Sven Francque

Sven Francque

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Sven Francque

Publications by authors named "Sven Francque"

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Nivolumab and anti-HCV activity, a case report.

Acta Clin Belg 2020 Mar 17:1-5. Epub 2020 Mar 17.

Department of Gastroenterology and Hepatology, Antwerp University Hospital (UZA), Antwerp, Belgium.

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http://dx.doi.org/10.1080/17843286.2020.1741897DOI Listing
March 2020

A randomized, double-blind, multicenter, phase 2b study to evaluate the safety and efficacy of a combination of tropifexor and cenicriviroc in patients with nonalcoholic steatohepatitis and liver fibrosis: Study design of the TANDEM trial.

Contemp Clin Trials 2020 Jan 13;88:105889. Epub 2019 Nov 13.

Institute of Translational & Clinical Research, Faculty of Medical Sciences, Newcastle University, Newcastle NIHR Biomedical Research Center, & Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2019.105889DOI Listing
January 2020

The Differential Roles of T Cells in Non-alcoholic Fatty Liver Disease and Obesity.

Front Immunol 2019 6;10:82. Epub 2019 Feb 6.

Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology and Hepatology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.3389/fimmu.2019.00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372559PMC
December 2019

Noninvasive Tests of Liver Fibrosis and Their Combination in Nonalcoholic Fatty Liver Disease: From Selected Patients to Real-Life Populations.

Hepatology 2019 Nov;70(5):1500-1502

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.

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http://dx.doi.org/10.1002/hep.30886DOI Listing
November 2019

Biobanking for Viral Hepatitis Research.

Front Med (Lausanne) 2019 20;6:183. Epub 2019 Aug 20.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.

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http://dx.doi.org/10.3389/fmed.2019.00183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710323PMC
August 2019

Effect of semaglutide on liver enzymes and markers of inflammation in subjects with type 2 diabetes and/or obesity.

Aliment Pharmacol Ther 2019 07 10;50(2):193-203. Epub 2019 Jun 10.

Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1111/apt.15316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617813PMC
July 2019

Pharmacological Treatment for Non-alcoholic Fatty Liver Disease.

Adv Ther 2019 05 19;36(5):1052-1074. Epub 2019 Mar 19.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.

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http://link.springer.com/10.1007/s12325-019-00898-6
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http://dx.doi.org/10.1007/s12325-019-00898-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824365PMC
May 2019

Post-colonoscopy colorectal cancer in Belgium: characteristics and influencing factors.

Endosc Int Open 2019 May 8;7(5):E717-E727. Epub 2019 May 8.

Medical Sociology and Health Policy, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1055/a-0751-2660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506335PMC
May 2019

A rare case of hemodialysis-related portosystemic encephalopathy and review of the literature.

Acta Clin Belg 2019 Mar 28:1-5. Epub 2019 Mar 28.

b Department of Gastro-enterology and Hepatology , University Hospital of Antwerp , Edegem , Belgium.

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http://dx.doi.org/10.1080/17843286.2019.1595836DOI Listing
March 2019

Targeting Myeloid-Derived Cells: New Frontiers in the Treatment of Non-alcoholic and Alcoholic Liver Disease.

Front Immunol 2019 27;10:563. Epub 2019 Mar 27.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00563
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http://dx.doi.org/10.3389/fimmu.2019.00563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446913PMC
March 2019

Identifying Therapeutic Targets for Sepsis Research: A Characterization Study of the Inflammatory Players in the Cecal Ligation and Puncture Model.

Mediators Inflamm 2018 5;2018:5130463. Epub 2018 Aug 5.

Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1155/2018/5130463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098915PMC
December 2018

Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population.

Atherosclerosis 2018 11 13;278:82-90. Epub 2018 Sep 13.

L'institut du thorax, Department of Endocrinology, CIC 1413 INSERM, CHU Nantes, Nantes, France; L'institut du thorax, INSERM, CNRS, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.008DOI Listing
November 2018

A fatty liver leads to decreased kidney function?

J Hepatol 2017 12 18;67(6):1137-1139. Epub 2017 Sep 18.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, Belgium; Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.08.018DOI Listing
December 2017

The future of diagnosing NASH - could a simple blood test be the key?

Expert Rev Gastroenterol Hepatol 2017 11 6;11(11):995-997. Epub 2017 Sep 6.

a Department of Gastroenterology and Hepatology , Antwerp University Hospital , Edegem , Belgium.

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http://dx.doi.org/10.1080/17474124.2017.1374851DOI Listing
November 2017

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects.

J Clin Endocrinol Metab 2017 10;102(10):3783-3794

Université Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes, F-59000 Lille, France.

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http://dx.doi.org/10.1210/jc.2017-01397DOI Listing
October 2017

Prediction of presence of oesophageal varices just by shear-wave elastography of the liver and spleen.

Liver Int 2017 09;37(9):1406-1407

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/liv.13446DOI Listing
September 2017

Animal Models of Nonalcoholic Fatty Liver Disease-A Starter's Guide.

Nutrients 2017 Sep 27;9(10). Epub 2017 Sep 27.

Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology and Hepatology, University of Antwerp, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.3390/nu9101072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691689PMC
September 2017

A stepwise algorithm using an at-a-glance first-line test for the non-invasive diagnosis of advanced liver fibrosis and cirrhosis.

J Hepatol 2017 06 12;66(6):1158-1165. Epub 2017 Jan 12.

Hepatology Department, University Hospital, Angers, France; HIFIH Laboratory, UPRES 3859, SFR 4208, Bretagne Loire University, Angers, France.

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http://dx.doi.org/10.1016/j.jhep.2017.01.003DOI Listing
June 2017

Innovative molecular targeted agents in hepatocellular carcinoma: new gladiators on the arena.

Minerva Chir 2017 Jun 14;72(3):206-218. Epub 2017 Feb 14.

Phase I, Early Clinical Trials Unit, Antwerp University Hospital and Center for Oncological Research (CORE), Antwerp University, Antwerp, Belgium -

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http://dx.doi.org/10.23736/S0026-4733.17.07311-4DOI Listing
June 2017

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease.

Annu Rev Physiol 2016 30;78:181-205. Epub 2015 Nov 30.

European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France; email: ,

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http://dx.doi.org/10.1146/annurev-physiol-021115-105331DOI Listing
December 2016

Screening for rare variants in the PNPLA3 gene in obese liver biopsy patients.

Clin Res Hepatol Gastroenterol 2016 Dec 7;40(6):715-721. Epub 2016 Jun 7.

Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, 2650 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.clinre.2016.05.004DOI Listing
December 2016

Successful antiviral treatment of chronic hepatitis C leads to a rapid decline of liver stiffness without an early effect on spleen stiffness.

Hepatology 2016 11 7;64(5):1809-1810. Epub 2016 Jun 7.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.

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http://dx.doi.org/10.1002/hep.28610DOI Listing
November 2016

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites.

Clin Gastroenterol Hepatol 2016 10 16;14(10):1463-1472.e6. Epub 2016 Jun 16.

Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.05.046DOI Listing
October 2016

Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice.

Am J Physiol Gastrointest Liver Physiol 2016 10 11;311(4):G599-G609. Epub 2016 Aug 11.

Laboratory of Experimental Medicine and Pediatrics (LEMP), University of Antwerp, Antwerp, Belgium; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem (Antwerp), Belgium.

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http://dx.doi.org/10.1152/ajpgi.00418.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142201PMC
October 2016

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments.

J Vis Exp 2016 10 25(116). Epub 2016 Oct 25.

Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology, University of Antwerp;

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http://dx.doi.org/10.3791/54576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092238PMC
October 2016

Alcohol intake increases the risk of HCC in hepatitis C virus-related compensated cirrhosis: A prospective study.

J Hepatol 2016 09 13;65(3):543-51. Epub 2016 May 13.

Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium; Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland. Electronic address:

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http://www.natap.org/2016/HCV/PIIS0168827816301842.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S016882781630184
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http://dx.doi.org/10.1016/j.jhep.2016.04.031DOI Listing
September 2016

Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications.

J Hepatol 2016 08 1;65(2):425-43. Epub 2016 Jun 1.

Laboratory of Experimental Medicine and Paediatrics (LEMP) - Gastroenterology & Hepatology, University of Antwerp, Wilrijk (Antwerp), Belgium; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem (Antwerp), Belgium.

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http://dx.doi.org/10.1016/j.jhep.2016.04.005DOI Listing
August 2016

Association study of PNPLA2 gene with histological parameters of NAFLD in an obese population.

Clin Res Hepatol Gastroenterol 2016 Jun 20;40(3):333-339. Epub 2015 Oct 20.

Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.clinre.2015.09.001DOI Listing
June 2016

Algorithm to rule out clinically significant portal hypertension combining Shear-wave elastography of liver and spleen: a prospective multicentre study.

Gut 2016 06 19;65(6):1057-8. Epub 2016 Feb 19.

Department of Internal Medicine I, University of Bonn, Bonn, Germany Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1136/gutjnl-2016-311536DOI Listing
June 2016

Liver Fibrosis Evaluation Using Real-time Shear Wave Elastography in Hepatitis C-Monoinfected and Human Immunodeficiency Virus/Hepatitis C-Coinfected Patients.

J Ultrasound Med 2016 Jun 5;35(6):1299-308. Epub 2016 May 5.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, BelgiumLaboratory of Experimental Medicine and Pediatrics, University of Antwerp, Edegem, Belgium.

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http://dx.doi.org/10.7863/ultra.15.08066DOI Listing
June 2016

CD4+ROR γ t++ and Tregs in a Mouse Model of Diet-Induced Nonalcoholic Steatohepatitis.

Mediators Inflamm 2015 1;2015:239623. Epub 2015 Jul 1.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, 2560 Antwerp, Belgium ; Laboratory of Experimental Medicine and Paediatrics, Division of Gastroenterology, University of Antwerp, 2560 Antwerp, Belgium.

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http://dx.doi.org/10.1155/2015/239623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503578PMC
May 2016

EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE.

Shock 2016 Apr;45(4):450-9

*Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology †Laboratory of Physiopharmacology ‡Laboratory of Medical Microbiology, University of Antwerp §Antwerp University Hospital, Department of Gastroenterology and Hepatology, Antwerp ||Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/SHK.0000000000000519DOI Listing
April 2016

Intensive Enteral Nutrition Is Ineffective for Patients With Severe Alcoholic Hepatitis Treated With Corticosteroids.

Gastroenterology 2016 Apr 5;150(4):903-10.e8. Epub 2016 Jan 5.

Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Cliniques Universitaires de Bruxelles Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium; Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1053/j.gastro.2015.12.038DOI Listing
April 2016

Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease.

Gastroenterology 2015 Sep 28;149(3):635-48.e14. Epub 2015 May 28.

Laboratory of Hepatology, Faculty of Medicine, University of Leuven, Leuven, Belgium; Department of Internal Medicine, Division of Liver, Gallbladder and Pancreaticobiliary Disorders, University Hospital Gasthuisberg, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.05.044DOI Listing
September 2015

Cross talk of the immune system in the adipose tissue and the liver in non-alcoholic steatohepatitis: Pathology and beyond.

World J Hepatol 2015 Jul;7(15):1905-12

Luisa Vonghia, Sven Francque, Department of Gastroenterology and Hepatology, University Hospital Antwerp, 2650 Edegem, Belgium.

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http://dx.doi.org/10.4254/wjh.v7.i15.1905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517150PMC
July 2015

Reply: To PMID 24375485.

Hepatology 2014 Oct 19;60(4):1451. Epub 2014 May 19.

Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.

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http://doi.wiley.com/10.1002/hep.27167
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http://dx.doi.org/10.1002/hep.27167DOI Listing
October 2014

The Role of Non-alcoholic Fatty Liver Disease in Cardiovascular Disease.

Authors:
Sven M Francque

Eur Cardiol 2014 Jul;9(1):10-15

Department of Gastroenterology Hepatology, University Hospital Antwerp & Laboratory of Experimental Medicine and Paediatrics, Division of Gastroenterology Hepatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.15420/ecr.2014.9.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159479PMC
July 2014

Diagnostic challenges in alcohol use disorder and alcoholic liver disease.

World J Gastroenterol 2014 Jul;20(25):8024-32

Luisa Vonghia, Peter Michielsen, Geert Dom, Sven Francque, Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium.

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http://www.wjgnet.com/1007-9327/full/v20/i25/8024.htm
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http://dx.doi.org/10.3748/wjg.v20.i25.8024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081672PMC
July 2014

Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: a controversial issue.

World J Gastroenterol 2014 Jun;20(23):7325-38

Wilhelmus J Kwanten, Peter P Michielsen, Sven M Francque, Laboratory of Experimental Medicine and Paediatrics, University of Antwerp, 2000 Antwerp, Province of Antwerp, Belgium.

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http://dx.doi.org/10.3748/wjg.v20.i23.7325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064078PMC
June 2014

Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Hepatology 2014 Jan 8;59(1):121-9. Epub 2013 Nov 8.

Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1002/hep.26510DOI Listing
January 2014

Immunological mechanisms in the pathophysiology of non-alcoholic steatohepatitis.

Int J Mol Sci 2013 Oct 1;14(10):19867-90. Epub 2013 Oct 1.

Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, Edegem 2650, Belgium.

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http://dx.doi.org/10.3390/ijms141019867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821591PMC
October 2013

Spontaneous liver bleeding in a patient with congenital arterioportal fistulisation. Presentation of a casus princeps and review of the literature.

Acta Gastroenterol Belg 2013 Mar;76(1):62-5

Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium.

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March 2013

Noninvasive assessment of nonalcoholic fatty liver disease in obese or overweight patients.

Clin Gastroenterol Hepatol 2012 Oct 14;10(10):1162-8; quiz e87. Epub 2012 Jul 14.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565120078
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http://dx.doi.org/10.1016/j.cgh.2012.06.019DOI Listing
October 2012

Epidemiology and treatment of autoimmune hepatitis.

Hepat Med 2012 Mar 16;4:1-10. Epub 2012 Mar 16.

Antwerp University Hospital, Department of Gastroenterology Hepatology, Antwerp, Belgium ; Antwerp University, Faculty of Medicine and Health Sciences, Laboratory of Experimental Medicine and Paediatrics, Antwerp, Belgium.

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http://dx.doi.org/10.2147/HMER.S16321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846915PMC
March 2012

Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis.

Eur J Gastroenterol Hepatol 2010 Dec;22(12):1449-57

Department of Gastroenterology and Hepatology, Diabetes and Metabolism cAbdominal Surgery dPathology, Antwerp University Hospital, Antwerp, Belgium.

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https://insights.ovid.com/crossref?an=00042737-900000000-996
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http://dx.doi.org/10.1097/MEG.0b013e32833f14a1DOI Listing
December 2010

Fine needle trucut biopsy in focal liver lesions: a reliable and safe method in identifying the malignant nature of liver lesions.

Acta Gastroenterol Belg 2007 Jan-Mar;70(1):1-5

Divisions of Gastroenterology, University Hospital Antwerp, Belgium.

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August 2007

Viral hepatitis and hepatocellular carcinoma.

World J Surg Oncol 2005 May 20;3:27. Epub 2005 May 20.

Division of Gastroenterology and Hepatology, University Hospital, Antwerp, Belgium.

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http://dx.doi.org/10.1186/1477-7819-3-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1166580PMC
May 2005

Bacillus Calmette-Guérin-induced granulomatous hepatitis in a patient with a superficial bladder carcinoma.

Eur J Gastroenterol Hepatol 2004 Oct;16(10):1027-32

Department of Gastroenterology and Hepatology, University Hospital of Antwerp, University of Antwerp, Belgium.

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http://dx.doi.org/10.1097/00042737-200410000-00012DOI Listing
October 2004

Bilateral adrenal haemorrhage and acute adrenal insufficiency in a blunt abdominal trauma: a case-report and literature review.

Eur J Emerg Med 2004 Jun;11(3):164-7

Department of Emergency Care, University Hospital Antwerp, Edegem, Belgium.

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http://dx.doi.org/10.1097/01.mej.0000127646.23587.cbDOI Listing
June 2004

Multifactorial aetiology of hepatic infarction: a case report with literature review.

Eur J Gastroenterol Hepatol 2004 Apr;16(4):411-5

Service d'Hépatologie and INSERM U481, Hôpital Beaujon, Clichy, France.

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http://dx.doi.org/10.1097/00042737-200404000-00008DOI Listing
April 2004

Coagulation disorders in patients with cirrhosis and severe sepsis.

Liver Int 2003 Dec;23(6):440-8

Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, et Service d'Hepatologie, Hôpital Beaujon, Clichy, France.

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http://dx.doi.org/10.1111/j.1478-3231.2003.00870.xDOI Listing
December 2003