Suzanne J Baker

Suzanne J Baker

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Suzanne J Baker

Publications by authors named "Suzanne J Baker"

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ChIPseqSpikeInFree: A ChIP-seq normalization approach to reveal global changes in histone modifications without spike-in.

Bioinformatics 2019 Sep 30. Epub 2019 Sep 30.

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz720DOI Listing
September 2019

CNS penetration of the CDK4/6 inhibitor ribociclib in non-tumor bearing mice and mice bearing pediatric brain tumors.

Cancer Chemother Pharmacol 2019 Aug 11;84(2):447-452. Epub 2019 May 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00280-019-03864-9DOI Listing
August 2019

p53: a tumor suppressor hiding in plain sight.

J Mol Cell Biol 2019 Jul;11(7):536-538

Ludwig Center & Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street St, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/jmcb/mjz068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736432PMC
July 2019

Engineering Inducible Knock-In Mice to Model Oncogenic Brain Tumor Mutations from Endogenous Loci.

Methods Mol Biol 2019 ;1869:207-230

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://link.springer.com/10.1007/978-1-4939-8805-1_18
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http://dx.doi.org/10.1007/978-1-4939-8805-1_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432641PMC
May 2019

Structure and evolution of double minutes in diagnosis and relapse brain tumors.

Acta Neuropathol 2019 Jan 28;137(1):123-137. Epub 2018 Sep 28.

Department of Computational Biology, St. Jude Children's Research Hospital, MS1135, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00401-018-1912-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338707PMC
January 2019

Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma.

Pediatr Blood Cancer 2017 Aug 13;64(8). Epub 2017 Jan 13.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.26416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796806PMC
August 2017

PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation.

Cancer Res 2017 01 4;77(1):123-133. Epub 2016 Nov 4.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214974PMC
January 2017

Detecting PTEN and PI3K Signaling in Brain.

Methods Mol Biol 2016 ;1388:53-62

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Room D2006C, 262 Danny Thomas Place, Memphis, TN, 38105-3678, USA.

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http://dx.doi.org/10.1007/978-1-4939-3299-3_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857604PMC
December 2016

Pediatric gliomas as neurodevelopmental disorders.

Glia 2016 Jun 6;64(6):879-95. Epub 2015 Dec 6.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1002/glia.22945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833573PMC
June 2016

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.

Elife 2015 Dec 3;4. Epub 2015 Dec 3.

Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, United States.

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http://dx.doi.org/10.7554/eLife.12703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744197PMC
December 2015

CONSERTING: integrating copy-number analysis with structural-variation detection.

Nat Methods 2015 Jun 4;12(6):527-30. Epub 2015 May 4.

1] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Pediatric Cancer Genome Project, St. Jude Children's Research Hospital and Washington University School of Medicine, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nmeth.3394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591043PMC
June 2015

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.

Am J Pathol 2015 Apr 16;185(4):1104-13. Epub 2015 Feb 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380850PMC
April 2015

Cell of origin for malignant gliomas and its implication in therapeutic development.

Cold Spring Harb Perspect Biol 2015 Jan 29;7(5). Epub 2015 Jan 29.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://dx.doi.org/10.1101/cshperspect.a020610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448618PMC
January 2015

The genetic signatures of pediatric high-grade glioma: no longer a one-act play.

Semin Radiat Oncol 2014 Oct;24(4):240-7

Developmental Neurobiology, St. Jude Children׳s Research Hospital, Memphis, TN; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN. Electronic address:

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http://dx.doi.org/10.1016/j.semradonc.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170681PMC
October 2014

Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma.

Acta Neuropathol Commun 2014 Oct 21;2:134. Epub 2014 Oct 21.

Division of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1186/s40478-014-0134-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210596PMC
October 2014

Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.

Cancer Res 2013 Oct 22;73(20):6219-29. Epub 2013 Aug 22.

Authors' Affiliations: Departments of Developmental Neurobiology, Computational Biology, Biostatistics, Oncology, and Pathology, St. Jude Children's Research Hospital; Interdisciplinary Biomedical Science Program, University of Tennessee Health Sciences Center, Memphis, Tennessee; Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia; Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom; and Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800209PMC
October 2013

Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects.

Development 2012 Sep 8;139(18):3422-31. Epub 2012 Aug 8.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1242/dev.083154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424045PMC
September 2012

Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration.

J Physiol 2012 Feb 6;590(4):777-92. Epub 2011 Dec 6.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1113/jphysiol.2011.220236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381310PMC
February 2012

Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models.

Oncotarget 2012 Jan;3(1):67-77

Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292893PMC
http://dx.doi.org/10.18632/oncotarget.425DOI Listing
January 2012

Magnetic resonance imaging-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model.

J Pharm Sci 2011 Oct 11;100(10):4210-4. Epub 2011 Aug 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163.

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http://dx.doi.org/10.1002/jps.22723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750095PMC
October 2011

Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.

Cancer Res 2011 Jun 20;71(12):4106-16. Epub 2011 Apr 20.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118569PMC
June 2011

Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma.

Cancer 2010 Oct;116(19):4632-7

Department of Oncology, St. Jude Children's Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA.

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http://doi.wiley.com/10.1002/cncr.25405
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http://dx.doi.org/10.1002/cncr.25405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989604PMC
October 2010

Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis.

PLoS Biol 2010 Aug 17;8(8). Epub 2010 Aug 17.

Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1000460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923090PMC
August 2010

Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.

Dev Biol 2009 Oct 25;334(1):285-98. Epub 2009 Jul 25.

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744847PMC
October 2009

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains.

Genes Dev 2009 Jul;23(14):1619-24

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1799609
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http://dx.doi.org/10.1101/gad.1799609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714713PMC
July 2009

PTEN and the PI3-kinase pathway in cancer.

Annu Rev Pathol 2009 ;4:127-50

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1146/annurev.pathol.4.110807.092311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710138PMC
May 2009

Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells.

Proc Natl Acad Sci U S A 2009 Apr 3;106(16):6685-90. Epub 2009 Apr 3.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0901596106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672506PMC
April 2009

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency.

Proc Natl Acad Sci U S A 2009 Feb 21;106(6):1880-5. Epub 2009 Jan 21.

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0806882106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644132PMC
February 2009

Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells.

Transgenic Res 2008 Oct 16;17(5):919-28. Epub 2008 May 16.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s11248-008-9185-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522290PMC
October 2008

Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells.

Proc Natl Acad Sci U S A 2008 Jan 4;105(2):781-5. Epub 2008 Jan 4.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0708061105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206613PMC
January 2008

EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice.

Mol Cell Biol 2007 Nov 17;27(22):7918-34. Epub 2007 Sep 17.

Department of Developmental Neurobiology, Hartwell Center, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1128/MCB.00099-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169157PMC
November 2007

PTEN enters the nuclear age.

Authors:
Suzanne J Baker

Cell 2007 Jan;128(1):25-8

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.cell.2006.12.023DOI Listing
January 2007

The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo.

Cancer Res 2006 Dec;66(23):11331-40

Brain Tumor Research Center, Department of Neurological Surgery, The University of California-San Francisco Comprehensive Cancer Center, CA 94115-0875, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1540DOI Listing
December 2006

Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells.

Dev Dyn 2006 Nov;235(11):2991-8

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://doi.wiley.com/10.1002/dvdy.20948
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http://dx.doi.org/10.1002/dvdy.20948DOI Listing
November 2006

PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia.

Clin Cancer Res 2006 Oct;12(20 Pt 1):5932-5

Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1375DOI Listing
October 2006

PTEN function in normal and neoplastic growth.

Cancer Lett 2006 Sep 18;241(2):184-96. Epub 2006 Jan 18.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.11.042DOI Listing
September 2006

S6k1 is not required for Pten-deficient neuronal hypertrophy.

Brain Res 2006 Jul 13;1100(1):32-41. Epub 2006 Jun 13.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.brainres.2006.05.013DOI Listing
July 2006

Pten regulates neuronal arborization and social interaction in mice.

Neuron 2006 May;50(3):377-88

Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089662730600220
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http://dx.doi.org/10.1016/j.neuron.2006.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902853PMC
May 2006

Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations.

Genesis 2006 Mar;44(3):130-5

Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, USA.

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http://dx.doi.org/10.1002/gene.20197DOI Listing
March 2006

The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.

J Biol Chem 2006 Feb 21;281(8):4816-22. Epub 2005 Dec 21.

Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA.

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http://dx.doi.org/10.1074/jbc.M508300200DOI Listing
February 2006

Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway.

J Neuropathol Exp Neurol 2005 Apr;64(4):341-9

Department of Pathology, Division of Neuropathology, Johns Hopkins University, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1093/jnen/64.4.341DOI Listing
April 2005

Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo.

Cancer Res 2004 Nov;64(21):7773-9

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-04-2487DOI Listing
November 2004

Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex.

Exp Cell Res 2004 Aug;298(1):197-206

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis 38103, USA.

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http://dx.doi.org/10.1016/j.yexcr.2004.04.008DOI Listing
August 2004

Tumour-suppressor function in the nervous system.

Nat Rev Cancer 2004 Mar;4(3):184-96

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/nrc1297DOI Listing
March 2004

Knudson's hypothesis and the TP53 revolution.

Genes Chromosomes Cancer 2003 Dec;38(4):329

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/gcc.10249DOI Listing
December 2003

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.

Proc Natl Acad Sci U S A 2003 Oct 8;100(22):12923-8. Epub 2003 Oct 8.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.2132711100
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http://dx.doi.org/10.1073/pnas.2132711100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC240720PMC
October 2003

Redefining p53--entering the tumor suppressor era.

Authors:
Suzanne J Baker

Cell Cycle 2003 Jan-Feb;2(1):7-8

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.4161/cc.2.1.288DOI Listing
August 2003

Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells.

Cancer Res 2003 Jul;63(13):3464-8

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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July 2003

Mouse models of human cancer consortium symposium on nervous system tumors.

Cancer Res 2003 Jun;63(11):3001-4

Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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June 2003