Publications by authors named "Susan J Done"

62Publications

Cell invasion in digital microfluidic microgel systems.

Sci Adv 2020 Jul 15;6(29):eaba9589. Epub 2020 Jul 15.

Institute for Biomaterials and Biomedical Engineering, University of Toronto, 164 College St., Toronto, ON M5S 3G9, Canada.

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http://dx.doi.org/10.1126/sciadv.aba9589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439438PMC
July 2020

Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis.

EBioMedicine 2020 Feb 12;52:102646. Epub 2020 Feb 12.

The Campbell Family for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, ON M5S 1A1, Canada; Laboratory Medicine Program, Department of Pathology, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th floor, Toronto, ON M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016384PMC
February 2020

Modelling the MYC-driven normal-to-tumour switch in breast cancer.

Dis Model Mech 2019 07 26;12(7). Epub 2019 Jul 26.

Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON M5G 0A3, Canada

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http://dx.doi.org/10.1242/dmm.038083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679384PMC
July 2019

Breast specimen handling and reporting in the post-neoadjuvant setting: challenges and advances.

J Clin Pathol 2019 Feb;72(2):120-132

Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada

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http://dx.doi.org/10.1136/jclinpath-2018-205598DOI Listing
February 2019

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

Mol Cell 2018 12 8;72(5):836-848.e7. Epub 2018 Nov 8.

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.09.031DOI Listing
December 2018

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.

Cell Rep 2018 10;25(3):702-714.e6

Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276789PMC
October 2018

Breast tumour resembling tall cell variant of papillary thyroid carcinoma: case presentation (in a patient with Lynch syndrome).

J Clin Pathol 2018 11 7;71(11):1031-1032. Epub 2018 Jul 7.

Division of Anatomical Pathology, Laboratory Medicine Program, Eastern Health, St John's, Newfoundland and Labrador, Canada.

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http://dx.doi.org/10.1136/jclinpath-2018-205337DOI Listing
November 2018

Negative Enrichment and Isolation of Circulating Tumor Cells for Whole Genome Amplification.

Methods Mol Biol 2017 ;1634:143-152

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/978-1-4939-7144-2_11DOI Listing
April 2018

Omitting radiation therapy after lumpectomy for pure DCIS does not reduce the risk of salvage mastectomy.

Breast 2018 Feb 3;37:181-186. Epub 2017 Aug 3.

Department of Radiation Oncology, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.breast.2017.07.002DOI Listing
February 2018

Molecular Profiling and Significance of Circulating Tumor Cell Based Genetic Signatures.

Adv Exp Med Biol 2017 ;994:143-167

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-3-319-55947-6_8DOI Listing
October 2017

Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy.

Biomed Opt Express 2016 Oct 15;7(10):4054-4068. Epub 2016 Sep 15.

Department of Physics and Institute for Optical Sciences, University of Toronto, 60 St. George Street, Toronto, ON M5S 1A7, Canada; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L 1C6, Canada.

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http://dx.doi.org/10.1364/BOE.7.004054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102540PMC
October 2016

Digital versus screen-film mammography: impact of mammographic density and hormone therapy on breast cancer detection.

Breast Cancer Res Treat 2015 Nov 30;154(2):377-87. Epub 2015 Oct 30.

Women's College Hospital, Sunnybrook Health Sciences Centre, Toronto, Canada.

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http://dx.doi.org/10.1007/s10549-015-3622-xDOI Listing
November 2015

Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.

Cancer Res 2015 Nov 23;75(22):4960-72. Epub 2015 Sep 23.

Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2992DOI Listing
November 2015

Digital Compared with Screen-Film Mammography: Measures of Diagnostic Accuracy among Women Screened in the Ontario Breast Screening Program.

Radiology 2016 Feb 2;278(2):365-73. Epub 2015 Sep 2.

From the Department of Prevention and Cancer Control, Cancer Care Ontario, 505 University Ave, Toronto, ON, Canada M5G 1X3 (M.V.P., D.M., R.S., V.M., P.B., H.J., A.M.C.); Dalla Lana School of Public Health, University of Toronto, Toronto, Ont, Canada (P.B., A.M.C.); Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ont, Canada (S.J.D.); and Department of Physical Sciences, Sunnybrook Health Sciences Centre, Toronto, Ont, Canada (M.J.Y.).

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http://dx.doi.org/10.1148/radiol.2015150733DOI Listing
February 2016

Identification of a Low-Risk Luminal A Breast Cancer Cohort That May Not Benefit From Breast Radiotherapy.

J Clin Oncol 2015 Jun 11;33(18):2035-40. Epub 2015 May 11.

Fei-Fei Liu, Anthony W. Fyles, Wei Shi, Susan J. Done, Naomi Miller, Melania Pintilie, and David R. McCready, Princess Margaret Cancer Centre/University Health Network; Sharon Nofech-Mozes, Sunnybrook Odette Cancer Center; Martin C. Chang, Mt. Sinai Hospital, University of Toronto, Toronto; Timothy J. Whelan, Juravinski Cancer Centre, McMaster University, Hamilton, ON; David Voduc, Torsten O. Nielsen, and Lorna M. Weir, British Columbia Cancer Agency, Vancouver; and Ivo A. Olivotto, British Columbia Cancer Agency, Victoria, BC, Canada.

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http://dx.doi.org/10.1200/JCO.2014.57.7999DOI Listing
June 2015

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

Cancer Cell 2015 Feb 22;27(2):211-22. Epub 2015 Jan 22.

The Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, ON M5G 2M9, Canada; Department of Medical Biophysics, University Health Network, 620 University Avenue, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.019DOI Listing
February 2015

Identification of genomic signatures in circulating tumor cells from breast cancer.

Int J Cancer 2015 Jul 12;137(2):332-44. Epub 2015 Jan 12.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.29399DOI Listing
July 2015

B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

Cancer Immunol Res 2015 Feb 19;3(2):184-95. Epub 2014 Dec 19.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Immunology, University of Toronto, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0113DOI Listing
February 2015

Preclinical pharmacokinetics, biodistribution, radiation dosimetry and acute toxicity studies required for regulatory approval of a Clinical Trial Application for a Phase I/II clinical trial of (111)In-BzDTPA-pertuzumab.

Nucl Med Biol 2015 Feb 14;42(2):78-84. Epub 2014 Oct 14.

Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada; Department of Medical Imaging, University of Toronto, Ontario, Canada; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2014.09.011DOI Listing
February 2015

Long-term outcomes of hypofractionation versus conventional radiation therapy after breast-conserving surgery for ductal carcinoma in situ of the breast.

Int J Radiat Oncol Biol Phys 2014 Dec 11;90(5):1017-24. Epub 2014 Sep 11.

University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2014.07.026DOI Listing
December 2014

Digital compared to screen-film mammography: breast cancer prognostic features in an organized screening program.

Breast Cancer Res Treat 2014 Sep 10;147(2):389-99. Epub 2014 Aug 10.

Prevention and Cancer Control, Cancer Care Ontario, 620 University Avenue, Toronto, ON, M5G 2L7, Canada,

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http://dx.doi.org/10.1007/s10549-014-3088-2DOI Listing
September 2014

Digital compared with screen-film mammography: performance measures in concurrent cohorts within an organized breast screening program.

Radiology 2013 Sep 14;268(3):684-93. Epub 2013 May 14.

Department of Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, Toronto, ON, Canada.

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http://dx.doi.org/10.1148/radiol.13122567DOI Listing
September 2013

Incidence of breast cancer in patients with pure flat epithelial atypia diagnosed at core-needle biopsy of the breast.

Ann Surg Oncol 2013 Jan 12;20(1):133-8. Epub 2012 Oct 12.

Women's Imaging, Department of Radiology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1245/s10434-012-2591-0DOI Listing
January 2013

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study.

Breast Cancer Res Treat 2012 Oct 30;135(3):821-30. Epub 2012 Aug 30.

Division of Medical Oncology and Hematology, Department of Medicine, Mount Sinai Hospital and Princess Margaret Hospital, University of Toronto, 1284-600 University Avenue, Toronto, ON M5G 1X5, Canada.

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http://link.springer.com/10.1007/s10549-012-2223-1
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http://dx.doi.org/10.1007/s10549-012-2223-1DOI Listing
October 2012

Embryonic protein nodal promotes breast cancer vascularization.

Cancer Res 2012 Aug;72(15):3851-63

Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3951DOI Listing
August 2012

Role of antibody-mediated tumor targeting and route of administration in nanoparticle tumor accumulation in vivo.

Mol Pharm 2012 Aug 18;9(8):2168-79. Epub 2012 Jul 18.

Departments of †Pharmaceutical Sciences, ‡Medical Biophysics, §Medical Imaging and ∥Laboratory Medicine and Pathobiology, University of Toronto , Toronto, ON, Canada.

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http://dx.doi.org/10.1021/mp300016pDOI Listing
August 2012

Comparison of whole genome amplification methods for analysis of DNA extracted from microdissected early breast lesions in formalin-fixed paraffin-embedded tissue.

ISRN Oncol 2012 14;2012:710692. Epub 2012 Mar 14.

Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.5402/2012/710692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317021PMC
August 2012

A new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis.

Breast Cancer Res 2011 Sep 22;13(5):R92. Epub 2011 Sep 22.

Ontario Cancer Institute and Campbell Family Institute of Cancer Research, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1186/bcr3017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262204PMC
September 2011

Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens.

BMC Cancer 2011 Jun 16;11:253:1-13. Epub 2011 Jun 16.

Ontario Cancer Institute and Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1186/1471-2407-11-253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128009PMC
June 2011

Expression of Abl interactor 1 and its prognostic significance in breast cancer: a tissue-array-based investigation.

Breast Cancer Res Treat 2011 Sep 3;129(2):373-86. Epub 2010 Nov 3.

Department of Pathology, University of Manitoba, Winnipeg, MB, Canada.

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http://dx.doi.org/10.1007/s10549-010-1241-0DOI Listing
September 2011

Amplification of the prolactin receptor gene in mammary lobular neoplasia.

Breast Cancer Res Treat 2011 Jul 24;128(1):31-40. Epub 2010 Jul 24.

Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, M5G 2C4, Canada.

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http://dx.doi.org/10.1007/s10549-010-1025-6DOI Listing
July 2011

Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells.

BMC Cancer 2010 Jul 22;10:390. Epub 2010 Jul 22.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/1471-2407-10-390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915983PMC
July 2010

Local control with conventional and hypofractionated adjuvant radiotherapy after breast-conserving surgery for ductal carcinoma in-situ.

Radiother Oncol 2010 Jun 17;95(3):317-20. Epub 2010 Apr 17.

Radiation Medicine Program, Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, Canada M5G2M9.

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http://dx.doi.org/10.1016/j.radonc.2010.03.021DOI Listing
June 2010

Cyclooxygenase-2 inhibition for the prophylaxis and treatment of preinvasive breast cancer in a her-2/neu mouse model.

Cancer Prev Res (Phila) 2010 Feb 26;3(2):202-11. Epub 2010 Jan 26.

Ontario Cancer Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0181DOI Listing
February 2010

The role of stromal factors in breast tumorigenicity.

Am J Pathol 2010 Mar 21;176(3):1072-4. Epub 2010 Jan 21.

Department of Pathology, University Health Network, University of Toronto, 200 Elizabeth Street, 11E444, Toronto, ON, M5G 2C4, Canada.

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http://dx.doi.org/10.2353/ajpath.2010.091128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832127PMC
March 2010

18F-FDG small-animal PET/CT differentiates trastuzumab-responsive from unresponsive human breast cancer xenografts in athymic mice.

J Nucl Med 2009 Nov 16;50(11):1848-56. Epub 2009 Oct 16.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2967/jnumed.109.067231DOI Listing
November 2009

Associations between the uptake of 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human tumour xenografts.

Eur J Nucl Med Mol Imaging 2009 Jan 19;36(1):81-93. Epub 2008 Aug 19.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00259-008-0923-xDOI Listing
January 2009

Quantification of the morphologic features of fibroepithelial tumors of the breast.

Arch Pathol Lab Med 2007 Oct;131(10):1568-73

Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1043/1543-2165(2007)131[1568:QOTMFO]2.0.CO;2DOI Listing
October 2007

Telomere length on chromosome 17q shortens more than global telomere length in the development of breast cancer.

Neoplasia 2007 Apr;9(4):265-70

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854852PMC
http://dx.doi.org/10.1593/neo.07106DOI Listing
April 2007

Quantitative detection of circulating epithelial cells by Q-RT-PCR.

Breast Cancer Res Treat 2008 Jan 9;107(1):145-54. Epub 2007 Mar 9.

CIHR Molecular Pathology of Cancer Fellowship Program, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s10549-007-9532-9DOI Listing
January 2008

Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis.

Cancer Res 2005 Nov;65(22):10363-70

Campbell Family Institute for Breast Cancer Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1633DOI Listing
November 2005

LAF-4 is aberrantly expressed in human breast cancer.

Int J Cancer 2005 Jul;115(4):568-74

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ijc.20881DOI Listing
July 2005