Susetta Finotto

Susetta Finotto

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Susetta Finotto

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Resolution of allergic asthma.

Authors:
Susetta Finotto

Semin Immunopathol 2019 Nov 8. Epub 2019 Nov 8.

Department of Molecular Pneumology, University of Erlangen-Nürnberg, Kussmaul Campus for Medical Research, Hartmannstr. 14, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00281-019-00770-3DOI Listing
November 2019

Immunoregulatory role of acid sphingomyelinase in allergic asthma.

Immunology 2019 04 13;156(4):373-383. Epub 2019 Jan 13.

Department of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1111/imm.13035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418424PMC
April 2019

Increased expression of the immunosuppressive interleukin-35 in patients with non-small cell lung cancer.

Br J Cancer 2019 Apr 8;120(9):903-912. Epub 2019 Apr 8.

Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

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http://dx.doi.org/10.1038/s41416-019-0444-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734661PMC
April 2019

B lymphocyte-induced maturation protein 1 (Blimp-1), a negative regulator of T9 development, orchestrates the resolution of airway inflammation in patients with allergic asthma.

Authors:
Susetta Finotto

J Allergy Clin Immunol 2019 Mar 5;143(3):937-939. Epub 2018 Sep 5.

Department of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.07.039DOI Listing
March 2019

STAT1 deficiency supports PD-1/PD-L1 signaling resulting in dysfunctional TNFα mediated immune responses in a model of NSCLC.

Oncotarget 2018 Dec 14;9(98):37157-37172. Epub 2018 Dec 14.

Department of Molecular Pneumology, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany.

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http://www.oncotarget.com/fulltext/26441
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http://dx.doi.org/10.18632/oncotarget.26441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324686PMC
December 2018

NFATc1 Promotes Antitumoral Effector Functions and Memory CD8 T-cell Differentiation during Non-Small Cell Lung Cancer Development.

Cancer Res 2018 07 24;78(13):3619-3633. Epub 2018 Apr 24.

Department of Molecular Pneumology, University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3297DOI Listing
July 2018

The role of Foxp3 and Tbet co-expressing Treg cells in lung carcinoma.

Oncoimmunology 2018 25;7(8):e1456612. Epub 2018 Apr 25.

Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1080/2162402X.2018.1456612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136856PMC
April 2018

Interleukin-10-regulated tumour tolerance in non-small cell lung cancer.

Br J Cancer 2017 Nov 10;117(11):1644-1655. Epub 2017 Oct 10.

Laboratory of Cellular and Molecular Lung Immunology, Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Hartmannstraβe 14, Erlangen 91052, Germany.

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http://dx.doi.org/10.1038/bjc.2017.336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729436PMC
November 2017

The Unresolved Role of Interferon-λ in .

Front Immunol 2017 15;8:989. Epub 2017 Aug 15.

Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559474PMC
August 2017

Role of TGF-β in anti-rhinovirus immune responses in asthmatic patients.

J Allergy Clin Immunol 2017 07 27;140(1):283-286.e10. Epub 2017 Jan 27.

Department of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.10.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754331PMC
July 2017

IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma.

Sci Rep 2017 03 6;7:43426. Epub 2017 Mar 6.

Abteilung für Molekulare Pneumologie, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1038/srep43426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338274PMC
March 2017

Th9 and other IL-9-producing cells in allergic asthma.

Semin Immunopathol 2017 01 17;39(1):55-68. Epub 2016 Nov 17.

Department of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, 91052, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00281-016-0601-1DOI Listing
January 2017

Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection.

PLoS Pathog 2016 Sep 28;12(9):e1005913. Epub 2016 Sep 28.

Airway Disease Infection Section, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1005913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040449PMC
September 2016

The transcription factor BATF modulates cytokine-mediated responses in T cells.

Cytokine Growth Factor Rev 2016 08 6;30:39-45. Epub 2016 Mar 6.

Department of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2016.03.004DOI Listing
August 2016

IL-9 signaling as key driver of chronic inflammation in mucosal immunity.

Cytokine Growth Factor Rev 2016 06 4;29:93-9. Epub 2016 Mar 4.

Department of Molecular Pulmonology, Friedrich-Alexander University of Erlangen-Nürnberg, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.cytogfr.2016.02.002DOI Listing
June 2016

Increased expression of nuclear factor of activated T cells 1 drives IL-9-mediated allergic asthma.

J Allergy Clin Immunol 2016 06 15;137(6):1898-1902.e7. Epub 2016 Mar 15.

Laboratory of Cellular and Molecular Lung Immunology, Department of Molecular Pneumology, Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.11.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889777PMC
June 2016

Role of Interferon-λ in Allergic Asthma.

J Innate Immun 2015 15;7(3):224-30. Epub 2015 Jan 15.

Department of Molecular Pneumology, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1159/000369459DOI Listing
January 2016

Impaired T-bet-pSTAT1α and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma.

Br J Cancer 2015 09 8;113(6):902-13. Epub 2015 Sep 8.

Department of Molecular Pneumology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.

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http://www.nature.com/articles/bjc2015255
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http://dx.doi.org/10.1038/bjc.2015.255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578079PMC
September 2015

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.

Eur J Immunol 2015 May 30;45(5):1426-40. Epub 2015 Mar 30.

Department of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1002/eji.201445150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681150PMC
May 2015

IL-10 and regulatory T cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma.

J Immunol 2015 Feb 19;194(3):887-97. Epub 2014 Dec 19.

Department of Pulmonology, University Medical Center Leiden, 2333 ZA Leiden, the Netherlands

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http://dx.doi.org/10.4049/jimmunol.1401612DOI Listing
February 2015

SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation.

Eur Respir J 2014 Aug 17;44(2):447-56. Epub 2014 Apr 17.

Institute of Anatomy, Dept II, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany These two authors contributed equally to this work.

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http://erj.ersjournals.com/cgi/doi/10.1183/09031936.00179813
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http://dx.doi.org/10.1183/09031936.00179813DOI Listing
August 2014

Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.

Sci Rep 2014 Aug 11;4:5865. Epub 2014 Aug 11.

Laboratory of Cellular and Molecular Immunology of the Lung, Institute of Molecular Pneumology, University of Erlangen-Nürnberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1038/srep05865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127519PMC
August 2014

IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy.

Sci Rep 2013 ;3:1754

Laboratory of Cellular and Molecular Lung Immunology, Institute of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

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http://dx.doi.org/10.1038/srep01754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639449PMC
February 2014

Establishing the role of tyrosine kinase 2 in cancer.

Oncoimmunology 2013 Jan;2(1):e22840

Laboratory of Cellular and Molecular Lung Immunology; Institute of Molecular Pneumology; University of Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.4161/onci.22840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583936PMC
January 2013

The emerging role of T cell cytokines in non-small cell lung cancer.

Cytokine Growth Factor Rev 2012 Dec 28;23(6):315-22. Epub 2012 Sep 28.

Department of Medicine I, University of Erlangen-Nuremberg, Germany.

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http://dx.doi.org/10.1016/j.cytogfr.2012.08.009DOI Listing
December 2012

Increased immunosuppressive function of CD4(+)CD25(+)Foxp3(+)GITR+ T regulatory cells from NFATc2((-/-)) mice controls allergen-induced experimental asthma.

Immunobiology 2012 Sep 11;217(9):905-11. Epub 2012 Jan 11.

Laboratory of Cellular and Molecular Immunology of the Lung, Institute of Molecular Medicine, University of Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.imbio.2012.01.004DOI Listing
September 2012

Therapeutical measures to control airway tolerance in asthma and lung cancer.

Front Immunol 2012 26;3:216. Epub 2012 Jul 26.

Laboratory of Cellular and Molecular Lung Immunology, Institute of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen, Germany.

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http://dx.doi.org/10.3389/fimmu.2012.00216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405289PMC
August 2012

IL-17A is a central regulator of lung tumor growth.

Oncoimmunology 2012 Aug;1(5):783-785

Laboratories of Cellular and Molecular Lung Immunology; Institute of Molecular Pneumology; Friedrich-Alexander-Universität; Erlangen-Nürnberg, Germany.

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http://dx.doi.org/10.4161/onci.19735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429594PMC
August 2012

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer.

Cytokine Growth Factor Rev 2011 Apr 5;22(2):83-9. Epub 2011 Mar 5.

1st Medical Clinic, University of Erlangen-Nürnberg, Germany.

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http://dx.doi.org/10.1016/j.cytogfr.2011.02.003DOI Listing
April 2011

Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma.

Int Immunol 2011 Jan 6;23(1):1-15. Epub 2010 Dec 6.

Laboratory of Cellular and Molecular Immunology of Lung, Institute of Molecular Medicine, Universitätsmedizin Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.1093/intimm/dxq451DOI Listing
January 2011

Dual role of interleukin-1alpha in delayed-type hypersensitivity and airway hyperresponsiveness.

Int Arch Allergy Immunol 2010 26;152(4):303-12. Epub 2010 Feb 26.

Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1159/000288283DOI Listing
September 2010

Translating inflammatory bowel disease research into clinical medicine.

Immunity 2009 Sep;31(3):357-61

Department of Medicine, University of Erlangen-Nürnberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.immuni.2009.08.016DOI Listing
September 2009

A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes.

Cancer Res 2009 Apr 24;69(7):3069-76. Epub 2009 Mar 24.

Laboratory of Cellular and Molecular Immunology of the Lung, I. Medical Clinic, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1678DOI Listing
April 2009

Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.

J Immunol 2008 Nov;181(9):6148-57

Laboratory of Cellular and Molecular Immunology of the Lung, I. Medical Clinic, University of Mainz, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996841PMC
http://dx.doi.org/10.4049/jimmunol.181.9.6148DOI Listing
November 2008

Transgenic models in allergic responses.

Curr Drug Targets 2008 Jun;9(6):503-10

Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany.

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http://dx.doi.org/10.2174/138945008784533570DOI Listing
June 2008

Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model.

J Allergy Clin Immunol 2008 Apr 10;121(4):992-9.e6. Epub 2008 Mar 10.

Laboratory of Cellular and Molecular Immunology of the Lung, I. Medical Clinic, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1016/j.jaci.2007.12.1172DOI Listing
April 2008

Divergent effects of biolistic gene transfer in a mouse model of allergic airway inflammation.

Am J Respir Cell Mol Biol 2008 Jan 19;38(1):38-46. Epub 2007 Jul 19.

Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 63, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1165/rcmb.2007-0067OCDOI Listing
January 2008

Isolation of CD4+ T cells from murine lungs: a method to analyze ongoing immune responses in the lung.

Nat Protoc 2006 ;1(6):2870-5

Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Germany.

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http://dx.doi.org/10.1038/nprot.2006.435DOI Listing
November 2007

A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators.

Nat Protoc 2007 ;2(1):105-12

Laboratory of Cellular and Molecular Immunology of the Lung University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1038/nprot.2007.8DOI Listing
June 2007

Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.

Int Immunol 2007 Jun 11;19(6):685-93. Epub 2007 May 11.

Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany.

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http://dx.doi.org/10.1093/intimm/dxm037DOI Listing
June 2007

Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma.

Eur J Immunol 2007 Jun;37(6):1663-77

Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/eji.200636675DOI Listing
June 2007

Mucosal immunoregulation: transcription factors as possible therapeutic targets.

Curr Drug Targets Inflamm Allergy 2005 Oct;4(5):565-75

Laboratory of Cellular and Molecular Lung Immunology and &Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany.

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http://dx.doi.org/10.2174/156801005774322153DOI Listing
October 2005

Asthmatic changes in mice lacking T-bet are mediated by IL-13.

Int Immunol 2005 Aug 6;17(8):993-1007. Epub 2005 Jul 6.

Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1093/intimm/dxh281DOI Listing
August 2005

Pathological role of IL-6 in the experimental allergic bronchial asthma in mice.

Clin Rev Allergy Immunol 2005 Jun;28(3):257-70

Laboratory of Cellular and Molecular Immunology of the Lung, I. Medical Clinic, University of Mainz, Germany.

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http://dx.doi.org/10.1385/CRIAI:28:3:257DOI Listing
June 2005

A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiation.

Eur J Immunol 2004 Dec;34(12):3401-12

Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany.

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http://dx.doi.org/10.1002/eji.200425121DOI Listing
December 2004

T cell directives for transcriptional regulation in asthma.

Springer Semin Immunopathol 2004 Feb 12;25(3-4):281-94. Epub 2003 Nov 12.

I Medical Clinic, Laboratory of Immunology, Verfügungsgebäude für Forschung und Entwicklung, University of Mainz, Germany.

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http://dx.doi.org/10.1007/s00281-003-0143-1DOI Listing
February 2004

Regulation of T cells in asthma: implications for genetic manipulation.

Curr Opin Allergy Clin Immunol 2004 Feb;4(1):69-74

I Medical Clinic, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1097/00130832-200402000-00014DOI Listing
February 2004

TGF-beta regulates airway responses via T cells.

J Immunol 2003 Feb;170(3):1313-9

I. Medizinische Klinik, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.4049/jimmunol.170.3.1313DOI Listing
February 2003

The role of Th1/Th2 polarization in mucosal immunity.

Nat Med 2002 Jun;8(6):567-73

Laboratory of Immunology, I. Department of Medicine, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1038/nm0602-567DOI Listing
June 2002

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.

Science 2002 Jan;295(5553):336-8

Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1065544
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http://dx.doi.org/10.1126/science.1065544DOI Listing
January 2002