Publications by authors named "Sylvie Mavel"

33Publications

Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS.

Talanta 2019 Apr 27;195:593-598. Epub 2018 Nov 27.

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France; CHRU de Tours, Service de Médecine Nucléaire In Vitro, Tours, France.

View Article and Find Full Text PDF
April 2019

Validation of metabolomics analysis of human perilymph fluid using liquid chromatography-mass spectroscopy.

Hear Res 2018 09 22;367:129-136. Epub 2018 May 22.

UMR 1253, iBrain. Université de Tours, Inserm, Tours, France. Electronic address:

View Article and Find Full Text PDF
September 2018

The Metabolic Disturbances of Motoneurons Exposed to Glutamate.

Mol Neurobiol 2018 Oct 12;55(10):7669-7676. Epub 2018 Feb 12.

INSERM U930 "Imagerie et Cerveau," CHRU de Tours, Université François-Rabelais, Tours, France.

View Article and Find Full Text PDF
October 2018

Identification of metabolic pathway disturbances using multimodal metabolomics in autistic disorders in a Middle Eastern population.

J Pharm Biomed Anal 2018 Apr 3;152:57-65. Epub 2018 Feb 3.

Université François-Rabelais, INSERM U930, Equipe neurogénétique et neurométabolomique, France; Laboratoire de Biochimie et Biologie moléculaire, CHRU de Tours, France. Electronic address:

View Article and Find Full Text PDF
April 2018

Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S.

Eur J Med Chem 2018 Jan 7;144:201-210. Epub 2017 Dec 7.

INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires, Equipe "Mécanismes Protéolytiques dans l'inflammation", Université François Rabelais, Tours, France. Electronic address:

View Article and Find Full Text PDF
January 2018

Workflow methodology for rat brain metabolome exploration using NMR, LC-MS and GC-MS analytical platforms.

J Pharm Biomed Anal 2017 Aug 13;142:270-278. Epub 2017 May 13.

Université François-Rabelais, INSERM U930 "Imagerie et Cerveau", CHRU de Tours, 10 Bv Tonnellé, 37044 Tours, France. Electronic address:

View Article and Find Full Text PDF
August 2017

NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity.

Front Cell Neurosci 2016 9;10:118. Epub 2016 May 9.

Institut National de la Santé et de la Recherche Médicale (INSERM U930) "Imagerie et Cerveau", CHRU de Tours, Université François-RabelaisTours, France; Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, CHRU de ToursTours, France.

View Article and Find Full Text PDF
May 2016

Analytical methodology for metabolomics study of adherent mammalian cells using NMR, GC-MS and LC-HRMS.

Anal Bioanal Chem 2015 Nov 7;407(29):8861-72. Epub 2015 Oct 7.

INSERM U930 "Imagerie et Cerveau", CHRU de Tours, Université François-Rabelais, 10 Bv Tonnellé, 37044, Tours, France.

View Article and Find Full Text PDF
November 2015

Combined 1H-NMR and 1H-13C HSQC-NMR to improve urinary screening in autism spectrum disorders.

Analyst 2014 Jul;139(13):3460-8

Equipe neurogénétique et neurométabolomique INSERM U930, Université François Rabelais, PPF "Analyses des Systèmes Biologiques", UFR de Médecine, 10 BlvdTonnellé, 37044 Tours Cedex 9, 37000 Tours, France.

View Article and Find Full Text PDF
July 2014

Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron disease.

Neurology 2014 Apr 28;82(13):1167-74. Epub 2014 Feb 28.

From UMR Inserm U930 (H.B., L.N.-D., C.A., C.V.-D., S.M., P.E., C.R.A., P.C.), Tours; Université François-Rabelais (H.B., L.N.-D., C.A., C.V.-D., S.M., P.E., C.R.A., P.C.), Tours; Laboratoire de Biochimie et Biologie Moléculaire (H.B., C.A., P.E., C.R.A.), CHRU de Tours; PPF-ASB (L.N.-D., P.E.), Université François-Rabelais, Tours; Fédération des Maladies du Système Nerveux (P.-F.P., P.H.G.), Centre Référent Maladie Rare SLA, Hôpital de la Pitié-Salpétrière, Paris; Service de Neurologie (C.M., D.D.), CHRU de Lille; and Centre SLA (P.C.), Service de Neurologie, CHRU Bretonneau, Tours, France.

View Article and Find Full Text PDF
April 2014

1H-13C NMR-based urine metabolic profiling in autism spectrum disorders.

Talanta 2013 Sep 9;114:95-102. Epub 2013 Apr 9.

Université François-Rabelais, INSERM U930, Equipe neurogénétique et neurométabolomique, CHRU de Tours, 10 Bv Tonnellé, 37044 Tours, France.

View Article and Find Full Text PDF
September 2013

3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors.

Eur J Med Chem 2013 Jun 19;64:448-63. Epub 2013 Apr 19.

Université François Rabelais, UMR INRA 1282 Infectiologie et Santé Publique, Recherche et Innovation en Chimie Médicinale, Faculté de Pharmacie, 31 avenue Monge, F-37200 Tours, France.

View Article and Find Full Text PDF
June 2013

GC-MS-based urine metabolic profiling of autism spectrum disorders.

Anal Bioanal Chem 2013 Jun 10;405(15):5291-300. Epub 2013 Apr 10.

INSERM U930, Equipe neurogénétique et neurométabolomique, CHRU de Tours, Hôpital Bretonneau, Université François-Rabelais, 10 Bv Tonnellé, 37044 Tours, France.

View Article and Find Full Text PDF
June 2013

QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).

Bioorg Med Chem 2012 Feb 18;20(4):1388-95. Epub 2012 Jan 18.

Université François-Rabelais, INSERM U930, CNRS ERL3106, 31 Avenue Monge, 37200 Tours, France.

View Article and Find Full Text PDF
February 2012

3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT).

Bioorg Med Chem 2010 Nov 17;18(21):7659-67. Epub 2010 Aug 17.

Université François-Rabelais de Tours, INSERM U930, CHRU, Hôpital Bretonneau, Service de Médecine Nucléaire, 37000 Tours, France.

View Article and Find Full Text PDF
November 2010

Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.

Bioorg Med Chem 2010 Jan 4;18(1):236-41. Epub 2009 Nov 4.

Université François Rabelais de Tours, INSERM U930, 37000 TOURS, France.

View Article and Find Full Text PDF
January 2010

Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging.

Bioorg Med Chem 2008 Oct 6;16(19):9050-5. Epub 2008 Aug 6.

INSERM U930, 37000 TOURS, France; Université François-Rabelais de Tours, 37000 TOURS, France.

View Article and Find Full Text PDF
October 2008

Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.

Bioorg Med Chem Lett 2006 Mar 7;16(5):1297-300. Epub 2005 Dec 7.

Université François Rabelais de Tours, INSERM U619, Laboratoire de Biophysique Médicale et Pharmaceutique, 31 avenue Monge, 37200 Tours, France.

View Article and Find Full Text PDF
March 2006

Fragmentation pathway of dopamine transporter ligands: N-substituted-2beta-carbomethoxy-3beta-phenylnortropane derivatives.

J Pharm Biomed Anal 2004 Apr;35(1):193-8

Laboratoire de Biophysique Médicale, Faculté de Pharmacie, INSERM U316, 31 av. Monge, 37200 Tours, France.

View Article and Find Full Text PDF
April 2004

Synthesis of imidazo[2,1-a]phthalazines, potential inhibitors of p38 MAP kinase. Prediction of binding affinities of protein ligands.

Arch Pharm (Weinheim) 2002 Jan;335(1):7-14

Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 31 Av. Monge, 37200 Tours, France.

View Article and Find Full Text PDF
January 2002