Susana Gonzalo

Susana Gonzalo

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Susana Gonzalo

Susana Gonzalo

Publications by authors named "Susana Gonzalo"

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Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and Bedside.

Subcell Biochem 2019;91:435-451

Edward A. Doisy Department of Biochemistry and Molecular Biology, Doisy Research Center, St Louis University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/978-981-13-3681-2_15DOI Listing
June 2019

Genomic instability and innate immune responses to self-DNA in progeria.

Geroscience 2019 06 6;41(3):255-266. Epub 2019 Jul 6.

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1100 S Grand Ave, St. Louis, MO, 63104, USA.

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http://dx.doi.org/10.1007/s11357-019-00082-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702534PMC
June 2019

Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet.

Aging Cell 2019 Feb 12;18(1):e12852. Epub 2018 Dec 12.

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/acel.12852
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http://dx.doi.org/10.1111/acel.12852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351834PMC
February 2019

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.

Cell Rep 2018 02;22(8):2006-2015

Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, MO 63104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848491PMC
February 2018

Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response.

Nucleus 2018 01;9(1):258-275

a Edward A. Doisy Department of Biochemistry and Molecular Biology , Saint Louis University School of Medicine , St. Louis , MO , USA.

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http://dx.doi.org/10.1080/19491034.2018.1454168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973265PMC
January 2018

Methods to Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina.

Methods Mol Biol 2016 ;1411:419-37

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St. Louis, MO, 63104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044759PMC
http://dx.doi.org/10.1007/978-1-4939-3530-7_26DOI Listing
December 2017

Mechanisms of oncogene-induced genomic instability.

Biophys Chem 2017 06 24;225:49-57. Epub 2016 Nov 24.

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bpc.2016.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526326PMC
June 2017

Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.

Ageing Res Rev 2017 Jan 29;33:18-29. Epub 2016 Jun 29.

Andalusian Center for Developmental Biology (CABD), CSIC/Junta de Andalucia/Universidad Pablo de Olavide, Carretera de Utrera, Km 1, 41013 Seville, Spain.

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http://dx.doi.org/10.1016/j.arr.2016.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195863PMC
January 2017

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes.

Oncotarget 2016 May;7(21):30018-31

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.18632/oncotarget.9065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058660PMC
May 2016

The nuclear lamina in health and disease.

Nucleus 2016 May 9;7(3):233-48. Epub 2016 May 9.

a Andalusian Center for Developmental Biology (CABD) , CSIC/Junta de Andalucia/Universidad Pablo de Olavide , Seville , Spain.

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http://dx.doi.org/10.1080/19491034.2016.1183848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991244PMC
May 2016

Tying up loose ends: telomeres, genomic instability and lamins.

Curr Opin Genet Dev 2016 04 21;37:109-118. Epub 2016 Mar 21.

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, 1100 South Grand Blvd., St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/j.gde.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914467PMC
April 2016

DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.

Curr Opin Cell Biol 2015 Jun 12;34:75-83. Epub 2015 Jun 12.

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/j.ceb.2015.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522337PMC
June 2015

Novel roles of 1α,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment.

Authors:
Susana Gonzalo

J Steroid Biochem Mol Biol 2014 Oct 27;144 Pt A:59-64. Epub 2013 Sep 27.

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St. Louis, MO 63104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2013.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968232PMC
October 2014

DNA damage and lamins.

Authors:
Susana Gonzalo

Adv Exp Med Biol 2014 ;773:377-99

Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1100 S Grand Ave, St. Louis, MO, 63104, USA,

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http://dx.doi.org/10.1007/978-1-4899-8032-8_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081481PMC
September 2014

Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability.

Nucleus 2013 Sep-Oct;4(5):410-9. Epub 2013 Oct 23.

Edward A Doisy Department of Biochemistry and Molecular Biology; School of Medicine; St Louis University; St Louis, MO USA; Departments of Radiation Oncology and Cell Biology & Physiology; School of Medicine; Washington University; St Louis, MO USA; Buck Institute for Research on Aging; Novato, CA USA; Institute of Medical Biology; Biopolis; Singapore.

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http://dx.doi.org/10.4161/nucl.26873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899131PMC
August 2014

Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.

Cell Cycle 2013 Dec 2;12(23):3629-39. Epub 2013 Oct 2.

Edward A. Doisy Department of Biochemistry and Molecular Biology; St Louis University School of Medicine; St. Louis, MO USA.

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http://dx.doi.org/10.4161/cc.26582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903714PMC
December 2013

The two faces of DNA repair: disease and therapy.

Mo Med 2013 Jul-Aug;110(4):314-9

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965295PMC
October 2013

Nurturing the genome: A-type lamins preserve genomic stability.

Nucleus 2010 Mar-Apr;1(2):129-35. Epub 2009 Nov 29.

Radiation and Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.4161/nucl.1.2.10797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030686PMC
January 2012

Regulating the levels of key factors in cell cycle and DNA repair: new pathways revealed by lamins.

Cell Cycle 2011 Nov 1;10(21):3652-7. Epub 2011 Nov 1.

Department of Radiation Oncology, Radiation and Cancer Biology Division, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.4161/cc.10.21.18201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918970PMC
November 2011

A dual role for A-type lamins in DNA double-strand break repair.

Cell Cycle 2011 Aug 1;10(15):2549-60. Epub 2011 Aug 1.

Radiation and Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180193PMC
http://dx.doi.org/10.4161/cc.10.15.16531DOI Listing
August 2011

A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.

EMBO J 2011 Jul 12;30(16):3383-96. Epub 2011 Jul 12.

Radiation and Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1038/emboj.2011.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160650PMC
July 2011

The mTOR inhibitor rapamycin suppresses DNA double-strand break repair.

Radiat Res 2011 Feb 26;175(2):214-24. Epub 2010 Oct 26.

Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Blvd., St. Louis, MO 63108, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412148PMC
http://dx.doi.org/10.1667/rr2323.1DOI Listing
February 2011

Epigenetic alterations in aging.

Authors:
Susana Gonzalo

J Appl Physiol (1985) 2010 Aug 6;109(2):586-97. Epub 2010 May 6.

Radiation and Cancer Biology Division, Dept. of Radiation Oncology, Washington Univ. School of Medicine, 4511 Forest Park, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1152/japplphysiol.00238.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928596PMC
August 2010

The role of RPA2 phosphorylation in homologous recombination in response to replication arrest.

Carcinogenesis 2010 Jun 3;31(6):994-1002. Epub 2010 Feb 3.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1093/carcin/bgq035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916738PMC
June 2010

Loss of A-type lamins and genomic instability.

Cell Cycle 2009 Dec 15;8(23):3860-5. Epub 2009 Dec 15.

Radiation and Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.4161/cc.8.23.10092DOI Listing
December 2009

Telomere recombination requires the MUS81 endonuclease.

Nat Cell Biol 2009 May 12;11(5):616-23. Epub 2009 Apr 12.

Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1038/ncb1867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675667PMC
May 2009

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.

PLoS Genet 2008 Sep 12;4(9):e1000190. Epub 2008 Sep 12.

Epigenetics Program, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527135PMC
September 2008

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

Nat Struct Mol Biol 2008 Mar 2;15(3):268-79. Epub 2008 Mar 2.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), 3 Melchor Fernández Almagro, Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/nsmb.1399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990406PMC
March 2008

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.

J Cell Biol 2007 Sep;178(6):925-36

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Madrid, Spain.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200703081
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http://dx.doi.org/10.1083/jcb.200703081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064618PMC
September 2007

DNA methyltransferases control telomere length and telomere recombination in mammalian cells.

Nat Cell Biol 2006 Apr 26;8(4):416-24. Epub 2006 Mar 26.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/ncb1386DOI Listing
April 2006

Role of Rb family in the epigenetic definition of chromatin.

Cell Cycle 2005 Jun 8;4(6):752-5. Epub 2005 Jun 8.

Spanish National Cancer Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.4161/cc.4.6.1720DOI Listing
June 2005

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.

Nat Cell Biol 2005 Apr 6;7(4):420-8. Epub 2005 Mar 6.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid E-28029, SPAIN.

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http://www.nature.com/articles/ncb1235
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http://dx.doi.org/10.1038/ncb1235DOI Listing
April 2005

A role for the Rb family of proteins in controlling telomere length.

Nat Genet 2002 Nov 15;32(3):415-9. Epub 2002 Oct 15.

Department of Immunology and Oncology, National Center of Biotechnology, E-28049 Madrid, Spain.

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http://dx.doi.org/10.1038/ng1011DOI Listing
November 2002