Susanne Krug

Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.

Authors:

Jia-Chen E Hu Christian Bojarski Federica Branchi Michael Fromm Susanne M Krug

Int J Mol Sci 2020 Oct 22;21(21). Epub 2020 Oct 22.

Institute of Clinical Physiology/Nutritional Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.

View Article and Find Full Text PDF

October 2020

Special Issue on "The Tight Junction and Its Proteins: More than Just a Barrier".

Authors:

Susanne M Krug Michael Fromm

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Institute of Clinical Physiology/Nutritional Medicine, Department of Gastroenterology, Rheumatology and Infectious Diseases, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.

View Article and Find Full Text PDF

June 2020

Molecular architecture and assembly of the tight junction backbone.

Authors:

Jörg Piontek Susanne M Krug Jonas Protze Gerd Krause Michael Fromm

Biochim Biophys Acta Biomembr 2020 07 26;1862(7):183279. Epub 2020 Mar 26.

Institute of Clinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology, Rheumatology, Charité - Universitätsmedizin Berlin, 12203 Berlin, Germany. Electronic address:

View Article and Find Full Text PDF

July 2020

Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?

Authors:

Sebastian Kjærgaard Morten M B Damm Joan Chang Lene B Riis Hanne B Rasmussen Rasmus Hytting-Andreasen Susanne M Krug Jörg-Dieter Schulzke Niels Bindslev Mark Berner Hansen

Int J Mol Sci 2020 Mar 10;21(5). Epub 2020 Mar 10.

Digestive Disease Center, Bispebjerg Hospital, 2400 Copenhagen, Denmark.

View Article and Find Full Text PDF

March 2020

Tricellulin Effect on Paracellular Water Transport.

Authors:

Carlos Ayala-Torres Susanne M Krug Jörg D Schulzke Rita Rosenthal Michael Fromm

Int J Mol Sci 2019 Nov 14;20(22). Epub 2019 Nov 14.

Institute of Clinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.

View Article and Find Full Text PDF

November 2019

[Motor fitness of 4- to 10-year-old children in Germany : Results of KiGGS Wave 2 and trends].

Authors:

Susanne Krug Annette Worth Jonas David Finger Stefan Damerow Kristin Manz

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Oct;62(10):1242-1252

Robert Koch-Institut, Nordufer 20, 13353, Berlin, Deutschland.

View Article and Find Full Text PDF

October 2019

Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1.

Authors:

Yosuke Hashimoto Keisuke Tachibana Susanne M Krug Jun Kunisawa Michael Fromm Masuo Kondoh

Int J Mol Sci 2019 Aug 17;20(16). Epub 2019 Aug 17.

Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

View Article and Find Full Text PDF

August 2019

Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells.

Authors:

Junsuke Uwada Takashi Yazawa Hitomi Nakazawa Daisuke Mikami Susanne M Krug Michael Fromm Kiyonao Sada Ikunobu Muramatsu Takanobu Taniguchi

Cell Signal 2019 11 8;63:109358. Epub 2019 Jul 8.

Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa 078-8510, Japan.

View Article and Find Full Text PDF

November 2019

Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2.

Authors:

Rita Rosenthal Dorothee Günzel Jörg Piontek Susanne M Krug Carlos Ayala-Torres Caroline Hempel Dian Theune Michael Fromm

Acta Physiol (Oxf) 2020 01 8;228(1):e13334. Epub 2019 Jul 8.

Department of Gastroenterology, Rheumatology and Infectious Diseases, Institute of Clinical Physiology/Nutritional Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF

January 2020

Associations between Physical Activity and Food Intake among Children and Adolescents: Results of KiGGS Wave 2.

Authors:

Kristin Manz Gert B M Mensink Jonas D Finger Marjolein Haftenberger Anna-Kristin Brettschneider Clarissa Lage Barbosa Susanne Krug Anja Schienkiewitz

Nutrients 2019 May 11;11(5). Epub 2019 May 11.

Department of Epidemiology and Health Monitoring, Robert Koch Institute, 13353 Berlin, Germany.

View Article and Find Full Text PDF

May 2019

Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats.

Authors:

Ann-Kristin Reinhold Shaobing Yang Jeremy Tsung-Chieh Chen Liu Hu Reine-Solange Sauer Susanne M Krug Egle M Mambretti Michael Fromm Alexander Brack Heike L Rittner

Biochim Biophys Acta Mol Basis Dis 2019 06 6;1865(6):1160-1169. Epub 2019 Jan 6.

Dept. of Anesthesiology, University Hospital of Würzburg, 97080 Würzburg, Germany. Electronic address:

View Article and Find Full Text PDF

June 2019

Participation in group-based physical activity programmes for adults in Germany and associated factors: data from a nationwide cohort study.

Authors:

Susanne Jordan Susanne Krug Elena von der Lippe

BMC Public Health 2018 Dec 12;18(1):1371. Epub 2018 Dec 12.

Robert Koch Institute, Department of Epidemiology and Health Monitoring, Box 65 0 61, 13302, Berlin, PO, Germany.

View Article and Find Full Text PDF

December 2018

Predictors of physical activity among older adults in Germany: a nationwide cohort study.

Authors:

Kristin Manz Gert B M Mensink Susanne Jordan Anja Schienkiewitz Susanne Krug Jonas D Finger

BMJ Open 2018 05 9;8(5):e021940. Epub 2018 May 9.

Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.

View Article and Find Full Text PDF

May 2018

Gelatinolytic activity of autocrine matrix metalloproteinase-9 leads to endothelial de-arrangement in Moyamoya disease.

Authors:

Kinga G Blecharz-Lang Vincent Prinz Małgorzata Burek Dietmar Frey Tobias Schenkel Susanne M Krug Michael Fromm Peter Vajkoczy

J Cereb Blood Flow Metab 2018 11 10;38(11):1940-1953. Epub 2018 Apr 10.

1 Department of Experimental Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF

November 2018

Campylobacter fetus impairs barrier function in HT-29/B6 cells through focal tight junction alterations and leaks.

Authors:

Roland Bücker Susanne M Krug Anja Fromm Hans Linde Nielsen Michael Fromm Henrik Nielsen Jörg-Dieter Schulzke

Ann N Y Acad Sci 2017 10 29;1405(1):189-201. Epub 2017 Jun 29.

Department of Gastroenterology, Infectious Diseases and Rheumatology, Institute of Clinical Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF

October 2017

Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.

Authors:

Anja Schuetz Veselina Radusheva Susanne M Krug Udo Heinemann

Ann N Y Acad Sci 2017 10 29;1405(1):147-159. Epub 2017 Jun 29.

Helmholtz Protein Sample Production Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany.

View Article and Find Full Text PDF

October 2017

Trictide, a tricellulin-derived peptide to overcome cellular barriers.

Authors:

Jimmi Cording Basak Arslan Christian Staat Sophie Dithmer Susanne M Krug Anneliese Krüger Philipp Berndt Ramona Günther Lars Winkler Ingolf E Blasig Reiner F Haseloff

Ann N Y Acad Sci 2017 10 20;1405(1):89-101. Epub 2017 Jun 20.

Department of Molecular Physiology and Cell Biology, Leibniz Institute of Molecular Pharmacology, Berlin, Germany.

View Article and Find Full Text PDF

October 2017

Lactoferrin protects against intestinal inflammation and bacteria-induced barrier dysfunction in vitro.

Authors:

Nina A Hering Julia Luettig Susanne M Krug Stephanie Wiegand Gabriele Gross Eric A van Tol Jörg D Schulzke Rita Rosenthal

Ann N Y Acad Sci 2017 10 14;1405(1):177-188. Epub 2017 Jun 14.

Institute of Clinical Physiology, Department of Gastroenterology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF

October 2017

Contribution of the tricellular tight junction to paracellular permeability in leaky and tight epithelia.

Authors:

Susanne M Krug

Ann N Y Acad Sci 2017 06 12;1397(1):219-230. Epub 2017 Jun 12.

Institute of Clinical Physiology, Charité, Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF

June 2017

Tight junctions of the proximal tubule and their channel proteins.

Authors:

Michael Fromm Jörg Piontek Rita Rosenthal Dorothee Günzel Susanne M Krug

Pflugers Arch 2017 Aug 9;469(7-8):877-887. Epub 2017 Jun 9.

Institut für Klinische Physiologie, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

View Article and Find Full Text PDF

August 2017

Mend Your Fences: The Epithelial Barrier and its Relationship With Mucosal Immunity in Inflammatory Bowel Disease.

Authors:

Eva Martini Susanne M Krug Britta Siegmund Markus F Neurath Christoph Becker

Cell Mol Gastroenterol Hepatol 2017 Jul 23;4(1):33-46. Epub 2017 Mar 23.

Medical Clinic 1, Friedrich-Alexander-University, Erlangen, Germany.

View Article and Find Full Text PDF

July 2017

Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.

Authors:

Susanne M Krug Tomohiro Hayaishi Daisuke Iguchi Akihiro Watari Azusa Takahashi Michael Fromm Masahiro Nagahama Hiroyuki Takeda Yoshiaki Okada Tatsuya Sawasaki Takefumi Doi Kiyohito Yagi Masuo Kondoh

J Control Release 2017 08 18;260:1-11. Epub 2017 May 18.

Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan. Electronic address:

View Article and Find Full Text PDF

August 2017

Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK.

Authors:

Junsuke Uwada Takashi Yazawa Md Tariqul Islam Md Rafiqul Islam Khan Susanne M Krug Michael Fromm Shin-Ichiro Karaki Yuichi Suzuki Atsukazu Kuwahara Hatsumi Yoshiki Kiyonao Sada Ikunobu Muramatsu Takanobu Taniguchi

Cell Signal 2017 07 12;35:188-196. Epub 2017 Apr 12.

Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa, Japan. Electronic address:

View Article and Find Full Text PDF

July 2017

[Recommendations for Physical Activity and Sedentary Behaviour for Children and Adolescents: Methods, Database and Rationale].

Authors:

Christine Graf Nina Ferrari Ralph Beneke Wilhelm Bloch Stefanie Eiser Benjamin Koch Wolfgang Lawrenz Susanne Krug Kristin Manz Renate Oberhoffer Günter Stibbe Alexander Woll

Gesundheitswesen 2017 Mar 11;79(S 01):S11-S19. Epub 2017 Apr 11.

Karlsruher Institut für Technologie, Sportwissenschaft, Karlsruhe.

View Article and Find Full Text PDF

March 2017

Myrrh exerts barrier-stabilising and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells.

Authors:

Rita Rosenthal Julia Luettig Nina A Hering Susanne M Krug Uwe Albrecht Michael Fromm Jörg-Dieter Schulzke

Int J Colorectal Dis 2017 May 15;32(5):623-634. Epub 2016 Dec 15.

Department of Gastroenterology, Rheumatology and Infectious Diseases, Section Nutritional Medicine/Clinical Physiology, Charité, Campus Benjamin Franklin, 12200, Berlin, Germany.

View Article and Find Full Text PDF

May 2017

Determinants of organised sports participation patterns during the transition from childhood to adolescence in Germany: results of a nationwide cohort study.

Authors:

Kristin Manz Susanne Krug Anja Schienkiewitz Jonas David Finger

BMC Public Health 2016 09 6;16:939. Epub 2016 Sep 6.

Department of Epidemiology and Health Monitoring, Robert Koch-Institute, PO Box 650261, 13302, Berlin, Germany.

View Article and Find Full Text PDF

September 2016

The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling.

Authors:

Julia Luettig Rita Rosenthal In-Fah M Lee Susanne M Krug Jörg D Schulzke

Mol Nutr Food Res 2016 12 16;60(12):2576-2586. Epub 2016 Sep 16.

Nutritional Medicine and Clinical Physiology, Department of Gastroenterology, Rheumatology and Infectious Diseases, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

View Article and Find Full Text PDF

December 2016