Susan Wallace

Susan Wallace

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The lyase activity of bifunctional DNA glycosylases and the 3'-diesterase activity of APE1 contribute to the repair of oxidized bases in nucleosomes.

Nucleic Acids Res 2019 04;47(6):2922-2931

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1093/nar/gky1315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451105PMC
April 2019

Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant.

Nucleic Acids Res 2019 04;47(6):3058-3071

Department of Microbiology and Molecular Genetics, Robert Larner College of Medicine and College of Agriculture and Life Sciences, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1093/nar/gkz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451117PMC
April 2019

Base Excision Repair Variants in Cancer.

Methods Enzymol 2017 5;591:119-157. Epub 2017 May 5.

The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT, United States; Yale University School of Medicine, New Haven, CT, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859333PMC
April 2018

The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation.

Oncotarget 2017 Oct 8;8(49):85883-85895. Epub 2017 Sep 8.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT, 05405, USA.

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http://dx.doi.org/10.18632/oncotarget.20716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689654PMC
October 2017

NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis.

Cell Rep 2017 Aug;20(9):2044-2056

Department of Microbiology and Molecular Genetics, College of Medicine and College of Agriculture and Life Sciences, University of Vermont, Burlington, VT 05405, USA; Graduate Program in Cell and Molecular Biology, University of Vermont, Burlington, VT 05405, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606162PMC
August 2017

Hide and seek: How do DNA glycosylases locate oxidatively damaged DNA bases amidst a sea of undamaged bases?

Free Radic Biol Med 2017 06 16;107:170-178. Epub 2016 Nov 16.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, 95 Carrigan Drive, Burlington, VT 05405, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433924PMC
June 2017

Probing the activity of NTHL1 orthologs by targeting conserved amino acid residues.

DNA Repair (Amst) 2017 05 6;53:43-51. Epub 2017 Mar 6.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421317PMC
May 2017

Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase.

Nucleic Acids Res 2017 03;45(5):2897-2909

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1093/nar/gkw1282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389659PMC
March 2017

The Human Ligase IIIα-XRCC1 Protein Complex Performs DNA Nick Repair after Transient Unwrapping of Nucleosomal DNA.

J Biol Chem 2017 Mar 8;292(13):5227-5238. Epub 2017 Feb 8.

From the Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405 and

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http://dx.doi.org/10.1074/jbc.M116.736728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392670PMC
March 2017

Visualizing the Search for Radiation-damaged DNA Bases in Real Time.

Radiat Phys Chem Oxf Engl 1993 2016 Nov 13;128:126-133. Epub 2016 May 13.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, 95 Carrigan Drive, Burlington, Vermont, 05405, USA.

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http://dx.doi.org/10.1016/j.radphyschem.2016.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091662PMC
November 2016

A decision tool to guide the ethics review of a challenging breed of emerging genomic projects.

Eur J Hum Genet 2016 08 20;24(8):1099-103. Epub 2016 Jan 20.

Centre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/ejhg.2015.279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970692PMC
August 2016

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.

PLoS Genet 2016 08 11;12(8):e1006208. Epub 2016 Aug 11.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, Vermont, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981402PMC
August 2016

What Does Anonymization Mean? DataSHIELD and the Need for Consensus on Anonymization Terminology.

Authors:
Susan E Wallace

Biopreserv Biobank 2016 Jun 24;14(3):224-30. Epub 2016 May 24.

Department of Health Sciences, University of Leicester , Centre for Medicine, Leicester, United Kingdom .

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http://dx.doi.org/10.1089/bio.2015.0119DOI Listing
June 2016

Compare and contrast: a cross-national study across UK, USA and Greek experts regarding return of incidental findings from clinical sequencing.

Eur J Hum Genet 2016 Mar 10;24(3):344-9. Epub 2015 Jun 10.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ejhg.2015.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755374PMC
March 2016

Family tree and ancestry inference: is there a need for a 'generational' consent?

BMC Med Ethics 2015 Dec 9;16(1):87. Epub 2015 Dec 9.

Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.

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http://dx.doi.org/10.1186/s12910-015-0080-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673846PMC
December 2015

"Praising What Is Lost. . .

Radiat Res 2015 Dec;184(6):563-4

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December 2015

Preventing Newborn Falls While Supporting Family Bonding.

Authors:
Susan C Wallace

Am J Nurs 2015 Nov;115(11):58-61

Susan C. Wallace is a patient safety analyst at the Pennsylvania Patient Safety Authority in Harrisburg, PA. This article is adapted from "Balancing Family Bonding with Newborn Safety," which appeared in a publication of the Pennsylvania Patient Safety Authority: Pennsylvania Patient Safety Advisory 2014;11(3):102-8. Contact author: The author has disclosed no potential conflicts of interest, financial or otherwise.

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http://pdfs.journals.lww.com/ajnonline/2015/11000/Preventing
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http://dx.doi.org/10.1097/01.NAJ.0000473316.09949.1fDOI Listing
November 2015

Data Safe Havens in health research and healthcare.

Bioinformatics 2015 Oct 25;31(20):3241-8. Epub 2015 Jun 25.

Public Population Project in Genomics and Society (PG), Montreal, QC H3A 0G1, Canada, Centre of Genomics and Policy, McGill University, Montreal, QC H3A 0G1, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btv279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595892PMC
October 2015

Misplacements of Enteral Feeding Tubes Increase After Hospitals Switch Brands.

Am J Nurs 2015 Aug;115(8):44-6

Susan C. Wallace is a patient safety analyst and Lea Anne Gardner is a senior patient safety analyst at the Pennsylvania Patient Safety Authority in Plymouth Meeting, PA. This article is adapted from "Training Suggested When Changing Brands of Enteral Feeding Tubes," which appeared in a publication of the Pennsylvania Patient Safety Authority: Pennsylvania Patient Safety Advisory 2014;11(2):78-81. Contact author: Susan C. Wallace, The authors have disclosed no potential conflicts of interest, financial or otherwise.

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http://dx.doi.org/10.1097/01.NAJ.0000470401.28683.deDOI Listing
August 2015

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?

ACS Cent Sci 2015 Aug 6;1(5):226-233. Epub 2015 Jul 6.

Department of Chemistry, University of Utah , Salt Lake City, Utah 84112, United States.

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http://dx.doi.org/10.1021/acscentsci.5b00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571166PMC
August 2015

DataSHIELD: an ethically robust solution to multiple-site individual-level data analysis.

Public Health Genomics 2015 13;18(2):87-96. Epub 2014 Dec 13.

Division of Epidemiology, Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.1159/000368959DOI Listing
July 2015

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures.

Nucleic Acids Res 2015 Apr 26;43(8):4039-54. Epub 2015 Mar 26.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA

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http://dx.doi.org/10.1093/nar/gkv252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417164PMC
April 2015

Protecting personal data in epidemiological research: DataSHIELD and UK law.

Public Health Genomics 2014 28;17(3):149-57. Epub 2014 Mar 28.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1159/000360255DOI Listing
February 2015

"I don't mind damaging my own body" a qualitative study of the factors that motivate smokers to quit.

BMC Public Health 2015 Jan 21;15. Epub 2015 Jan 21.

Department of Health Sciences, The University of Leicester, Adrian Building, University Road, LE1 7RH Leicester, UK.

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http://dx.doi.org/10.1186/1471-2458-15-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324408PMC
January 2015

DataSHIELD: taking the analysis to the data, not the data to the analysis.

Int J Epidemiol 2014 Dec 26;43(6):1929-44. Epub 2014 Sep 26.

School of Social and Community Medicine, University of Bristol, Bristol, UK, Maelstrom Research Group, Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada, Norwegian Institute of Public Health, Oslo, Norway, Department Statistical Science, University College London, London, UK, Department of Infection, Immunity and Inflammation, Health Sciences, University of Leicester, Leicester, UK, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland, Department of Health Sciences, University of Leicester, Leicester, UK, Department of Sociology, University of Leicester, Leicester, UK, Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands, Institut für Community Medicine, University Medicine of Greifswald, Greifswald, Germany, International Prevention Research Institute, Lyon, France, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia, School of Geosciences, University of Edinburgh, Edinburgh, UK, Norwegian University of Science and Technology, Levanger, Norway, HRB Centre for Diet and Health Research, Department of Epidemiology and Public Health, University College Cork, Cork, Ireland, Research Unit of Molecular Epidemiology, Research Center for Environmental Health, Neuherberg, Germany, MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK, University of Tartu, Estonian Genome Center, Tartu, Estonia, University Medical Center Groningen, Medical Statistics, Groningen, The Netherlands, Centre of Genomics and Policy, McGill University, Montreal, Canada, University Medical Center Groningen, LifeLines Cohort Study, Groningen, The Netherlands, Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands, School of Social and Community Medicine, University of Bristol, Bristol, UK and Onta

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http://dx.doi.org/10.1093/ije/dyu188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276062PMC
December 2014

Insights into the glycosylase search for damage from single-molecule fluorescence microscopy.

DNA Repair (Amst) 2014 Aug 20;20:23-31. Epub 2014 Feb 20.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, 95 Carrigan Drive, Stafford Hall, Burlington, VT 05405-0084, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112009PMC
August 2014

Returning findings within longitudinal cohort studies: the 1958 birth cohort as an exemplar.

Emerg Themes Epidemiol 2014 4;11:10. Epub 2014 Aug 4.

Director of Cohorts and Longitudinal Studies Enhancement Resources (CLOSER), Centre for Longitudinal Studies, Institute of Education, London, UK.

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http://dx.doi.org/10.1186/1742-7622-11-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131774PMC
August 2014

Base excision repair: a critical player in many games.

Authors:
Susan S Wallace

DNA Repair (Amst) 2014 Jul 26;19:14-26. Epub 2014 Apr 26.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, 95 Carrigan Drive, Stafford Hall, Burlington, VT 05405-0084, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100245PMC
July 2014

Nucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damages.

J Biol Chem 2014 Jul 2;289(29):19881-93. Epub 2014 Jun 2.

From the Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405

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http://dx.doi.org/10.1074/jbc.M114.571588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106309PMC
July 2014

Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases.

Proc Natl Acad Sci U S A 2014 May 5;111(20):E2091-9. Epub 2014 May 5.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, Burlington, VT 05405-0084

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http://dx.doi.org/10.1073/pnas.1400386111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034194PMC
May 2014

Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.

DNA Repair (Amst) 2014 Feb 29;14:17-26. Epub 2013 Dec 29.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864130029
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http://dx.doi.org/10.1016/j.dnarep.2013.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926126PMC
February 2014

Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases.

DNA Repair (Amst) 2013 Dec 10;12(12):1062-71. Epub 2013 Oct 10.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, United States.

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http://dx.doi.org/10.1016/j.dnarep.2013.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856876PMC
December 2013

DNA glycosylases search for and remove oxidized DNA bases.

Authors:
Susan S Wallace

Environ Mol Mutagen 2013 Dec 7;54(9):691-704. Epub 2013 Oct 7.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, Vermont.

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http://dx.doi.org/10.1002/em.21820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997179PMC
December 2013

Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes.

DNA Repair (Amst) 2013 Nov 17;12(11):964-71. Epub 2013 Sep 17.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.dnarep.2013.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877670PMC
November 2013

The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage.

Prog Mol Biol Transl Sci 2012 ;110:71-91

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, Vermont, USA.

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http://dx.doi.org/10.1016/B978-0-12-387665-2.00004-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101889PMC
September 2013

Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.

Mutat Res 2013 Mar-Apr;743-744:4-11. Epub 2012 Dec 26.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405-0086, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2012.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657305PMC
September 2013

Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context.

J Biol Chem 2013 Sep 7;288(38):27263-72. Epub 2013 Aug 7.

From the Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, Burlington, Vermont 05405-0068 and.

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http://dx.doi.org/10.1074/jbc.M113.479055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779722PMC
September 2013

Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation.

Proc Natl Acad Sci U S A 2013 Aug 12;110(35):14314-9. Epub 2013 Aug 12.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405-0068, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1306752110
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http://dx.doi.org/10.1073/pnas.1306752110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761600PMC
August 2013

Personal reflections of a woman scientist growing up in a man’s world.

Authors:
Susan S Wallace

DNA Repair (Amst) 2013 May;12(5):313-25

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, 95 Carrigan Drive, Stafford Hall, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1016/j.dnarep.2013.01.007DOI Listing
May 2013

Rules of engagement for base excision repair in chromatin.

J Cell Physiol 2013 Feb;228(2):258-66

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1002/jcp.24134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468691PMC
February 2013

Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA.

Structure 2013 Feb 9;21(2):247-56. Epub 2013 Jan 9.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1016/j.str.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856655PMC
February 2013

Base excision repair and cancer.

Cancer Lett 2012 Dec 15;327(1-2):73-89. Epub 2012 Jan 15.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, 05405-0068, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835120002
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http://dx.doi.org/10.1016/j.canlet.2011.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361536PMC
December 2012

Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.

DNA Repair (Amst) 2012 Sep 11;11(9):714-25. Epub 2012 Jul 11.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1016/j.dnarep.2012.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419285PMC
September 2012

Expression and purification of active mouse and human NEIL3 proteins.

Protein Expr Purif 2012 Jul 5;84(1):130-9. Epub 2012 May 5.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Dr. Burlington, VT 05405-0086, USA.

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http://dx.doi.org/10.1016/j.pep.2012.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378769PMC
July 2012

The needle in the haystack: international consortia and the return of individual research results.

Authors:
Susan E Wallace

J Law Med Ethics 2011 ;39(4):631-9

Population and Public Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/j.1748-720X.2011.00630.xDOI Listing
March 2012

Using shifts in amino acid frequency and substitution rate to identify latent structural characters in base-excision repair enzymes.

PLoS One 2011 6;6(10):e25246. Epub 2011 Oct 6.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025246PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188539PMC
February 2012

Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.

J Biol Chem 2012 Feb 14;287(6):4288-98. Epub 2011 Dec 14.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.315309
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http://dx.doi.org/10.1074/jbc.M111.315309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281731PMC
February 2012

Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair.

Mol Cell Biol 2011 Nov 19;31(22):4623-32. Epub 2011 Sep 19.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1128/MCB.05715-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209256PMC
November 2011

The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site.

Biochemistry 2011 Nov 3;50(47):10350-8. Epub 2011 Nov 3.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, United States.

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http://pubs.acs.org/doi/abs/10.1021/bi201219s
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http://dx.doi.org/10.1021/bi201219sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280588PMC
November 2011

Population biobanks and returning individual research results: mission impossible or new directions?

Hum Genet 2011 Sep 5;130(3):393-401. Epub 2011 Jun 5.

Department of Health Sciences, University of Leicester, 212a Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1007/s00439-011-1021-xDOI Listing
September 2011

Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA.

Nucleic Acids Res 2011 Sep 11;39(17):7487-98. Epub 2011 Jun 11.

The Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1093/nar/gkr459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177204PMC
September 2011

DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions.

Curr Opin Struct Biol 2011 Jun 7;21(3):358-69. Epub 2011 Apr 7.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.

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June 2011

Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

J Mol Biol 2011 Jan 2;405(3):642-52. Epub 2010 Nov 2.

Department of Microbiology and Molecular Genetics, University of Vermont, 95 Carrigan Drive, Burlington, VT 05405, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025778PMC
January 2011

Variant base excision repair proteins: contributors to genomic instability.

Semin Cancer Biol 2010 Oct 16;20(5):320-8. Epub 2010 Oct 16.

Department of Therapeutic Radiology, 15 York Street, New Haven, CT 06510, United States.

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October 2010

International network of cancer genome projects.

Authors:
Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili Montserrat Marcos González-Díaz Xose S Puente Pedro Jares Alfonso Valencia Heinz Himmelbauer Heinz Himmelbaue Victor Quesada Silvia Bea Michael R Stratton P Andrew Futreal Peter J Campbell Anne Vincent-Salomon Andrea L Richardson Jorge S Reis-Filho Marc van de Vijver Gilles Thomas Jocelyne D Masson-Jacquemier Samuel Aparicio Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Hendrik G Stunnenberg Laura van't Veer Douglas F Easton Paul T Spellman Sancha Martin Anna D Barker Lynda Chin Francis S Collins Carolyn C Compton Martin L Ferguson Daniela S Gerhard Gad Getz Chris Gunter Alan Guttmacher Mark Guyer D Neil Hayes Eric S Lander Brad Ozenberger Robert Penny Jane Peterson Chris Sander Kenna M Shaw Terence P Speed Paul T Spellman Joseph G Vockley David A Wheeler Richard K Wilson Thomas J Hudson Lynda Chin Bartha M Knoppers Eric S Lander Peter Lichter Lincoln D Stein Michael R Stratton Warwick Anderson Anna D Barker Cindy Bell Martin Bobrow Wylie Burke Francis S Collins Carolyn C Compton Ronald A DePinho Douglas F Easton P Andrew Futreal Daniela S Gerhard Anthony R Green Mark Guyer Stanley R Hamilton Tim J Hubbard Olli P Kallioniemi Karen L Kennedy Timothy J Ley Edison T Liu Youyong Lu Partha Majumder Marco Marra Brad Ozenberger Jane Peterson Alan J Schafer Paul T Spellman Hendrik G Stunnenberg Brandon J Wainwright Richard K Wilson Huanming Yang

Nature 2010 Apr;464(7291):993-8

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April 2010

The C-terminal lysine of Ogg2 DNA glycosylases is a major molecular determinant for guanine/8-oxoguanine distinction.

J Mol Biol 2010 Mar 18;397(1):46-56. Epub 2010 Jan 18.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085930PMC
March 2010

Kinetics of mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69.

Biochemistry 2010 Mar;49(11):2317-25

Department of Microbiology and Molecular Genetics, 95 Carrigan Drive, University of Vermont, Burlington, Vermont 05405, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849760PMC
March 2010

Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin.

Biochemistry 2010 Mar;49(11):2502-9

Department of Microbiology and Molecular Genetics, Stafford Hall, University of Vermont, Burlington, Vermont 05405, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840191PMC
March 2010

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.

Proc Natl Acad Sci U S A 2010 Mar 25;107(11):4925-30. Epub 2010 Feb 25.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0086, USA.

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March 2010

Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1.

DNA Repair (Amst) 2010 Feb 11;9(2):134-43. Epub 2009 Dec 11.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829949PMC
February 2010

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

DNA Repair (Amst) 2010 Feb 23;9(2):177-90. Epub 2009 Dec 23.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Dr., Burlington, VT 05405-0068, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836239PMC
February 2010

How multidisciplinary research advanced the mission of cervical cancer prevention.

Public Health Genomics 2009 11;12(5-6):264-7. Epub 2009 Aug 11.

McGill University, Montreal, Que., H2W 1S6 Canada.

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November 2009

Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.

DNA Repair (Amst) 2009 Nov 10;8(11):1283-9. Epub 2009 Sep 10.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1016/j.dnarep.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779579PMC
November 2009

Structural characterization of a viral NEIL1 ortholog unliganded and bound to abasic site-containing DNA.

J Biol Chem 2009 Sep 22;284(38):26174-83. Epub 2009 Jul 22.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405-0068, USA.

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http://dx.doi.org/10.1074/jbc.M109.021907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758016PMC
September 2009

A novel bicistronic vector for overexpressing Mycobacterium tuberculosis proteins in Escherichia coli.

Protein Expr Purif 2009 Jun 30;65(2):230-7. Epub 2008 Dec 30.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Dr. Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1016/j.pep.2008.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747733PMC
June 2009

Consent and population genomics: the creation of generic tools.

IRB 2009 Mar-Apr;31(2):15-20

Centre de recherche en droit public, University of Montreal, Quebec, Canada.

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June 2009

Crystal structures of two archaeal 8-oxoguanine DNA glycosylases provide structural insight into guanine/8-oxoguanine distinction.

Structure 2009 May;17(5):703-12

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1016/j.str.2009.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758660PMC
May 2009

Structural characterization of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase in its apo form and in complex with 8-oxodeoxyguanosine.

J Mol Biol 2009 Apr 9;387(3):669-79. Epub 2009 Feb 9.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.01.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678946PMC
April 2009

Clostridium acetobutylicum 8-oxoguanine DNA glycosylase (Ogg) differs from eukaryotic Oggs with respect to opposite base discrimination.

Biochemistry 2008 Jul 26;47(29):7626-36. Epub 2008 Jun 26.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, Vermont 05405-0068, USA.

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http://dx.doi.org/10.1021/bi800162eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574669PMC
July 2008

Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1.

Mol Cell Biol 2007 Dec 8;27(24):8442-53. Epub 2007 Oct 8.

Department of Microbiology and Molecular Genetics, University of Vermont, 95 Carrigan Drive, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1128/MCB.00791-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169407PMC
December 2007

Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus.

DNA Repair (Amst) 2007 Nov 12;6(11):1629-41. Epub 2007 Jul 12.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0068, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096709PMC
November 2007

Estimation of DNA sequence context-dependent mutation rates using primate genomic sequences.

J Mol Evol 2007 Sep 4;65(3):207-14. Epub 2007 Aug 4.

Department of Medicine, University of Chicago, 515 CLSC, Chicago, IL 60637, USA.

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September 2007

Caught bending the A-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide.

Biochemistry 2007 Sep 24;46(37):10551-61. Epub 2007 Aug 24.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, USA.

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September 2007

Rapid determination of the active fraction of DNA repair glycosylases: a novel fluorescence assay for trapped intermediates.

Nucleic Acids Res 2007 8;35(5):1601-11. Epub 2007 Feb 8.

Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, University of Vermont, Burlington, VT, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865064PMC
April 2007

Oxidative DNA glycosylases: recipes from cloning to characterization.

Methods Enzymol 2006 ;408:15-33

Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, University of Vermont, Burlington, USA.

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February 2007

Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family.

J Biol Chem 2007 Jan 9;282(2):1432-44. Epub 2006 Nov 9.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, USA.

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January 2007

A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol.

Proc Natl Acad Sci U S A 2007 Jan 8;104(3):814-8. Epub 2007 Jan 8.

Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, University of Vermont, 95 Carrigan Drive, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1073/pnas.0606648104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783396PMC
January 2007

Kinetics of error generation in homologous B-family DNA polymerases.

Nucleic Acids Res 2006 10;34(9):2528-35. Epub 2006 May 10.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1093/nar/gkl300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459414PMC
June 2006

Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells.

DNA Repair (Amst) 2006 Jan 18;5(1):43-51. Epub 2005 Aug 18.

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, 95 Carrigan Drive, Stafford Hall, Burlington, VT 05405-0068, USA.

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January 2006

Investigation of nocturnal oviposition by necrophilous flies in central Texas.

J Forensic Sci 2006 Jan;51(1):125-6

Department of Biology, Baylor University, Waco, TX 76798, USA.

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January 2006

Engineering functional changes in Escherichia coli endonuclease III based on phylogenetic and structural analyses.

J Biol Chem 2005 Oct 11;280(40):34378-84. Epub 2005 Aug 11.

Department of Microbiology and Molecular Genetics, The University of Vermont, Burlington, Vermont 05405, USA.

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October 2005

A new technique for the quantitative assessment of 8-oxoguanine in nuclear DNA as a marker of oxidative stress. Application to dystrophin-deficient DMD skeletal muscles.

Histochem Cell Biol 2005 Sep 28;124(3-4):335-45. Epub 2005 Oct 28.

Department of Oral and Maxillofacial Anatomy, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8504, Japan.

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September 2005

Solution-state NMR investigation of DNA binding interactions in Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg): a dynamic description of the DNA/protein interface.

DNA Repair (Amst) 2005 Mar;4(3):327-39

Biological Sciences Division, Battelle, Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA 99352, USA.

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March 2005

Knowledge sharing and 'genomic' healthcare.

Nat Biotechnol 2005 Feb;23(2):169-70

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February 2005

Bumps in the road: how replicative DNA polymerases see DNA damage.

Curr Opin Struct Biol 2005 Feb;15(1):86-93

Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.sbi.2005.01.014DOI Listing
February 2005