Syed Sikander Azam

Syed Sikander Azam

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Syed Sikander Azam

Syed Sikander Azam

Publications by authors named "Syed Sikander Azam"

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36Publications

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Visualizing protein-ligand binding with chemical energy-wise decomposition (CHEWD): application to ligand binding in the kallikrein-8 S1 Site.

J Comput Aided Mol Des 2019 May 15;33(5):461-475. Epub 2019 Apr 15.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University Islamabad, Islamabad, 45320, Pakistan.

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http://link.springer.com/10.1007/s10822-019-00200-4
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http://dx.doi.org/10.1007/s10822-019-00200-4DOI Listing
May 2019

Identification of glucosyl-3-phosphoglycerate phosphatase as a novel drug target against resistant strain of Mycobacterium tuberculosis (XDR1219) by using comparative metabolic pathway approach.

Comput Biol Chem 2019 Apr 24;79:91-102. Epub 2019 Jan 24.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.

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https://linkinghub.elsevier.com/retrieve/pii/S14769271183077
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http://dx.doi.org/10.1016/j.compbiolchem.2019.01.011DOI Listing
April 2019

Combating tigecycline resistant Acinetobacter baumannii: A leap forward towards multi-epitope based vaccine discovery.

Eur J Pharm Sci 2019 Apr 21;132:1-17. Epub 2019 Feb 21.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.02.023DOI Listing
April 2019

Screening pipeline for Flavivirus based Inhibitors for Zika Virus NS1.

IEEE/ACM Trans Comput Biol Bioinform 2019 Apr 15. Epub 2019 Apr 15.

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http://dx.doi.org/10.1109/TCBB.2019.2911081DOI Listing
April 2019

Toward novel inhibitors against KdsB: a highly specific and selective broad-spectrum bacterial enzyme.

J Biomol Struct Dyn 2019 Mar 18;37(5):1326-1345. Epub 2018 Apr 18.

a Computational Biology Lab, National Center for Bioinformatics , Quaid-i-Azam University , Islamabad 45320 , Pakistan.

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http://dx.doi.org/10.1080/07391102.2018.1459318DOI Listing
March 2019

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis.

Microb Pathog 2019 Mar 11;128:28-35. Epub 2018 Dec 11.

Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.

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http://dx.doi.org/10.1016/j.micpath.2018.12.015DOI Listing
March 2019

Subtractive proteomics and immunoinformatics revealed novel B-cell derived T-cell epitopes against Yersinia enterocolitica: An etiological agent of Yersiniosis.

Microb Pathog 2018 Dec 28;125:336-348. Epub 2018 Sep 28.

Computational Biology Lab, National Center of Bioinformatics (NCB), Quaid-i-Azam University, Islamabad, 45320, Pakistan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08824010173126
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http://dx.doi.org/10.1016/j.micpath.2018.09.042DOI Listing
December 2018

Antiproliferative, antioxidant and binding mechanism analysis of prodigiosin from newly isolated radio-resistant Streptomyces sp. strain WMA-LM31.

Mol Biol Rep 2018 Dec 10;45(6):1787-1798. Epub 2018 Oct 10.

Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

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http://link.springer.com/10.1007/s11033-018-4324-3
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http://dx.doi.org/10.1007/s11033-018-4324-3DOI Listing
December 2018

Moleculer dynamics simulaiton revealed reciever domain of Acinetobacter baumannii BfmR enzyme as the hot spot for future antibiotics designing.

J Biomol Struct Dyn 2018 Oct 22:1-16. Epub 2018 Oct 22.

a Computational Biology Lab, National Center for Bioinformatics , Quaid-i-Azam University , Islamabad , Pakistan.

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http://dx.doi.org/10.1080/07391102.2018.1498805DOI Listing
October 2018

Proteome-wide identification of epitope-based vaccine candidates against multi-drug resistant Proteus mirabilis.

Biologicals 2018 Sep 2;55:27-37. Epub 2018 Aug 2.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.biologicals.2018.07.004DOI Listing
September 2018

A novel approach of virulome based reverse vaccinology for exploring and validating peptide-based vaccine candidates against the most troublesome nosocomial pathogen: Acinetobacter baumannii.

J Mol Graph Model 2018 Aug 5;83:1-11. Epub 2018 May 5.

Computational Biology Lab, National Center for Bioinformatics (NCB), Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2018.04.020DOI Listing
August 2018

Comparative subtractive proteomics based ranking for antibiotic targets against the dirtiest superbug: Acinetobacter baumannii.

J Mol Graph Model 2018 Jun 21;82:74-92. Epub 2018 Apr 21.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 45320, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2018.04.005DOI Listing
June 2018

Selective glycosidase inhibitors: A patent review (2012-present).

Int J Biol Macromol 2018 May 2;111:82-91. Epub 2018 Jan 2.

Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, Pakistan.

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http://dx.doi.org/10.1016/j.ijbiomac.2017.12.148DOI Listing
May 2018

Subtractive Genomics, Molecular Docking and Molecular Dynamics Simulation Revealed LpxC as a Potential Drug Target Against Multi-Drug Resistant Klebsiella pneumoniae.

Interdiscip Sci 2018 May 2. Epub 2018 May 2.

Structural Bioinformatics and High Performance Computing Research Group (BIO-HPC), Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain.

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http://dx.doi.org/10.1007/s12539-018-0299-yDOI Listing
May 2018

Immuno-informatics driven proteome-wide investigation revealed novel peptide-based vaccine targets against emerging multiple drug resistant Providencia stuartii.

J Mol Graph Model 2018 Mar 31;80:238-250. Epub 2018 Jan 31.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan; Biocatalyst and Environmental Biotechnology Research unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2018.01.010DOI Listing
March 2018

AFD: an application for bi-molecular interaction using axial frequency distribution.

J Mol Model 2018 Mar 6;24(4):84. Epub 2018 Mar 6.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.

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http://link.springer.com/10.1007/s00894-018-3601-3
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http://dx.doi.org/10.1007/s00894-018-3601-3DOI Listing
March 2018

Towards a peptide-based vaccine against Shigella sonnei: A subtractive reverse vaccinology based approach.

Biologicals 2017 Nov 18;50:87-99. Epub 2017 Aug 18.

Computational Biology Lab, National Center for Bioinformatics (NCB), Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.biologicals.2017.08.004DOI Listing
November 2017

Binding mode analysis, dynamic simulation and binding free energy calculations of the MurF ligase from Acinetobacter baumannii.

J Mol Graph Model 2017 10 5;77:72-85. Epub 2017 Aug 5.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2017.07.024DOI Listing
October 2017

Identification of Histone Deacetylase (HDAC) as a drug target against MRSA via interolog method of protein-protein interaction prediction.

Eur J Pharm Sci 2017 Aug 4;106:198-211. Epub 2017 Jun 4.

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.

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http://dx.doi.org/10.1016/j.ejps.2017.06.003DOI Listing
August 2017

Molecular dynamics simulation studies of novel β-lactamase inhibitor.

J Mol Graph Model 2017 06 4;74:143-152. Epub 2017 Apr 4.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 45320, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2017.03.002DOI Listing
June 2017

In-vitro antileishmanial potential of peptide drug hirudin.

Chem Biol Drug Des 2017 Jan 31;89(1):67-73. Epub 2016 Aug 31.

Sulaiman Bin Abdullah Aba Al-Khail - Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS), International Islamic University, Islamabad, Pakistan.

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http://dx.doi.org/10.1111/cbdd.12831DOI Listing
January 2017

Binding pattern analysis and structural insight into the inhibition mechanism of Sterol 24-C methyltransferase by docking and molecular dynamics approach.

J Biomol Struct Dyn 2015 11;33(12):2563-77. Epub 2015 Feb 11.

a National Center for Bioinformatics , Quaid-i-Azam University , Islamabad 45320 , Pakistan.

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http://dx.doi.org/10.1080/07391102.2014.1002423DOI Listing
October 2016

Structural Characterization of Alpha-methylacyl-CoA Racemase: Comparative Structural Modeling, Molecular Docking and Dynamic Simulations Studies.

Curr Cancer Drug Targets 2015 ;15(9):822-35

National Center for Bioinformatics, Quaid-i-Azam University, Islamabad-45320, Pakistan.

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September 2016

Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies.

Drug Des Devel Ther 2015 29;9:2449-61. Epub 2015 Apr 29.

National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.

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http://dx.doi.org/10.2147/DDDT.S79784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425240PMC
February 2016

Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies.

Bioorg Chem 2016 Feb 23;64:29-36. Epub 2015 Nov 23.

Faculty of Applied Science, UiTM Shah Alam, 40450 Shah Alam, Selangor D.E., Malaysia.

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https://linkinghub.elsevier.com/retrieve/pii/S00452068153003
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http://dx.doi.org/10.1016/j.bioorg.2015.11.006DOI Listing
February 2016

Structural and dynamical aspects of Streptococcus gordonii FabH through molecular docking and MD simulations.

J Mol Graph Model 2015 Jul 27;60:180-96. Epub 2015 May 27.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2015.05.013DOI Listing
July 2015

Investigation of novel chemical inhibitors of human lysosomal acid lipase: virtual screening and molecular docking studies.

Comb Chem High Throughput Screen 2014 ;17(5):473-82

National Center for Bioinformatics, Quaid-i-Azam University, Islamabad-45320, Pakistan.

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April 2015

Metabolic pathway analysis approach: identification of novel therapeutic target against methicillin resistant Staphylococcus aureus.

Gene 2015 Feb 28;556(2):213-26. Epub 2014 Nov 28.

Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.

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http://dx.doi.org/10.1016/j.gene.2014.11.056DOI Listing
February 2015

Ferrocene-based guanidine derivatives: in vitro antimicrobial, DNA binding and docking supported urease inhibition studies.

Eur J Med Chem 2014 Oct 1;85:438-49. Epub 2014 Aug 1.

Department of Chemistry, Gomal University, Dera Ismail Khan 29050, Pakistan.

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http://dx.doi.org/10.1016/j.ejmech.2014.07.109DOI Listing
October 2014

An insight into the exploration of druggable genome of Streptococcus gordonii for the identification of novel therapeutic candidates.

Genomics 2014 Sep 25;104(3):203-14. Epub 2014 Jul 25.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad 45320, Pakistan.

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http://dx.doi.org/10.1016/j.ygeno.2014.07.007DOI Listing
September 2014

Comparative modeling and virtual screening for the identification of novel inhibitors for myo-inositol-1-phosphate synthase.

Mol Biol Rep 2014 Aug 22;41(8):5039-52. Epub 2014 Apr 22.

National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 45320, Pakistan,

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http://dx.doi.org/10.1007/s11033-014-3370-8DOI Listing
August 2014

Structure and dynamics studies of sterol 24-C-methyltransferase with mechanism based inactivators for the disruption of ergosterol biosynthesis.

Mol Biol Rep 2014 Jul 27;41(7):4279-93. Epub 2014 Feb 27.

Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, 45320, Pakistan,

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http://dx.doi.org/10.1007/s11033-014-3299-yDOI Listing
July 2014

Molecular docking studies for the identification of novel melatoninergic inhibitors for acetylserotonin-O-methyltransferase using different docking routines.

Theor Biol Med Model 2013 Oct 24;10:63. Epub 2013 Oct 24.

National Center for Bioinformatics, Quaid-i-Azam University, 45320 Islamabad, Pakistan.

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http://dx.doi.org/10.1186/1742-4682-10-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819668PMC
October 2013

Cloning and functional characterization of endo-β-1,4-glucanase gene from metagenomic library of vermicompost.

J Microbiol 2013 Jun 28;51(3):329-35. Epub 2013 Jun 28.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

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http://link.springer.com/10.1007/s12275-013-2697-5
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http://dx.doi.org/10.1007/s12275-013-2697-5DOI Listing
June 2013