Susan Gilfillan

Susan Gilfillan

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Susan Gilfillan

Publications by authors named "Susan Gilfillan"

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ILC2s are the predominant source of intestinal ILC-derived IL-10.

J Exp Med 2020 Feb;217(2)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1084/jem.20191520DOI Listing
February 2020

DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis.

Dev Biol 2019 Nov 29;455(1):42-50. Epub 2019 Jun 29.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.06.023DOI Listing
November 2019

ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands.

J Exp Med 2019 Oct 11;216(10):2231-2241. Epub 2019 Jul 11.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO

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http://dx.doi.org/10.1084/jem.20180549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781001PMC
October 2019

ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands.

J Exp Med 2019 Oct;216(10):2231-2241

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1084/jem.20180549DOI Listing
October 2019

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.

J Exp Med 2018 03 10;215(3):745-760. Epub 2018 Jan 10.

Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO

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http://dx.doi.org/10.1084/jem.20171529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839761PMC
March 2018

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling.

Nat Immunol 2017 Sep 31;18(9):995-1003. Epub 2017 Jul 31.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.1038/ni.3809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712491PMC
September 2017

Expression of CD226 is associated to but not required for NK cell education.

Nat Commun 2017 05 31;8:15627. Epub 2017 May 31.

Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, F59, 14186 Stockholm, Sweden.

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http://dx.doi.org/10.1038/ncomms15627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460037PMC
May 2017

IL-15 sustains IL-7R-independent ILC2 and ILC3 development.

Nat Commun 2017 03 31;8:14601. Epub 2017 Mar 31.

Department of Pathology &Immunology, Washington University School of Medicine, 509 S. Euclid Ave Box 8118, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ncomms14601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380969PMC
March 2017

MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes.

J Exp Med 2016 09 22;213(10):1951-9. Epub 2016 Aug 22.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1084/jem.20160486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030807PMC
September 2016

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.

Immunity 2015 Dec 8;43(6):1112-24. Epub 2015 Dec 8.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745883PMC
December 2015

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation.

J Exp Med 2015 Oct 12;212(11):1869-82. Epub 2015 Oct 12.

Department of Pathology and Immunology and Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1084/jem.20151403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612098PMC
October 2015

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.

Nat Immunol 2015 Mar 26;16(3):306-17. Epub 2015 Jan 26.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/ni.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372143PMC
March 2015

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model.

J Exp Med 2014 Sep 1;211(10):1977-91. Epub 2014 Sep 1.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1084/jem.20132620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172228PMC
September 2014

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions.

Nat Immunol 2014 May 23;15(5):431-8. Epub 2014 Mar 23.

1] Cellular Immunity Laboratory, Cancer Immunology Program, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. [2] Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Prahran, Australia. [3] Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Australia. [4] Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia. [5] School of Medicine, University of Queensland, Herston, Australia.

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http://dx.doi.org/10.1038/ni.2850DOI Listing
May 2014

Cutting edge: Salivary gland NK cells develop independently of Nfil3 in steady-state.

J Immunol 2014 May 16;192(10):4487-91. Epub 2014 Apr 16.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.

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http://dx.doi.org/10.4049/jimmunol.1303469DOI Listing
May 2014

CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.

J Exp Med 2014 Apr 31;211(4):623-33. Epub 2014 Mar 31.

Department of Pathology and Immunology, 2 Department of Internal Medicine, 3 Department of Molecular Microbiology, and 4 Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110.

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http://www.jem.org/lookup/doi/10.1084/jem.20130904
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http://dx.doi.org/10.1084/jem.20130904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978276PMC
April 2014

Plasmacytoid dendritic cells contribute to systemic but not local antiviral responses to HSV infections.

PLoS Pathog 2013 Oct 24;9(10):e1003728. Epub 2013 Oct 24.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812046PMC
October 2013

Transepithelial migration of neutrophils into the lung requires TREM-1.

J Clin Invest 2013 Jan 17;123(1):138-49. Epub 2012 Dec 17.

Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 200 Hawkins Dr., Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1172/JCI64181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533287PMC
January 2013

Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection.

Cell Host Microbe 2012 Jun;11(6):631-42

Department of Pathology and Immunology, Washington University School of Medicine, 425 S. Euclid, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.chom.2012.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572910PMC
June 2012

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia.

Nat Immunol 2012 Jun 24;13(8):753-60. Epub 2012 Jun 24.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/ni.2360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941469PMC
June 2012

TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.

J Immunol 2012 Mar 6;188(6):2612-21. Epub 2012 Feb 6.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.1102836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732181PMC
March 2012

Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection.

J Immunol 2012 Mar 10;188(6):2488-92. Epub 2012 Feb 10.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.1103145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522186PMC
March 2012

Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo.

J Exp Med 2011 Nov 14;208(12):2367-74. Epub 2011 Nov 14.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20110654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256963PMC
November 2011

RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice.

J Clin Invest 2011 Apr 14;121(4):1497-507. Epub 2011 Mar 14.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jci.org/articles/view/44005
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http://dx.doi.org/10.1172/JCI44005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069767PMC
April 2011

Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.

Immunity 2010 Dec 2;33(6):955-66. Epub 2010 Dec 2.

Department of Pathology and Immunology, Washington University School of Medicine, 425 S. Euclid, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.immuni.2010.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588567PMC
December 2010

Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.

J Immunol 2010 Sep 28;185(5):2960-7. Epub 2010 Jul 28.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1001428
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http://dx.doi.org/10.4049/jimmunol.1001428DOI Listing
September 2010

Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.

J Immunol 2010 Mar 17;184(6):2751-5. Epub 2010 Feb 17.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0903201
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http://dx.doi.org/10.4049/jimmunol.0903201DOI Listing
March 2010

DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases.

J Immunol 2010 Jan 11;184(2):902-11. Epub 2009 Dec 11.

Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.4049/jimmunol.0903225DOI Listing
January 2010

Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.

PLoS Pathog 2010 Jan 22;6(1):e1000734. Epub 2010 Jan 22.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809771PMC
January 2010

Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells.

J Exp Med 2009 Dec 7;206(13):2967-76. Epub 2009 Dec 7.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20091181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806445PMC
December 2009

Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization.

Eur J Immunol 2009 May;39(5):1369-78

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/eji.200839313DOI Listing
May 2009

DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.

Eur J Immunol 2009 Apr;39(4):1129-35

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/eji.200838972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128836PMC
April 2009

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.

J Exp Med 2008 Dec 24;205(13):2965-73. Epub 2008 Nov 24.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20081752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605240PMC
December 2008

NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.

Blood 2008 Nov 10;112(10):4109-16. Epub 2008 Sep 10.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1182/blood-2008-02-139527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581989PMC
November 2008

MDA-5 recognition of a murine norovirus.

PLoS Pathog 2008 Jul 18;4(7):e1000108. Epub 2008 Jul 18.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443291PMC
July 2008

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells.

J Exp Med 2008 May 28;205(5):1201-11. Epub 2008 Apr 28.

Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20072579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373850PMC
May 2008

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.

J Exp Med 2007 Nov 5;204(12):2889-97. Epub 2007 Nov 5.

Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20071283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118522PMC
November 2007

p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells.

Immunity 2007 Aug;27(2):214-27

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.immuni.2007.07.014DOI Listing
August 2007

Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice.

FEBS Lett 2007 Feb 10;581(3):394-400. Epub 2007 Jan 10.

Immunogénétique Moléculaire Humaine, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Hôpitaux Universitaires de Strasbourg, 4 Rue Kirschleger, 67085 Strasbourg Cedex, France.

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http://dx.doi.org/10.1016/j.febslet.2006.12.047DOI Listing
February 2007

Cutting edge: TREM-2 attenuates macrophage activation.

J Immunol 2006 Sep;177(6):3520-4

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.177.6.3520DOI Listing
September 2006

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.

Proc Natl Acad Sci U S A 2006 May 19;103(22):8459-64. Epub 2006 May 19.

Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0603082103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464000PMC
May 2006

MR1-restricted V alpha 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response.

J Immunol 2006 Feb;176(3):1618-27

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.176.3.1618DOI Listing
February 2006

Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.

J Immunol 2005 Jul;175(2):749-54

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.175.2.749DOI Listing
July 2005

Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.

J Biol Chem 2005 Jun 31;280(22):21183-93. Epub 2005 Mar 31.

Department of Pathology and Immunology, Washington University, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M501087200DOI Listing
June 2005

Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset.

Microbes Infect 2005 Mar 12;7(3):552-9. Epub 2005 Feb 12.

Laboratoire d'Immunologie and Inserm U520, Institut Curie, 26, rue d'Ulm, 70005 Paris, France.

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http://linkinghub.elsevier.com/retrieve/pii/S128645790500020
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http://dx.doi.org/10.1016/j.micinf.2004.12.013DOI Listing
March 2005

Biochemical features of the MHC-related protein 1 consistent with an immunological function.

J Immunol 2003 Jun;170(12):6090-8

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.170.12.6090DOI Listing
June 2003

NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.

Nat Immunol 2002 Dec 11;3(12):1150-5. Epub 2002 Nov 11.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/ni857DOI Listing
December 2002

A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.

Genomics 2002 Jan;79(1):114-23

INSERM-CReS, Centre de Recherche d'Immunologie et d'Hématologie, 4 rue Kirschleger, 67085 Strasbourg Cedex, France.

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http://dx.doi.org/10.1006/geno.2001.6673DOI Listing
January 2002