Susanne Arnold

Susanne Arnold

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Susanne Arnold

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Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors.

Invest New Drugs 2019 12 28;37(6):1218-1230. Epub 2019 Feb 28.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, KY, 40536, USA.

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http://link.springer.com/10.1007/s10637-019-00744-0
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http://dx.doi.org/10.1007/s10637-019-00744-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713628PMC
December 2019

Spatiotemporal Analysis of Lung Cancer Histological Types in Kentucky, 1995-2014.

Cancer Control 2019 Jan-Dec;26(1):1073274819845873

8 Department of Internal Medicine, Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1177/1073274819845873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482657PMC
November 2019

Biliary tract large cell neuroendocrine carcinoma: current evidence.

Orphanet J Rare Dis 2019 Nov 21;14(1):266. Epub 2019 Nov 21.

Department of Surgery, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1186/s13023-019-1230-2DOI Listing
November 2019

SDA: a semi-parametric differential abundance analysis method for metabolomics and proteomics data.

BMC Bioinformatics 2019 Oct 17;20(1):501. Epub 2019 Oct 17.

Markey Cancer Center, University of Kentucky, Lexington, 40536, USA.

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http://dx.doi.org/10.1186/s12859-019-3067-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798423PMC
October 2019

Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain.

J Cereb Blood Flow Metab 2019 Sep 9;39(9):1790-1802. Epub 2018 Apr 9.

1 School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, Belfast, UK.

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http://dx.doi.org/10.1177/0271678X18770331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727140PMC
September 2019

Cross-registry neural domain adaptation to extract mutational test results from pathology reports.

J Biomed Inform 2019 Sep 8;97:103267. Epub 2019 Aug 8.

Division of Biomedical Informatics, Dept. of Internal Medicine, University of Kentucky, USA; Computer Science Department, University of Kentucky, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2019.103267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736690PMC
September 2019

Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 Sep 23;10(1):4386. Epub 2019 Sep 23.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-019-12095-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757065PMC
September 2019

Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 515.33 TERT-CLPTM1Ll Region.

J Thorac Oncol 2019 Aug 19;14(8):1360-1369. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833942PMC
August 2019

Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.

Int J Epidemiol 2019 06;48(3):751-766

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/ije/dyy140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659464PMC
June 2019

Outcomes in surgically resectable oropharynx cancer treated with transoral robotic surgery versus definitive chemoradiation.

Am J Otolaryngol 2019 Sep - Oct;40(5):673-677. Epub 2019 Jun 4.

Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, KY, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.amjoto.2019.06.001DOI Listing
June 2019

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.

Cancer Epidemiol Biomarkers Prev 2019 May 30;28(5):935-942. Epub 2019 Jan 30.

Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0356DOI Listing
May 2019

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019

Pharmacogenomic potential in advanced cancer patients.

Am J Health Syst Pharm 2019 Mar;76(7):415-423

University of Kentucky College of Pharmacy, Lexington, KY.

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http://dx.doi.org/10.1093/ajhp/zxy079DOI Listing
March 2019

Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc.

Nat Struct Mol Biol 2019 01 31;26(1):78-83. Epub 2018 Dec 31.

Institute of Structural and Molecular Biology, Birkbeck College, London, UK.

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http://dx.doi.org/10.1038/s41594-018-0172-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330080PMC
January 2019

Integrating a 92-Gene Expression Analysis for the Management of Neuroendocrine Tumors of Unknown Primary

Asian Pac J Cancer Prev 2019 Jan 25;20(1):113-116. Epub 2019 Jan 25.

Department of Internal Medicine, Division of Medical Oncology, University of Kentucky, Lexington, KY, United States. Email:

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http://dx.doi.org/10.31557/APJCP.2019.20.1.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485590PMC
January 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Exosomal lipids for classifying early and late stage non-small cell lung cancer.

Anal Chim Acta 2018 Dec 9;1037:256-264. Epub 2018 Mar 9.

Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183027
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http://dx.doi.org/10.1016/j.aca.2018.02.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582997PMC
December 2018

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity.

Nat Commun 2018 09 25;9(1):3927. Epub 2018 Sep 25.

International Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France.

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http://dx.doi.org/10.1038/s41467-018-05890-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156406PMC
September 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

Global burden of neuroendocrine tumors and changing incidence in Kentucky.

Oncotarget 2018 Apr 10;9(27):19245-19254. Epub 2018 Apr 10.

Markey Cancer Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.18632/oncotarget.24983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922392PMC
April 2018

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.

Carcinogenesis 2018 03;39(3):336-346

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.1093/carcin/bgx113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248554PMC
March 2018

Immune checkpoint inhibitors in large cell neuroendocrine carcinoma: current status.

Oncotarget 2018 Mar 22;9(18):14738-14740. Epub 2018 Feb 22.

Markey Cancer Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.18632/oncotarget.24553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865703PMC
March 2018

Epidemiologic Analysis Along the Mevalonate Pathway Reveals Improved Cancer Survival in Patients Who Receive Statins Alone and in Combination With Bisphosphonates.

JCO Clin Cancer Inform 2017 11;1:1-12

Sherif M. El-Refai, Susan M. Arnold, Esther P. Black, Markos Leggas, and Jeffery C. Talbert, University of Kentucky, Lexington, KY; and Joshua D. Brown, University of Florida, Gainesville, FL.

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http://dx.doi.org/10.1200/CCI.17.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467073PMC
November 2017

Update of a Prospective Study of Stereotactic Body Radiation Therapy for Post-Chemoradiation Residual Disease in Stage II/III Non-Small Cell Lung Cancer.

Int J Radiat Oncol Biol Phys 2017 11 29;99(3):652-659. Epub 2017 Jul 29.

Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.07.036DOI Listing
November 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

Identification and evolutionary analysis of tissue-specific isoforms of mitochondrial complex I subunit NDUFV3.

Biochim Biophys Acta Bioenerg 2017 Mar 15;1858(3):208-217. Epub 2016 Dec 15.

Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2016.12.004DOI Listing
March 2017

The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.

Cell Metab 2017 01 6;25(1):128-139. Epub 2016 Oct 6.

OXPHOS Biogenesis Group, Radboud Center for Mitochondrial Medicine, Department of Pediatrics, Radboud University Medical Center, Geert-Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.002DOI Listing
January 2017

Historical Y. pestis Genomes Reveal the European Black Death as the Source of Ancient and Modern Plague Pandemics.

Cell Host Microbe 2016 Jun;19(6):874-81

Max Planck Institute for the Science of Human History, Jena 07743, Germany; Department of Archeological Sciences, University of Tuebingen, Tuebingen 72070, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.05.012DOI Listing
June 2016

Responsive Hydrogel Nanoparticles for Pulmonary Delivery.

J Drug Deliv Sci Technol 2015 Oct;29:143-151

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.jddst.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553694PMC
October 2015

p16INK4a Status and Response to Induction Low-Dose Fractionated Radiation in Advanced Head and Neck Cancer.

Ann Otol Rhinol Laryngol 2015 Sep 25;124(9):714-20. Epub 2015 Mar 25.

Department of Otolaryngology HNS, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1177/0003489415579220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555599PMC
September 2015

Formulation and characterization of inhalable magnetic nanocomposite microparticles (MnMs) for targeted pulmonary delivery via spray drying.

Int J Pharm 2015 Feb 24;479(2):320-8. Epub 2014 Dec 24.

College of Engineering, Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.12.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818718PMC
February 2015

Autoantibody profiling for lung cancer screening longitudinal retrospective analysis of CT screening cohorts.

PLoS One 2014 3;9(2):e87947. Epub 2014 Feb 3.

Division of Pulmonary and Critical Care Medicine, University of Kentucky, Lexington, Kentucky, United States of America ; Lexington Veteran's Administration Medical Center, Lexington, Kentucky, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912196PMC
October 2014

Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans.

Cancer Chemother Pharmacol 2014 Jul 8;74(1):45-54. Epub 2014 May 8.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Room 323, Lexington, KY, 40536, USA.

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http://dx.doi.org/10.1007/s00280-014-2472-2DOI Listing
July 2014

Microvascular reconstruction after intra-arterial chemotherapy with concomitant radiation.

Otolaryngol Head Neck Surg 2013 Oct 26;149(4):541-6. Epub 2013 Jul 26.

Department of Otolaryngology-Head and Neck Surgery, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1177/0194599813497923DOI Listing
October 2013

Stereotactic body radiation therapy can be used safely to boost residual disease in locally advanced non-small cell lung cancer: a prospective study.

Int J Radiat Oncol Biol Phys 2013 Apr 19;85(5):1325-31. Epub 2012 Dec 19.

Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2012.11.011DOI Listing
April 2013

Cytochrome c oxidase and its role in neurodegeneration and neuroprotection.

Authors:
Susanne Arnold

Adv Exp Med Biol 2012 ;748:305-39

Institute for Neuroanatomy, RWTH Aachen University, Wendlingweg 2, Aachen, Germany.

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http://dx.doi.org/10.1007/978-1-4614-3573-0_13DOI Listing
September 2012

Estrogen and the regulation of mitochondrial structure and function in the brain.

J Steroid Biochem Mol Biol 2012 Aug 2;131(1-2):2-9. Epub 2012 Feb 2.

Institute of Neuroanatomy, RWTH Aachen University,Aachen, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2012.01.012DOI Listing
August 2012

Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients.

Int J Cancer 2012 Jul 20;131(2):E1-9. Epub 2011 Oct 20.

Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1002/ijc.26432DOI Listing
July 2012

A phase I dose escalation study of TTI-237 in patients with advanced malignant solid tumors.

Invest New Drugs 2012 Feb 10;30(1):266-72. Epub 2010 Aug 10.

Department of Internal Medicine, Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1007/s10637-010-9506-3DOI Listing
February 2012

The power of life--cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival.

Authors:
Susanne Arnold

Mitochondrion 2012 Jan 26;12(1):46-56. Epub 2011 May 26.

Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.mito.2011.05.003DOI Listing
January 2012

Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability.

J Neurosci Res 2011 Dec 19;89(12):2068-82. Epub 2011 May 19.

Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

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http://doi.wiley.com/10.1002/jnr.22669
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December 2011

Nuclear protein in testis midline carcinomas: a lethal and underrecognized entity.

Arch Pathol Lab Med 2011 Nov;135(11):1494-8

Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.5858/arpa.2010-0389-CRDOI Listing
November 2011

Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/β-catenin pathway in human colorectal adenocarcinoma DLD1 cells.

Toxicol Appl Pharmacol 2011 Oct 11;256(2):114-21. Epub 2011 Aug 11.

Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.taap.2011.07.016DOI Listing
October 2011

Inducers of chemical hypoxia act in a gender- and brain region-specific manner on primary astrocyte viability and cytochrome C oxidase.

Neurotox Res 2011 Jul 24;20(1):1-14. Epub 2010 Aug 24.

Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.

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http://link.springer.com/10.1007/s12640-010-9213-z
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July 2011

Metabolic pathways of the camptothecin analog AR-67.

Drug Metab Dispos 2011 Apr 28;39(4):683-92. Epub 2010 Dec 28.

Department of Pharmaceutical Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1124/dmd.110.037390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063719PMC
April 2011

Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells.

Mol Cancer Ther 2011 Feb 7;10(2):292-302. Epub 2011 Jan 7.

Department of Radiation Oncology, University of Miami, 1475 NW 12th Ave (D-31), Miami, FL 33136, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0630DOI Listing
February 2011

Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):1178-88. Epub 2010 Apr 20.

Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2010.04.009DOI Listing
January 2011

Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase.

Neurochem Int 2010 Oct 23;57(3):297-305. Epub 2010 Jun 23.

Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, D-52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.neuint.2010.06.008DOI Listing
October 2010

Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression.

Cell Tissue Res 2010 Jul 3;341(1):83-93. Epub 2010 Jul 3.

Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1007/s00441-010-0995-3DOI Listing
July 2010

Gender differences in psychosocial responses to lung cancer.

Gend Med 2010 Apr;7(2):137-48

University of Kentucky, Lexington, 40536-0200, USA.

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http://dx.doi.org/10.1016/j.genm.2010.03.002DOI Listing
April 2010

The relationship between lung cancer patients' educational level and evaluation of their treatment information needs.

J Cancer Educ 2009 ;24(4):346-50

Graduate Center for Gerontology, University of Kentucky, Lexington, KT, USA.

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http://dx.doi.org/10.1080/08858190902876601DOI Listing
January 2010

Human rRNA gene clusters are recombinational hotspots in cancer.

Cancer Res 2009 Dec 17;69(23):9096-104. Epub 2009 Nov 17.

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536-0096, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2680DOI Listing
December 2009

Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes.

Glia 2009 Nov;57(14):1480-91

Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1002/glia.20864DOI Listing
November 2009

A pregnancy wellness guide to enhance care through self-assessment, personal reflection, and self-referral.

J Obstet Gynecol Neonatal Nurs 2009 Mar-Apr;38(2):134-47

Prenatal Community Programs, Alberta Health Services Calgary, AB, Canada.

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http://dx.doi.org/10.1111/j.1552-6909.2009.01008.xDOI Listing
July 2009

Neuroprotection by estrogen in the brain: the mitochondrial compartment as presumed therapeutic target.

J Neurochem 2009 Jul 29;110(1):1-11. Epub 2009 Apr 29.

Institute of Neuroanatomy, RWTH Aachen University, Aachen, Germany.

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http://doi.wiley.com/10.1111/j.1471-4159.2009.06133.x
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July 2009

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones.

J Mol Endocrinol 2008 Nov 27;41(5):289-300. Epub 2008 Aug 27.

Faculty of Medicine, Institute for Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany.

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http://dx.doi.org/10.1677/JME-08-0085DOI Listing
November 2008

Confronting death: perceptions of a good death in adults with lung cancer.

Am J Hosp Palliat Care 2008 Feb-Mar;25(1):39-44. Epub 2007 Dec 26.

University of Kentucky College of Medicine, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1177/1049909107307377DOI Listing
April 2008

Expression of enzymes involved in the prostanoid metabolism by cortical astrocytes after LPS-induced inflammation.

J Mol Neurosci 2008 Feb 3;34(2):177-85. Epub 2008 Jan 3.

Institute of Neuroanatomy, Medical Clinic, RWTH, Aachen, Germany.

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http://link.springer.com/10.1007/s12031-007-9028-4
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http://dx.doi.org/10.1007/s12031-007-9028-4DOI Listing
February 2008

Distress screening in a multidisciplinary lung cancer clinic: prevalence and predictors of clinically significant distress.

Lung Cancer 2007 Feb 3;55(2):215-24. Epub 2006 Nov 3.

Cancer Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven Street, NW, Suite 4100, Washington, DC 20007, USA.

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http://dx.doi.org/10.1016/j.lungcan.2006.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857305PMC
February 2007

Estrogen and the development and protection of nigrostriatal dopaminergic neurons: concerted action of a multitude of signals, protective molecules, and growth factors.

Front Neuroendocrinol 2006 Dec 1;27(4):376-90. Epub 2006 Sep 1.

Institute of Neuroanatomy, University Hospital RWTH Aachen, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.yfrne.2006.07.001DOI Listing
December 2006

Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons.

J Neurochem 2006 Nov 18;99(3):937-51. Epub 2006 Sep 18.

Institute for Neuroanatomy, Faculty of Medicine RWTH Aachen, Aachen, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04134.xDOI Listing
November 2006

Analysis of unknown primary carcinomas metastatic to the neck: diagnosis, treatment, and outcomes.

J Ky Med Assoc 2006 Feb;104(2):57-64

Division of Otolaryngology-HNS, University of Kentucky, Lexington, USA.

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February 2006

Deficient inhibition of return in schizophrenia-further evidence from an independent sample.

Prog Neuropsychopharmacol Biol Psychiatry 2006 Jan 12;30(1):42-9. Epub 2005 Jul 12.

Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany.

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http://dx.doi.org/10.1016/j.pnpbp.2005.06.016DOI Listing
January 2006

Estrogen suppresses the impact of glucose deprivation on astrocytic calcium levels and signaling independently of the nuclear estrogen receptor.

Authors:
Susanne Arnold

Neurobiol Dis 2005 Oct;20(1):82-92

Emmy Noether Research Group Brain Energy Metabolism, Cellular Neurosciences, Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, 13092 Berlin, Germany.

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http://dx.doi.org/10.1016/j.nbd.2005.02.002DOI Listing
October 2005

Long-term results of hyperfractionated radiation and high-dose intraarterial cisplatin for unresectable oropharyngeal carcinoma.

Cancer 2005 Oct;104(8):1765-71

Division of Otolaryngology-Head and Neck Surgery, University of Kentucky Chandler Medical Center, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1002/cncr.21368DOI Listing
October 2005

Comparison of iodixanol with iohexol for delayed pelvic venous opacification: a preliminary study of potential use for CT venography.

AJR Am J Roentgenol 2004 Jul;183(1):123-6

Department of Diagnostic Radiology, University of Kentucky, 800 Rose St., HX 318, Lexington, KY 40536, USA.

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http://dx.doi.org/10.2214/ajr.183.1.1830123DOI Listing
July 2004

The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases.

Biochim Biophys Acta 2004 Apr;1655(1-3):400-8

Fachbereich Chemie, Philipps-Universität, Hans-Meerwein-Strasse, D-35032 Marburg, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2003.06.005DOI Listing
April 2004