Publications by authors named "Susanne M A van der Pol"

48Publications

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.

Neurobiol Aging 2020 05 10;89:89-98. Epub 2020 Jan 10.

Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.01.003DOI Listing
May 2020

Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma.

J Neurooncol 2020 Jan 24;146(2):239-246. Epub 2019 Dec 24.

Department of Radiation Oncology, Amsterdam University Medical Centers, Location VUmc & Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s11060-019-03365-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971148PMC
January 2020

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function.

Front Immunol 2019 31;10:1811. Epub 2019 Jul 31.

Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2019.01811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685401PMC
September 2020

Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation.

J Neuroinflammation 2019 Jun 27;16(1):130. Epub 2019 Jun 27.

Department of Molecular Cell Biology and Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, O|2 building, room 11 E 41, PO Box 7057, Amsterdam, 1007MB, Noord-Holland, The Netherlands.

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http://dx.doi.org/10.1186/s12974-019-1522-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598247PMC
June 2019

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology.

Cell Death Dis 2019 01 18;10(2):45. Epub 2019 Jan 18.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, Amsterdam Neuroscience, de Boelelaan 1117, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41419-018-1294-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361981PMC
January 2019

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner.

Brain Behav Immun 2018 03 28;69:48-56. Epub 2017 Dec 28.

Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, VUmc MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2017.12.016DOI Listing
March 2018

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.

J Neuroinflammation 2017 Dec 22;14(1):259. Epub 2017 Dec 22.

Department of Molecular Cell Biology and Immunology, VUmc MS Center Amsterdam, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12974-017-1034-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741931PMC
December 2017

Oxidative Injury and Iron Redistribution Are Pathological Hallmarks of Marmoset Experimental Autoimmune Encephalomyelitis.

J Neuropathol Exp Neurol 2017 Jun;76(6):467-478

From the Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands (JD, NvD, BAH, YSK); Department of Neuroscience, University Medical Center, University of Groningen, Groningen, The Netherlands (JD, BAH, JDL); Medical University of Vienna, Center for Brain Research, Vienna, Austria (JB, HL); Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom (GRC, DJM); and Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands (SMAvdP, JvH).

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http://dx.doi.org/10.1093/jnen/nlx034DOI Listing
June 2017

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

J Neuroinflammation 2017 05 12;14(1):105. Epub 2017 May 12.

Department of Medical Biochemistry, Subdivision of Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12974-017-0875-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427621PMC
May 2017

Protandim Protects Oligodendrocytes against an Oxidative Insult.

Antioxidants (Basel) 2016 Sep 7;5(3). Epub 2016 Sep 7.

Department of Molecular Cell Biology and Immunology, VU University Medical Center, Neuroscience Campus Amsterdam, 1081 HZ Amsterdam, the Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039579PMC
http://dx.doi.org/10.3390/antiox5030030DOI Listing
September 2016

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.

Brain 2016 09 19;139(Pt 9):2406-19. Epub 2016 Jul 19.

1 INSERM, INSERM-U919, Caen Cedex, F-14074 France 2 Universite' de Caen BasseNormandie, Caen Cedex, F-14074 France 3 GIP Cyceron, Caen, F-14074 France

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http://dx.doi.org/10.1093/brain/aww172DOI Listing
September 2016

Protective effects of monomethyl fumarate at the inflamed blood-brain barrier.

Microvasc Res 2016 May 8;105:61-9. Epub 2015 Dec 8.

Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.mvr.2015.12.003DOI Listing
May 2016

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions.

Acta Neuropathol Commun 2015 Dec 4;3:79. Epub 2015 Dec 4.

Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40478-015-0261-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670517PMC
December 2015

Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells.

J Immunol 2016 Jan 23;196(1):72-9. Epub 2015 Nov 23.

Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, the Netherlands;

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http://dx.doi.org/10.4049/jimmunol.1500702DOI Listing
January 2016

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis.

Acta Neuropathol 2014 Nov 23;128(5):691-703. Epub 2014 Aug 23.

Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00401-014-1335-6DOI Listing
November 2014

In vivo MR imaging of intercellular adhesion molecule-1 expression in an animal model of multiple sclerosis.

Contrast Media Mol Imaging 2015 Mar-Apr;10(2):111-21. Epub 2014 Apr 22.

Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Yalelaan 2, 3584 CM, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/cmmi.1602DOI Listing
January 2016

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma.

Acta Neuropathol 2014 May 16;127(5):699-711. Epub 2014 Jan 16.

Blood-Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00401-014-1244-8DOI Listing
May 2014

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.

Acta Neuropathol 2014 Aug 20;128(2):267-77. Epub 2013 Dec 20.

Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00401-013-1227-1DOI Listing
August 2014

Roles for HB-EGF and CD9 in multiple sclerosis.

Glia 2013 Nov 3;61(11):1890-905. Epub 2013 Sep 3.

Department of Anatomy and Neurosciences, Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/glia.22565DOI Listing
November 2013

Nanoclusters of iron oxide: effect of core composition on structure, biocompatibility, and cell labeling efficacy.

Bioconjug Chem 2012 May 3;23(5):941-50. Epub 2012 May 3.

Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht , Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/bc200543kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419767PMC
May 2012

Brain endothelial barrier passage by monocytes is controlled by the endothelin system.

J Neurochem 2012 Jun 12;121(5):730-7. Epub 2011 Aug 12.

Blood-brain barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07393.xDOI Listing
June 2012

Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions.

Free Radic Biol Med 2011 Feb 8;50(3):469-76. Epub 2010 Dec 8.

Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.11.033DOI Listing
February 2011

Dynamics and fate of USPIO in the central nervous system in experimental autoimmune encephalomyelitis.

NMR Biomed 2010 Nov;23(9):1087-96

Image Sciences Institute, University Medical Centre Utrecht, the Netherlands.

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http://dx.doi.org/10.1002/nbm.1536DOI Listing
November 2010

The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier.

J Neurochem 2010 Apr 18;113(2):447-53. Epub 2010 Jan 18.

Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06598.xDOI Listing
April 2010

Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier.

J Immunol 2008 Sep;181(5):3567-74

Neuroimmunology Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.181.5.3567DOI Listing
September 2008

Protective effects of peroxiredoxin-1 at the injured blood-brain barrier.

Free Radic Biol Med 2008 Aug 16;45(3):256-64. Epub 2008 Apr 16.

Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.03.024DOI Listing
August 2008

Comparison of SPIO and USPIO for in vitro labeling of human monocytes: MR detection and cell function.

Radiology 2007 May;243(2):467-74

Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://pubs.rsna.org/doi/10.1148/radiol.2432060120
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http://dx.doi.org/10.1148/radiol.2432060120DOI Listing
May 2007

Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells.

FASEB J 2006 Dec 25;20(14):2550-2. Epub 2006 Oct 25.

Neuroimmunology Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.

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http://www.fasebj.org/doi/10.1096/fj.06-6099fje
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http://dx.doi.org/10.1096/fj.06-6099fjeDOI Listing
December 2006

Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis.

J Exp Med 2004 Dec;200(12):1667-72

Dept. of Molecular Cell Biology and Immunology, VUMC, FdG, PO Box 7057, 1007 MB Amsterdam, Netherlands.

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http://dx.doi.org/10.1084/jem.20040819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212002PMC
December 2004

RhoA activation promotes transendothelial migration of monocytes via ROCK.

J Leukoc Biol 2004 Mar 21;75(3):523-8. Epub 2003 Nov 21.

Department of Molecular Cell Biology, VU Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1189/jlb.0203054DOI Listing
March 2004

Heparan sulfate proteoglycans modulate monocyte migration across cerebral endothelium.

J Neuropathol Exp Neurol 2003 Jul;62(7):780-90

Department of Molecular Cell Biology , Vrije Universiteit Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/jnen/62.7.780DOI Listing
July 2003

Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study.

Biochem Pharmacol 2003 Mar;65(5):877-85

Department of Molecular Cell Biology, VU Medical Centre, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s0006-2952(02)01609-xDOI Listing
March 2003

Interferon-beta directly influences monocyte infiltration into the central nervous system.

J Neuroimmunol 2002 Jun;127(1-2):69-79

Department of Molecular Cell Biology, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s0165-5728(02)00098-xDOI Listing
June 2002