Publications by authors named "Suzanne A Eccles"

100Publications

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Br J Cancer 2018 10 31;119(9):1118-1128. Epub 2018 Oct 31.

Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, SW7 3RP, United Kingdom.

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October 2018

Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI.

Neoplasia 2017 Sep 4;19(9):684-694. Epub 2017 Aug 4.

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, SM2 5NG, UK. Electronic address:

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September 2017

Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells.

Cell Signal 2017 09 20;37:12-30. Epub 2017 May 20.

Diabetic Kidney Disease Centre, Renal Unit, Barts Health NHS Trust, The Royal London Hospital, Whitechapel Road, London E1 1BB, UK; Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary's University of London, London EC1M 6BQ, UK.

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September 2017

High ASMA Fibroblasts and Low Cytoplasmic HMGB1 Breast Cancer Cells Predict Poor Prognosis.

Clin Breast Cancer 2017 10 21;17(6):441-452.e2. Epub 2017 Apr 21.

Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

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October 2017

In Vitro Assays for Endothelial Cell Functions Required for Angiogenesis: Proliferation, Motility, Tubular Differentiation, and Matrix Proteolysis.

Methods Mol Biol 2016 ;1430:121-47

Cancer Research UK Cancer Therapeutics Unit, Centre for Cancer Imaging, The Institute of Cancer Research, Cotswold Rd., Sutton, Surrey, SM2 5NG, UK.

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December 2017

Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.

Mol Cancer Ther 2016 06 5;15(6):1412-24. Epub 2016 Apr 5.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom. Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.

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June 2016

Three-dimensional (3D) tumor spheroid invasion assay.

J Vis Exp 2015 May 1(99):e52686. Epub 2015 May 1.

Division of Cancer Therapeutics, The Institute of Cancer Research.

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May 2015

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger.

J Biol Chem 2015 Jul 15;290(30):18412-28. Epub 2015 May 15.

From Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary's University of London, London EC1M 6BQ, United Kingdom.

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July 2015

Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells.

BMC Cancer 2014 Dec 15;14:955. Epub 2014 Dec 15.

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

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December 2014

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.

Cancer Biol Ther 2014 Oct 14;15(10):1350-7. Epub 2014 Jul 14.

CR-UK/MRC Oxford Institute for Radiation Oncology; Department of Oncology; University of Oxford; Oxford, UK.

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October 2014

Preclinical evaluation of imaging biomarkers for prostate cancer bone metastasis and response to cabozantinib.

J Natl Cancer Inst 2014 Apr 14;106(4):dju033. Epub 2014 Mar 14.

Affiliations of authors: Division of Radiotherapy and Imaging (TJG, NT, TJS, SPR), Cancer Research UK Cancer Therapeutics Unit (GB, MC, SM, GA, JdB, SAE, FED), and Molecular Pathology (FED), Institute of Cancer Research and Royal Marsden NHS Trust, Surrey, UK.

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April 2014

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Breast Cancer Res 2013 Oct 1;15(5):R92. Epub 2013 Oct 1.

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October 2013

Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo.

Clin Cancer Res 2013 Nov 5;19(21):5940-51. Epub 2013 Aug 5.

Authors' Affiliations: Divisions of Clinical Studies, Cancer Therapeutics, and Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey; Histopathology Department, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom; and Department of Neuropathology, University of Bonn, Bonn, Germany.

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November 2013

Kurt Hellmann D. M., D. Phil. Oxon 1922–2013.

Authors:
Suzanne A Eccles

Clin Exp Metastasis 2013 Jun;30(5):553-4

Tumour Biology and Metastasis, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey, UK.

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June 2013

A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma.

Eur J Cancer 2013 Jul 10;49(11):2512-21. Epub 2013 Apr 10.

Tumour Biology & Metastasis Team, Division of Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. Electronic address:

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July 2013

Tumor spheroid-based migration assays for evaluation of therapeutic agents.

Methods Mol Biol 2013 ;986:253-66

Division of Cancer Therapeutics, McElwain Laboratories, The Institute of Cancer Research, Surrey, UK.

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August 2013

Two-dimensional vs. three-dimensional in vitro tumor migration and invasion assays.

Methods Mol Biol 2013 ;986:227-52

Tumour Biology and Metastasis, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, McElwain Laboratories, The Institute of Cancer Research, Surrey, UK.

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August 2013

Erratum to: Kurt Hellmann D.M., D.Phil. Oxon. A happy 90th birthday!

Clin Exp Metastasis 2015 Jun;32(5):517-20

Tumour Biology and Metastasis, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey, UK,

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June 2015

Kurt Hellmann D.M., D.Phil. Oxon. A happy 90th birthday!

Clin Exp Metastasis 2012 Aug;29(6):523-6

Tumour Biology and Metastasis, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey, UK.

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August 2012

Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.

J Clin Immunol 2012 Oct 17;32(5):1059-70. Epub 2012 Apr 17.

King's College London, King's Health Partners Integrated Cancer Center, Department of Research Oncology, Guy's Hospital Campus, Great Maze Pond, London, SE1 9RT, UK.

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October 2012

The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology.

Authors:
Suzanne A Eccles

Int J Dev Biol 2011 ;55(7-9):685-96

UK Cancer Therapeutics Unit, The Institute of Cancer Research, McElwain Laboratories, Cotswold Rd., Belmont, Sutton, Surrey, UK.

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March 2012

The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo.

Mol Cancer Ther 2011 Nov 1;10(11):2115-23. Epub 2011 Sep 1.

Cancer Research UK, Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, United Kingdom.

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November 2011

Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells.

J Biol Chem 2011 Nov 26;286(44):37919-31. Epub 2011 Aug 26.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, McElwain Laboratories, Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, United Kingdom.

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November 2011

Simple experimental and spontaneous metastasis assays in mice.

Methods Mol Biol 2011 ;769:311-29

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey, UK.

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November 2011

Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts.

Int J Cancer 2012 Mar 1;130(6):1284-93. Epub 2011 Aug 1.

Cancer Research UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.

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March 2012

Angiogenic functions of voltage-gated Na+ Channels in human endothelial cells: modulation of vascular endothelial growth factor (VEGF) signaling.

J Biol Chem 2011 May 8;286(19):16846-60. Epub 2011 Mar 8.

Division of Cell and Molecular Biology, Neuroscience Solutions to Cancer Research Group, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.

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May 2011

Preclinical drug development for childhood cancer.

Expert Opin Drug Discov 2011 Jan 24;6(1):49-64. Epub 2010 Nov 24.

The Royal Marsden NHS Foundation Trust, Children and Young People's Unit, Sutton, Surrey, UK.

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January 2011

Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: part 2.

Authors:
Suzanne A Eccles

IDrugs 2010 Nov;13(11):768-71

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, McElwain Labs, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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November 2010

Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 1.

Authors:
Suzanne A Eccles

IDrugs 2010 Nov;13(11):765-7

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, McElwain Labs, 15 Cotswold Road, Sutton, Surrey, SM2 5NG.

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November 2010

Bayesian estimation of changes in transverse relaxation rates.

Magn Reson Med 2010 Sep;64(3):914-21

Cancer Research UK & EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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September 2010

Tumour-microenvironmental interactions: paths to progression and targets for treatment.

Semin Cancer Biol 2010 Jun 3;20(3):128-38. Epub 2010 Jul 3.

Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Rd, Belmont, Sutton, Surrey SM2 5NG, United Kingdom.

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June 2010

Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.

Mol Cancer Ther 2010 May;9(5):1219-33

Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK.

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May 2010

The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.

Mol Cancer Ther 2010 Jan 6;9(1):89-100. Epub 2010 Jan 6.

Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Surrey, United Kingdom.

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January 2010

Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.

Am J Pathol 2009 Sep 6;175(3):1226-34. Epub 2009 Aug 6.

Brunel Institute for Cancer Genetics and Pharmacogenomics, Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, Middlesex, United Kingdom.

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September 2009

Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells.

Mol Cancer Ther 2009 May 5;8(5):1305-11. Epub 2009 May 5.

Cancer Research UK Clinical Magnetic Resonance Research Group, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom.

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May 2009

The identification of novel PLC-gamma inhibitors using virtual high throughput screening.

Bioorg Med Chem 2009 Apr 3;17(8):3169-76. Epub 2009 Mar 3.

Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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April 2009

In vitro assays for endothelial cell functions related to angiogenesis: proliferation, motility, tubular differentiation, and proteolysis.

Methods Mol Biol 2009 ;467:159-81

Cancer Research UK Centre for Cancer Therapeutics, McElwain Laboratories, Institute of Cancer Research, Surrey, UK.

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April 2009

Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck.

J Pathol 2009 May;218(1):122-30

Tumour Biology and Metastasis Team, McElwain Laboratories, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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May 2009

Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma.

Cell Cycle 2009 Feb 16;8(3):443-53. Epub 2009 Feb 16.

Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK.

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February 2009

A microRNA DNA methylation signature for human cancer metastasis.

Proc Natl Acad Sci U S A 2008 Sep 3;105(36):13556-61. Epub 2008 Sep 3.

Cancer Epigenetics Laboratory, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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September 2008

An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Cancer Chemother Pharmacol 2008 Oct 10;62(5):769-78. Epub 2008 Jan 10.

Cancer Research UK Centre for Cancer Therapeutics, Haddow Laboratories, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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October 2008

AACR-NCI-EORTC--19th symposium. Molecular Targets and Cancer Therapeutics--Part 4.

Authors:
Suzanne A Eccles

IDrugs 2007 Dec;10(12):844-7

Institute of Cancer Research, McElwain Labs, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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December 2007

Plexin-B1 mutations in prostate cancer.

Proc Natl Acad Sci U S A 2007 Nov 16;104(48):19040-5. Epub 2007 Nov 16.

Prostate Cancer Research Centre, Institute of Urology, University College London, 67 Riding House Street, London W1W 7EJ, United Kingdom.

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November 2007