Publications by authors named "Susanna Chiocca"

57Publications

Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma.

Front Cell Infect Microbiol 2020 8;10:143. Epub 2020 Apr 8.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

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http://dx.doi.org/10.3389/fcimb.2020.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156594PMC
April 2020

Human papillomavirus as a driver of head and neck cancers.

Br J Cancer 2020 02 11;122(3):306-314. Epub 2019 Nov 11.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Via Adamello 16, 20139, Milan, Italy.

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http://dx.doi.org/10.1038/s41416-019-0602-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000688PMC
February 2020

Recent Highlights: Onco Viral Exploitation of the SUMO System.

Curr Issues Mol Biol 2020 18;35:1-16. Epub 2019 Aug 18.

Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.

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http://dx.doi.org/10.21775/cimb.035.001DOI Listing
October 2020

The role of the T-N tract in advanced stage tongue cancer.

Head Neck 2019 08 3;41(8):2756-2767. Epub 2019 Apr 3.

Division of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, Milan, Italy.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25761
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http://dx.doi.org/10.1002/hed.25761DOI Listing
August 2019

Synergistic antitumour activity of HDAC inhibitor SAHA and EGFR inhibitor gefitinib in head and neck cancer: a key role for ΔNp63α.

Br J Cancer 2019 03 15;120(6):658-667. Epub 2019 Feb 15.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Via Adamello 16, 20139, Milan, Italy.

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http://www.nature.com/articles/s41416-019-0394-9
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http://dx.doi.org/10.1038/s41416-019-0394-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461861PMC
March 2019

Human Papilloma Virus and Autophagy.

Int J Mol Sci 2018 Jun 15;19(6). Epub 2018 Jun 15.

Department of Experimental Oncology, European Institute of Oncology, 20139 Milan, Italy.

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http://dx.doi.org/10.3390/ijms19061775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032050PMC
June 2018

Assessing the Role of Paralog-Specific Sumoylation of HDAC1.

Methods Mol Biol 2017 ;1510:329-337

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, Milan, 20139, Italy.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_24DOI Listing
January 2018

Detection of Sumo Modification of Endogenous Histone Deacetylase 2 (HDAC2) in Mammalian Cells.

Methods Mol Biol 2016 ;1436:15-22

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, 20139, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-4939-3667-0_2DOI Listing
December 2017

Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions.

Expert Rev Anti Infect Ther 2016 ;14(5):465-77

d Department of Experimental Oncology , European Institute of Oncology (IEO) , Milan , Italy.

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http://dx.doi.org/10.1586/14787210.2016.1174065DOI Listing
December 2016

SUMOylation regulates p27Kip1 stability and localization in response to TGFβ.

J Mol Cell Biol 2016 Feb 8;8(1):17-30. Epub 2015 Oct 8.

Division of Experimental Oncology 2 Centro di Riferimento Oncologico, National Cancer Institute, Aviano 33081, Italy

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http://dx.doi.org/10.1093/jmcb/mjv056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943672PMC
February 2016

SUMO pathway components as possible cancer biomarkers.

Future Oncol 2015 ;11(11):1599-610

1Department of Experimental Oncology, European Institute of Oncology@ IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.2217/fon.15.41DOI Listing
February 2016

The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections.

Ecancermedicalscience 2015 29;9:534. Epub 2015 Apr 29.

European Institute of Oncology, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.3332/ecancer.2015.534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435752PMC
May 2015

Human papillomavirus in anal squamous cell carcinoma: an angel rather than a devil?

Ecancermedicalscience 2015 29;9:529. Epub 2015 Apr 29.

Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.

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http://dx.doi.org/10.3332/ecancer.2015.529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431401PMC
May 2015

Role of human papillomaviruses in carcinogenesis.

Ecancermedicalscience 2015 29;9:526. Epub 2015 Apr 29.

Infections and Cancer Biology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France.

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http://dx.doi.org/10.3332/ecancer.2015.526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431404PMC
May 2015

PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer: a novel regulation of estrogen receptor expression.

J Mol Cell Biol 2015 Apr 23;7(2):132-42. Epub 2015 Mar 23.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, via Adamello 16, 20139 Milan, Italy

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http://dx.doi.org/10.1093/jmcb/mjv021DOI Listing
April 2015

Expression and in vitro functional analyses of recombinant Gam1 protein.

Protein Expr Purif 2015 Jan 16;105:47-53. Epub 2014 Oct 16.

Department of Chemistry, University of Texas at El Paso, 500 W. University Avenue, El Paso, TX 79968-0519, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400194PMC
January 2015

The chicken adenovirus Gam1 protein, an inhibitor of the sumoylation pathway, partially complements ICP0-null mutant herpes simplex virus 1.

J Virol 2014 May 5;88(10):5873-6. Epub 2014 Mar 5.

MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/JVI.00080-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019079PMC
May 2014

SUMO Ubc9 enzyme as a viral target.

IUBMB Life 2014 Jan 6;66(1):27-33. Epub 2014 Jan 6.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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http://dx.doi.org/10.1002/iub.1240DOI Listing
January 2014

Viral manipulation of cellular protein conjugation pathways: The SUMO lesson.

World J Virol 2013 May;2(2):79-90

Domenico Mattoscio, Chiara V Segré, Susanna Chiocca, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.5501/wjv.v2.i2.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785051PMC
May 2013

BC-box protein domain-related mechanism for VHL protein degradation.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18168-73. Epub 2013 Oct 21.

Department of Experimental Oncology, European Institute of Oncology, 20139 Milan, Italy.

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http://dx.doi.org/10.1073/pnas.1311382110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831490PMC
November 2013

A role for paralog-specific sumoylation in histone deacetylase 1 stability.

J Mol Cell Biol 2013 Dec 25;5(6):416-27. Epub 2013 Sep 25.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, 20139 Milan, Italy.

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http://dx.doi.org/10.1093/jmcb/mjt032DOI Listing
December 2013

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Blood 2013 Apr 25;121(17):3459-68. Epub 2013 Feb 25.

Department of Experimental Oncology at the IFOM-IEO Campus, European Institute of Oncology, via Adamello 16, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2012-10-461988DOI Listing
April 2013

Sumo paralogs: redundancy and divergencies.

Front Biosci (Schol Ed) 2013 Jan 1;5:544-53. Epub 2013 Jan 1.

Department of Experimental Oncology, European Institute of Oncology at the IFOM-IEO Campus, Milan, Italy.

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http://dx.doi.org/10.2741/s388DOI Listing
January 2013

Lifting the threshold between life and death: SUMO and HDAC fine-tune HIPK2 to sense redox status.

Mol Cell 2012 May;46(4):382-3

European Institute of Oncology, Department of Experimental Oncology, IFOM-IEO Campus, Milan, Italy.

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http://dx.doi.org/10.1016/j.molcel.2012.05.010DOI Listing
May 2012

Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.

J Biomed Biotechnol 2011 9;2011:690848. Epub 2010 Dec 9.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1155/2011/690848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004424PMC
April 2011

A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.

J Biol Chem 2010 Dec 14;285(52):41062-73. Epub 2010 Oct 14.

Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, A-1030 Vienna, Austria.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.184481
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http://dx.doi.org/10.1074/jbc.M110.184481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003405PMC
December 2010

Listeria monocytogenes: a bacterial pathogen to hit on the SUMO pathway.

Cell Res 2010 Jul 8;20(7):738-40. Epub 2010 Jun 8.

European Institute of Oncology, Department of Experimental Oncology, Milan, Italy.

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http://dx.doi.org/10.1038/cr.2010.76DOI Listing
July 2010

The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.

Mol Cell Biol 2010 Mar 22;30(5):1171-81. Epub 2009 Dec 22.

Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna Biocenter, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria.

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http://dx.doi.org/10.1128/MCB.01500-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820891PMC
March 2010

Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

Mol Biol Cell 2009 Dec 30;20(23):4976-84. Epub 2009 Sep 30.

Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Université Joseph Fourier, F-38706 Grenoble, France.

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http://dx.doi.org/10.1091/mbc.e09-04-0295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785740PMC
December 2009

Inhibition of the SUMO pathway by Gam1.

Methods Mol Biol 2009 ;497:285-301

FIRC Institute of Molecular Oncology, European Institute of Oncology (IFOM-IEO), Milan, Italy.

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http://dx.doi.org/10.1007/978-1-59745-566-4_19DOI Listing
February 2009

The polycomb repressive complex 2 is a potential target of SUMO modifications.

PLoS One 2008 Jul 16;3(7):e2704. Epub 2008 Jul 16.

Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002704PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442188PMC
July 2008

Nuclear ubiquitin ligases, NF-kappaB degradation, and the control of inflammation.

Sci Signal 2008 Jan 8;1(1):pe1. Epub 2008 Jan 8.

Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1126/stke.11pe1DOI Listing
January 2008

Gam1-associated alterations of drug responsiveness through activation of apoptosis.

Mol Cancer Ther 2007 Jun;6(6):1823-30

Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0771DOI Listing
June 2007

Role for histone deacetylase 1 in human tumor cell proliferation.

Mol Cell Biol 2007 Jul 30;27(13):4784-95. Epub 2007 Apr 30.

European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milan, Italy.

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http://dx.doi.org/10.1128/MCB.00494-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951481PMC
July 2007

Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation.

J Biol Chem 2007 May 28;282(21):15376-82. Epub 2007 Mar 28.

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

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http://dx.doi.org/10.1074/jbc.M700889200DOI Listing
May 2007

Negative and positive regulation of gene expression by mouse histone deacetylase 1.

Mol Cell Biol 2006 Nov 28;26(21):7913-28. Epub 2006 Aug 28.

Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A-1030 Vienna, Austria.

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http://dx.doi.org/10.1128/MCB.01220-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636735PMC
November 2006

Viruses and sumoylation: recent highlights.

Curr Opin Microbiol 2006 Aug 3;9(4):430-6. Epub 2006 Jul 3.

European Institute of Oncology, Department of Experimental Oncology, Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S136952740600091
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http://dx.doi.org/10.1016/j.mib.2006.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108358PMC
August 2006

Sumoylation induced by the Arf tumor suppressor: a p53-independent function.

Proc Natl Acad Sci U S A 2005 May 16;102(21):7689-94. Epub 2005 May 16.

Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0502978102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129025PMC
May 2005

Gam1 and the SUMO pathway.

Cell Cycle 2005 Apr 15;4(4):533-5. Epub 2005 Apr 15.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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http://dx.doi.org/10.4161/cc.4.4.1605DOI Listing
April 2005

A mechanism for inhibiting the SUMO pathway.

Mol Cell 2004 Nov;16(4):549-61

European Institute of Oncology, Department of Experimental Oncology, 20141 Milan, Italy.

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http://dx.doi.org/10.1016/j.molcel.2004.11.007DOI Listing
November 2004

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.

Oncogene 2003 May;22(17):2541-7

Department of Experimental Oncology, European Institute of Oncology, via Ripamonti, 435, 20141 Milan, Italy.

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http://dx.doi.org/10.1038/sj.onc.1206379DOI Listing
May 2003

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

EMBO Rep 2002 Nov 22;3(11):1062-8. Epub 2002 Oct 22.

European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milan, Italy.

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http://dx.doi.org/10.1093/embo-reports/kvf213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307602PMC
November 2002

Histone deacetylase 1 inactivation by an adenovirus early gene product.

Curr Biol 2002 Apr;12(7):594-8

Department of Experimental Oncology, European Institute of Oncology, 20141, Milan, Italy.

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http://dx.doi.org/10.1016/s0960-9822(02)00720-0DOI Listing
April 2002