Susanne Mandrup

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.

Authors:

Lam O Huang Alexander Rauch Eugenia Mazzaferro Michael Preuss Stefania Carobbio Cigdem S Bayrak Nathalie Chami Zhe Wang Ursula M Schick Nancy Yang Yuval Itan Antonio Vidal-Puig Marcel den Hoed Susanne Mandrup Tuomas O Kilpeläinen Ruth J F Loos

Nat Metab 2021 Feb 22;3(2):228-243. Epub 2021 Feb 22.

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA.

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February 2021

An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors.

Authors:

David A Garcia Thomas A Johnson Diego M Presman Gregory Fettweis Kaustubh Wagh Lorenzo Rinaldi Diana A Stavreva Ville Paakinaho Rikke A M Jensen Susanne Mandrup Arpita Upadhyaya Gordon L Hager

Mol Cell 2021 Feb 3. Epub 2021 Feb 3.

Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA. Electronic address:

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February 2021

Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution.

Authors:

Anitta Kinga Sárvári Elvira Laila Van Hauwaert Lasse Kruse Markussen Ellen Gammelmark Ann-Britt Marcher Morten Frendø Ebbesen Ronni Nielsen Jonathan Richard Brewer Jesper Grud Skat Madsen Susanne Mandrup

Cell Metab 2021 Feb 29;33(2):437-453.e5. Epub 2020 Dec 29.

Center for Functional Genomics and Tissue Plasticity, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M 5230, Denmark. Electronic address:

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February 2021

Epidermal Acyl-CoA-binding protein is indispensable for systemic energy homeostasis.

Authors:

Ditte Neess Vibeke Kruse Ann-Britt Marcher Mie Rye Wæde Julie Vistisen Pauline M Møller Rikke Petersen Jonathan R Brewer Tao Ma Georgia Colleluori Ilenia Severi Saverio Cinti Zach Gerhart-Hines Susanne Mandrup Nils J Færgeman

Mol Metab 2021 Feb 18;44:101144. Epub 2020 Dec 18.

Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark. Electronic address:

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February 2021

Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells.

Authors:

Jesper G S Madsen Maria S Madsen Alexander Rauch Sofie Traynor Elvira L Van Hauwaert Anders K Haakonsson Biola M Javierre Mette Hyldahl Peter Fraser Susanne Mandrup

Nat Genet 2020 11 5;52(11):1227-1238. Epub 2020 Oct 5.

Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

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November 2020

Co-Administration of Propionate or Protocatechuic Acid Does Not Affect DHA-Specific Transcriptional Effects on Lipid Metabolism in Cultured Hepatic Cells.

Authors:

Francesca Danesi Bjørk D Larsen Mattia Di Nunzio Ronni Nielsen Dario de Biase Veronica Valli Susanne Mandrup Alessandra Bordoni

Nutrients 2020 Sep 26;12(10). Epub 2020 Sep 26.

Department of Agricultural and Food Sciences (DISTAL), University of Bologna, 47521 Cesena, Italy.

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September 2020

C57BL/6J substrain differences in response to high-fat diet intervention.

Authors:

Majken Storm Siersbæk Nicholas Ditzel Eva Kildall Hejbøl Stine Marie Præstholm Lasse Kruse Markussen Fabio Avolio Lingzi Li Lasse Lehtonen Axel Kornerup Hansen Henrik Daa Schrøder Lukasz Krych Susanne Mandrup Louise Langhorn Peter Bollen Lars Grøntved

Sci Rep 2020 08 20;10(1):14052. Epub 2020 Aug 20.

Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, 5230, Odense M, Denmark.

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August 2020

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress.

Authors:

Thierry Brun Cecilia Jiménez-Sánchez Jesper Grud Skat Madsen Noushin Hadadi Dominique Duhamel Clarissa Bartley Lucie Oberhauser Mirko Trajkovski Susanne Mandrup Pierre Maechler

Int J Mol Sci 2020 Jun 1;21(11). Epub 2020 Jun 1.

Department of Cell Physiology and Metabolism & Faculty Diabetes Center, University of Geneva Medical Center,1206 Geneva, Switzerland.

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June 2020

Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.

Authors:

Mike K Terkelsen Sofie M Bendixen Daniel Hansen Emma A H Scott Andreas F Moeller Ronni Nielsen Susanne Mandrup Anders Schlosser Thomas L Andersen Grith L Sorensen Aleksander Krag Kedar N Natarajan Sönke Detlefsen Henrik Dimke Kim Ravnskjaer

Hepatology 2020 Dec 20;72(6):2119-2133. Epub 2020 Oct 20.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.

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December 2020

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination.

Authors:

Elisabeth Søndergaard Alexander Rauch Magali Michaut Nicolas Rapin Matilda Rehn Anna S Wilhelmson Alessandro Camponeschi Marie S Hasemann Frederik O Bagger Johan Jendholm Kasper J Knudsen Susanne Mandrup Inga-Lill Mårtensson Bo T Porse

Cell Rep 2019 11;29(9):2756-2769.e6

The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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November 2019

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.

Authors:

Stephanie Pearson Anne Loft Prashant Rajbhandari Judith Simcox Sanghoon Lee Peter Tontonoz Susanne Mandrup Claudio J Villanueva

Genes Dev 2019 07 23;33(13-14):747-762. Epub 2019 May 23.

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.

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July 2019

Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets.

Authors:

Christian Wiwie Irina Kuznetsova Ahmed Mostafa Alexander Rauch Anders Haakonsson Inigo Barrio-Hernandez Blagoy Blagoev Susanne Mandrup Harald H H W Schmidt Stephan Pleschka Richard Röttger Jan Baumbach

Syst Med (New Rochelle) 2019 28;2(1):1-9. Epub 2019 Mar 28.

Institute of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.

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March 2019

Author Correction: Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Authors:

Alexander Rauch Anders K Haakonsson Jesper G S Madsen Mette Larsen Isabel Forss Martin R Madsen Elvira L Van Hauwaert Christian Wiwie Naja Z Jespersen Michaela Tencerova Ronni Nielsen Bjørk D Larsen Richard Röttger Jan Baumbach Camilla Scheele Moustapha Kassem Susanne Mandrup

Nat Genet 2019 04;51(4):766

Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

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April 2019

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Authors:

Alexander Rauch Anders K Haakonsson Jesper G S Madsen Mette Larsen Isabel Forss Martin R Madsen Elvira L Van Hauwaert Christian Wiwie Naja Z Jespersen Michaela Tencerova Ronni Nielsen Bjørk D Larsen Richard Röttger Jan Baumbach Camilla Scheele Moustapha Kassem Susanne Mandrup

Nat Genet 2019 04 4;51(4):716-727. Epub 2019 Mar 4.

Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

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April 2019

Transcriptional regulation of Hepatic Stellate Cell activation in NASH.

Authors:

Ann-Britt Marcher Sofie M Bendixen Mike K Terkelsen Sonja S Hohmann Maria H Hansen Bjørk D Larsen Susanne Mandrup Henrik Dimke Sönke Detlefsen Kim Ravnskjaer

Sci Rep 2019 02 20;9(1):2324. Epub 2019 Feb 20.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230, Odense M, Denmark.

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February 2019

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.

Authors:

Adrija Kalvisa Majken S Siersbæk Stine M Præstholm Line J L Christensen Ronni Nielsen Oliver Stohr Sabine Vettorazzi Jan Tuckermann Morris White Susanne Mandrup Lars Grøntved

PLoS Biol 2018 12 10;16(12):e2006249. Epub 2018 Dec 10.

Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense, Denmark.

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December 2018

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.

Cell Metab 2018 Jul 31;28(1):159-174.e11. Epub 2018 May 31.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address:

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July 2018