Sven Perner

Sven Perner

UNVERIFIED PROFILE

Are you Sven Perner?   Register this Author

Register author
Sven Perner

Sven Perner

Publications by authors named "Sven Perner"

Are you Sven Perner?   Register this Author

100Publications

3764Reads

44Profile Views

TRIM24 as an independent prognostic biomarker for prostate cancer.

Urol Oncol 2019 Sep 7;37(9):576.e1-576.e10. Epub 2019 Jun 7.

Institute of Pathology, University Hospital Schleswig-Holstein, Luebeck, Germany; Pathology of the Research Center Borstel, Leibniz Lung Center, Borstel, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2019.05.006DOI Listing
September 2019

[Status quo 5 years after the introduction of the new ISUP 2014/WHO 2016 prostate cancer grade groups].

Aktuelle Urol 2019 Aug 7. Epub 2019 Aug 7.

Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Institut für Pathologie.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0918-9473DOI Listing
August 2019

Intralesional interleukin-2: A novel option to maximize response to systemic immune checkpoint therapy in loco-regional metastatic melanoma.

Dermatol Ther 2019 05 29;32(3):e12901. Epub 2019 Apr 29.

Department of Dermatology, University of Luebeck, Lubeck, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12901DOI Listing
May 2019

The BET-inhibitor PFI-1 diminishes AR/AR-V7 signaling in prostate cancer cells.

World J Urol 2019 Feb 22;37(2):343-349. Epub 2018 Jun 22.

Department of Urology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-018-2382-8DOI Listing
February 2019

In silico analysis of anti-leukemia immune response and immune evasion in acute myeloid leukemia.

Leuk Lymphoma 2018 10 12;59(10):2493-2496. Epub 2018 Feb 12.

a Pathology of the University Hospital Schleswig-Holstein, Campus Luebeck and Research Center Borstel, Leibniz Center for Medicine and Biosciences , Luebeck and Borstel , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2018.1434883DOI Listing
October 2018

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Cell Rep 2018 10;25(4):1027-1039.e6

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Straße 26, 50931 Cologne, Germany; Center for Molecular Medicine, University Hospital Cologne, Robert Koch Straße 21, 50931 Cologne. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183153
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.09.079DOI Listing
October 2018

Preselection of EGFR mutations in non-small-cell lung cancer patients by immunohistochemistry: comparison with DNA-sequencing, EGFR wild-type expression, gene copy number gain and clinicopathological data.

Rom J Morphol Embryol 2017 ;58(4):1175-1184

Pathology of the University of Lübeck and the Research Center Borstel, Site Borstel, Clinical and Experimental Pathology, Borstel, Airway Research Center North (ARCN), German Center for Lung Research, Borstel, Germany;

View Article

Download full-text PDF

Source
September 2018

Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.

Clin Epigenetics 2017 28;9:123. Epub 2017 Nov 28.

Pathology of the University Medical Center Schleswig-Holstein (UKSH), Campus Lübeck and the Research Center Borstel Parkallee 3, 23845 Borstel, Germany.

View Article

Download full-text PDF

Source
https://clinicalepigeneticsjournal.biomedcentral.com/article
Publisher Site
http://dx.doi.org/10.1186/s13148-017-0423-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704452PMC
July 2018

Epigenetic modifications of the immune-checkpoint genes and in non-small cell lung cancer results in increased expression.

Clin Epigenetics 2017 11;9:51. Epub 2017 May 11.

Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences, Pathology of the University Medical Center Schleswig-Holstein, 23538 Luebeck, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13148-017-0354-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426039PMC
March 2018

Effect of Antigen Retrieval Methods on Nonspecific Binding of Antibody-Metal Nanoparticle Conjugates on Formalin-Fixed Paraffin-Embedded Tissue.

Anal Chem 2018 01 11;90(1):760-768. Epub 2017 Dec 11.

Physical Chemistry I, Department of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen , Universitätsstrasse 5, 45141 Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.7b03144DOI Listing
January 2018

IL-4/5 signalling plays an important role during Litomosoides sigmodontis infection, influencing both immune system regulation and tissue pathology in the thoracic cavity.

Int J Parasitol 2017 12 30;47(14):951-960. Epub 2017 Aug 30.

Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Germany; German Centre for Infection Research (DZIF), Partner Site, Bonn-Cologne, Bonn, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpara.2017.06.009DOI Listing
December 2017

FirebrowseR: an R client to the Broad Institute's Firehose Pipeline.

Database (Oxford) 2017 6;2017. Epub 2017 Jan 6.

Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23538 Luebeck and 23845 Borstel, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/database/baw160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216271PMC
November 2017

Prognostic Value of the New Prostate Cancer International Society of Urological Pathology Grade Groups.

Front Med (Lausanne) 2017 29;4:157. Epub 2017 Sep 29.

Pathology of the University Hospital Schleswig-Holstein, Campus Luebeck and Research Center Borstel, Leibniz Center for Medicine and Biosciences, Luebeck, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2017.00157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626925PMC
September 2017

Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma.

Cancer Res 2017 06 31;77(11):3040-3056. Epub 2017 Mar 31.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-3398DOI Listing
June 2017

Prominent Oncogenic Roles of EVI1 in Breast Carcinoma.

Cancer Res 2017 04 16;77(8):2148-2160. Epub 2017 Feb 16.

Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-0593DOI Listing
April 2017

Mediator Complex Subunit MED1 Protein Expression Is Decreased during Bladder Cancer Progression.

Front Med (Lausanne) 2017 17;4:30. Epub 2017 Mar 17.

Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences , Luebeck , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2017.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355444PMC
March 2017

Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib.

Int J Cancer 2016 11 30;139(10):2359-69. Epub 2016 Jul 30.

Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences, Luebeck and Borstel, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.30279DOI Listing
November 2016

Identification of aberrant tRNA-halves expression patterns in clear cell renal cell carcinoma.

Sci Rep 2016 11 24;6:37158. Epub 2016 Nov 24.

University Hospital Bonn, Department of Urology, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep37158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121638PMC
November 2016

Immunohistochemical assessment of lymphatic and blood vessel invasion in T1 urothelial carcinoma of the bladder.

Scand J Urol 2015 28;49(5):382-7. Epub 2015 Apr 28.

b 2 Institute of Pathology, Department of Prostate Cancer Research , Bonn, Germany , and.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.3109/21681805.2015.10
Publisher Site
http://dx.doi.org/10.3109/21681805.2015.1040449DOI Listing
September 2016

MED15: a potential biomarker for head and neck squamous cell carcinoma?

Biomark Med 2015 12;9(10):939-41. Epub 2015 Oct 12.

Pathology Network of the University Hospital of Luebeck and Leibniz Research Center Borstel, Institution of Pathology, Ratzeburger Allee 160 (Building 50), 23538 Lübeck, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm.15.57DOI Listing
August 2016

Expression Pattern of Matrix Metalloproteinase 20 (MMP20) in Human Tumors.

Anticancer Res 2016 Jun;36(6):2713-8

Neuro- and Tumor Cell Biology Group, Department of Nuclear Medicine, University Hospital of Bonn, Bonn, Germany

View Article

Download full-text PDF

Source
June 2016

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.

PLoS One 2015 26;10(6):e0131702. Epub 2015 Jun 26.

Institute of Molecular Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482750PMC
May 2016

PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.

Oncoimmunology 2016 May 16;5(5):e1131379. Epub 2016 Mar 16.

Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/2162402X.2015.1131379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910698PMC
May 2016

IL-6 Overexpression in ERG-Positive Prostate Cancer Is Mediated by Prostaglandin Receptor EP2.

Am J Pathol 2016 Apr;186(4):974-84

Section of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne/Bonn, University Hospital of Bonn, Bonn, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2015.12.009DOI Listing
April 2016

Web-TCGA: an online platform for integrated analysis of molecular cancer data sets.

BMC Bioinformatics 2016 Feb 6;17:72. Epub 2016 Feb 6.

Pathology of the University Hospital of Luebeck and Leibniz Research Center Borstel, Luebeck and Borstel, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-016-0917-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744375PMC
February 2016

Prognostic relevance of proliferation markers (Ki-67, PHH3) within the cross-relation of ERG translocation and androgen receptor expression in prostate cancer.

Pathology 2015 Dec;47(7):629-36

1Institute of Pathology, University of Bonn, Germany 2Institute of Pathology, University of Bern, Switzerland 3Institute of Pathology, Section for Prostate Cancer Research, University of Bonn 4Department of Urology, Charité - Universitätsmedizin Berlin, Berlin 5Berlin Institute for Urologic Research, Berlin 6Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAT.0000000000000320DOI Listing
December 2015

Prognostic Significance and Functional Role of CEP57 in Prostate Cancer.

Transl Oncol 2015 Dec;8(6):487-96

Molecular Urooncology, Department of Urology, Medical Faculty Heidelberg, University of Heidelberg, Im Neuenheimer Feld 517, D-69120 Heidelberg, Germany; Department of Urology, University of Heidelberg School of Medicine, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tranon.2015.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700294PMC
December 2015

Glutathione S-transferase-pi protein expression in prostate cancer--not always a useful diagnostic tool.

Histopathology 2015 Oct 9;67(4):577-9. Epub 2015 Apr 9.

Institute of Pathology, University of Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/his.12671DOI Listing
October 2015

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.

Clin Cancer Res 2015 Oct 26;21(19):4356-64. Epub 2015 May 26.

Section of Prostate Cancer Research, University Hospital of Bonn, Center for Integrated Oncology Cologne-Bonn, Bonn, Germany. Institute of Pathology, University Hospital of Bonn, Center for Integrated Oncology Cologne-Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-14-3357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592392PMC
October 2015

Fibroblast growth factor receptor 1 gene amplification in gastric adenocarcinoma.

Hum Pathol 2015 Oct 23;46(10):1488-95. Epub 2015 Jun 23.

Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany; Center for Integrated Oncology Cologne/Bonn, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2015.06.007DOI Listing
October 2015

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861069PMC
August 2015

Analysis of receptor tyrosine kinase gene amplification on the example of FGFR1.

Methods Mol Biol 2015 ;1233:67-79

Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-1789-1_7DOI Listing
June 2015

Clinical and molecular implications of MED15 in head and neck squamous cell carcinoma.

Am J Pathol 2015 Apr 16;185(4):1114-22. Epub 2015 Mar 16.

Department of Prostate Cancer Research, University Hospital of Bonn, Bonn, Germany; Institute of Pathology, University Hospital of Bonn, Bonn, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2014.12.010DOI Listing
April 2015

Comparison of different prostatic markers in lymph node and distant metastases of prostate cancer.

Mod Pathol 2015 Jan 13;28(1):138-45. Epub 2014 Jun 13.

Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn and Centre for Integrated Oncology (CIO) Cologne-Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/modpathol.2014.77DOI Listing
January 2015

MED12 overexpression is a frequent event in castration-resistant prostate cancer.

Endocr Relat Cancer 2014 Aug 17;21(4):663-75. Epub 2014 Jun 17.

Department of Prostate Cancer ResearchInstitute of PathologyUniversity Hospital of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, GermanyInstitute for PathologyUniversity Hospital Basel, Basel, SwitzerlandDepartment of UrologySt. Claraspital, Basel, SwitzerlandDepartment of UrologyUniversity Hospital Basel, Basel, SwitzerlandDepartment of UrologyUniversity Hospital of Örebro, Örebro, SwedenSchool of Health and Medical SciencesÖrebro University, Örebro, SwedenCenter for Genomics and TranscriptomicsCeGaT GmbH, Tuebingen, GermanyClinic for Urology and Pediatric UrologyUniversity Hospital of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, GermanySection of Molecular UrooncologyDepartment of Urology, School of Medicine, University of Heidelberg, Heidelberg, GermanyDepartment of Prostate Cancer ResearchInstitute of PathologyUniversity Hospital of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, GermanyInstitute for PathologyUniversity Hospital Basel, Basel, SwitzerlandDepartment of UrologySt. Claraspital, Basel, SwitzerlandDepartment of UrologyUniversity Hospital Basel, Basel, SwitzerlandDepartment of UrologyUniversity Hospital of Örebro, Örebro, SwedenSchool of Health and Medical SciencesÖrebro University, Örebro, SwedenCenter for Genomics and TranscriptomicsCeGaT GmbH, Tuebingen, GermanyClinic for Urology and Pediatric UrologyUniversity Hospital of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, GermanySection of Molecular UrooncologyDepartment of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-14-0171DOI Listing
August 2014

Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma.

Carcinogenesis 2014 Jul 17;35(7):1636-42. Epub 2014 Apr 17.

Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgu094DOI Listing
July 2014

FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.

Clin Cancer Res 2014 Jun 25;20(12):3299-309. Epub 2014 Apr 25.

Authors' Affiliations: Departments of Medicine, Pathology, Craniofacial Biology, and Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts; Medical University of Gdańsk, Poland; and Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Bonn, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-13-3060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062100PMC
June 2014

FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area.

Ann Transl Med 2013 Oct;1(3):23

1 Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Germany ; 2 Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3978/j.issn.2305-5839.2013.06.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200677PMC
October 2013