Sylvain Chemtob

Sylvain Chemtob

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Sylvain Chemtob

Publications by authors named "Sylvain Chemtob"

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Assessing therapeutic response non-invasively in a neonatal rat model of acute inflammatory white matter injury using high-field MRI.

Brain Behav Immun 2019 Oct 24;81:348-360. Epub 2019 Jun 24.

Departments of Pediatrics, Ophthalmology and Pharmacology, CHU Sainte-Justine Research Centre, Montréal, Canada; Department of Pharmacology, Université de Montréal, Montréal, Canada; Montreal Heart Institute, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.06.032DOI Listing
October 2019

Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways.

Cytokine 2019 Sep 31;121:154738. Epub 2019 May 31.

Department of Immunology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, Quebec H1T 2M4, Canada; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montreal, Quebec H3C 3J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2019.154738DOI Listing
September 2019

Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Am J Pathol 2019 Sep 18;189(9):1878-1896. Epub 2019 Jun 18.

Departments of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada; Department of Pharmacology, Université de Montréal, Montréal, Quebec, Canada; Research Center, Maisonneuve-Rosemont Hospital, Montréal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.05.016DOI Listing
September 2019

The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.

Am J Pathol 2019 Aug 17. Epub 2019 Aug 17.

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Hospital, Université de Montréal, Montréal, Québec, Canada; Department of Ophthalmology, Centre Hospitalier Universitaire Sainte-Justine Hospital, Université de Montréal, Montréal, Québec, Canada; Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Hospital, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.07.009DOI Listing
August 2019

New insights into mechanisms of nuclear translocation of G-protein coupled receptors.

Small GTPases 2019 Jul 10;10(4):254-263. Epub 2017 Feb 10.

a Department of Pharmacology and Therapeutics , McGill University , Montréal , Québec , Canada.

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http://dx.doi.org/10.1080/21541248.2017.1282402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548292PMC
July 2019

Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists.

Curr Pharm Des 2017 ;23(40):6132-6141

Departments of Pediatrics, Ophthalmology and Pharmacology, CHU Sainte-Justine Research Center, Montreal, H3T 1C5, Canada.

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http://dx.doi.org/10.2174/1381612823666170825145114DOI Listing
July 2019

MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model.

PLoS One 2019 12;14(6):e0218282. Epub 2019 Jun 12.

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, University of Montréal, Montréal, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218282PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561584PMC
June 2019

Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators That Delay Preterm Birth.

J Med Chem 2019 May 23;62(9):4500-4525. Epub 2019 Apr 23.

Département de Chimie , Université de Montréal , C.P. 6128 Succursale Centre-Ville , Montréal H3C 3J7 QC , Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00056DOI Listing
May 2019

Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.

J Cell Physiol 2019 Mar 21;234(3):2851-2865. Epub 2018 Aug 21.

Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1002/jcp.27103DOI Listing
March 2019

Evaluating the neuroprotective effect of 17β-estradiol in rodent models of oxidative retinopathies.

Doc Ophthalmol 2018 12 27;137(3):151-168. Epub 2018 Oct 27.

Departments of Ophthalmology and Neurology-Neurosurgery, Faculty of Medicine, McGill University and Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Glen Site, Block E, Room EM03238, Montréal, QC, H4A 3J1, Canada.

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http://link.springer.com/10.1007/s10633-018-9658-6
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http://dx.doi.org/10.1007/s10633-018-9658-6DOI Listing
December 2018

Ischemic Retinopathies: Oxidative Stress and Inflammation.

Oxid Med Cell Longev 2017 19;2017:3940241. Epub 2017 Dec 19.

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, University of Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1155/2017/3940241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749295PMC
August 2018

miR-126-5p promotes retinal endothelial cell survival through SetD5 regulation in neurons.

Development 2018 01 8;145(1). Epub 2018 Jan 8.

University of Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Target Therapies, F-59000 Lille, France

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http://dev.biologists.org/lookup/doi/10.1242/dev.156232
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http://dx.doi.org/10.1242/dev.156232DOI Listing
January 2018

Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

J Med Chem 2017 11 1;60(22):9263-9274. Epub 2017 Nov 1.

Département de Chimie, ‡Département de Pédiatrie, and §Faculté de Pharmacie, Université de Montréal , C.P. 6128, Succursale, Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01209DOI Listing
November 2017

Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina.

J Neuroinflammation 2017 Sep 6;14(1):181. Epub 2017 Sep 6.

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, Université de Montréal, 5415 Blvd de l'Assomption, Montréal, Québec, H1T 2M4, Canada.

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http://dx.doi.org/10.1186/s12974-017-0955-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586016PMC
September 2017

Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies.

J Neuroinflammation 2017 Aug 22;14(1):165. Epub 2017 Aug 22.

Department of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Research Center, 3175, Chemin Côte Ste-Catherine, Montréal, Québec, Canada.

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http://dx.doi.org/10.1186/s12974-017-0943-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567917PMC
August 2017

Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation.

Mol Ther 2017 03 28;25(3):634-653. Epub 2017 Jan 28.

Unit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation asile des aveugles, 1004 Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016164549
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http://dx.doi.org/10.1016/j.ymthe.2016.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363218PMC
March 2017

Neonatal microglia: The cornerstone of brain fate.

Brain Behav Immun 2017 Jan 3;59:333-345. Epub 2016 Sep 3.

Sainte-Justine Hospital and Research Center, Department of Pediatrics, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec, Canada; Montreal Heart Institute, 5000 Rue Bélanger, Montreal, Quebec, Canada; Department of Neuroscience, Université de Montréal, Montreal, Quebec, Canada; Departments of Pharmacology, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2016.08.018DOI Listing
January 2017

Lactate produced during labor modulates uterine inflammation via GPR81 (HCA).

Am J Obstet Gynecol 2017 Jan 9;216(1):60.e1-60.e17. Epub 2016 Sep 9.

Department of Pediatrics, Ophthalmology, and Pharmacology, CHU Sainte-Justine Research Center, Montréal, Québec, Canada; Department of Pediatrics and Ophthalmology, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; Maisonneuve-Rosemont Hospital, Research Center, Montreal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajog.2016.09.072DOI Listing
January 2017

Preventing Corneal Calcification Associated With Xylazine for Longitudinal Optical Coherence Tomography in Young Rodents.

Invest Ophthalmol Vis Sci 2017 01;58(1):461-469

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada 2Hôpital Maisonneuve-Rosemont Research Center, Montréal, Québec, Canada 4Department of Ophthalmology, Université de Montréal, Montréal, Québec, Canada 5Department of Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada 6Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Center, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1167/iovs.16-20526DOI Listing
January 2017

Review of the mechanisms and therapeutic avenues for retinal and choroidal vascular dysfunctions in retinopathy of prematurity.

Acta Paediatr 2016 Dec 28;105(12):1421-1433. Epub 2016 Sep 28.

Department of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.

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http://dx.doi.org/10.1111/apa.13586DOI Listing
December 2016

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1β.

Am J Pathol 2016 12 18;186(12):3100-3116. Epub 2016 Oct 18.

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Centre, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada; Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada; Department of Ophthalmology, Centre Hospitalier Universitaire Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.08.004DOI Listing
December 2016

Sterile inflammation and pregnancy complications: a review.

Reproduction 2016 12 27;152(6):R277-R292. Epub 2016 Sep 27.

Department of PharmacologyUniversité de Montréal, Montreal, Quebec, Canada

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http://dx.doi.org/10.1530/REP-16-0453DOI Listing
December 2016

Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth.

Biol Reprod 2016 Sep 10;95(3):72. Epub 2016 Aug 10.

Departments of Pediatrics, Ophthalmology, and Pharmacology, CHU Sainte-Justine Research Centre, Montreal, Quebec, Canada Department of Pharmacology, Université de Montréal, Montreal, Quebec, Canada Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1095/biolreprod.116.140905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394981PMC
September 2016

Erratum: Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.

Cell Discov 2016 20;2:16034. Epub 2016 Sep 20.

Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada; CHU Sainte Justine Hospital Research Centre, University of Montréal, Montréal, QC, Canada; Department of Ophthalmology, Research Centre of Hôpital Maisonneuve-Rosemont, University of Montréal, Montréal, QC, Canada; Department of Pharmacology, University of Montréal, Montréal, QC, Canada; Departments of Pediatrics and Ophthalmology, Faculty of Medicine, University of Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1038/celldisc.2016.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029542PMC
September 2016

Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways.

PLoS One 2016 1;11(4):e0152838. Epub 2016 Apr 1.

Department of Physiology, Second Military Medical University, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152838PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817991PMC
August 2016

Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.

Cell Discov 2016 12;2:16017. Epub 2016 Jul 12.

Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada; CHU Sainte Justine Hospital Research Centre, University of Montréal, Montréal, QC, Canada; Department of Ophthalmology, Research Centre of Hôpital Maisonneuve-Rosemont, University of Montréal, Montréal, QC, Canada; Department of Pharmacology, University of Montréal, Montréal, QC, Canada; Departments of Pediatrics and Ophthalmology, Faculty of Medicine, University of Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1038/celldisc.2016.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941644PMC
July 2016

ECL1i, d(LGTFLKC), a novel, small peptide that specifically inhibits CCL2-dependent migration.

FASEB J 2016 06 15;30(6):2370-81. Epub 2016 Mar 15.

*Sorbonne Universités, Université Pierre et Marie Curie (UPMC)/Univ Paris 06, Unité Mixte de Recherche Scientifique (UMRS) 1135, INSERM Unité 1135, Centre National de la Recherche Scientifique, Equipe de Recherche Labellisée (ERL) 8255, Centre d'Immunologie et des Maladies Infectieuses, Paris, France;

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http://dx.doi.org/10.1096/fj.201500116DOI Listing
June 2016

A critical role of interleukin-1 in preterm labor.

Cytokine Growth Factor Rev 2016 Apr 30;28:37-51. Epub 2015 Nov 30.

Departments of Pediatrics, Ophthalmology and Pharmacology, CHU Sainte-Justine Research Center, Montréal H3T 1C5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2015.11.001DOI Listing
April 2016

BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy.

Invest Ophthalmol Vis Sci 2015 Dec;56(13):7897-907

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, Université de Montréal, Montréal, Quebec, Canada 2Department of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Research Center, Univer.

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http://dx.doi.org/10.1167/iovs.15-17146DOI Listing
December 2015

Tailoring Myopic CNV Treatment Based on Preexisting Ophthalmic Condition.

Invest Ophthalmol Vis Sci 2015 Dec;56(13):8362-3

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada 3Hôpital Maisonneuve-Rosemont Research Center, Université de Montréal, Montréal, Québec, Canada 4Departments of Pediatrics and Ophthalmology, Centre Hospitalier Unive.

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http://dx.doi.org/10.1167/iovs.15-18314DOI Listing
December 2015

Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.

J Immunol 2015 Oct 24;195(7):3402-15. Epub 2015 Aug 24.

Department of Pediatrics, CHU Sainte-Justine Research Center, Montreal, Quebec H3T 1C5, Canada; Department of Ophthalmology, CHU Sainte-Justine Research Center, Montreal, Quebec H3T 1C5, Canada; Department of Pharmacology, CHU Sainte-Justine Research Center, Montreal, Quebec H3T 1C5, Canada; Maisonneuve-Rosemont Hospital, Research Center, Montreal, Quebec H1T 2M4, Canada;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1500758
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http://dx.doi.org/10.4049/jimmunol.1500758DOI Listing
October 2015

High resolution imaging and function of nuclear G protein-coupled receptors (GPCRs).

Methods Mol Biol 2015 ;1234:81-97

Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-4939-1755-6_8DOI Listing
June 2015

Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity.

Expert Opin Ther Targets 2015 Jun;19(6):717-21

Université de Montréal, CHU Ste-Justine Hospital Research Centre, Departments of Pediatrics, Ophthalmology and Pharmacology , 3175 Côte Ste-Catherine, Montréal, Qc, H3T 1C5 , Canada +1 514 345 4931 Ext. 2978 ; +1 514 345 4801 ; ;

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http://dx.doi.org/10.1517/14728222.2015.1042365DOI Listing
June 2015

[New insights to prevent preterm labor].

Med Sci (Paris) 2015 Apr 8;31(4):374-6. Epub 2015 May 8.

Département de pédiatrie, pharmacologie et ophtalmologie, CHU Sainte-Justine, centre de recherche, 3175 chemin Côte-Sainte-Catherine, Montréal, H3T 1C5 Canada.

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http://dx.doi.org/10.1051/medsci/20153104010DOI Listing
April 2015

Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.

Am J Pathol 2015 Feb 3;185(2):581-95. Epub 2014 Dec 3.

Department of Pharmacology, CHU Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, University of Montréal, Montréal, Québec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; Department of Pediatrics, CHU Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.10.020DOI Listing
February 2015

Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response.

Am J Physiol Regul Integr Comp Physiol 2014 Nov 20;307(10):R1216-30. Epub 2014 Aug 20.

Departments of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Research Centre, Montréal, Canada;

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http://dx.doi.org/10.1152/ajpregu.00540.2013DOI Listing
November 2014

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.

Nat Med 2014 Oct 14;20(10):1165-73. Epub 2014 Sep 14.

1] Department of Pediatrics, Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Université de Montréal, Montréal, Québec, Canada. [2] Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Université de Montreal, Montreal, Québec, Canada. [3] Department of Pharmacology, Université de Montréal, Montréal, Québec, Canada. [4] Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/nm.3669DOI Listing
October 2014

Growth factors expression in hyaluronic acid fat graft myringoplasty.

Laryngoscope 2014 Jun 10;124(6):E224-30. Epub 2014 Apr 10.

Division of Otolaryngology-Head and Neck Surgery, Sainte-Justine University Hospital Center, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/lary.24468DOI Listing
June 2014

G-protein-coupled receptor 91 and succinate are key contributors in neonatal postcerebral hypoxia-ischemia recovery.

Arterioscler Thromb Vasc Biol 2014 Feb 27;34(2):285-93. Epub 2013 Nov 27.

From the Department of Pediatrics, Research Center-CHU Ste-Justine, Montréal, Quebec, Canada (D.H., O.R., J.C.H., T.Z., X.H., J.-C.L., G.A.M., S.C.); Departments of Pharmacology (D.H., F.D., S.C.) and Biomedical Sciences (O.R., M.N.-V.), Université de Montréal, Montréal, Quebec, Canada; and Department of Pharmacology and Therapeutics (M.S., B.N., S.C.), Goodman Cancer Research and Metabolomics Core Facility (O.A.M.), McGill University, Montréal, Quebec, Canada.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.113.302131
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http://dx.doi.org/10.1161/ATVBAHA.113.302131DOI Listing
February 2014

Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function.

Invest Ophthalmol Vis Sci 2013 Dec 17;54(13):8125-39. Epub 2013 Dec 17.

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.13-12496DOI Listing
December 2013

p75 neurotrophin receptor participates in the choroidal antiangiogenic and apoptotic effects of T-lymphocyte-derived microparticles.

Invest Ophthalmol Vis Sci 2013 Sep 9;54(9):6084-92. Epub 2013 Sep 9.

Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1167/iovs.13-11896DOI Listing
September 2013

Microglia and interleukin-1β in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A.

Arterioscler Thromb Vasc Biol 2013 Aug 13;33(8):1881-91. Epub 2013 Jun 13.

Department of Pediatrics, Ophthalmology, and Pharmacology, CHU Sainte-Justine Research Center, Paris, France.

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http://dx.doi.org/10.1161/ATVBAHA.113.301331DOI Listing
August 2013

Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents.

Arterioscler Thromb Vasc Biol 2013 May 21;33(5):954-61. Epub 2013 Mar 21.

Department of Pediatrics, Research Center-CHU Ste-Justine, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.112.300943DOI Listing
May 2013

Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A.

Acta Paediatr 2012 Aug 5;101(8):819-26. Epub 2012 May 5.

Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montréal, QC, Canada.

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http://dx.doi.org/10.1111/j.1651-2227.2012.02692.xDOI Listing
August 2012

Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.

J Med Chem 2012 Jul 9;55(14):6502-11. Epub 2012 Jul 9.

Département de Chimie, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jm300557tDOI Listing
July 2012

Role of receptor-mediated endocytosis in the antiangiogenic effects of human T lymphoblastic cell-derived microparticles.

Am J Physiol Regul Integr Comp Physiol 2012 Apr 15;302(8):R941-9. Epub 2012 Feb 15.

Departments of Pediatrics and Pharmacology, Research Center of Centre hospitalier universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.

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http://www.physiology.org/doi/10.1152/ajpregu.00527.2011
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http://dx.doi.org/10.1152/ajpregu.00527.2011DOI Listing
April 2012

Understanding retinopathy of prematurity: update on pathogenesis.

Neonatology 2011 3;100(4):343-53. Epub 2011 Oct 3.

Department of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, Qué., Canada.

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http://dx.doi.org/10.1159/000330174DOI Listing
March 2012

Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical administration.

Invest Ophthalmol Vis Sci 2012 Mar 9;53(3):1195-203. Epub 2012 Mar 9.

Department of Pediatrics, Ophthalmology, Pharmacology, Hôpital Ste-Justine, Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1167/iovs.11-9064DOI Listing
March 2012

Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.

J Med Chem 2011 Sep 9;54(17):6085-97. Epub 2011 Aug 9.

Department of Medicine, McGill University Health Center Research Institute, Montréal H3A 1A1, Québec, Canada.

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http://dx.doi.org/10.1021/jm200608kDOI Listing
September 2011

Choroidal involution is a key component of oxygen-induced retinopathy.

Invest Ophthalmol Vis Sci 2011 Aug 5;52(9):6238-48. Epub 2011 Aug 5.

Department of Ophthalmology and Pharmacology, Hôpital Sainte-Justine Research Center, Montreal, Canada.

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http://dx.doi.org/10.1167/iovs.10-6742DOI Listing
August 2011

Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment.

J Pediatr 2011 Jun 30;158(6):919-923.e1-2. Epub 2010 Dec 30.

Department of Pediatrics, University of California San Francisco CA, USA.

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http://dx.doi.org/10.1016/j.jpeds.2010.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095765PMC
June 2011

Immunohistochemical evidence of synaptic retraction, cytoarchitectural remodeling, and cell death in the inner retina of the rat model of oygen-induced retinopathy (OIR).

Invest Ophthalmol Vis Sci 2011 Mar 25;52(3):1693-708. Epub 2011 Mar 25.

Department of Pharmacology, McGill University-Montreal Children’s Hospital Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1167/iovs.10-6197DOI Listing
March 2011

Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration.

Am J Physiol Regul Integr Comp Physiol 2011 Mar 15;300(3):R577-85. Epub 2010 Dec 15.

Department of Pediatrics, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajpregu.00137.2010DOI Listing
March 2011

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.

J Clin Invest 2010 Sep 1;120(9):3022-32. Epub 2010 Sep 1.

Department of Ophthalmology, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI42142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929716PMC
September 2010

Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress.

Am J Physiol Regul Integr Comp Physiol 2010 Jun 31;298(6):R1522-30. Epub 2010 Mar 31.

Department of Pediatrics, Research Center-Centre Hospitalier Universitaire Ste-Justine, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajpregu.00807.2009DOI Listing
June 2010

Postmenopausal hormone therapy increases retinal blood flow and protects the retinal nerve fiber layer.

Invest Ophthalmol Vis Sci 2010 May 17;51(5):2587-600. Epub 2009 Dec 17.

Department of Ophthalmology, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1167/iovs.09-3710DOI Listing
May 2010

Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns.

Biopolymers 2010 ;94(2):183-91

Départment de Chimie, Universitè de Montréal, C.P, 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1002/bip.21288DOI Listing
May 2010

A convenient alternative approach to screen for retinopathy of prematurity.

Authors:
Sylvain Chemtob

Acta Paediatr 2010 Apr;99(4):494-6

Department of Pediatrics, Centre Hospitalier Universitaire Ste Justine, Montreal, QC, Canada.

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http://dx.doi.org/10.1111/j.1651-2227.2010.01756.xDOI Listing
April 2010

Proliferative retinopathies: angiogenesis that blinds.

Int J Biochem Cell Biol 2010 Jan 15;42(1):5-12. Epub 2009 Oct 15.

Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.biocel.2009.10.006DOI Listing
January 2010

Vessel remodeling in the newborn: platelets fill the gap.

Nat Med 2010 Jan;16(1):33-5

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http://dx.doi.org/10.1038/nm0110-33DOI Listing
January 2010

Quantitative and regional measurement of retinal blood flow in rats using N-isopropyl-p-[14C]-iodoamphetamine ([14C]-IMP).

Exp Eye Res 2009 Dec 19;89(6):960-6. Epub 2009 Aug 19.

School of Optometry, University of Montreal, C.P. 6128, succursale Centre-Ville, Montréal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1016/j.exer.2009.08.005DOI Listing
December 2009

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

J Pharmacol Exp Ther 2009 Oct 7;331(1):297-307. Epub 2009 Jul 7.

Department of Biochemistry, Université de Montréal, Québec, Canada.

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http://dx.doi.org/10.1124/jpet.109.156398DOI Listing
October 2009

Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms.

J Biol Chem 2009 Sep 29;284(39):26695-707. Epub 2009 Jul 29.

Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1074/jbc.M109.033480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785357PMC
September 2009

Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides.

J Am Chem Soc 2009 Jun;131(22):7917-27

Chemistry Department, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ja9010628DOI Listing
June 2009

Functional and structural changes resulting from strain differences in the rat model of oxygen-induced retinopathy.

Invest Ophthalmol Vis Sci 2009 May 24;50(5):2436-50. Epub 2009 Jan 24.

Department of Pharmacology and Therapeutics, University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1167/iovs.08-2297DOI Listing
May 2009

The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration.

Invest Ophthalmol Vis Sci 2009 Mar 31;50(3):1290-8. Epub 2008 Oct 31.

Department of Paediatrics, Research Center of Sainte-Justine Hospital, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1167/iovs.08-1920DOI Listing
March 2009

Genetic ablation of CD36 induces age-related corneal neovascularization.

Cornea 2008 Oct;27(9):1037-41

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/ICO.0b013e31817780b6DOI Listing
October 2008

Trans-arachidonic acids: new mediators of nitro-oxidative stress.

Pharmacol Ther 2008 Sep 27;119(3):275-90. Epub 2008 May 27.

New York Medical College, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2008.05.003DOI Listing
September 2008

Early manifestations of postnatal hyperoxia on the retinal structure and function of the neonatal rat.

Invest Ophthalmol Vis Sci 2008 Jan;49(1):458-66

Department of Pharmacology and Therapeutics, McGill University-Montreal Children's Hospital Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1167/iovs.07-0916DOI Listing
January 2008