Publications by authors named "Susan M Rosenberg"

73Publications

Tools To Live By: Bacterial DNA Structures Illuminate Cancer.

Trends Genet 2019 05 5;35(5):383-395. Epub 2019 Apr 5.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX 77030, USA. Electronic address:

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May 2019

Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response.

Mol Cell 2019 05 1;74(4):785-800.e7. Epub 2019 Apr 1.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; The Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77030, USA; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX 77030, USA. Electronic address:

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May 2019

What is mutation? A chapter in the series: How microbes "jeopardize" the modern synthesis.

PLoS Genet 2019 04 1;15(4):e1007995. Epub 2019 Apr 1.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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April 2019

Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.

Cell 2019 01;176(1-2):127-143.e24

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Systems, Synthetic and Physical Biology Program, Rice University, Houston, TX 77030, USA. Electronic address:

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January 2019

Fluorescent fusions of the N protein of phage Mu label DNA damage in living cells.

DNA Repair (Amst) 2018 12 14;72:86-92. Epub 2018 Sep 14.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA; Systems, Synthetic and Physical Biology Program, Rice University, Houston, Texas 77030, USA. Electronic address:

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December 2018

Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.

Annu Rev Cancer Biol 2017 Mar;1:119-140

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030.

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March 2017

Oxygen and RNA in stress-induced mutation.

Curr Genet 2018 Aug 2;64(4):769-776. Epub 2018 Jan 2.

Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77303, USA.

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August 2018

A radical way to die.

Nat Microbiol 2017 12;2(12):1582-1583

Department of Molecular and Human Genetics and the Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine, Houston, TX, USA.

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December 2017

The transcription fidelity factor GreA impedes DNA break repair.

Nature 2017 10 4;550(7675):214-218. Epub 2017 Oct 4.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

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October 2017

Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli.

PLoS Genet 2017 Jul 20;13(7):e1006733. Epub 2017 Jul 20.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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July 2017

Driving cancer evolution.

Elife 2017 03 10;6. Epub 2017 Mar 10.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.

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March 2017

Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase.

Sci Adv 2016 Nov 18;2(11):e1601605. Epub 2016 Nov 18.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Biochemistry, Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX 77030, USA.

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November 2016

The Small RNA GcvB Promotes Mutagenic Break Repair by Opposing the Membrane Stress Response.

J Bacteriol 2016 12 18;198(24):3296-3308. Epub 2016 Nov 18.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

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December 2016

The DNA polymerase III holoenzyme contains γ and is not a trimeric polymerase.

Nucleic Acids Res 2016 Feb 18;44(3):1285-97. Epub 2016 Jan 18.

Department of Chemistry and Biochemistry, University of Colorado-Boulder, 3415 Colorado Avenue, Boulder, CO 80303, USA

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February 2016

An ultra-dense library resource for rapid deconvolution of mutations that cause phenotypes in Escherichia coli.

Nucleic Acids Res 2016 Mar 17;44(5):e41. Epub 2015 Nov 17.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA

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March 2016

Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli.

Genetics 2015 Dec 23;201(4):1349-62. Epub 2015 Oct 23.

Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, 77030 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030

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December 2015

Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli.

PLoS One 2015 11;10(5):e0123315. Epub 2015 May 11.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.

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April 2016

Emergence of antibiotic resistance from multinucleated bacterial filaments.

Proc Natl Acad Sci U S A 2015 Jan 9;112(1):178-83. Epub 2014 Dec 9.

Department of Physics, Princeton University, Princeton, NJ 08544-0708;

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January 2015

Medicine. Combating evolution to fight disease.

Science 2014 Mar;343(6175):1088-9

Departments of Molecular and Human Genetics, Biochemistry and Molecular Biology, Molecular Virology and Microbiology, and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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March 2014

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells.

Elife 2013 Oct 29;2:e01222. Epub 2013 Oct 29.

Department of Molecular and Human Genetics , Baylor College of Medicine , Houston , United States ; Department of Molecular Virology and Microbiology , Baylor College of Medicine , Houston , United States ; Dan L Duncan Cancer Center, Baylor College of Medicine , Houston , United States ; Department of Biochemistry, Molecular Biology , Baylor College of Medicine , Houston , United States.

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October 2013

Thymineless death is inhibited by CsrA in Escherichia coli lacking the SOS response.

DNA Repair (Amst) 2013 Nov 25;12(11):993-9. Epub 2013 Sep 25.

Departments of Molecular and Human Genetics, Biochemistry and Molecular Biology, Molecular Virology and Microbiology and the Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030-3411, United States.

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November 2013

Evolutionary dynamics and information hierarchies in biological systems.

Ann N Y Acad Sci 2013 Dec 20;1305:1-17. Epub 2013 May 20.

BEYOND: Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona; Blue Marble Space Institute of Science, Seattle, Washington.

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December 2013

Two mechanisms produce mutation hotspots at DNA breaks in Escherichia coli.

Cell Rep 2012 Oct 4;2(4):714-21. Epub 2012 Oct 4.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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October 2012

Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli.

Ann N Y Acad Sci 2012 Sep;1267:103-9

Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.

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September 2012

Stress-induced mutation via DNA breaks in Escherichia coli: a molecular mechanism with implications for evolution and medicine.

Bioessays 2012 Oct 22;34(10):885-92. Epub 2012 Aug 22.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

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October 2012

What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?

J Mol Microbiol Biotechnol 2011 13;21(1-2):8-19. Epub 2012 Jan 13.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

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May 2012

Genomic rearrangement in three dimensions.

Nat Biotechnol 2011 Dec 8;29(12):1096-8. Epub 2011 Dec 8.

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December 2011

Microbiology. Antibiotic resistance, not shaken or stirred.

Science 2011 Sep;333(6050):1713-4

Department of Molecular and Human Genetics, and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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September 2011

Stress-induced loss of heterozygosity in Candida: a possible missing link in the ability to evolve.

mBio 2011 20;2(5). Epub 2011 Sep 20.

Department of Molecular and Human Genetics,Baylor College of Medicine, Houston, Texas, USA.

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January 2012

Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli.

Proc Natl Acad Sci U S A 2011 Aug 1;108(33):13659-64. Epub 2011 Aug 1.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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August 2011

Pathways of resistance to thymineless death in Escherichia coli and the function of UvrD.

Genetics 2011 Sep 29;189(1):23-36. Epub 2011 Jul 29.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030-3411, USA.

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September 2011

Spontaneous mutation: real-time in living cells.

Curr Biol 2010 Sep;20(18):R810-1

Department of Molecular and Human Genetics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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September 2010

Separate DNA Pol II- and Pol IV-dependent pathways of stress-induced mutation during double-strand-break repair in Escherichia coli are controlled by RpoS.

J Bacteriol 2010 Sep 16;192(18):4694-700. Epub 2010 Jul 16.

Department of Molecular and Human Genetics, Baylor College of Medicine,Baylor College of Medicine, Houston, Texas 77030-3411, USA.

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September 2010

Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells.

PLoS One 2010 May 27;5(5):e10862. Epub 2010 May 27.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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May 2010

Role of RecA and the SOS response in thymineless death in Escherichia coli.

PLoS Genet 2010 Mar 5;6(3):e1000865. Epub 2010 Mar 5.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

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March 2010

RecQ-dependent death-by-recombination in cells lacking RecG and UvrD.

DNA Repair (Amst) 2010 Apr 4;9(4):403-13. Epub 2010 Feb 4.

Baylor College of Medicine, Houston, TX, United States.

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April 2010

An SOS-regulated type 2 toxin-antitoxin system.

J Bacteriol 2009 Dec 16;191(24):7456-65. Epub 2009 Oct 16.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030-3411, USA.

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December 2009

Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome.

J Bacteriol 2009 Oct 31;191(19):5881-9. Epub 2009 Jul 31.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030-3411, USA.

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October 2009

Mechanisms of change in gene copy number.

Nat Rev Genet 2009 Aug;10(8):551-64

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

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August 2009

Extreme genome repair.

Cell 2009 Mar;136(6):998-1000

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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March 2009

Life, death, differentiation, and the multicellularity of bacteria.

PLoS Genet 2009 Mar 13;5(3):e1000418. Epub 2009 Mar 13.

Department of Molecular and Human Genetics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.

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March 2009

DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli.

Genetics 2009 May 6;182(1):55-68. Epub 2009 Mar 6.

Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030-3411, USA.

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May 2009

Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.

PLoS Genet 2008 Oct 3;4(10):e1000208. Epub 2008 Oct 3.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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October 2008

Physical analyses of E. coli heteroduplex recombination products in vivo: on the prevalence of 5' and 3' patches.

PLoS One 2007 Nov 28;2(11):e1242. Epub 2007 Nov 28.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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November 2007

Mutation as a stress response and the regulation of evolvability.

Crit Rev Biochem Mol Biol 2007 Sep-Oct;42(5):399-435

Department of Molecular and Human Genetics, Baylor College, Houston, Texas 77030-3411, USA.

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January 2008

Spontaneous DNA breakage in single living Escherichia coli cells.

Nat Genet 2007 Jun 27;39(6):797-802. Epub 2007 May 27.

Interdepartmental Program in Cell and Molecular Biology and Department of Molecular and Human Genetics, Houston, Texas 77030-3411, USA.

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June 2007

RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins.

Mol Cell 2007 Apr;26(2):273-86

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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April 2007

On the mechanism of gene amplification induced under stress in Escherichia coli.

PLoS Genet 2006 Apr 7;2(4):e48. Epub 2006 Apr 7.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

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April 2006

Single-strand-specific exonucleases prevent frameshift mutagenesis by suppressing SOS induction and the action of DinB/DNA polymerase IV in growing cells.

J Bacteriol 2006 Apr;188(7):2336-42

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3411, USA.

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April 2006

Roles of E. coli double-strand-break-repair proteins in stress-induced mutation.

DNA Repair (Amst) 2006 Feb 28;5(2):258-73. Epub 2005 Nov 28.

Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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February 2006

A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation.

Mol Cell 2005 Sep;19(6):791-804

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

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September 2005

A role for topoisomerase III in a recombination pathway alternative to RuvABC.

Mol Microbiol 2005 Oct;58(1):80-101

Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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October 2005

Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms.

PLoS Biol 2004 Dec 23;2(12):e399. Epub 2004 Nov 23.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

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December 2004

Measurement of SOS expression in individual Escherichia coli K-12 cells using fluorescence microscopy.

Mol Microbiol 2004 Sep;53(5):1343-57

Department of Microbiology, Morrill Science Center IV N203, University of Massachusetts at Amherst, Amherst, MA 01003, USA.

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September 2004

Antibiotic-induced lateral transfer of antibiotic resistance.

Trends Microbiol 2004 Sep;12(9):401-4

Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030-3411, USA.

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September 2004

Rebuttal: growth under selection stimulates Lac(+) reversion (Roth and Andersson).

J Bacteriol 2004 Aug;186(15):4862-3

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM-S809A, Mail Stop BCM225, Houston, TX 77030-3411, USA.

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August 2004

Rebuttal: adaptive mutation in Escherichia coli (Foster).

J Bacteriol 2004 Aug;186(15):4853

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3411, USA.

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August 2004

Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.

J Bacteriol 2004 Aug;186(15):4838-43

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM-S809A Mail Stop BCM225, Houston, TX 77030-3411, USA.

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August 2004

Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress.

Res Microbiol 2004 Jun;155(5):352-9

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S809, Mail Stop 225, Houston, TX 77030-3411, USA.

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June 2004

General stress response regulator RpoS in adaptive mutation and amplification in Escherichia coli.

Genetics 2004 Feb;166(2):669-80

Department of Molecular Genetics, Baylor College of Medicine, Houston, TX 77030-3411, USA.

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February 2004

xni-deficient Escherichia coli are proficient for recombination and multiple pathways of repair.

DNA Repair (Amst) 2003 Nov;2(11):1175-83

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S809A Mail Stop BCM225, Houston, TX 77030-3411, USA.

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November 2003

The dinB operon and spontaneous mutation in Escherichia coli.

J Bacteriol 2003 Jul;185(13):3972-7

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030-3411, USA.

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July 2003

Microbiology and evolution. Modulating mutation rates in the wild.

Science 2003 May;300(5624):1382-3

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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May 2003

Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity.

Genesis 2003 Apr;35(4):220-6

Graduate Program in Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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April 2003

In pursuit of a molecular mechanism for adaptive gene amplification.

DNA Repair (Amst) 2002 Feb;1(2):111-23

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room T809 Mail Stop 225, Houston, TX 77030-3411, USA.

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February 2002

Chromosomal system for studying AmpC-mediated beta-lactam resistance mutation in Escherichia coli.

Antimicrob Agents Chemother 2002 May;46(5):1535-9

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030-3411, USA.

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May 2002