Swee Lay Thein

Swee Lay Thein

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Optimal disease management and health monitoring in adults with sickle cell disease.

Hematology Am Soc Hematol Educ Program 2019 Dec;2019(1):505-512

Sickle Cell Branch, National Heart, Lung, and Blood Institute/National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/hematology.2019000055DOI Listing
December 2019

Pro-inflammatory cytokines associate with NETosis during sickle cell vaso-occlusive crises.

Cytokine 2019 Nov 25;127:154933. Epub 2019 Nov 25.

Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2019.154933DOI Listing
November 2019

A Growing Population of Older Adults with Sickle Cell Disease.

Clin Geriatr Med 2019 08 9;35(3):349-367. Epub 2019 May 9.

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Building 10-CRC, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cger.2019.03.006DOI Listing
August 2019

The carrier state for sickle cell disease is not completely harmless.

Haematologica 2019 Jun 16;104(6):1106-1111. Epub 2019 May 16.

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MA, USA

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http://dx.doi.org/10.3324/haematol.2018.206060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545856PMC
June 2019

Genetic Modifiers of Fetal Haemoglobin in Sickle Cell Disease.

Mol Diagn Ther 2019 04;23(2):235-244

Sickle Cell Branch, National Heart, Lung and Blood Institute, The National Institutes of Health, Building 10, Room 5-5142, 10 Center Drive, Bethesda, MD, 20814, USA.

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http://dx.doi.org/10.1007/s40291-018-0370-8DOI Listing
April 2019

Voxelotor treatment of a patient with sickle cell disease and very severe anemia.

Am J Hematol 2019 Apr 8;94(4):E88-E90. Epub 2019 Jan 8.

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/ajh.25389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408257PMC
April 2019

Abnormal Ventilation-Perfusion Scan Is Associated with Pulmonary Hypertension in Sickle Cell Adults.

J Nucl Med 2019 01 7;60(1):86-92. Epub 2018 Jun 7.

Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.2967/jnumed.118.211466DOI Listing
January 2019

GlycA is not a useful biomarker of inflammation in sickle cell disease.

Int J Lab Hematol 2018 Dec 27;40(6):704-709. Epub 2018 Aug 27.

Sickle Cell Branch, National Heart, Lung and Blood Institute, The National Institutes of Health, Bethesda, Maryland.

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http://doi.wiley.com/10.1111/ijlh.12907
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http://dx.doi.org/10.1111/ijlh.12907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419740PMC
December 2018

How I treat the older adult with sickle cell disease.

Blood 2018 10 11;132(17):1750-1760. Epub 2018 Sep 11.

Department of Haematology, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, King's College London, United Kingdom.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-03
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http://dx.doi.org/10.1182/blood-2018-03-818161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202910PMC
October 2018

Sickle Cell Anemia and Its Phenotypes.

Annu Rev Genomics Hum Genet 2018 08 11;19:113-147. Epub 2018 Apr 11.

Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1589, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-genom-0831
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http://dx.doi.org/10.1146/annurev-genom-083117-021320DOI Listing
August 2018

MYB - A regulatory factor in hematopoiesis.

Gene 2018 Jul 25;665:6-17. Epub 2018 Apr 25.

National Heart, Lung and Blood Institute/NIH, Sickle Cell Branch, Bethesda, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03781119183043
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http://dx.doi.org/10.1016/j.gene.2018.04.065DOI Listing
July 2018

Heterogeneity of respiratory disease in children and young adults with sickle cell disease.

Thorax 2018 06 29;73(6):575-577. Epub 2017 Nov 29.

Division of Asthma, Allergy and Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2017-210206DOI Listing
June 2018

Molecular basis of β thalassemia and potential therapeutic targets.

Authors:
Swee Lay Thein

Blood Cells Mol Dis 2018 05 20;70:54-65. Epub 2017 Jun 20.

Sickle Cell Branch, National Heart, Lung, and Blood Institute/National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738298PMC
May 2018

Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease.

Authors:
Swee Lay Thein

Adv Exp Med Biol 2017 ;1013:27-57

Sickle Cell Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 6S241 MSC 1589, 10 Center Dr., Bethesda, MD, 20892-1589, USA.

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http://dx.doi.org/10.1007/978-1-4939-7299-9_2DOI Listing
April 2018

Switching from fetal to adult hemoglobin.

Nat Genet 2018 04;50(4):478-480

National Heart, Lung and Blood Institute/NIH, Sickle Cell Branch, Bethesda, MD, USA.

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http://www.nature.com/articles/s41588-018-0094-z
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http://dx.doi.org/10.1038/s41588-018-0094-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419756PMC
April 2018

Sickle cell disease-Unanswered questions and future directions in therapy.

Semin Hematol 2018 04 26;55(2):51-52. Epub 2018 May 26.

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http://dx.doi.org/10.1053/j.seminhematol.2018.05.010DOI Listing
April 2018

Platelets at the crossroads of thrombosis, inflammation and haemolysis.

Br J Haematol 2018 03 30;180(5):761-767. Epub 2018 Jan 30.

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/bjh.15117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419732PMC
March 2018

Catheter-related right atrial thrombus in sickle cell disease.

Clin Case Rep 2017 11 20;5(11):1898-1900. Epub 2017 Sep 20.

Sickle Cell Branch National Heart, Lung, and Blood Institute Bethesda Maryland.

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http://dx.doi.org/10.1002/ccr3.1187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676286PMC
November 2017

Association of plasma CD40L with acute chest syndrome in sickle cell anemia.

Cytokine 2017 09 10;97:104-107. Epub 2017 Jun 10.

King's College London Faculty of Life Sciences & Medicine, Department of Molecular Haematology, Division of Cancer Studies, UK.

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http://dx.doi.org/10.1016/j.cyto.2017.05.017DOI Listing
September 2017

Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania.

EBioMedicine 2017 Sep 8;23:146-149. Epub 2017 Aug 8.

Sickle Cell Programme, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania; Nuffield Department of Medicine, University of Oxford, UK.

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http://dx.doi.org/10.1016/j.ebiom.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605324PMC
September 2017

Increased prevalence of renal cysts in patients with sickle cell disease.

BMC Nephrol 2017 Sep 21;18(1):298. Epub 2017 Sep 21.

Department of Renal Sciences, Division of Transplantation Immunology and Mucosal Biology, Faculty of Life Sciences and Medicine, King's College London, London, SE5 9RJ, UK.

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http://dx.doi.org/10.1186/s12882-017-0714-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609069PMC
September 2017

Therapeutic advances in sickle cell disease in the last decade.

Indian J Med Res 2017 Jun;145(6):708-712

Sickle Cell Branch, National Heart, Lung & Blood Institute, The National Institutes of Health, Bethesda, MD 20892-1589, USA.

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http://www.ijmr.org.in/text.asp?2017/145/6/708/216958
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http://dx.doi.org/10.4103/ijmr.IJMR_1153_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674537PMC
June 2017

Genetic control of erythropoiesis.

Curr Opin Hematol 2017 May;24(3):173-182

National Heart, Lung and Blood Institute/NIH, Sickle Cell Branch, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000333DOI Listing
May 2017

A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin.

Hemoglobin 2017 May 5;41(3):216-217. Epub 2017 Sep 5.

c King's College London, 1st Floor Cheyne Wing, King's College Hospital , London , UK.

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http://dx.doi.org/10.1080/03630269.2017.1360336DOI Listing
May 2017

Detection of Hb Rothschild HBB: c.[112T>A or 112T>C], Through High Index of Suspicion on Abnormal Pulse Oximetry.

Hemoglobin 2017 Mar 16;41(2):137-139. Epub 2017 Jun 16.

d Department of Haematological Medicine , Kings College Hospital , London , UK.

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https://www.tandfonline.com/doi/full/10.1080/03630269.2017.1
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http://dx.doi.org/10.1080/03630269.2017.1324796DOI Listing
March 2017

Sickle cell disease in the older adult.

Pathology 2017 Jan 30;49(1):1-9. Epub 2016 Nov 30.

Sickle Cell Branch, National Heart Lung and Blood Institute, National Institute of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2016.10.002DOI Listing
January 2017

Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression.

Hum Mutat 2016 11 25;37(11):1153-1156. Epub 2016 Aug 25.

Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah.

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http://dx.doi.org/10.1002/humu.23061DOI Listing
November 2016

Survival in adults with sickle cell disease in a high-income setting.

Blood 2016 09 20;128(10):1436-8. Epub 2016 Jul 20.

Molecular Haematology, Division of Cancer Studies, King's College London, London, United Kingdom; Department of Haematological Medicine, King's College Hospital National Health Service (NHS) Foundation Trust, London, United Kingdom;

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http://dx.doi.org/10.1182/blood-2016-05-716910DOI Listing
September 2016

Longitudinal assessment of lung function in children with sickle cell disease.

Pediatr Pulmonol 2016 Jul 22;51(7):717-23. Epub 2015 Dec 22.

Division of Asthma, Allergy, and Lung Biology MRC Center for Allergic Mechanisms in Asthma, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1002/ppul.23367DOI Listing
July 2016

Intracranial Aneurysms in Sickle-Cell Disease Are Associated With the Hemoglobin SS Genotype But Not With Moyamoya Syndrome.

Stroke 2016 07 14;47(7):1710-3. Epub 2016 Jun 14.

From the Department of Neurosurgery, King's College Hospital, London, United Kingdom (P.B., C.M.T.); Departments of Neurosurgery (P.B., F.R.P.) and Orthopaedic Surgery (J.L.), Odense University Hospital, Denmark; Molecular Haematology, King's College London, London, United Kingdom (K.G., S.L.T.); Department of Haematology, Guy's and St. Thomas Hospital, London, United Kingdom (R.K.-A.); Department of Anaesthetics, Derriford Hospital, Plymouth, United Kingdom (J.D.); Institute of Clinical Research, University of Southern Denmark, Odense, Denmark (J.L., F.R.P.); and Sickle Cell Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (S.L.T.).

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http://dx.doi.org/10.1161/STROKEAHA.116.012664DOI Listing
July 2016

Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

Br J Haematol 2016 05 16;173(3):456-60. Epub 2016 Feb 16.

Department of Molecular Haematology, Division of Cancer Studies, King's College London Faculty of Life Sciences & Medicine, London, UK.

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http://dx.doi.org/10.1111/bjh.13961DOI Listing
May 2016

The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin.

Blood Cells Mol Dis 2016 May 1;58:6-12. Epub 2015 Dec 1.

Cyprus Institute of Neurology and Genetics, Molecular Genetics Thalassaemia Dept, Nicosia, Cyprus.

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http://dx.doi.org/10.1016/j.bcmd.2015.11.007DOI Listing
May 2016

Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease.

Pediatr Res 2016 Feb 22;79(2):313-7. Epub 2015 Oct 22.

Division of Asthma, Allergy and Lung Biology, MRC Centre for Allergic Mechanisms in Asthma, King's College London, London, UK.

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http://dx.doi.org/10.1038/pr.2015.217DOI Listing
February 2016

Alpha-thalassaemia trait as a cause of unexplained microcytosis in a South African population.

S Afr Med J 2016 Feb 22;106(3):276-9. Epub 2016 Feb 22.

Department of Molecular Medicine and Haematology, School of Pathology, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa.

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http://dx.doi.org/10.7196/SAMJ.2016.v106i3.10005DOI Listing
February 2016

Super-elevated LDH and thrombocytopenia are markers of a severe subtype of vaso-occlusive crisis in sickle cell disease.

Am J Hematol 2015 Oct 1;90(10):E206-7. Epub 2015 Sep 1.

Division of Cancer Studies, Faculty of Life Sciences & Medicine, Molecular Haematology, King's College London, London, SE5 9NU, United Kingdom.

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http://dx.doi.org/10.1002/ajh.24126DOI Listing
October 2015

First reported duplication of the entire beta globin gene cluster causing an unusual sickle cell trait phenotype.

Br J Haematol 2015 Jul 18;170(1):128-31. Epub 2014 Dec 18.

Molecular Haematology, Division of Cancer Studies, King's College London Faculty of Life Sciences & Medicine, London, UK.

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http://doi.wiley.com/10.1111/bjh.13274
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http://dx.doi.org/10.1111/bjh.13274DOI Listing
July 2015

Spectral domain optical coherence tomography in patients with sickle cell disease.

Br J Ophthalmol 2015 Jul 16;99(7):967-72. Epub 2015 Jan 16.

Laser and Retinal Research Unit, Department of Ophthalmology, King's College Hospital NHS Foundation Trust, London, UK NIHR Moorfields Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1136/bjophthalmol-2014-305532DOI Listing
July 2015

Response to hydroxyurea among Kuwaiti patients with sickle cell disease and elevated baseline HbF levels.

Am J Hematol 2015 Jul;90(7):E138-9

Faculty of Life Sciences & Medicine, , King's College London, London, United Kingdom.

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http://dx.doi.org/10.1002/ajh.24027DOI Listing
July 2015

Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania.

Am J Hematol 2015 Jan 20;90(1):E1-4. Epub 2014 Oct 20.

Muhimbili Wellcome Programme, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania; Department of Biological Sciences, Dar es Salaam University College of Education, Dar es Salaam, Tanzania.

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http://doi.wiley.com/10.1002/ajh.23859
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http://dx.doi.org/10.1002/ajh.23859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737118PMC
January 2015

Next generation sequencing identifies a novel rearrangement in the HBB cluster permitting to-the-base characterization.

Hum Mutat 2015 Jan;36(1):142-50

King's College London, Faculty of Life Sciences and Medicine, Molecular Haematology, London, UK.

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http://dx.doi.org/10.1002/humu.22707DOI Listing
January 2015

Two novel mutations (HBG1: c.-250C > T and HBG2: c.-250C > T) associated with hereditary persistence of fetal hemoglobin.

Hemoglobin 2014 21;38(1):67-9. Epub 2013 Oct 21.

Department of Haematological Medicine, King's College Hospital National Health Service (NHS) Foundation Trust , London , UK.

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http://www.tandfonline.com/doi/full/10.3109/03630269.2013.84
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http://dx.doi.org/10.3109/03630269.2013.848365DOI Listing
September 2014

Pulmonary function, CT and echocardiographic abnormalities in sickle cell disease.

Thorax 2014 Aug 28;69(8):746-51. Epub 2014 Mar 28.

Division of Asthma, Allergy and Lung Biology, MCR Centre for Allergic Mechanisms in Asthma, King's College London, London, UK National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2013-204809DOI Listing
August 2014

Genetic association studies in β-hemoglobinopathies.

Authors:
Swee Lay Thein

Hematology Am Soc Hematol Educ Program 2013 ;2013:354-61

1Department of Haematological Medicine, King's College Hospital National Health Service Foundation Trust, King's College London School of Medicine, London, United Kingdom.

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http://dx.doi.org/10.1182/asheducation-2013.1.354DOI Listing
July 2014

Anemia in the elderly: clinical implications and new therapeutic concepts.

Haematologica 2014 Jul;99(7):1127-30

King's College London, Department of Molecular Haematology, James Black Centre, London, UK King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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http://dx.doi.org/10.3324/haematol.2014.109967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077071PMC
July 2014

Leucocyte telomere length in patients with sickle cell disease.

Br J Haematol 2014 Jun 14;165(5):725-7. Epub 2014 Feb 14.

Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, UK; Molecular Haematology, Division of Cancer Studies, King's College London School of Medicine, London, UK.

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http://dx.doi.org/10.1111/bjh.12776DOI Listing
June 2014

How I treat renal complications in sickle cell disease.

Blood 2014 Jun 24;123(24):3720-6. Epub 2014 Apr 24.

Division of Cancer Studies, Molecular Haematology, King's College London, London, United Kingdom; and Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2014-02-557439DOI Listing
June 2014

How we treat sickle hepatopathy and liver transplantation in adults.

Blood 2014 Apr 24;123(15):2302-7. Epub 2014 Feb 24.

Division of Cancer Studies, Molecular Haematology, King's College London School of Medicine, London, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-12-542076DOI Listing
April 2014

Nontraumatic extradural hematoma in sickle cell anemia: a rare neurological complication not to be missed.

Am J Hematol 2014 Feb 30;89(2):225-7. Epub 2013 Sep 30.

Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, Denmark Hill, London, United Kingdom.

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http://dx.doi.org/10.1002/ajh.23579DOI Listing
February 2014

Red blood cell alloimmunization in sickle cell disease-prevalence and trends: a single-center cross-sectional study from United Kingdom.

Transfusion 2013 Dec;53(12):3279-80

Department of Haematological Medicine, King's College Hospital, London, UK.

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http://dx.doi.org/10.1111/trf.12382DOI Listing
December 2013

Genetic regulation of fetal haemoglobin in inherited bone marrow failure syndromes.

Br J Haematol 2013 Aug 29;162(4):542-6. Epub 2013 May 29.

Clinical Genetics Branch, Division of Clinical Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DCEG/CGB Branch, 9609 Medical Center Dr, Rm 6E452, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/bjh.12399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720816PMC
August 2013

The molecular basis of β-thalassemia.

Authors:
Swee Lay Thein

Cold Spring Harb Perspect Med 2013 May 1;3(5):a011700. Epub 2013 May 1.

Department of Haematological Medicine, King's College London School of Medicine/King's College Hospital NHS Foundation Trust, London SE5 9NU, United Kingdom.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a011700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633182PMC
May 2013

A novel 506kb deletion causing εγδβ thalassemia.

Blood Cells Mol Dis 2012 Oct 15-Dec 15;49(3-4):121-7. Epub 2012 Jun 5.

King's College London, Molecular Haematology, James Black Centre, London SE5 9NU, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S107997961200121
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http://dx.doi.org/10.1016/j.bcmd.2012.05.010DOI Listing
March 2013

HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.

Br J Haematol 2013 Jan 9;160(1):101-5. Epub 2012 Oct 9.

Molecular Haematology, James Black Centre, King's College London, 125 Coldharbour Lane, London, UK.

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http://dx.doi.org/10.1111/bjh.12084DOI Listing
January 2013

The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia.

Authors:
Swee Lay Thein

Blood Rev 2012 Apr;26 Suppl 1:S35-9

King's College Hospital/King's College London School of Medicine, London, UK.

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http://dx.doi.org/10.1016/S0268-960X(12)70011-5DOI Listing
April 2012

Milestones in the history of hemoglobin research (in memory of professor Titus H.J. Huisman).

Authors:
Swee Lay Thein

Hemoglobin 2011 20;35(5-6):450-62. Epub 2011 Sep 20.

Department of Molecular Haematology, King's College London, London, UK.

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http://dx.doi.org/10.3109/03630269.2011.613506DOI Listing
March 2012

Genetic modifiers of sickle cell disease.

Authors:
Swee Lay Thein

Hemoglobin 2011 3;35(5-6):589-606. Epub 2011 Oct 3.

Department of Molecular Haematology, King's College London, London, UK.

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http://dx.doi.org/10.3109/03630269.2011.615876DOI Listing
March 2012

Association between hemolysis and albuminuria in adults with sickle cell anemia.

Haematologica 2012 Feb 11;97(2):201-5. Epub 2011 Oct 11.

King’s College London School of Medicine, Molecular Haematology, London, UK.

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http://dx.doi.org/10.3324/haematol.2011.050336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269478PMC
February 2012

Sickle cell/β0-thalassemia associated with the 1393 bp deletion can be associated with a severe phenotype.

Hemoglobin 2011 ;35(4):406-10

Blood Sciences, Guy's and St. Thomas' Pathology, St. Thomas' Hospital, London, UK.

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http://www.tandfonline.com/doi/full/10.3109/03630269.2011.59
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http://dx.doi.org/10.3109/03630269.2011.592555DOI Listing
December 2011

New gene functions in megakaryopoiesis and platelet formation.

Authors:
Christian Gieger Aparna Radhakrishnan Ana Cvejic Weihong Tang Eleonora Porcu Giorgio Pistis Jovana Serbanovic-Canic Ulrich Elling Alison H Goodall Yann Labrune Lorna M Lopez Reedik Mägi Stuart Meacham Yukinori Okada Nicola Pirastu Rossella Sorice Alexander Teumer Katrin Voss Weihua Zhang Ramiro Ramirez-Solis Joshua C Bis David Ellinghaus Martin Gögele Jouke-Jan Hottenga Claudia Langenberg Peter Kovacs Paul F O'Reilly So-Youn Shin Tõnu Esko Jaana Hartiala Stavroula Kanoni Federico Murgia Afshin Parsa Jonathan Stephens Pim van der Harst C Ellen van der Schoot Hooman Allayee Antony Attwood Beverley Balkau François Bastardot Saonli Basu Sebastian E Baumeister Ginevra Biino Lorenzo Bomba Amélie Bonnefond François Cambien John C Chambers Francesco Cucca Pio D'Adamo Gail Davies Rudolf A de Boer Eco J C de Geus Angela Döring Paul Elliott Jeanette Erdmann David M Evans Mario Falchi Wei Feng Aaron R Folsom Ian H Frazer Quince D Gibson Nicole L Glazer Chris Hammond Anna-Liisa Hartikainen Susan R Heckbert Christian Hengstenberg Micha Hersch Thomas Illig Ruth J F Loos Jennifer Jolley Kay Tee Khaw Brigitte Kühnel Marie-Christine Kyrtsonis Vasiliki Lagou Heather Lloyd-Jones Thomas Lumley Massimo Mangino Andrea Maschio Irene Mateo Leach Barbara McKnight Yasin Memari Braxton D Mitchell Grant W Montgomery Yusuke Nakamura Matthias Nauck Gerjan Navis Ute Nöthlings Ilja M Nolte David J Porteous Anneli Pouta Peter P Pramstaller Janne Pullat Susan M Ring Jerome I Rotter Daniela Ruggiero Aimo Ruokonen Cinzia Sala Nilesh J Samani Jennifer Sambrook David Schlessinger Stefan Schreiber Heribert Schunkert James Scott Nicholas L Smith Harold Snieder John M Starr Michael Stumvoll Atsushi Takahashi W H Wilson Tang Kent Taylor Albert Tenesa Swee Lay Thein Anke Tönjes Manuela Uda Sheila Ulivi Dirk J van Veldhuisen Peter M Visscher Uwe Völker H-Erich Wichmann Kerri L Wiggins Gonneke Willemsen Tsun-Po Yang Jing Hua Zhao Paavo Zitting John R Bradley George V Dedoussis Paolo Gasparini Stanley L Hazen Andres Metspalu Mario Pirastu Alan R Shuldiner L Joost van Pelt Jaap-Jan Zwaginga Dorret I Boomsma Ian J Deary Andre Franke Philippe Froguel Santhi K Ganesh Marjo-Riitta Jarvelin Nicholas G Martin Christa Meisinger Bruce M Psaty Timothy D Spector Nicholas J Wareham Jan-Willem N Akkerman Marina Ciullo Panos Deloukas Andreas Greinacher Steve Jupe Naoyuki Kamatani Jyoti Khadake Jaspal S Kooner Josef Penninger Inga Prokopenko Derek Stemple Daniela Toniolo Lorenz Wernisch Serena Sanna Andrew A Hicks Augusto Rendon Manuel A Ferreira Willem H Ouwehand Nicole Soranzo

Nature 2011 Nov 30;480(7376):201-8. Epub 2011 Nov 30.

Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nature10659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335296PMC
November 2011

Transient aplastic crisis as presentation of a previously unknown G6PD deficiency with iron overload.

Br J Haematol 2011 Aug 27;154(3):288. Epub 2011 Apr 27.

Department of Haematology, Princess Royal University Hospital, Orpington, Kent, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08666.xDOI Listing
August 2011

Multiple loci are associated with white blood cell phenotypes.

PLoS Genet 2011 Jun 30;7(6):e1002113. Epub 2011 Jun 30.

Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128114PMC
June 2011

Transfusion and chelation practices in sickle cell disease: a regional perspective.

Pediatr Hematol Oncol 2011 Mar 30;28(2):124-33. Epub 2010 Jul 30.

Hematology/Oncology Department, Children's Hospital & Research Center Oakland, California 94609, USA.

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http://dx.doi.org/10.3109/08880018.2010.505506DOI Listing
March 2011

Blood transfusion usage among adults with sickle cell disease - a single institution experience over ten years.

Br J Haematol 2011 Mar 31;152(6):766-70. Epub 2011 Jan 31.

Molecular Haematology, Division of Gene and Cell Based Therapy, King's College London School of Medicine, Denmark Hill, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08451.xDOI Listing
March 2011

Experimental generation of SNP haplotype signatures in patients with sickle cell anaemia.

PLoS One 2010 Sep 24;5(9):e13004. Epub 2010 Sep 24.

Division of Gene and Cell Based Therapy, King's College London School of Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013004PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945316PMC
September 2010

Extracranial internal carotid arterial disease in children with sickle cell anemia.

Haematologica 2010 Aug 10;95(8):1287-92. Epub 2010 Mar 10.

Department of Paediatric Haematology, King's College London, School of Medicine, King's College Hospital, Denmark Hill, London SE5 9RS, UK.

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http://dx.doi.org/10.3324/haematol.2010.022624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913076PMC
August 2010

Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus.

Blood Cells Mol Dis 2010 Aug 12;45(2):140-6. Epub 2010 Jun 12.

King's College London, The James Black Centre, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10799796100014
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http://dx.doi.org/10.1016/j.bcmd.2010.05.006DOI Listing
August 2010

Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer.

Rapid Commun Mass Spectrom 2010 May;24(9):1251-9

Pharmaceutical Sciences Division, King's College London, 150 Stamford Street, Waterloo, London SE1 9NH, UK.

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http://doi.wiley.com/10.1002/rcm.4512
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http://dx.doi.org/10.1002/rcm.4512DOI Listing
May 2010

Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease.

Br J Haematol 2010 Apr 7;149(2):289-91. Epub 2010 Jan 7.

Department of Haematological Medicine, King's College Hospital NHS Trust, Denmark Hill, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2009.08062.xDOI Listing
April 2010