Gonzalez Marjolein J Peters Siri E Håberg Zongli Xu Joyce B van Meurs Tom R Gaunt Marjan Kerkhof Eva Corpeleijn Andrew P Feinberg Celeste Eng Andrea A Baccarelli Sara E Benjamin Neelon Asa Bradman Simon Kebede Merid Anna Bergström Zdenko Herceg Hector Hernandez-Vargas Bert Brunekreef Mariona Pinart Barbara Heude Susan Ewart Jin Yao Nathanaël Lemonnier Oscar H Franco Michael C Wu Albert Hofman Wendy McArdle Pieter Van der Vlies Fahimeh Falahi Matthew W Gillman Lisa F Barcellos Ashish Kumar Magnus Wickman Stefano Guerra Marie-Aline Charles John Holloway Charles Auffray Henning W Tiemeier George Davey Smith Dirkje Postma Marie-France Hivert Brenda Eskenazi Martine Vrijheid Hasan Arshad Josep M Antó Abbas Dehghan Wilfried Karmaus Isabella Annesi-Maesano Jordi Sunyer Akram Ghantous Göran Pershagen Nina Holland Susan K Murphy Dawn L DeMeo Esteban G Burchard Christine Ladd-Acosta Harold Snieder Wenche Nystad Gerard H Koppelman Caroline L Relton Vincent W V Jaddoe Allen Wilcox Erik Melén Stephanie J London

Am J Hum Genet 2016 Apr 31;98(4):680-96. Epub 2016 Mar 31.

National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833289PMC
April 2016

Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors.

Circ Res 2016 Jan 20;118(1):83-94. Epub 2015 Oct 20.

From the Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (M.L., B.K.A.); Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, and Research Support Services, Oslo University Hospital, Oslo, Norway (M.L., A.F.); NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (V.Z., A.W., F.B., Y.W., S.D., O.A.A.); Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (V.Z., A.W., F.B., S.D., O.A.A.); Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, Norway (B.K.A.); Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (L.Z., H.S.); Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Munich Heart Alliance, Munich, Germany (L.Z., H.S.); Multimodal Imaging Laboratory, University of California at San Diego, La Jolla (Y.W., L.K.M., A.J.S., R.S.D., A.M.D., O.A.A.); Department of Neurosciences, University of California, San Diego, La Jolla, (Y.W., A.M.D.); Department of Radiology, University of California, San Diego, La Jolla (L.K.M., R.S.D., A.M.D.); Department of Psychiatry, University of California, San Diego, La Jolla (W.K.T., A.M.D.); Cognitive Sciences Graduate Program, University of California, San Diego, La Jolla, (A.J.S.); Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway (S.R.); Department of Medical Biochemistry, Lovisenberg Diakonale Hospital, Oslo, Norway (S.R., K.M.G.); Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (S.R., K.M.G.); Family and Preventive Medicine, Division of Epidemiology, University of California, San Diego, La Jolla (E.B.-C.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (S.L., A.D.); Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (C.P.N.,

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609485PMC
January 2016

Lifetime risk of developing impaired glucose metabolism and eventual progression from prediabetes to type 2 diabetes: a prospective cohort study.

Lancet Diabetes Endocrinol 2016 Jan 11;4(1):44-51. Epub 2015 Nov 11.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(15)00362-9DOI Listing
January 2016

Tobacco smoking is associated with methylation of genes related to coronary artery disease.

Clin Epigenetics 2015 14;7:54. Epub 2015 May 14.

Department of Epidemiology, Erasmus University Medical Centre, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13148-015-0088-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443552PMC
May 2015

Incremental predictive value of 152 single nucleotide polymorphisms in the 10-year risk prediction of incident coronary heart disease: the Rotterdam Study.

Int J Epidemiol 2015 Apr 6;44(2):682-8. Epub 2015 May 6.

Department of Epidemiology, and Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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http://dx.doi.org/10.1093/ije/dyv070DOI Listing
April 2015

EN-RAGE: a novel inflammatory marker for incident coronary heart disease.

Arterioscler Thromb Vasc Biol 2014 Dec 23;34(12):2695-9. Epub 2014 Oct 23.

From the Department of Epidemiology (S.L., S.S., M.A.I., A.H., O.H.F., A.D.), Department of Neurology (M.A.I.), and Department of Radiology (M.A.I.), Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.114.304306DOI Listing
December 2014

Pleiotropic genes for metabolic syndrome and inflammation.

Mol Genet Metab 2014 Aug 9;112(4):317-38. Epub 2014 May 9.

Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2014.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122618PMC
August 2014