Publications by authors named "Syam Mohan"

63Publications

An Overview of , , and Computational Techniques for Cancer-Associated Angiogenesis Studies.

Authors:
Heshu Sulaiman Rahman Bee Ling Tan Hemn Hassan Othman Max Stanley Chartrand Yashwant Pathak Syam Mohan Rasedee Abdullah Noorjahan Banu Alitheen

Biomed Res Int 2020 10;2020:8857428. Epub 2020 Dec 10.

Department of Cell and Molecular Biology, Faculty of Biotechnology and Bio-Molecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

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December 2020

Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules.

Authors:
Syam Mohan Manal Mohamed Elhassan Taha Hafiz A Makeen Hassan A Alhazmi Mohammed Al Bratty Shahnaz Sultana Waquar Ahsan Asim Najmi Asaad Khalid

Molecules 2020 Oct 22;25(21). Epub 2020 Oct 22.

Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia.

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October 2020

An updated knowledge of Black seed ( Linn.): Review of phytochemical constituents and pharmacological properties.

Authors:
Md Faruque Ahmad Fakhruddin Ali Ahmad Syed Amir Ashraf Hisham H Saad Shadma Wahab Mohammed Idreesh Khan M Ali Syam Mohan Khalid Rehman Hakeem Md Tanwir Athar

J Herb Med 2021 Feb 19;25:100404. Epub 2020 Sep 19.

Bioactive Natural Product Laboratory, Hamdard University, India.

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February 2021

Antileukemic Effect of Palladium Nanoparticles Mediated by White Tea () Extract and in WEHI-3B-Induced Leukemia .

Authors:
Hemn Othman Heshu Rahman Syam Mohan Sadat Aziz Hardi Marif Dianne Ford Nozlena Abdulsamad Kawa Amin Rasedee Abdullah

Evid Based Complement Alternat Med 2020 19;2020:8764096. Epub 2020 Aug 19.

Faculty of Veterinary Medicine, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.

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August 2020

Recent Advancements in the Diagnosis, Prevention, and Prospective Drug Therapy of COVID-19.

Authors:
Waquar Ahsan Hassan A Alhazmi Kuldeep Singh Patel Bharti Mangla Mohammed Al Bratty Shamama Javed Asim Najmi Muhammad Hadi Sultan Hafiz A Makeen Asaad Khalid Syam Mohan Manal M E Taha Shahnaz Sultana

Front Public Health 2020 10;8:384. Epub 2020 Jul 10.

Department of Pharmacognosy, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

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July 2020

Ameliorative effect of Boesenbergin A, a chalcone isolated from Boesenbergia rotunda (Fingerroot) on oxidative stress and inflammation in ethanol-induced gastric ulcer in vivo.

Authors:
Syam Mohan Yahya Hasan Hobani Emad Shaheen Alaa Sayed Abou-Elhamd Aymen Abdelhaleem Hassan A Alhazmi Siddig Ibrahim Abdelwahab

J Ethnopharmacol 2020 Oct 19;261:113104. Epub 2020 Jun 19.

Medical Research Centre, Jazan University, PO Box 114, Jazan, Saudi Arabia.

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October 2020

Gefitinib loaded nanostructured lipid carriers: characterization, evaluation and anti-human colon cancer activity .

Authors:
Hafiz A Makeen Syam Mohan Mohamed Ahmed Al-Kasim Ibraheem M Attafi Rayan A Ahmed Nabeel Kashan Syed Muhammad Hadi Sultan Mohammed Al-Bratty Hassan A Alhazmi Mohammed M Safhi Raisuddin Ali M Intakhab Alam

Drug Deliv 2020 Dec;27(1):622-631

Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

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December 2020

Girinimbine from curry leaves promotes gastro protection against ethanol induced peptic ulcers and improves healing via regulation of anti-inflammatory and antioxidant mechanisms.

Authors:
Syam Mohan Yahya Hasan Hobani Emad Shaheen Alaa Sayed Abou-Elhamd Aymen Abdelhaleem Hassan A Alhazmi Siddig Ibrahim Abdelwahab

Food Funct 2020 Apr;11(4):3493-3505

Medical Research Centre, Jazan University, PO Box 114 Jazan, Saudi Arabia.

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April 2020

Khat Induced Toxicity: Role on Its Modulating Effects on Inflammation and Oxidative Stability.

Authors:
Siddig Ibrahim Abdelwahab Rashad Alsanosy Manal Mohamed Elhassan Taha Syam Mohan

Biomed Res Int 2018 30;2018:5896041. Epub 2018 May 30.

Substance Abuse Research Centre, Jazan University, Jazan, Saudi Arabia.

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January 2019

An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach.

Authors:
Syam Mohan Suvitha Syam Siddig Ibrahim Abdelwahab Neelaveni Thangavel

Food Funct 2018 Jul;9(7):3860-3871

Medical Research Centre, Jazan University, PO Box 114, Jazan, Saudi Arabia.

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July 2018

Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G/G cell-cycle arrest.

Authors:
Fatima Abdelmutaal Ahmed Omer Najihah Binti Mohd Hashim Mohamed Yousif Ibrahim Firouzeh Dehghan Maizatulakmal Yahayu Hamed Karimian Landa Zeenelabdin Ali Salim Syam Mohan

Tumour Biol 2017 Nov;39(11):1010428317731451

5 Medical Research Centre, Jazan University, Jazan, Saudi Arabia.

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November 2017

Forsk. (Khat): Evaluation of its Antidepressant-like Activity.

Authors:
Hassan Alfaifi Siddig Ibrahim Abdelwahab Syam Mohan Manal Mohamed Elhassan Taha Sohier M Syame Lamiaa A Shaala Rashad Alsanosy

Pharmacogn Mag 2017 Jul 11;13(Suppl 2):S354-S358. Epub 2017 Jul 11.

Substance Abuse Research Centre, Jazan University, 11420, Jazan, Saudi Arabia.

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July 2017

Beta-mangostin demonstrates apoptogenesis in murine leukaemia (WEHI-3) cells in vitro and in vivo.

Authors:
Fatima Abdelmutaal Ahmed Omer Najihah Mohd Hashim Mohamed Yousif Ibrahim Abdulmannan F Aldoubi Pouya Hassandarvish Firouzeh Dehghan Noraziah Nordin Hamed Karimian Landa Zeenelabdin Ali Salim Mahmood Ameen Abdulla Karim Al-Jashamy Syam Mohan

BMC Complement Altern Med 2017 Jul 17;17(1):366. Epub 2017 Jul 17.

Medical Research Centre, Jazan University, Jazan, 11420, Saudi Arabia.

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July 2017

The ethyl acetate fraction of a methanolic extract of unripe noni (Morinda citrifolia Linn.) fruit exhibits a biphasic effect on the dopaminergic system in mice.

Authors:
Vijayapandi Pandy Megala Narasingam Kamini Vijeepallam Syam Mohan Vasudevan Mani Zahurin Mohamed

Exp Anim 2017 Aug 26;66(3):283-291. Epub 2017 Apr 26.

Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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August 2017

Anticancer and anti-inflammatory activities of girinimbine isolated from .

Authors:
Venoos Iman Syam Mohan Siddig Ibrahim Abdelwahab Hamed Karimian Noraziah Nordin Mehran Fadaeinasab Mohamad Ibrahim Noordin Suzita Mohd Noor

Drug Des Devel Ther 2017 28;11:103-121. Epub 2016 Dec 28.

Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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May 2017

(khat) Induces Apoptosis in Madin-Darby Bovine Kidney Cell Line.

Authors:
Hussein M Ageely Ahmed E Agag Syam Mohan Atef Shehata

Pharmacogn Mag 2016 Jul;12(Suppl 4):S454-S459

Department of Microbiology and Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; Department of Microbiology and Immunology, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

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July 2016

Catha edulis Extract Induces H9c2 Cell Apoptosis by Increasing Reactive Oxygen Species Generation and Activation of Mitochondrial Proteins.

Authors:
Syam Mohan Siddig Ibrahim Abdelwahab Yahya Hasan Hobani Suvitha Syam Adel S Al-Zubairi Rashad Al-Sanousi Magbool Essa Oraiby

Pharmacogn Mag 2016 May;12(Suppl 3):S321-6

Confirmatory and Specialized Analyzers Unit, Poison Control Centre, Jazan, Kingdom of Saudi Arabia.

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May 2016

Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway.

Authors:
Noraziah Nordin Mehran Fadaeinasab Syam Mohan Najihah Mohd Hashim Rozana Othman Hamed Karimian Venus Iman Noorlela Ramli Hapipah Mohd Ali Nazia Abdul Majid

PLoS One 2016 2;11(5):e0154023. Epub 2016 May 2.

Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

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July 2017

Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells.

Authors:
Mashitoh Abd Rahman Faiqah Ramli Hamed Karimian Firouzeh Dehghan Noraziah Nordin Hapipah Mohd Ali Syam Mohan Najihah Mohd Hashim

PLoS One 2016 28;11(3):e0151466. Epub 2016 Mar 28.

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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August 2016

Cleistopholine isolated from Enicosanthellum pulchrum exhibits apoptogenic properties in human ovarian cancer cells.

Authors:
Noraziah Nordin Nazia Abdul Majid Syam Mohan Firouzeh Dehghan Hamed Karimian Mashitoh Abdul Rahman Hapipah Mohd Ali Najihah Mohd Hashim

Phytomedicine 2016 Apr 3;23(4):406-16. Epub 2016 Mar 3.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address:

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April 2016

Evidence of the gastroprotective and anti- Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume.

Authors:
Heyam Mohamed Ali Sidahmed Najihah Mohd Hashim Syam Mohan Siddig Ibrahim Abdelwahab Manal Mohamed Elhassan Taha Firouzeh Dehghan Maizatulakmal Yahayu Gwendoline Cheng Lian Ee Mun Fai Loke Jamuna Vadivelu

Drug Des Devel Ther 2016 13;10:297-313. Epub 2016 Jan 13.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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October 2016

Khat (Catha edulis Forsk.) Dependence Potential and Pattern of Use in Saudi Arabia.

Authors:
Siddig Ibrahim Abdelwahab Rashad Mohammed Alsanosy Bahaa-Eldin E A Rahim Syam Mohan Sara Taha Manal Mohamed Elhassan Maged El-Setouhy

Biomed Res Int 2015 24;2015:604526. Epub 2015 Aug 24.

Substance Abuse Research Centre, Jazan University, Jazan 11420, Saudi Arabia.

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June 2016

Glutamine treatment attenuates hyperglycemia-induced mitochondrial stress and apoptosis in umbilical vein endothelial cells.

Authors:
Sher Zaman Safi Kalaivani Batumalaie Marzida Mansor Karuthan Chinna Syam Mohan Hamed Karimian Rajes Qvist Muhammad Aqeel Ashraf Garcie Ong Siok Yan

Clinics (Sao Paulo) 2015 Aug;70(8):569-76

Faculty of Medicine, University of Malaya, Kuala Lumpur, Kuala Lumpur, Malaysia.

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August 2015

The Chemopreventive Effect of Tanacetum Polycephalum Against LA7-Induced Breast Cancer in Rats and the Apoptotic Effect of a Cytotoxic Sesquiterpene Lactone in MCF7 Cells: A Bioassay-Guided Approach.

Authors:
Hamed Karimian Mehran Fadaeinasab Soheil Zorofchian Moghadamtousi Maryam Hajrezaei Maryam Zahedifard Mahboubeh Razavi Sher Zaman Safi Syam Mohan Shaden A M Khalifa Hesham R El-Seedi Mahmood Amin Abdulla Hapipah Mohd Ali Mohamad Ibrahim Noordin

Cell Physiol Biochem 2015 15;36(3):988-1003. Epub 2015 Jun 15.

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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March 2016

Antisecretory, gastroprotective, antioxidant and anti-Helicobcter pylori activity of zerumbone from Zingiber zerumbet (L.) Smith.

Authors:
Heyam Mohamed Ali Sidahmed Najihah Mohd Hashim Mahmood Ameen Abdulla Hapipah Mohd Ali Syam Mohan Siddig Ibrahim Abdelwahab Manal Mohamed Elhassan Taha Loke Mun Fai Jamuna Vadivelu

PLoS One 2015 23;10(3):e0121060. Epub 2015 Mar 23.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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February 2016

In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii.

Authors:
Venoos Iman Hamed Karimian Syam Mohan Yahya Hasan Hobani Mohamed Ibrahim Noordin Mohd Rais Mustafa Suzita Mohd Noor

Drug Des Devel Ther 2015 3;9:1281-92. Epub 2015 Mar 3.

Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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August 2016

Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): an in vitro study.

Authors:
Fatemeh Ahmadipour Mohamed Ibrahim Noordin Syam Mohan Aditya Arya Mohammadjavad Paydar Chung Yeng Looi Yeap Swee Keong Ebrahimi Nigjeh Siyamak Somayeh Fani Maryam Firoozi Chung Lip Yong Mohamed Aspollah Sukari Behnam Kamalidehghan

Drug Des Devel Ther 2015 24;9:1193-208. Epub 2015 Feb 24.

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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August 2016

Thymoquinone inhibits murine leukemia WEHI-3 cells in vivo and in vitro.

Authors:
Landa Zeenelabdin Ali Salim Rozana Othman Mahmood Ameen Abdulla Karim Al-Jashamy Hapipah Mohd Ali Pouya Hassandarvish Firouzeh Dehghan Mohamed Yousif Ibrahim Fatima Abd Elmutaal Ahmed Omer Syam Mohan

PLoS One 2014 22;9(12):e115340. Epub 2014 Dec 22.

Medical Research Centre, Jazan University, Jazan, Saudi Arabia.

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August 2015

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens.

Authors:
Mohamed Yousif Ibrahim Najihah Mohd Hashim Syam Mohan Mahmood Ameen Abdulla Siddig Ibrahim Abdelwahab Behnam Kamalidehghan Mostafa Ghaderian Firouzeh Dehghan Landa Zeenelabdin Ali Hamed Karimian Maizatulakmal Yahayu Gwendoline Cheng Lian Ee Abdoreza Soleimani Farjam Hapipah Mohd Ali

Drug Des Devel Ther 2014 6;8:2193-211. Epub 2014 Nov 6.

Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.

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August 2015

α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo.

Authors:
Mohamed Yousif Ibrahim Najihah Mohd Hashim Syam Mohan Mahmood Ameen Abdulla Behnam Kamalidehghan Mostafa Ghaderian Firouzeh Dehghan Landa Zeenelabdin Ali Ismail Adam Arbab Maizatulakmal Yahayu Gwendoline Ee Cheng Lian Fatemeh Ahmadipour Hapipah Mohd Ali

Drug Des Devel Ther 2014 27;8:1629-47. Epub 2014 Sep 27.

Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.

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July 2015

Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27.

Authors:
Hamed Karimian Soheil Zorofchian Moghadamtousi Mehran Fadaeinasab Shahram Golbabapour Mahboubeh Razavi Maryam Hajrezaie Aditya Arya Mahmood Ameen Abdulla Syam Mohan Hapipah Mohd Ali Mohamad Ibrahim Noordin

Drug Des Devel Ther 2014 22;8:1481-97. Epub 2014 Sep 22.

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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July 2015

Tanacetum polycephalum (L.) Schultz-Bip. induces mitochondrial-mediated apoptosis and inhibits migration and invasion in MCF7 cells.

Authors:
Hamed Karimian Syam Mohan Soheil Zorofchian Moghadamtousi Mehran Fadaeinasab Mahboubeh Razavi Aditya Arya Behnam Kamalidehghan Hapipah Mohd Ali Mohamad Ibrahim Noordin

Molecules 2014 Jul 3;19(7):9478-501. Epub 2014 Jul 3.

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

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July 2014

β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo.

Authors:
Suvitha Syam Ahmad Bustamam Rasedee Abdullah Mohamed Aspollah Sukari Najihah Mohd Hashim Syam Mohan Chung Yeng Looi Won Fen Wong Maizatul Akmal Yahayu Siddig Ibrahim Abdelwahab

J Ethnopharmacol 2014 Apr 6;153(2):435-45. Epub 2014 Mar 6.

Medical Research Centre, Jazan University, PO Box 114, Jazan, Saudi Arabia.

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April 2014

Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro.

Authors:
Landa Zeenelabdin Ali Salim Syam Mohan Rozana Othman Siddig Ibrahim Abdelwahab Behnam Kamalidehghan Bassem Y Sheikh Mohamed Yousif Ibrahim

Molecules 2013 Sep 12;18(9):11219-40. Epub 2013 Sep 12.

Department of Pharmacy, Faculty of Medicine, University of Malaya, KualaLumpur 50603, Malaysia.

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September 2013

Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity.

Authors:
Heyam Mohamed Ali Sidahmed Ainnul Hamidah Syahadah Azizan Syam Mohan Mahmood Ameen Abdulla Siddig Ibrahim Abdelwahab Manal Mohamed Elhassan Taha A Hamid A Hadi Kamal Aziz Ketuly Najihah Mohd Hashim Mun Fai Loke Jamuna Vadivelu

BMC Complement Altern Med 2013 Jul 19;13:183. Epub 2013 Jul 19.

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July 2013

Inclusion Complex of Zerumbone with Hydroxypropyl- β -Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio.

Authors:
Nabilah Muhammad Nadzri Ahmad Bustamam Abdul Mohd Aspollah Sukari Siddig Ibrahim Abdelwahab Eltayeb E M Eid Syam Mohan Behnam Kamalidehghan Theebaa Anasamy Kuan Beng Ng Suvitha Syam Ismail Adam Arbab Heshu Sulaiman Rahman Hapipah Mohd Ali

Evid Based Complement Alternat Med 2013 8;2013:810632. Epub 2013 May 8.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia (UPM), Serdang, 43400 Selangor, Malaysia.

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July 2013

A Phenylbutenoid Dimer, cis-3-(3',4'-Dimethoxyphenyl)-4-[(E)-3''',4'''-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway.

Authors:
Theebaa Anasamy Ahmad Bustamam Abdul Mohd Aspollah Sukari Siddig Ibrahim Abdelwahab Syam Mohan Behnam Kamalidehghan Mohd Zulkhairi Azid Nabilah Muhammad Nadzri A Reenaa Joys Andas Ng Kuan Beng A Hamid A Hadi Heshu Sulaiman Rahman

Evid Based Complement Alternat Med 2013 28;2013:939810. Epub 2013 Feb 28.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

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May 2013

α -Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study.

Authors:
Heyam M A Sidahmed Siddig Ibrahim Abdelwahab Syam Mohan Mahmood Ameen Abdulla Manal Mohamed Elhassan Taha Najihah Mohd Hashim A Hamid A Hadi Jamunarani Vadivelu Mun Loke Fai Mawardi Rahmani Maizatulakmal Yahayu

Evid Based Complement Alternat Med 2013 24;2013:450840. Epub 2013 Mar 24.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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May 2013

Gastroprotective mechanism of Bauhinia thonningii Schum.

Authors:
Siddig Ibrahim Abdelwahab Manal Mohamed Elhassan Taha Mahmood Ameen Abdulla Norazie Nordin A Hamid A Hadi Syam Mohan Jaime Jacqueline Jayapalan Onn Haji Hashim

J Ethnopharmacol 2013 Jun 21;148(1):277-86. Epub 2013 Apr 21.

Biomedical Research Unit, Medical Research Centre, Jazan University, Jazan, Saudi Arabia.

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June 2013

Apoptosis Effect of Girinimbine Isolated from Murraya koenigii on Lung Cancer Cells In Vitro.

Authors:
Syam Mohan Siddig Ibrahim Abdelwahab Shiau-Chuen Cheah Mohd Aspollah Sukari Suvitha Syam Noorasyikin Shamsuddin Mohd Rais Mustafa

Evid Based Complement Alternat Med 2013 13;2013:689865. Epub 2013 Mar 13.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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July 2013

Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo.

Authors:
Heyam M A Sidahmed Najihah Mohd Hashim Junaidah Amir Mahmood Ameen Abdulla A Hamid A Hadi Siddig Ibrahim Abdelwahab Manal Mohamed Elhassan Taha Pouya Hassandarvish Xinsheng Teh Mun Fai Loke Jamuna Vadivelu Mawardi Rahmani Syam Mohan

Phytomedicine 2013 Jul 6;20(10):834-43. Epub 2013 Apr 6.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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July 2013

Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest.

Authors:
Kuan-Beng Ng Ahmad Bustamam Mohd Aspollah Sukari Siddig Ibrahim Abdelwahab Syam Mohan Michael James Christopher Buckle Behnam Kamalidehghan Nabilah Muhammad Nadzri Theebaa Anasamy A Hamid A Hadi Heshu Sulaiman Rahman

BMC Complement Altern Med 2013 Feb 22;13:41. Epub 2013 Feb 22.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

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February 2013

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: a bioassay-guided approach.

Authors:
Ismail Adam Arbab Ahmad Bustamam Abdul Mohd Aspollah Sukari Rasedee Abdullah Suvitha Syam Behnam Kamalidehghan Mohamed Yousif Ibrahim Manal Mohamed Elhassan Taha Siddig Ibrahim Abdelwahab Hapipah Mohd Ali Syam Mohan

J Ethnopharmacol 2013 Jan 23;145(1):343-54. Epub 2012 Nov 23.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.

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January 2013

Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition.

Authors:
Ismail Adam Arbab Chung Yeng Looi Ahmad Bustamam Abdul Foo Kit Cheah Won Fen Wong Mohd Aspollah Sukari Rasedee Abdullah Syam Mohan Suvitha Syam Aditya Arya Manal Mohamed Elhassan Taha Bushra Muharram Mohd Rais Mustafa Siddig Ibrahim Abdelwahab

Evid Based Complement Alternat Med 2012 3;2012:856029. Epub 2012 Oct 3.

Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Malaysia.

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October 2012

Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A.

Authors:
Syam Mohan Siddig Ibrahim Abdelwahab Behnam Kamalidehghan Suvitha Syam Koh Sue May Nabil Saad Mohammed Harmal Noor Shafifiyaz A Hamid A Hadi Najihah Mohd Hashim Mawardi Rahmani Manal Mohamed Elhassan Taha Shiau-Chuen Cheah Asdren Zajmi

Phytomedicine 2012 Aug 26;19(11):1007-15. Epub 2012 Jun 26.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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August 2012

Cucurbitacin L 2-O-β-Glucoside Demonstrates Apoptogenesis in Colon Adenocarcinoma Cells (HT-29): Involvement of Reactive Oxygen and Nitrogen Species Regulation.

Authors:
Siddig Ibrahim Abdelwahab Loiy Elsir Ahmed Hassan Amin M S Abdul Majid Sakina M Ahmed Yagi Syam Mohan Manal Mohamed Elhassan Taha Syahida Ahmad Cheah Shiau Chuen Putri Narrima Mohd Mustafa Rais Suvitha Syam Bushra Abdulkarim Moharam A Hamid A Hadi

Evid Based Complement Alternat Med 2012 26;2012:490136. Epub 2012 Feb 26.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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August 2012

Synthesis of chalcones with anticancer activities.

Authors:
Suvitha Syam Siddig Ibrahim Abdelwahab Mohammed Ali Al-Mamary Syam Mohan

Molecules 2012 May 25;17(6):6179-95. Epub 2012 May 25.

UPM-MAKNA Cancer Research Lab, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

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May 2012

Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells.

Authors:
Aditya Arya Mouna Achoui Shiau-Chuen Cheah Siddig Ibrahim Abdelwahab Putri Narrima Syam Mohan Mohd Rais Mustafa Mustafa Ali Mohd

Evid Based Complement Alternat Med 2012 28;2012:627256. Epub 2012 Feb 28.

Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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August 2012

Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity.

Authors:
Anbu Jeba Sunilson John Samuel Syam Mohan Dinesh Kumar Chellappan Anandarajagopal Kalusalingam Saraswathi Ariamuthu

J Ethnopharmacol 2012 May 6;141(1):396-402. Epub 2012 Mar 6.

School of Pharmacy, KPJ International University College of Nursing and Health Sciences, Lot PT 17010, Persian Seriemas, Nilai, Malaysia.

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May 2012

In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation.

Authors:
Siddig Ibrahim Abdelwahab Waleed Syaed Koko Manal Mohamed Elhassan Taha Syam Mohan Mouna Achoui Mahmood Ameen Abdulla Mohd Rais Mustafa Syahida Ahmad Mohamed Ibrahim Noordin Chung Lip Yong Mohd Roslan Sulaiman Rozana Othman Asfarina Amir Hassan

Eur J Pharmacol 2012 Mar 27;678(1-3):61-70. Epub 2011 Dec 27.

Faculty of Medicine and Drug Design and Development Research Group, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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March 2012

Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition.

Authors:
Siddig Ibrahim Abdelwahab Loiy Elsir Ahmed Hassan Hasnah Mohd Sirat Sakina M Ahmed Yagi Waleed S Koko Syam Mohan Manal Mohamed Elhassan Taha Syahida Ahmad Cheah Shiau Chuen Putri Narrima Mohd Mustafa Rais A Hamid A Hadi

Fitoterapia 2011 Dec 11;82(8):1190-7. Epub 2011 Aug 11.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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December 2011

The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest.

Authors:
Suvitha Syam Ahmad Bustamam Abdul Mohd Aspollah Sukari Syam Mohan Siddig Ibrahim Abdelwahab Tang Sook Wah

Molecules 2011 Aug 23;16(8):7155-70. Epub 2011 Aug 23.

UPM-Makna Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

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August 2011

In Vitro Ultramorphological Assessment of Apoptosis on CEMss Induced by Linoleic Acid-Rich Fraction from Typhonium flagelliforme Tuber.

Authors:
Syam Mohan Ahmad Bustamam Siddig Ibrahim Adel S Al-Zubairi Mohammed Aspollah Rasedee Abdullah Manal Mohamed Elhassan

Evid Based Complement Alternat Med 2011 2;2011:421894. Epub 2011 May 2.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, 43400 UPM Serdang, University Putra Malaysia, Malaysia.

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November 2011

The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: possible involvement of indirect antioxidant action.

Authors:
Siddig Ibrahim Abdelwahab Syam Mohan Mahmmod Ameen Abdulla Mohd Aspollah Sukari Ahmad Bustamam Abdul Manal Mohamed Elhassan Taha Suvitha Syam Syahida Ahmad Ka-Heng Lee

J Ethnopharmacol 2011 Sep 8;137(2):963-70. Epub 2011 Jul 8.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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September 2011

Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition.

Authors:
Siddig Ibrahim Abdelwahab Abdelwahab Hassan Mohamed Osama Yousif Mohamed Mahjoub Oall Manal Mohamed Elhassan Taha Syam Mohan Mohamed Ibrahim Noordin Mohd Rais Mustafa Khalid M Alkharfy

Evid Based Complement Alternat Med 2012 13;2012:137386. Epub 2011 Jun 13.

Faculty of Medicine, University of Malaya, Petaling Jaya, Kuala Lumpur 50603, Malaysia.

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July 2011

Antiapoptotic and Antioxidant Properties of Orthosiphon stamineus Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic Pathway.

Authors:
Siddig Ibrahim Abdelwahab Syam Mohan Manal Mohamed Elhassan Nabil Al-Mekhlafi Abdelbasit Adam Mariod Ahmad Bustamam Abdul Mahmood Ameen Abdulla Khalid M Alkharfy

Evid Based Complement Alternat Med 2011 30;2011:156765. Epub 2010 Dec 30.

Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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July 2011

Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells.

Authors:
Siddig Ibrahim Abdelwahab Ahmad Bustamam Abdul Syam Mohan Manal Mohamed Elhassan Taha Suvitha Syam Mohamed Yousif Ibrahim Abdelbasit Adam Mariod

Leuk Res 2011 Feb 13;35(2):268-71. Epub 2010 Aug 13.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Malaysia.

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February 2011

Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: its activation coupled with G0/G1 phase cell cycle arrest.

Authors:
Syam Mohan Ahmad Bustamam Abdul Siddig Ibrahim Abdelwahab Adel S Al-Zubairi Mohamed Aspollah Sukari Rasedee Abdullah Manal Mohamed Elhassan Taha Mohamed Yousif Ibrahim Suvitha Syam

J Ethnopharmacol 2010 Oct 29;131(3):592-600. Epub 2010 Jul 29.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Malaysia.

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October 2010

Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo.

Authors:
Syam Mohan Ahmad Bustamam Abdul Siddig Ibrahim Abdelwahab Adel S Al-Zubairi Mohamed Aspollah Sukari Rasedee Abdullah Manal Mohamed Elhassan Taha Ng Kuan Beng Nurbaity Mohd Isa

Leuk Res 2010 Nov 1;34(11):1483-92. Epub 2010 Jun 1.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Malaysia.

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November 2010

Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).

Authors:
Manal Mohamed Elhassan Taha Ahmad Bustamam Abdul Rasedee Abdullah Tengku Azmi Tengku Ibrahim Siddig Ibrahim Abdelwahab Syam Mohan

Chem Biol Interact 2010 Aug 7;186(3):295-305. Epub 2010 May 7.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400 UPM Serdang, Selangor, Malaysia.

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August 2010

Eleucine indica Possesses Antioxidant, Antibacterial and Cytotoxic Properties.

Authors:
Adel S Al-Zubairi Ahmad Bustamam Abdul Siddig Ibrahim Abdelwahab Chew Yuan Peng Syam Mohan Manal Mohamed Elhassan

Evid Based Complement Alternat Med 2011 5;2011:965370. Epub 2011 Jun 5.

Laboratory of Cancer Research MAKNA-UPM, Institute of Biosciences (IBS), Universiti Putra Malaysia, Serdang, Selangor DE 43400, Malaysia.

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August 2012

Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: involvement of mitochondria-regulated apoptosis.

Authors:
Siddig Ibrahim Abdelwahab Ahmad Bustamam Abdul Nirmala Devi Manal Mohamed Ehassan Taha Adel Sharaf Al-zubairi Syam Mohan Abdelbasit Adam Mariod

Exp Toxicol Pathol 2010 Sep 5;62(5):461-9. Epub 2009 Jul 5.

MAKNA-UPM Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

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September 2010

In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa).

Authors:
Siddig Ibrahim Abdel Wahab Ahmad Bustamam Abdul Adel Sharaf Alzubairi Manal Mohamed Elhassan Syam Mohan

J Biomed Biotechnol 2009 25;2009:769568. Epub 2009 Mar 25.

UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, 43400 Selangor, Malaysia.

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May 2009