Sven Horke

Sven Horke

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Sven Horke

Sven Horke

Publications by authors named "Sven Horke"

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Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response.

FASEB J 2017 09 15;31(9):3868-3881. Epub 2017 May 15.

Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center, Johannes-Gutenberg University, Mainz, Germany;

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http://dx.doi.org/10.1096/fj.201700012RDOI Listing
September 2017

From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension.

Thromb Haemost 2017 04 2;117(4):769-783. Epub 2017 Feb 2.

Katrin Schäfer, MD FESC FAHA, Center for Cardiology, Cardiology I, University Medical Center Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany, Tel.: +49 6131 17 4221, E-mail:

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http://dx.doi.org/10.1160/TH16-10-0790DOI Listing
April 2017

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice.

Arterioscler Thromb Vasc Biol 2016 Jan 19;36(1):78-85. Epub 2015 Nov 19.

From the Department of Pharmacology (N.X., S.H., A.H., E.I.C., G.R., U.F., H.L.), Center for Thrombosis and Hemostasis (S.H.), Department of Ophthalmology (A.G.), and Second Medical Department, Cardiology and Angiology (Y.M., T.M., A.D.), Johannes Gutenberg University Medical Center, Mainz, Germany; and German Center for Cardiovascular Research (DZHK), partner site Rhine-Main, Mainz, Germany (T.M., A.D., H.L.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306263DOI Listing
January 2016

Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis.

J Cancer Res Clin Oncol 2015 Oct 24;141(10):1757-66. Epub 2015 Feb 24.

Department of Oral and Maxillofacial Surgery, University Medical Center of the Johannes Gutenberg-University, Augustusplatz 2, 55131, Mainz, Germany,

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http://dx.doi.org/10.1007/s00432-015-1941-2DOI Listing
October 2015

Novel Paraoxonase 2-Dependent Mechanism Mediating the Biological Effects of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxo-Dodecanoyl)-L-Homoserine Lactone.

Infect Immun 2015 Sep 8;83(9):3369-80. Epub 2015 Jun 8.

Department of Internal Medicine, Division of Epidemiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

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http://dx.doi.org/10.1128/IAI.00141-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534671PMC
September 2015

Vascular oxidative stress, nitric oxide and atherosclerosis.

Atherosclerosis 2014 Nov 9;237(1):208-19. Epub 2014 Sep 9.

Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.09.001DOI Listing
November 2014

Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane.

FASEB J 2014 Apr 13;28(4):1769-79. Epub 2014 Jan 13.

1Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. P.T.B.,

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http://dx.doi.org/10.1096/fj.13-240309DOI Listing
April 2014

Oxidative stress in vascular disease and its pharmacological prevention.

Trends Pharmacol Sci 2013 Jun 19;34(6):313-9. Epub 2013 Apr 19.

Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.tips.2013.03.007DOI Listing
June 2013

Hyperglycemia and oxidative stress in cultured endothelial cells--a comparison of primary endothelial cells with an immortalized endothelial cell line.

J Diabetes Complications 2012 May-Jun;26(3):155-62. Epub 2012 Apr 20.

2nd Medical Clinic, Department of Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.jdiacomp.2012.03.011DOI Listing
October 2012

The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis.

J Pharmacol Exp Ther 2012 Oct 5;343(1):106-14. Epub 2012 Jul 5.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.112.19204
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http://dx.doi.org/10.1124/jpet.112.192047DOI Listing
October 2012

Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells.

Basic Res Cardiol 2012 Sep 13;107(5):283. Epub 2012 Jul 13.

Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, Mainz, Germany.

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http://dx.doi.org/10.1007/s00395-012-0283-3DOI Listing
September 2012

Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties.

J Lipids 2012 12;2012:352857. Epub 2012 Apr 12.

Institute of Pharmacology, University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Straße 67, 55131 Mainz, Germany.

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http://dx.doi.org/10.1155/2012/352857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335252PMC
August 2012

Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer.

J Lipids 2012 13;2012:342806. Epub 2012 May 13.

Department of Pharmacology, University Medical Center of the Johannes-Gutenberg University Mainz, Obere Zahlbacher Street 67, 55131 Mainz, Germany.

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http://dx.doi.org/10.1155/2012/342806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361228PMC
August 2012

Assessment of endoplasmic reticulum stress and the unfolded protein response in endothelial cells.

Methods Enzymol 2011 ;489:127-46

Institute of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.

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http://dx.doi.org/10.1016/B978-0-12-385116-1.00008-XDOI Listing
May 2011

One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity.

J Biol Chem 2010 Aug 8;285(32):24398-403. Epub 2010 Jun 8.

Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany.

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http://dx.doi.org/10.1074/jbc.M110.118604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915675PMC
August 2010

Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.

Cardiovasc Res 2009 Oct 4;84(1):145-54. Epub 2009 Jun 4.

The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel.

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http://dx.doi.org/10.1093/cvr/cvp184DOI Listing
October 2009

Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis.

Biochem J 2008 Dec;416(3):395-405

Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55131, Mainz, Germany.

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http://dx.doi.org/10.1042/BJ20080775DOI Listing
December 2008

Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone.

Infect Immun 2008 Jun 17;76(6):2512-9. Epub 2008 Mar 17.

The University of Texas Southwestern Medical Center, Department of Internal Medicine, Division of Epidemiology, 5323 Harry Hines Blvd., Dallas, TX 75390-8874, USA.

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http://iai.asm.org/cgi/doi/10.1128/IAI.01606-07
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http://dx.doi.org/10.1128/IAI.01606-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423076PMC
June 2008

Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells.

Free Radic Biol Med 2008 Apr 7;44(8):1656-67. Epub 2008 Feb 7.

Department of Pharmacology, Johannes Gutenberg University, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.01.023DOI Listing
April 2008

Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells.

J Pharmacol Exp Ther 2007 Aug 11;322(2):836-42. Epub 2007 May 11.

Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1124/jpet.107.123356DOI Listing
August 2007

Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation.

Circulation 2007 Apr 2;115(15):2055-64. Epub 2007 Apr 2.

Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.6
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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.681700DOI Listing
April 2007

The La motif and the RNA recognition motifs of human La autoantigen contribute individually to RNA recognition and subcellular localization.

J Biol Chem 2004 Nov 15;279(48):50302-9. Epub 2004 Sep 15.

Heinrich-Pette-Institute for Experimental Virology and Immunology at the University of Hamburg, Martinistrasse 52, 20251 Hamburg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M407504200
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http://dx.doi.org/10.1074/jbc.M407504200DOI Listing
November 2004

Functional characterization of the interaction between human La and hepatitis B virus RNA.

J Biol Chem 2004 Oct 9;279(42):43437-47. Epub 2004 Aug 9.

Heinrich-Pette Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistrasse 52, D-20251, Germany.

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http://dx.doi.org/10.1074/jbc.M402227200DOI Listing
October 2004

Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.

J Biol Chem 2004 Jun 1;279(25):26563-70. Epub 2004 Apr 1.

Heinrich-Pette-Institut fur Experimentelle Virologie und Immunologie an der Universitaat Hamburg, Martinistrasse 52, D-20251 Hamburg, Germany.

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http://dx.doi.org/10.1074/jbc.M401017200DOI Listing
June 2004

Molecular characterization of the human La protein.hepatitis B virus RNA.B interaction in vitro.

J Biol Chem 2002 Sep 16;277(38):34949-58. Epub 2002 Jul 16.

Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie Universität Hamburg, Martinistrasse 52, Hamburg D-20251, Germany.

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http://dx.doi.org/10.1074/jbc.M201911200DOI Listing
September 2002