Susanne Schoch

Susanne Schoch

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Susanne Schoch

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New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

J Cell Sci 2019 Jun 17;132(12). Epub 2019 Jun 17.

Ubiquitin Signaling Group, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany

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http://dx.doi.org/10.1242/jcs.229252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602300PMC
June 2019

Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.

J Neurosci 2019 Apr 21;39(17):3175-3187. Epub 2019 Feb 21.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.1731-18.2019DOI Listing
April 2019

Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.

Mol Neurobiol 2019 Mar 22;56(3):1825-1840. Epub 2018 Jun 22.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

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http://link.springer.com/10.1007/s12035-018-1181-y
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http://dx.doi.org/10.1007/s12035-018-1181-yDOI Listing
March 2019

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018

Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis.

Mol Neurobiol 2018 May 1;55(5):4463-4472. Epub 2017 Jul 1.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s12035-017-0660-xDOI Listing
May 2018

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy.

Brain 2018 05;141(5):1350-1374

Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and VU Medical Center, de Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/brain/awy046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917748PMC
May 2018

The structural and functional evidence for vesicular release from astrocytes in situ.

Brain Res Bull 2018 01 22;136:65-75. Epub 2017 Jan 22.

Institute of Cellular Neurosciences, University of Bonn Medical School, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute of Neurology, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2017.01.015DOI Listing
January 2018

Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus.

Epilepsia 2017 07 24;58(7):1159-1171. Epub 2017 May 24.

Unit of Epileptology and Experimental Neurophysiology, Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1111/epi.13795DOI Listing
July 2017

Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates.

Glia 2017 02 3;65(2):342-359. Epub 2016 Nov 3.

Department of Neurosurgery, Experimental Neurophysiology, University Clinic Bonn, Bonn, 53105, Germany.

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http://dx.doi.org/10.1002/glia.23095DOI Listing
February 2017

Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice.

Neurobiol Dis 2016 Nov 15;95:134-44. Epub 2016 Jul 15.

Section for Translational Epilepsy Research, Dept. of Neuropathology, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.07.006DOI Listing
November 2016

CASK stabilizes neurexin and links it to liprin-α in a neuronal activity-dependent manner.

Cell Mol Life Sci 2016 09 25;73(18):3599-621. Epub 2016 Mar 25.

Virginia Tech Carilion Research Institute, 2 Riverside Cir., Roanoke, VA, 24016, USA.

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http://dx.doi.org/10.1007/s00018-016-2183-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982824PMC
September 2016

NG2 glial cells integrate synaptic input in global and dendritic calcium signals.

Elife 2016 09 19;5. Epub 2016 Sep 19.

Department of Neurosurgery, University Clinic Bonn, Bonn, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052029PMC
http://dx.doi.org/10.7554/eLife.16262DOI Listing
September 2016

Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy.

Acta Neuropathol 2016 08 18;132(2):277-88. Epub 2016 Mar 18.

Division of Neurochemistry, Department of Epileptology, University Bonn Medical Center, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00401-016-1561-1DOI Listing
August 2016

Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas.

Life Sci 2016 Jun 30;155:70-5. Epub 2016 Apr 30.

Dept. of Neurosurgery, University of Bonn Medical Center, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2016.01.049DOI Listing
June 2016

Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus.

Neuron 2016 05 5;90(4):853-65. Epub 2016 May 5.

Laboratory for Experimental Epileptology and Cognition Research, Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.04.003DOI Listing
May 2016

Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration.

J Neurosci 2016 Mar;36(9):2561-70

Section of Translational Epilepsy Research at the Department of Neuropathology, and Department of Epileptology, University of Bonn Medical Center, D-53105 Bonn, Germany

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http://dx.doi.org/10.1523/JNEUROSCI.2027-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604865PMC
March 2016

Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance.

Neurobiol Dis 2016 Feb 26;86:121-30. Epub 2015 Nov 26.

Dept. of Neuropathology, University of Bonn Medical Center, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.11.011DOI Listing
February 2016

LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization.

Neurobiol Dis 2016 Feb 2;86:170-6. Epub 2015 Dec 2.

Dept. of Neuropathology/Section for Translational Epilepsy Research, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1016/j.nbd.2015.11.021DOI Listing
February 2016

Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.

J Neurosci 2015 Nov;35(46):15240-53

Laboratory for Experimental Epileptology and Cognition Research, Department of Epileptology, and Deutsches Zentrum für Neurodegenerative Erkrankungen e.V., 53175 Bonn, Germany

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http://dx.doi.org/10.1523/JNEUROSCI.0493-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605494PMC
November 2015

Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.

Nat Commun 2015 Oct 26;6:8688. Epub 2015 Oct 26.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany.

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http://dx.doi.org/10.1038/ncomms9688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846312PMC
October 2015

Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.

Brain Struct Funct 2015 Sep 3;220(5):3067-73. Epub 2014 Jun 3.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00429-014-0801-1DOI Listing
September 2015

Investigation of GRIN2A in common epilepsy phenotypes.

Epilepsy Res 2015 Sep 2;115:95-9. Epub 2015 Jun 2.

Division of Human Genetics, University Children's Hospital Inselspital, Bern, Switzerland; Institute of Human Genetics, University Medical Center Leipzig, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2015.05.010DOI Listing
September 2015

The presynaptic active zone: A dynamic scaffold that regulates synaptic efficacy.

Exp Cell Res 2015 Jul 23;335(2):157-64. Epub 2015 Feb 23.

Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany; Department of Epileptology University of Bonn Medical Center, 53105 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2015.02.011DOI Listing
July 2015

Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit.

Neuron 2015 Jun 14;86(5):1253-64. Epub 2015 May 14.

Neuronal Networks Group, German Center for Neurodegenerative Diseases, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany; Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud Strasse 25, 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.05.001DOI Listing
June 2015

Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.

Proc Natl Acad Sci U S A 2015 Jun 1;112(24):E3141-9. Epub 2015 Jun 1.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099 Göttingen, Germany; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37099 Göttingen, Germany; Collaborative Sensory Research Center 889, University of Göttingen, 37099 Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, 37073 Göttingen, Germany;

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http://dx.doi.org/10.1073/pnas.1417207112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475996PMC
June 2015

Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.

J Neurosci 2015 Jun;35(22):8394-410

Laboratory for Experimental Epileptology and Cognition Research, Department of Epileptology, Deutsches Zentrum für Neurodegenerative Erkrankungen, 53105 Bonn, Germany

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.4460-1
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http://dx.doi.org/10.1523/JNEUROSCI.4460-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605336PMC
June 2015

Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies.

Epilepsia 2015 Feb 20;56(2):234-43. Epub 2014 Dec 20.

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/epi.12890DOI Listing
February 2015

Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease.

Neuron 2014 Dec 13;84(5):1023-33. Epub 2014 Nov 13.

Neuronal Networks Group, Deutsches Zentrum für Neurodegenerative Erkrankungen, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany; Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53125 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.10.024DOI Listing
December 2014

RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.

J Mol Cell Biol 2014 Oct 19;6(5):434-7. Epub 2014 Sep 19.

Walther Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany

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http://dx.doi.org/10.1093/jmcb/mju037DOI Listing
October 2014

Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi.

Neurobiol Dis 2013 Dec 7;60:115-25. Epub 2013 Sep 7.

Dept. of Neuropathology, University of Bonn Medical Center, Germany.

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http://dx.doi.org/10.1016/j.nbd.2013.08.015DOI Listing
December 2013

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue.

Seizure 2013 Oct 22;22(8):675-8. Epub 2013 May 22.

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1016/j.seizure.2013.04.023DOI Listing
October 2013

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A.

Brain 2013 Oct 6;136(Pt 10):3140-50. Epub 2013 Sep 6.

1 NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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https://academic.oup.com/brain/article/136/10/3140/330027
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http://dx.doi.org/10.1093/brain/awt233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784283PMC
October 2013

Tuning local calcium availability: cell-type-specific immobile calcium buffer capacity in hippocampal neurons.

J Neurosci 2013 Sep;33(36):14431-45

Department of Neurosurgery, Experimental Neurophysiology, University Clinic Bonn, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.4118-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618380PMC
September 2013

RIM3γ and RIM4γ are key regulators of neuronal arborization.

J Neurosci 2013 Jan;33(2):824-39

Department of Neuropathology, Department of Epileptology, Laboratory for Experimental Epileptology and Cognition Research, University of Bonn, 53105 Bonn, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.2229-12.2013DOI Listing
January 2013

Tritium-labeled brivaracetam with high specific activity: preparation, characterization and application in human brain samples.

ChemMedChem 2012 Aug 27;7(8):1369-74. Epub 2012 Jun 27.

Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

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http://doi.wiley.com/10.1002/cmdc.201200183
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http://dx.doi.org/10.1002/cmdc.201200183DOI Listing
August 2012

Depression of release by mGluR8 alters Ca2+ dependence of release machinery.

Cereb Cortex 2012 Jul 7;22(7):1498-509. Epub 2011 Sep 7.

Department of Neurosurgery, University Clinic Bonn, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1093/cercor/bhr217DOI Listing
July 2012

Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins.

J Comp Neurol 2011 Oct;519(15):3019-39

Department of Neuropathology, Bonn, Germany.

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http://dx.doi.org/10.1002/cne.22664DOI Listing
October 2011

Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis.

Epilepsia 2010 Dec 13;51(12):2478-83. Epub 2010 Oct 13.

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/j.1528-1167.2010.02741.xDOI Listing
December 2010

RIM proteins and their role in synapse function.

Biol Chem 2010 Jun;391(6):599-606

Department of Epileptology, University of Bonn, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1515/BC.2010.064DOI Listing
June 2010

Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro.

J Neuropathol Exp Neurol 2009 Oct;68(10):1136-46

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, Bonn, Germany.

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http://dx.doi.org/10.1097/NEN.0b013e3181b9a699DOI Listing
October 2009

The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.

Genomics 2009 Mar 13;93(3):243-53. Epub 2008 Dec 13.

Department of Neuropathology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.ygeno.2008.10.007DOI Listing
March 2009

Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain.

J Comp Neurol 2009 Feb;512(4):514-28

Institute of Neuropathology, University of Bonn, 53105 Bonn, Germany.

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http://dx.doi.org/10.1002/cne.21908DOI Listing
February 2009

Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors.

Brain 2008 Nov 26;131(Pt 11):3034-50. Epub 2008 Sep 26.

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1093/brain/awn233DOI Listing
November 2008

Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis.

Epilepsy Res 2008 Jul 28;80(1):93-7. Epub 2008 Apr 28.

Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str. 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.eplepsyres.2008.03.007DOI Listing
July 2008

Structure and evolution of RIM-BP genes: identification of a novel family member.

Gene 2007 Nov 22;403(1-2):70-9. Epub 2007 Aug 22.

Department of Neuropathology and Epileptology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.gene.2007.08.004DOI Listing
November 2007

Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue.

Epilepsia 2007 ;48 Suppl 2:4-12

Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/j.1528-1167.2007.01062.xDOI Listing
July 2007

Deletion of CASK in mice is lethal and impairs synaptic function.

Proc Natl Acad Sci U S A 2007 Feb 7;104(7):2525-30. Epub 2007 Feb 7.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.

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http://dx.doi.org/10.1073/pnas.0611003104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892970PMC
February 2007

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

EMBO J 2006 Dec 23;25(24):5852-63. Epub 2006 Nov 23.

Emmy Noether Research Group, Institute of Neuropathology, Department of Epileptology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601425
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http://dx.doi.org/10.1038/sj.emboj.7601425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698877PMC
December 2006

Molecular organization of the presynaptic active zone.

Cell Tissue Res 2006 Nov 25;326(2):379-91. Epub 2006 Jul 25.

Emmy Noether Research Group, Institute of Neuropathology and Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1007/s00441-006-0244-yDOI Listing
November 2006

Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.

Proc Natl Acad Sci U S A 2005 Jun 20;102(26):9365-70. Epub 2005 Jun 20.

Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0503777102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1166627PMC
June 2005

Synaptobrevin is essential for fast synaptic-vesicle endocytosis.

Nat Cell Biol 2004 Nov 10;6(11):1102-8. Epub 2004 Oct 10.

Center for Basic Neuroscience, Howard Hughes Medical Institute, USA.

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http://dx.doi.org/10.1038/ncb1185DOI Listing
November 2004

Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.

Neuron 2004 Jun;42(6):889-96

Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089662730400326
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http://dx.doi.org/10.1016/j.neuron.2004.05.014DOI Listing
June 2004

Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses.

Cell 2003 Oct;115(1):49-60

Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)00727-xDOI Listing
October 2003

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.

Nature 2002 Jan;415(6869):321-6

The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA.

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http://dx.doi.org/10.1038/415321aDOI Listing
January 2002

RIM1alpha is required for presynaptic long-term potentiation.

Nature 2002 Jan;415(6869):327-30

Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304, USA.

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http://dx.doi.org/10.1038/415327aDOI Listing
January 2002