Suzanne Norval

Suzanne Norval

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Suzanne Norval

Suzanne Norval

Publications by authors named "Suzanne Norval"

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27Publications

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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

J Med Chem 2018 09 12;61(18):8374-8389. Epub 2018 Sep 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167002PMC
September 2018

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Antimicrob Agents Chemother 2018 08 27;62(8). Epub 2018 Jul 27.

Wellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.00235-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105827PMC
August 2018

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.

Biochem J 2018 08 30;475(16):2593-2610. Epub 2018 Aug 30.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BCJ20180232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117947PMC
August 2018

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.

PLoS Pathog 2016 Nov 3;12(11):e1005971. Epub 2016 Nov 3.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Building, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1005971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094698PMC
November 2016

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.

Elife 2016 05 24;5. Epub 2016 May 24.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.7554/eLife.09744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878867PMC
May 2016

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

J Med Chem 2015 Oct 29;58(19):7695-706. Epub 2015 Sep 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Sir James Black Centre, Dundee, DD1 5EH, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601051PMC
October 2015

The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.

Antimicrob Agents Chemother 2013 Oct 15;57(10):4699-706. Epub 2013 Jul 15.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00722-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811480PMC
October 2013

Structure-activity relationship studies of pyrrolone antimalarial agents.

ChemMedChem 2013 Sep 5;8(9):1537-44. Epub 2013 Aug 5.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow St, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201300177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963473PMC
September 2013

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Sci Transl Med 2012 Feb;4(119):119re1

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1126/scitranslmed.3003326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457684PMC
February 2012

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

ChemMedChem 2011 Oct 10;6(10):1832-40. Epub 2011 Aug 10.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229842PMC
October 2011

Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum.

Eur J Drug Metab Pharmacokinet 2011 Sep 13;36(3):151-8. Epub 2011 Jul 13.

Department of Medicinal Chemistry, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910-7500, USA,

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http://dx.doi.org/10.1007/s13318-011-0047-8DOI Listing
September 2011

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.

J Med Chem 2010 Aug;53(16):6071-8

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1021/jm1004754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923871PMC
August 2010