Publications by authors named "Susanne Unger"

27Publications

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes.

Authors:
Ekaterina Friebel Konstantina Kapolou Susanne Unger Nicolás Gonzalo Núñez Sebastian Utz Elisabeth Jane Rushing Luca Regli Michael Weller Melanie Greter Sonia Tugues Marian Christoph Neidert Burkhard Becher

Cell 2020 06 28;181(7):1626-1642.e20. Epub 2020 May 28.

Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland. Electronic address:

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June 2020

Oncogenic Kras causes myeloproliferation via NLRP3 inflammasome activation.

Authors:
Shaima'a Hamarsheh Lena Osswald Benedikt S Saller Susanne Unger Donatella De Feo Janaki Manoja Vinnakota Martina Konantz Franziska M Uhl Heiko Becker Michael Lübbert Khalid Shoumariyeh Christoph Schürch Geoffroy Andrieux Nils Venhoff Annette Schmitt-Graeff Sandra Duquesne Dietmar Pfeifer Matthew A Cooper Claudia Lengerke Melanie Boerries Justus Duyster Charlotte M Niemeyer Miriam Erlacher Bruce R Blazar Burkard Becher Olaf Groß Tilman Brummer Robert Zeiser

Nat Commun 2020 04 3;11(1):1659. Epub 2020 Apr 3.

Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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April 2020

Exhausted phenotype of follicular CD8 T cells in CVID.

Authors:
Adam Klocperk Susanne Unger David Friedmann Maximilian Seidl Katharina Zoldan Jens Pfeiffer Oliver Hausmann Vladimir Benes Geoffroy Andrieux Tobias Boettler Anna Sediva Bertram Bengsch Klaus Warnatz

J Allergy Clin Immunol 2020 Oct 10;146(4):912-915.e13. Epub 2020 Mar 10.

Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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October 2020

Extracorporeal Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy.

Authors:
Petya Apostolova Susanne Unger Dagmar von Bubnoff Frank Meiss Burkhard Becher Robert Zeiser

N Engl J Med 2020 01;382(3):294-296

University Medical Center Freiburg, Freiburg, Germany

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January 2020

Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective.

Authors:
Pascale Zwicky Susanne Unger Burkhard Becher

J Exp Med 2020 01;217(1)

Institute of Experimental Immunology, Department of Inflammation Research, University of Zurich, Zurich, Switzerland.

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January 2020

Immunization against poly--acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity.

Authors:
Jan Hülsdünker Oliver S Thomas Eileen Haring Susanne Unger Nicolás Gonzalo Núñez Sonia Tugues Zhan Gao Sandra Duquesne Colette Cywes-Bentley Ozlem Oyardi Susanne Kirschnek Annette Schmitt-Graeff Oliver Pabst Christian Koenecke Justus Duyster Petya Apostolova Martin J Blaser Burkhard Becher Gerald B Pier Georg Häcker Robert Zeiser

Proc Natl Acad Sci U S A 2019 10 16;116(41):20700-20706. Epub 2019 Sep 16.

Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Faculty of Medicine, 79106 Freiburg, Germany;

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October 2019

TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes.

Authors:
Julian Staniek Raquel Lorenzetti Bianca Heller Iga Janowska Pascal Schneider Susanne Unger Klaus Warnatz Maximilian Seidl Nils Venhoff Jens Thiel Cristian Roberto Smulski Marta Rizzi

Front Immunol 2019 30;10:951. Epub 2019 Apr 30.

Clinic for Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.

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September 2020

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in .

Authors:
Christian Klemann Nadezhda Camacho-Ordonez Linlin Yang Zoya Eskandarian Jessica L Rojas-Restrepo Natalie Frede Alla Bulashevska Maximilian Heeg Moudjahed Saleh Al-Ddafari Julian Premm Maximilian Seidl Sandra Ammann Roya Sherkat Nita Radhakrishnan Klaus Warnatz Susanne Unger Robin Kobbe Anja Hüfner T Ronan Leahy Winnie Ip Siobhan O Burns Manfred Fliegauf Bodo Grimbacher

Front Immunol 2019 19;10:297. Epub 2019 Mar 19.

Faculty of Medicine, Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, Freiburg, Germany.

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May 2020

The end of omics? High dimensional single cell analysis in precision medicine.

Authors:
Edoardo Galli Ekaterina Friebel Florian Ingelfinger Susanne Unger Nicolás Gonzalo Núñez Burkhard Becher

Eur J Immunol 2019 02 25;49(2):212-220. Epub 2019 Jan 25.

Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

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February 2019

Follicular Helper T Cells in DiGeorge Syndrome.

Authors:
Adam Klocperk Zuzana Paračková Markéta Bloomfield Michal Rataj Jan Pokorný Susanne Unger Klaus Warnatz Anna Šedivá

Front Immunol 2018 23;9:1730. Epub 2018 Jul 23.

Department of Immunology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czechia.

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July 2018

T NK IL-2 Receptor γ Chain Mutation: a Challenging Diagnosis of Atypical Severe Combined Immunodeficiency.

Authors:
Polina Stepensky Baerbel Keller Oded Shamriz Caroline von Spee-Mayer David Friedmann Bella Shadur Susanne Unger Sebastian Fuchs Adeeb NaserEddin Nisreen Rumman Sara Amro Vered Molho Pessach Omar Abuzaitoun Raz Somech Orly Elpeleg Stephan Ehl Klaus Warnatz

J Clin Immunol 2018 05 9;38(4):527-536. Epub 2018 Jun 9.

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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May 2018

Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation.

Authors:
David Friedmann Baerbel Keller Ina Harder Jonas Schupp Yakup Tanriver Susanne Unger Klaus Warnatz

J Clin Immunol 2017 Nov 21;37(8):759-769. Epub 2017 Sep 21.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacherstr. 115, 79106, Freiburg, Germany.

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November 2017

Correction: Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in .

Authors:
Baerbel Keller Irina Zaidman O Sascha Yousefi Dov Hershkovitz Jerry Stein Susanne Unger Kristina Schachtrup Mikael Sigvardsson Amir A Kuperman Avraham Shaag Wolfgang W Schamel Orly Elpeleg Klaus Warnatz Polina Stepensky

J Exp Med 2017 07 1;214(7):2165. Epub 2017 Jun 1.

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July 2017

The T1 phenotype of follicular helper T cells indicates an IFN-γ-associated immune dysregulation in patients with CD21low common variable immunodeficiency.

Authors:
Susanne Unger Maximilian Seidl Pauline van Schouwenburg Mirzokhid Rakhmanov Alla Bulashevska Natalie Frede Bodo Grimbacher Jens Pfeiffer Klaudia Schrenk Luis Munoz Leif Hanitsch Ina Stumpf Fabian Kaiser Oliver Hausmann Florian Kollert Sigune Goldacker Mirjam van der Burg Baerbel Keller Klaus Warnatz

J Allergy Clin Immunol 2018 02 26;141(2):730-740. Epub 2017 May 26.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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February 2018

Autosomal dominant gain of function STAT1 mutation and severe bronchiectasis.

Authors:
Oded Breuer Hagit Daum Malena Cohen-Cymberknoh Susanne Unger David Shoseyov Polina Stepensky Baerbel Keller Klaus Warnatz Eitan Kerem

Respir Med 2017 05 22;126:39-45. Epub 2017 Mar 22.

Department of Pediatrics and Pediatric Pulmonary Unit, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.

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May 2017

Increase of circulating α4β7 conventional memory CD4 and regulatory T cells in patients with common variable immunodeficiency (CVID).

Authors:
Karina Mescouto de Melo Susanne Unger Baerbel Keller Sylvia Gutenberger Ina Stumpf Sigune Goldacker Klaus Warnatz

Clin Immunol 2017 07 18;180:80-83. Epub 2017 Mar 18.

Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

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July 2017

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

Authors:
Baerbel Keller Irina Zaidman O Sascha Yousefi Dov Hershkovitz Jerry Stein Susanne Unger Kristina Schachtrup Mikael Sigvardsson Amir A Kuperman Avraham Shaag Wolfgang W Schamel Orly Elpeleg Klaus Warnatz Polina Stepensky

J Exp Med 2016 06 30;213(7):1185-99. Epub 2016 May 30.

Monique and Jacques Roboh Department of Genetic Research, Hadassah Medical Center, Hebrew University, Jerusalem 91120, Israel Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University, Jerusalem 91120, Israel

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June 2016

Secondary Antibody Deficiency in Glucocorticoid Therapy Clearly Differs from Primary Antibody Deficiency.

Authors:
Clemens Wirsum Cornelia Glaser Sylvia Gutenberger Baerbel Keller Susanne Unger Reinhard E Voll Werner Vach Thomas Ness Klaus Warnatz

J Clin Immunol 2016 05 15;36(4):406-12. Epub 2016 Mar 15.

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Str. 117, 79106, Freiburg, Germany.

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May 2016

Generalized verrucosis and HPV-3 susceptibility associated with CD4 T-cell lymphopenia caused by inherited human interleukin-7 deficiency.

Authors:
Liran Horev Susanne Unger Vered Molho-Pessach Tomer Meir Alex Maly Polina Stepensky Mariana Zamir Baerbel Keller Sofia Babay Klaus Warnatz Yuval Ramot Abraham Zlotogorski

J Am Acad Dermatol 2015 Jun;72(6):1082-4

Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; The Center for Genetic Diseases of the Skin and Hair, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

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June 2015

Enteroviral Infection in a Patient with BLNK Adaptor Protein Deficiency.

Authors:
Adeeb NaserEddin Oded Shamriz Baerbel Keller Raed M Alzyoud Susanne Unger Paul Fisch Evgenia Prus Yakov Berkun Diana Averbuch Avraham Shaag Adel M Wahadneh Mary Ellen Conley Klaus Warnatz Orly Elpeleg Polina Stepensky

J Clin Immunol 2015 May 17;35(4):356-60. Epub 2015 Apr 17.

Pediatric Division, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.

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May 2015

β2-Microglobulin deficiency causes a complex immunodeficiency of the innate and adaptive immune system.

Authors:
Ömür Ardeniz Susanne Unger Hüseyin Onay Sandra Ammann Caroline Keck Corina Cianga Bengü Gerçeker Bianca Martin Ilka Fuchs Ulrich Salzer Aydan İkincioğulları Deniz Güloğlu Tuğrul Dereli Robert Thimme Stephan Ehl Klaus Schwarz Annette Schmitt-Graeff Petru Cianga Paul Fisch Klaus Warnatz

J Allergy Clin Immunol 2015 Aug 19;136(2):392-401. Epub 2015 Feb 19.

Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.

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August 2015

Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency.

Authors:
Polina Stepensky Baerbel Keller Omar Abuzaitoun Avraham Shaag Barak Yaacov Susanne Unger Maximilian Seidl Marta Rizzi Michael Weintraub Orly Elpeleg Klaus Warnatz

Haematologica 2015 Feb 14;100(2):e72-6. Epub 2014 Nov 14.

Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Germany

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February 2015

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.

Authors:
Desirée Schubert Claudia Bode Rupert Kenefeck Tie Zheng Hou James B Wing Alan Kennedy Alla Bulashevska Britt-Sabina Petersen Alejandro A Schäffer Björn A Grüning Susanne Unger Natalie Frede Ulrich Baumann Torsten Witte Reinhold E Schmidt Gregor Dueckers Tim Niehues Suranjith Seneviratne Maria Kanariou Carsten Speckmann Stephan Ehl Anne Rensing-Ehl Klaus Warnatz Mirzokhid Rakhmanov Robert Thimme Peter Hasselblatt Florian Emmerich Toni Cathomen Rolf Backofen Paul Fisch Maximilian Seidl Annette May Annette Schmitt-Graeff Shinji Ikemizu Ulrich Salzer Andre Franke Shimon Sakaguchi Lucy S K Walker David M Sansom Bodo Grimbacher

Nat Med 2014 Dec 20;20(12):1410-1416. Epub 2014 Oct 20.

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.

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December 2014

High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation.

Authors:
Mirzokhid Rakhmanov Heiko Sic Anne-Kathrin Kienzler Beate Fischer Marta Rizzi Maximilian Seidl Kerstina Melkaoui Susanne Unger Luisa Moehle Nadine E Schmit Sachin D Deshmukh Cemil Korcan Ayata Wolfgang Schuh Zhibing Zhang François-Loic Cosset Els Verhoeyen Hans-Hartmut Peter Reinhard E Voll Ulrich Salzer Hermann Eibel Klaus Warnatz

PLoS One 2014 19;9(6):e100328. Epub 2014 Jun 19.

Center for Chronic Immunodeficiency (CCI), University Medical Center and University Freiburg, Freiburg, Germany; Division of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany.

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March 2015

Cytokines in common variable immunodeficiency as signs of immune dysregulation and potential therapeutic targets - a review of the current knowledge.

Authors:
Farnaz Najmi Varzaneh Bärbel Keller Susanne Unger Asghar Aghamohammadi Klaus Warnatz Nima Rezaei

J Clin Immunol 2014 Jul 15;34(5):524-43. Epub 2014 May 15.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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July 2014

Ill-defined germinal centers and severely reduced plasma cells are histological hallmarks of lymphadenopathy in patients with common variable immunodeficiency.

Authors:
Susanne Unger Maximilian Seidl Annette Schmitt-Graeff Joachim Böhm Klaudia Schrenk Claudia Wehr Sigune Goldacker Ruth Dräger Barbara C Gärtner Paul Fisch Martin Werner Klaus Warnatz

J Clin Immunol 2014 Aug 2;34(6):615-26. Epub 2014 May 2.

Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Breisacher Str.117, 79106, Freiburg, Germany.

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August 2014

Common variable immunodeficiency (CVID): exploring the multiple dimensions of a heterogeneous disease.

Authors:
Ulrich Salzer Susanne Unger Klaus Warnatz

Ann N Y Acad Sci 2012 Feb 2;1250:41-9. Epub 2012 Feb 2.

Centre of Chronic Immunodeficiency, University Medical Centre Freiburg, Germany.

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February 2012