Publications by authors named "Sven Nelander"

58Publications

Growth-Inhibitory Activity of Bone Morphogenetic Protein 4 in Human Glioblastoma Cell Lines Is Heterogeneous and Dependent on Reduced SOX2 Expression.

Mol Cancer Res 2020 Jul 31;18(7):981-991. Epub 2020 Mar 31.

Department of Immunology, Genetics and Pathology, and Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0638DOI Listing
July 2020

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells.

Cell Death Dis 2019 11 21;10(12):881. Epub 2019 Nov 21.

Department of Immunology, Genetics and Pathology, Science For Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1038/s41419-019-2120-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872649PMC
November 2019

Increasing the accuracy of glioblastoma subtypes: Factoring in the tumor's cell of origin.

Authors:
Sven Nelander

Mol Cell Oncol 2019 27;6(1):1302907. Epub 2018 Nov 27.

Rudbeck Laboratory, Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, SE, Sweden.

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http://dx.doi.org/10.1080/23723556.2017.1302907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370376PMC
November 2018

Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes.

Bioinformatics 2019 09;35(18):3357-3364

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1093/bioinformatics/btz066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748729PMC
September 2019

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients.

J Pathol 2019 02 10;247(2):228-240. Epub 2019 Jan 10.

Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Rudbeck Laboratory, Uppsala, Sweden.

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http://doi.wiley.com/10.1002/path.5186
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http://dx.doi.org/10.1002/path.5186DOI Listing
February 2019

Image-Based Detection of Patient-Specific Drug-Induced Cell-Cycle Effects in Glioblastoma.

SLAS Discov 2018 12 3;23(10):1030-1039. Epub 2018 Aug 3.

2 Centre for Image Analysis, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1177/2472555218791414DOI Listing
December 2018

FC1000: normalized gene expression changes of systematically perturbed human cells.

Stat Appl Genet Mol Biol 2017 09;16(4):217-242

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http://dx.doi.org/10.1515/sagmb-2016-0072DOI Listing
September 2017

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.

Cell Rep 2017 01;18(4):977-990

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.003DOI Listing
January 2017

Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma.

EBioMedicine 2016 Oct 18;12:72-85. Epub 2016 Sep 18.

Dept of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Rudbecklaboratoriet, SE-751 85 Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.08.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078587PMC
October 2016

Origin of the U87MG glioma cell line: Good news and bad news.

Sci Transl Med 2016 08;8(354):354re3

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.

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http://stm.sciencemag.org/content/scitransmed/8/354/354re3.f
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http://dx.doi.org/10.1126/scitranslmed.aaf6853DOI Listing
August 2016

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer.

BMC Cancer 2016 Aug 25;16(1):683. Epub 2016 Aug 25.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsv 20, Uppsala, 751 85, Sweden.

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http://dx.doi.org/10.1186/s12885-016-2725-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000422PMC
August 2016

Travelling wave analysis of a mathematical model of glioblastoma growth.

Math Biosci 2016 06 25;276:75-81. Epub 2016 Mar 25.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.mbs.2016.03.004DOI Listing
June 2016

Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells.

Cell Rep 2016 Jan 31;14(2):380-9. Epub 2015 Dec 31.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75108, Sweden; Science for Life Laboratory, Uppsala University, Uppsala 75108, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713867PMC
January 2016

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.

Exp Cell Res 2015 Dec 25;339(2):280-8. Epub 2015 Oct 25.

Section of Receptor Biology & Signaling, Deptartment Physiology & Pharmacology, Karolinska Institutet, S17177, Stockholm, Sweden; Faculty of Science, Institute of Experimental Biology, Masaryk University, 611 37 Brno, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2015.10.022DOI Listing
December 2015

Efficient exploration of pan-cancer networks by generalized covariance selection and interactive web content.

Nucleic Acids Res 2015 Sep 7;43(15):e98. Epub 2015 May 7.

Department of Immunology, Genetics and Pathology (IGP) and Science for Life Laboratory, Uppsala University, Rudbecklaboratoriet, SE-751 85 Uppsala, Sweden

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http://dx.doi.org/10.1093/nar/gkv413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551906PMC
September 2015

Avoiding pitfalls in L1-regularised inference of gene networks.

Mol Biosyst 2015 Jan 7;11(1):287-96. Epub 2014 Nov 7.

Stockholm Bioinformatics Centre, Science for Life Laboratory, Box 1031, 17121 Solna, Sweden.

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http://dx.doi.org/10.1039/c4mb00419aDOI Listing
January 2015

Functional association networks as priors for gene regulatory network inference.

Bioinformatics 2014 Jun;30(12):i130-8

Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-171 65 Solna, Sweden, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden, Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE-751 05 Uppsala, Sweden and Swedish eScience Research Center, SE-100 44 Stockholm, SwedenStockholm Bioinformatics Centre, Science for Life Laboratory, SE-171 65 Solna, Sweden, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden, Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE-751 05 Uppsala, Sweden and Swedish eScience Research Center, SE-100 44 Stockholm, SwedenStockholm Bioinformatics Centre, Science for Life Laboratory, SE-171 65 Solna, Sweden, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden, Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE-751 05 Uppsala, Sweden and Swedish eScience Research Center, SE-100 44 Stockholm, Sweden.

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http://dx.doi.org/10.1093/bioinformatics/btu285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058914PMC
June 2014

Bridging the gaps in systems biology.

Mol Genet Genomics 2014 Oct 13;289(5):727-34. Epub 2014 Apr 13.

Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Chalmers Tvärgata 3, 412 96, Göteborg, Sweden,

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http://dx.doi.org/10.1007/s00438-014-0843-3DOI Listing
October 2014

Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions.

Neuro Oncol 2013 Nov 6;15(11):1469-78. Epub 2013 Oct 6.

Corresponding Author: Sven Nelander, PhD, Immunology, Genetics and Pathology (IGP), Uppsala University; and Science for Life Laboratory, SE-751 85 Uppsala, Sweden..

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http://dx.doi.org/10.1093/neuonc/not111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813417PMC
November 2013

The impact of phenotypic switching on glioblastoma growth and invasion.

PLoS Comput Biol 2012 14;8(6):e1002556. Epub 2012 Jun 14.

Sahlgrenska Cancer Center, Institute of Medicine, Göteborg, Sweden.

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http://dx.doi.org/10.1371/journal.pcbi.1002556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375261PMC
October 2012

Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.

Genes Chromosomes Cancer 2012 Aug 16;51(8):805-17. Epub 2012 Apr 16.

Sahlgrenska Cancer Center, Department of Pathology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/gcc.21965DOI Listing
August 2012

System-scale network modeling of cancer using EPoC.

Adv Exp Med Biol 2012 ;736:617-43

Mathematical Sciences, University of Gothenburg and Chalmers University of Technology, 412 96 Gothenburg, Sweden.

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http://dx.doi.org/10.1007/978-1-4419-7210-1_37DOI Listing
January 2013

Models from experiments: combinatorial drug perturbations of cancer cells.

Mol Syst Biol 2008 2;4:216. Epub 2008 Sep 2.

Computational Biology center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/msb.2008.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564730PMC
November 2008

Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle?

Mol Genet Genomics 2008 Aug 29;280(2):127-37. Epub 2008 May 29.

Institution for Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, Bruna stråket 16, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s00438-008-0349-yDOI Listing
August 2008

An improved method for detecting and delineating genomic regions with altered gene expression in cancer.

Genome Biol 2008 Jan 21;9(1):R13. Epub 2008 Jan 21.

Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1186/gb-2008-9-1-r13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395254PMC
January 2008

DNA microarray study on gene expression profiles in co-cultured endothelial and smooth muscle cells in response to 4- and 24-h shear stress.

Mol Cell Biochem 2006 Jan;281(1-2):1-15

Wallenberg Laboratory for Vascular Research, Department of Surgery and Vascular Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.

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http://link.springer.com/10.1007/s11010-006-0168-6
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http://dx.doi.org/10.1007/s11010-006-0168-6DOI Listing
January 2006

Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals.

BMC Genomics 2005 May 9;6:68. Epub 2005 May 9.

Department of medical and physiological biochemistry, Sahlgrenska Academy, Box 440, SE-405 30 Göteborg, Sweden.

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http://dx.doi.org/10.1186/1471-2164-6-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134656PMC
May 2005

Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.

J Biol Chem 2003 Oct 28;278(40):38528-36. Epub 2003 Jul 28.

Gastroenterology Laboratory, Biomedical Center, B11, Lund University, S-221 84 Lund, Sweden.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M305437200
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http://dx.doi.org/10.1074/jbc.M305437200DOI Listing
October 2003

Prediction of cell type-specific gene modules: identification and initial characterization of a core set of smooth muscle-specific genes.

Genome Res 2003 Aug 17;13(8):1838-54. Epub 2003 Jul 17.

Department of Medical Biochemistry, Göteborg University, SE 40530 Gothenburg, Sweden.

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http://www.genome.org/cgi/doi/10.1101/gr.1197303
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http://dx.doi.org/10.1101/gr.1197303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC403775PMC
August 2003