Syed Z Imam

Syed Z Imam

UNVERIFIED PROFILE

Are you Syed Z Imam?   Register this Author

Register author
Syed Z Imam

Syed Z Imam

Publications by authors named "Syed Z Imam"

Are you Syed Z Imam?   Register this Author

37Publications

664Reads

15Profile Views

Amyloid Beta 25-35 induces blood-brain barrier disruption in vitro.

Metab Brain Dis 2019 10 2;34(5):1365-1374. Epub 2019 Jul 2.

Division of Neurotoxicology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11011-019-00447-8DOI Listing
October 2019

Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells.

J Appl Toxicol 2019 Jul 19;39(7):966-973. Epub 2019 Feb 19.

Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3786
Publisher Site
http://dx.doi.org/10.1002/jat.3786DOI Listing
July 2019

Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration.

Exp Biol Med (Maywood) 2018 09 25;243(13):1037-1045. Epub 2018 Sep 25.

3 Apconix, Alderley Park, SK10 4TG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1535370218801309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434454PMC
September 2018

Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier.

Neurosci Lett 2018 04 16;672:123-129. Epub 2018 Feb 16.

Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043940183009
Publisher Site
http://dx.doi.org/10.1016/j.neulet.2018.02.019DOI Listing
April 2018

Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier.

Mol Neurobiol 2018 01;55(1):258-266

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-017-0738-5DOI Listing
January 2018

Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study.

Neurosci Lett 2017 Aug 3;655:76-81. Epub 2017 Jul 3.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Rd, HFT-132, Jefferson, AR, 72079, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043940173055
Publisher Site
http://dx.doi.org/10.1016/j.neulet.2017.06.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176714PMC
August 2017

Protein Kinases and Parkinson's Disease.

Int J Mol Sci 2016 Sep 20;17(9). Epub 2016 Sep 20.

Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms17091585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037850PMC
September 2016

Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage.

Neurosci Lett 2013 Apr 7;541:233-7. Epub 2013 Mar 7.

Division of Neurotoxicology, National Center for Toxicological Research/US FDA, Jefferson, AR 72079, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2013.02.047DOI Listing
April 2013

Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease.

Neurosci Lett 2013 Feb 4;535:24-9. Epub 2013 Jan 4.

Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2012.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645298PMC
February 2013

Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction.

Int J Environ Res Public Health 2011 12 16;8(12):4702-13. Epub 2011 Dec 16.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph8124702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290988PMC
December 2011

Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease.

Mol Ther 2010 Aug 8;18(8):1536-44. Epub 2010 Jun 8.

Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2010.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927058PMC
August 2010

Role of tuberin in neuronal degeneration.

Neurochem Res 2008 Jun 5;33(6):1113-6. Epub 2008 Mar 5.

Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11064-007-9558-8
Publisher Site
http://dx.doi.org/10.1007/s11064-007-9558-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429521PMC
June 2008

alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.

J Biol Chem 2008 Mar 14;283(11):6979-87. Epub 2008 Jan 14.

Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92039-0624, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M710418200DOI Listing
March 2008

Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase.

Nucleic Acids Res 2007 11;35(15):4941-51. Epub 2007 Jul 11.

Laboratory of Molecular Gerontology, National Institutes on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkm386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976445PMC
October 2007

Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates.

Nucleic Acids Res 2007 12;35(12):4103-13. Epub 2007 Jun 12.

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkm404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919475PMC
August 2007

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.

Neurobiol Aging 2006 Aug 6;27(8):1129-36. Epub 2005 Jul 6.

Laboratory of Molecular Gerontology, National Institute on Aging, Gerontology Research Center, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2005.06.002DOI Listing
August 2006

Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta.

Cancer Res 2006 Jan;66(1):113-24

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-05-2742DOI Listing
January 2006

Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice.

FASEB J 2005 Sep;19(11):1441-50

South Texas Veteran Health Care System and Department of Medicine of UT Health Science, San Antonio, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.04-3362comDOI Listing
September 2005

Role of peroxynitrite in methamphetamine-induced dopaminergic neurodegeneration and neuroprotection by antioxidants and selective NOS inhibitors.

Ann N Y Acad Sci 2005 Aug;1053:97-8

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1344.053DOI Listing
August 2005

Cocaine induces a differential dose-dependent alteration in the expression profile of immediate early genes, transcription factors, and caspases in PC12 cells: a possible mechanism of neurotoxic damage in cocaine addiction.

Ann N Y Acad Sci 2005 Aug;1053:482-90

South Texas Veterans Health Care System and Department of Medicine, University of Texas, Health Science Center, San Antonio, Texas 78229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1344.042DOI Listing
August 2005

Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function.

Nucleic Acids Res 2005 7;33(10):3271-82. Epub 2005 Jun 7.

Laboratory of Molecular Gerontology, National Institute on Aging, NIH Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gki636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143695PMC
June 2005

Lack of hydroxyl radical generation upon central administration of methamphetamine in rat caudate nucleus: a microdialysis study.

Neurotox Res 2004 ;6(2):149-52

Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, NCTR/FDA, Jefferson, AR 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/bf03033217DOI Listing
October 2004

Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.

Brain Res 2004 May;1006(2):150-6

Department of Neurology, Medical University of South Carolina, 96 Jonathan Lucas Street, PO Box 250606, Charleston, SC 29425, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2004.01.065DOI Listing
May 2004

Role of nitric oxide in rotenone-induced nigro-striatal injury.

J Neurochem 2003 Sep;86(6):1338-45

Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1471-4159.2003.01938.xDOI Listing
September 2003

The role of caspase III inhibition in methamphetamine-induced alterations in p53 and bcl-2 expression: correlation with dopaminergic neurotoxicity.

Ann N Y Acad Sci 2003 May;993:350; discussion 387-93

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA.

View Article

Download full-text PDF

Source
May 2003

Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cells.

Ann N Y Acad Sci 2003 May;993:362; discussion 387-93

Division of Neurotoxicology, US FDA/NCTR, Jefferson, Arkansas 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2003.tb07545.xDOI Listing
May 2003

Molecular mechanisms of dopaminergic neurodegeneration: genetic and environmental basis.

Authors:
Syed Z Imam

Ann N Y Acad Sci 2003 May;993:377; discussion 387-93

Division of Neurotoxicology, US FDA/NCTR, Jefferson, Arkansas 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2003.tb07547.xDOI Listing
May 2003

Peroxynitrite and the regulation of Na(+),K(+)-ATPase activity by angiotensin II in the rat proximal tubule.

Nitric Oxide 2002 Aug;7(1):30-5

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Mail Slot 611, 4301 W. Markham Street, Little Rock, AR 72205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1089-8603(02)00003-4DOI Listing
August 2002

Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cells.

Ann N Y Acad Sci 2002 Jun;965:204-13

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Resarch/US FDA, Jefferson, Arkansas 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2002.tb04162.xDOI Listing
June 2002

Calpain upregulation and neuron death in spinal cord of MPTP-induced parkinsonism in mice.

Ann N Y Acad Sci 2002 Jun;965:274-80

Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2002.tb04169.xDOI Listing
June 2002

Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis study.

Ann N Y Acad Sci 2002 Jun;965:410-20

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2002.tb04182.xDOI Listing
June 2002