Publications by authors named "Susanna M Hofmann"

48Publications

Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice.

Diabetes Obes Metab 2020 Oct 1. Epub 2020 Oct 1.

Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

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http://dx.doi.org/10.1111/dom.14215DOI Listing
October 2020

Glucagon Regulation of Energy Expenditure.

Int J Mol Sci 2019 Oct 30;20(21). Epub 2019 Oct 30.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Centre Munich, Ingolstädter Landstraße 1, 85764 Oberschleißheim, Germany.

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http://dx.doi.org/10.3390/ijms20215407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862306PMC
October 2019

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.

Cell Metab 2019 04 10;29(4):932-949.e4. Epub 2019 Jan 10.

Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447452PMC
April 2019

Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

Mol Metab 2019 02 26;20:28-37. Epub 2018 Nov 26.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.molmet.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358537PMC
February 2019

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.

Nat Rev Endocrinol 2019 02;15(2):90-104

Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

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http://www.nature.com/articles/s41574-018-0118-x
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http://dx.doi.org/10.1038/s41574-018-0118-xDOI Listing
February 2019

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Mol Metab 2018 10 28;16:180-190. Epub 2018 Jun 28.

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany; Center for Innovative Medical Models (CiMM), Department of Veterinary Sciences, LMU Munich, Hackerstr. 27, 85764, Oberschleißheim, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany.

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http://dx.doi.org/10.1016/j.molmet.2018.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157610PMC
October 2018

Animal models of obesity and diabetes mellitus.

Nat Rev Endocrinol 2018 03 19;14(3):140-162. Epub 2018 Jan 19.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nrendo.2017.161DOI Listing
March 2018

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.

Mol Metab 2017 10 19;6(10):1226-1239. Epub 2017 Jul 19.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany.

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http://dx.doi.org/10.1016/j.molmet.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641636PMC
October 2017

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Cell Metab 2017 Oct 21;26(4):620-632.e6. Epub 2017 Sep 21.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Ingolstädter Landstraße, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.023DOI Listing
October 2017

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Mol Metab 2017 05 1;6(5):440-446. Epub 2017 Mar 1.

German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404097PMC
May 2017

Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance.

EBioMedicine 2017 Feb 7;16:204-211. Epub 2017 Jan 7.

Institute for Cardiovascular Prevention (IPEK), LMU Munich, Munich 80336, Germany; Department of Pathology, AMC, 1105 AZ Amsterdam, The Netherlands; DZHK, Partner Site Munich Heart Alliance, Munich 80336, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474437PMC
February 2017

High density lipoprotein and metabolic disease: Potential benefits of restoring its functional properties.

Mol Metab 2016 May 18;5(5):321-327. Epub 2016 Mar 18.

Department of Medicine and Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.molmet.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837296PMC
May 2016

The good, the bad, and the unknown: Fructose and FGF21.

Mol Metab 2015 Jan 14;4(1):1-2. Epub 2014 Nov 14.

Department of Molecular Biosciences, School of Veterinary Medicine University of California, Davis, CA 95616, USA ; Department of Nutrition, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.molmet.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314528PMC
January 2015

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

EMBO Mol Med 2015 Mar;7(3):288-98

Institute for Diabetes and Obesity & Helmholtz Diabetes Center, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), Neuherberg, Germany Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany

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http://dx.doi.org/10.15252/emmm.201404508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364946PMC
March 2015

Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions.

FASEB J 2014 Feb 7;28(2):761-70. Epub 2013 Nov 7.

2Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute for Diabetes and Regeneration Research, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.

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http://www.fasebj.org/doi/10.1096/fj.13-238725
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http://dx.doi.org/10.1096/fj.13-238725DOI Listing
February 2014

High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.

Circulation 2013 Nov 29;128(22):2364-71. Epub 2013 Oct 29.

Diabetes Research Department (IDO and IDR), Helmholtz Zentrum München, German Research Center for Environmental Health, München/Neuherberg, Germany (M.L., M.K., T.O., C.S., S.C., P.T.P., S.M.H.); Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH (M.L., E.D., W.A., O.A.-M., K.M.H., J.W., C.R., J.M., S.S., C.T., R.K., S.M.G., R.A.G.D.S., D.D., W.S.D., S.M.H.); LIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland (M.L.); Energy Metabolism Laboratory ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland (J.M.); Department of Pharmacology and Toxicology, Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, India (C.T.); Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, Paris, France (S.L., J.C., S.M.); Centre National de la Recherche Scientifique, Paris, France (S.L., J.C., S.M.); and Medizinische Klinik, Ludwig Maximilians University, Munich, Germany (S.M.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.001551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957345PMC
November 2013

Caloric restriction chronically impairs metabolic programming in mice.

Diabetes 2012 Nov 10;61(11):2734-42. Epub 2012 Jul 10.

Department of Internal Medicine, Metabolic Diseases Institute, Division of Endocrinology, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.2337/db11-1621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478536PMC
November 2012

Exercise protects against high-fat diet-induced hypothalamic inflammation.

Physiol Behav 2012 Jun 29;106(4):485-90. Epub 2012 Mar 29.

Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/j.physbeh.2012.03.021DOI Listing
June 2012

High-fat-diet exposure induces IgG accumulation in hypothalamic microglia.

Dis Model Mech 2012 Sep 1;5(5):686-90. Epub 2012 Mar 1.

Institute for Diabetes and Obesity, Helmholtz Centre for Health and Environment, Technical University Munich, Munich, Germany.

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http://dx.doi.org/10.1242/dmm.009464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424466PMC
September 2012

Neural regulation of cholesterol metabolism.

Curr Opin Lipidol 2011 Aug;22(4):283-7

Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati. Cincinnati, OH 45237, USA.

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http://dx.doi.org/10.1097/MOL.0b013e328348a459DOI Listing
August 2011

CNS regulation of plasma cholesterol.

Ann Med 2012 Nov 4;44(7):656-63. Epub 2011 Jul 4.

Department of Internal Medicine, Metabolic Diseases Institute & Cincinnati Diabetes and Obesity Centre, Cincinnati, OH 45237, USA.

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http://dx.doi.org/10.3109/07853890.2011.590819DOI Listing
November 2012

Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion.

Gastroenterology 2011 Sep 18;141(3):939-949.e1-4. Epub 2011 May 18.

Metabolic Diseases Institute and Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163733PMC
September 2011

Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice.

J Biol Chem 2011 Apr 22;286(15):13079-87. Epub 2011 Feb 22.

Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA.

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http://dx.doi.org/10.1074/jbc.M111.229369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075654PMC
April 2011

Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice.

Front Endocrinol (Lausanne) 2011 2;2:67. Epub 2011 Nov 2.

Division of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati Cincinnati, OH, USA.

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http://dx.doi.org/10.3389/fendo.2011.00067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355901PMC
August 2012

Dietary sugars: a fat difference.

J Clin Invest 2009 May;119(5):1089-92

Department of Medicine, Obesity Research Center, University of Cincinnati College of Medicine, Ohio, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673865PMC
http://dx.doi.org/10.1172/jci39332DOI Listing
May 2009

Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice.

Diabetes 2008 Jan 3;57(1):5-12. Epub 2007 Oct 3.

Department of Pathology and Laboratory Medicine, Genome Research Institute (ML0507), University of Cincinnati, 2120 E. Galbraith Rd., Cincinnati, OH 45237, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db07-04
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http://dx.doi.org/10.2337/db07-0403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830804PMC
January 2008

Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.

Diabetes 2002 Jul;51(7):2082-9

Brookdale Department of Genetics, Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA.

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http://dx.doi.org/10.2337/diabetes.51.7.2082DOI Listing
July 2002