Publications by authors named "Sven Sauer"

47Publications

ADP-dependent glucokinase as a novel onco-target for haematological malignancies.

Sci Rep 2020 08 12;10(1):13584. Epub 2020 Aug 12.

Division of Child Neurology and Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-020-70014-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423609PMC
August 2020

Impairment of astrocytic glutaminolysis in glutaric aciduria type I.

J Inherit Metab Dis 2018 01 2;41(1):91-99. Epub 2017 Nov 2.

Center for Child and Adolescent Medicine, Division of Neuropediatrics and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 669, D-69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s10545-017-0096-5
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http://dx.doi.org/10.1007/s10545-017-0096-5DOI Listing
January 2018

Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.

J Mol Med (Berl) 2017 08 5;95(8):851-860. Epub 2017 Jun 5.

Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 350, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-017-1551-3DOI Listing
August 2017

Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism.

Biochim Biophys Acta Mol Basis Dis 2017 09 22;1863(9):2220-2228. Epub 2017 May 22.

Institute of Human Genetics, Technical University Munich, Trogerstr. 32, 81675 Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum Munich, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.05.018DOI Listing
September 2017

Genetic cause and prevalence of hydroxyprolinemia.

J Inherit Metab Dis 2016 09 2;39(5):625-632. Epub 2016 May 2.

Department of General Pediatrics, Division of Neuropaediatrics and Metabolic Medicine, University Hospital Heidelberg, 69120, Heidelberg, Germany.

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http://doi.wiley.com/10.1007/s10545-016-9940-2
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http://dx.doi.org/10.1007/s10545-016-9940-2DOI Listing
September 2016

TNF-a stimulation enhances ROS-dependent cell migration via NF-?B activation in liver cells.

Free Radic Biol Med 2014 Oct 10;75 Suppl 1:S32. Epub 2014 Dec 10.

German Cancer Research Center (DKFZ), Immunogenetics (D030), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.765DOI Listing
October 2014

FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.

RNA 2015 Nov 14;21(11):1873-84. Epub 2015 Sep 14.

European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1261/rna.052365.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604428PMC
November 2015

Multifactorial modulation of susceptibility to l-lysine in an animal model of glutaric aciduria type I.

Biochim Biophys Acta 2015 May 2;1852(5):768-77. Epub 2015 Jan 2.

Department of General Pediatrics, Division of Inherited Metabolic Diseases, University Children's Hospital Heidelberg, D-69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.12.022DOI Listing
May 2015

Understanding cerebral L-lysine metabolism: the role of L-pipecolate metabolism in Gcdh-deficient mice as a model for glutaric aciduria type I.

J Inherit Metab Dis 2015 Mar 12;38(2):265-72. Epub 2014 Sep 12.

Division of Inherited Metabolic Diseases, University Children's Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10545-014-9762-zDOI Listing
March 2015

Current concepts in organic acidurias: understanding intra- and extracerebral disease manifestation.

J Inherit Metab Dis 2013 Jul 20;36(4):635-44. Epub 2013 Mar 20.

Department of General Pediatrics, Division of Inherited Metabolic Diseases, Centre for Child and Adolescent Medicine, Clinic I, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10545-013-9600-8DOI Listing
July 2013

T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation.

Cell Rep 2012 Nov 15;2(5):1300-15. Epub 2012 Nov 15.

Division of Immunogenetics (D030), Tumour Immunology Program, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.celrep.2012.10.009DOI Listing
November 2012

Renal dysfunction in methylmalonic acidurias: review for the pediatric nephrologist.

Pediatr Nephrol 2013 Feb 20;28(2):227-35. Epub 2012 Jul 20.

Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00467-012-2245-2DOI Listing
February 2013

Triphenylene silanes for direct surface anchoring in binary mixed self-assembled monolayers.

Langmuir 2012 Jun 23;28(22):8399-407. Epub 2012 May 23.

Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany.

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http://dx.doi.org/10.1021/la300775nDOI Listing
June 2012

Manganese superoxide dismutase: a regulator of T cell activation-induced oxidative signaling and cell death.

Biochim Biophys Acta 2012 May 9;1823(5):1041-52. Epub 2012 Mar 9.

Division of Immunogenetics (D030), Tumor Immunology Program, German Cancer Research Center (DFKZ), Im Neuenheimer Feld 280, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2012.03.003DOI Listing
May 2012

Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease.

Biochim Biophys Acta 2011 Dec 2;1812(12):1607-15. Epub 2011 Sep 2.

Department of Pediatrics, University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2011.08.011DOI Listing
December 2011

Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I.

Brain 2011 Jan 4;134(Pt 1):157-70. Epub 2010 Oct 4.

Department of General Paediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Im Neuenheimer Feld 430, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/brain/awq269DOI Listing
January 2011

Iron regulatory proteins secure mitochondrial iron sufficiency and function.

Cell Metab 2010 Aug;12(2):194-201

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cmet.2010.06.007DOI Listing
August 2010

Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression.

J Immunol 2010 May 24;184(9):4827-41. Epub 2010 Mar 24.

Division of Immunogenetics, Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.4049/jimmunol.0901662DOI Listing
May 2010

Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism.

FASEB J 2010 Aug 24;24(8):2938-50. Epub 2010 Mar 24.

German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1096/fj.10-155846DOI Listing
August 2010

Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus.

Biochim Biophys Acta 2010 Jun 17;1802(6):552-60. Epub 2010 Mar 17.

Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2010.03.003DOI Listing
June 2010

Impact of short- and medium-chain organic acids, acylcarnitines, and acyl-CoAs on mitochondrial energy metabolism.

Biochim Biophys Acta 2008 Oct 3;1777(10):1276-82. Epub 2008 Jun 3.

Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2008.05.447DOI Listing
October 2008

Discotic liquid crystals: from tailor-made synthesis to plastic electronics.

Angew Chem Int Ed Engl 2007 ;46(26):4832-87

Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany.

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http://dx.doi.org/10.1002/anie.200604203DOI Listing
September 2007

Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins.

Biochem J 2006 Aug;398(1):107-12

Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1042/BJ20060221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525008PMC
August 2006

Synthesis of new sugar-based surfactants and evaluation of their hemolytic activities.

J Org Chem 2006 Apr;71(9):3623-6

KTH Chemical Science and Engineering, Organic Chemistry, S-100 44 Stockholm, Sweden.

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http://dx.doi.org/10.1021/jo051904bDOI Listing
April 2006

Phenylalanine reduces synaptic density in mixed cortical cultures from mice.

Pediatr Res 2006 Apr;59(4 Pt 1):544-8

Department of General Pediatrics, University of Children's Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1203/01.pdr.0000203091.45988.8dDOI Listing
April 2006

Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency: a role for glutaryl-coenzyme A.

J Biol Chem 2005 Jun 19;280(23):21830-6. Epub 2005 Apr 19.

Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital of Heidelberg, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M502845200DOI Listing
June 2005

Neuropathological, biochemical and molecular findings in a glutaric acidemia type 1 cohort.

Brain 2005 Apr 2;128(Pt 4):711-22. Epub 2005 Feb 2.

Department of Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

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https://academic.oup.com/brain/article-lookup/doi/10.1093/br
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http://dx.doi.org/10.1093/brain/awh401DOI Listing
April 2005

Optimized spectrophotometric assay for the completely activated pyruvate dehydrogenase complex in fibroblasts.

Clin Chem 2005 Jan 18;51(1):151-60. Epub 2004 Nov 18.

Division of Metabolic and Endocrine Diseases, University Children's Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1373/clinchem.2004.033852DOI Listing
January 2005

Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain.

J Biol Chem 2003 Nov 12;278(48):47388-93. Epub 2003 Sep 12.

Department of General Pediatrics, Division of Metabolic and Endocrine Diseases, University Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M308861200DOI Listing
November 2003

Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity.

J Biol Chem 2002 Apr 14;277(17):14674-80. Epub 2002 Feb 14.

Department of Pediatrics, Division of Metabolic and Endocrine Diseases, Im Neuenheimer Feld 150, Federal Republic of Germany.

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http://dx.doi.org/10.1074/jbc.M200997200DOI Listing
April 2002