Publications by authors named "Syeda S Jaffery"

4 Publications

  • Page 1 of 1

Natalizumab-associated Progressive Multifocal Leukoencephalopathy in Patients with Multiple Sclerosis: A Mini Review.

Cureus 2018 Aug 3;10(8):e3093. Epub 2018 Aug 3.

Research, CiBNP, Fairfield, USA.

Progressive multifocal leukoencephalopathy is a fatal demyelinating disease caused by the John Cunningham virus. It causes white matter inflammation in multiple areas of the brain. Although rare, it has been known to occur in patients with immunodeficiency states and those taking chronic immunosuppressive medications for diseases such as multiple sclerosis and psoriasis. In this article, we will discuss about the drug-induced progressive multifocal encephalopathy and its diagnosis and management in patients taking natalizumab and other disease-modifying therapies among patients with multiple sclerosis.
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http://dx.doi.org/10.7759/cureus.3093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171776PMC
August 2018

The Effect of Physical Activity in Parkinson's Disease: A Mini-Review.

Cureus 2018 Jul 18;10(7):e2995. Epub 2018 Jul 18.

Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA.

This article will discuss the effects of physical activity in patients with Parkinson's disease. Presently, the motor and non-motor symptoms are difficult to treat with the current treatment of Parkinson's; therefore, as an adjuvant to the current treatment physical activity, has been recommended. Physical activity has been known to improve many symptoms in patients with Parkinson's disease. Some of these symptoms include the physical capacities, physical and cognitive functional capacities. Physical activity also slows the disease process, decreases the pain associated with Parkinson`s disease, prolongs the independent mobility (gait, balance, strength) and improves sleep, mood, memory hence improving the overall quality of life. Furthermore, physical activity has the potential to improve the non-motor symptoms (depression, apathy, fatigue, constipation) and the secondary complications of immobility (cardiovascular, osteoporosis) in Parkinson's disease.
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http://dx.doi.org/10.7759/cureus.2995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143369PMC
July 2018

The Role of Vitamin D in Brain Health: A Mini Literature Review.

Cureus 2018 Jul 10;10(7):e2960. Epub 2018 Jul 10.

Medicine, Sherif Medical City Hospital, Lahore, PAK.

Vitamin D is vital for our body as it regulates calcium homeostasis and maintains bone integrity. In this article, we will discuss how vitamin D aids in the function of neuronal and glial tissue and the many health consequences in a person with vitamin D deficiency. Some of the effects of vitamin D deficiency that will be discussed include the development of dementia caused by the increase of cerebral soluble and insoluble amyloid-β (Aβ) peptides and a decrease of its anti-inflammatory/antioxidant properties, the link to depression by a reduction of the buffering of increased calcium in the brain, and vitamin D deficiency in expecting mothers linking to the development of autism and schizophrenic-like disorders, hypoxic brain injury, and other mental illnesses. Lastly, we will discuss how vitamin D deficiency is linked to the development of diabetes mellitus, its role in neuronal development and a decrease of microglial inflammatory function leading to increased brain infections.
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http://dx.doi.org/10.7759/cureus.2960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132681PMC
July 2018

Sugar Beverages and Dietary Sodas Impact on Brain Health: A Mini Literature Review.

Cureus 2018 Jun 7;10(6):e2756. Epub 2018 Jun 7.

Department of Cardiology, University of Pennsylvania, Philadelphia, USA.

Sugar-sweetened beverages containing caffeine are widely used among humans nowadays and can have negative consequences on the overall health. Our study aims to discuss the effects of these sugar-sweetened beverages (SSB) and how they can impact the health in different ways particularly on the brain. Some of the mechanisms by which soft drinks can exert adverse effects include an increase in glutathione-6-dehydrogenase level, increased levels of gamma-aminobutyric acid (GABA), glutamate and dopamine alteration in brain waves on electroencephalography (EEG) eventually leading to stroke and dementia. They can increase the oxidative stress by a decreasing monoamine oxidase and acetylcholine esterase and antioxidants such as glutathione and catalase. The sleep quality and duration of sleep is also significantly affected by their increased consumption. Also, the consumption of sodium benzoate (found in beverages) on impairing memory, motor coordination, affecting reduced glutathione (GSH), increasing the malondialdehyde (MDA) level in the brain and producing attention deficit hyperactivity disorder (ADHD) in children is emphasized. Finally, we will highlight how diet drinks can also be harmful and the maternal consumption of chocolate or soft drinks during pregnancy and postnatal period can be linked to cognitive impairment and child obesity.
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http://dx.doi.org/10.7759/cureus.2756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080735PMC
June 2018
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