Susan Edgerton

Susan Edgerton

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Susan Edgerton

Susan Edgerton

Publications by authors named "Susan Edgerton"

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Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells.

Sci Rep 2018 05 1;8(1):6829. Epub 2018 May 1.

Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, North Carolina Research Campus, Kannapolis, North Carolina, USA.

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http://dx.doi.org/10.1038/s41598-018-25284-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931511PMC
May 2018

Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells.

Oncotarget 2017 Aug 19;8(35):58847-58864. Epub 2017 Jul 19.

Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biological and Biomedical Sciences, North Carolina Central University, Kannapolis, North Carolina, USA.

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http://www.oncotarget.com/fulltext/19375
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http://dx.doi.org/10.18632/oncotarget.19375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601698PMC
August 2017

Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer.

Cell Cycle 2016 ;15(8):1046-59

a Department of Pathology , University of Colorado , Anschutz Medical Campus Mail Stop B216, 12631 East 17th Ave, Room 2215A, Aurora , CO , USA.

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http://dx.doi.org/10.1080/15384101.2016.1152432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889288PMC
January 2017

Increased erbB3 promotes erbB2/neu-driven mammary tumor proliferation and co-targeting of erbB2/erbB3 receptors exhibits potent inhibitory effects on breast cancer cells.

Int J Clin Exp Pathol 2015 1;8(6):6143-56. Epub 2015 Jun 1.

Cancer Research Institute and Affiliated Cancer Hospital of Guangzhou Medical University Guangzhou, Guangdong, China ; Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus Aurora, CO, USA.

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http://www.ijcep.com/files/ijcep0008604.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525826PMC
May 2016

Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models.

Cancer Prev Res (Phila) 2014 Feb 9;7(2):199-210. Epub 2013 Dec 9.

Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, North Carolina Research Campus, 500 Laureate Way, Room 4301, Kannapolis, NC 28081.

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http://dx.doi.org/10.1158/1940-6207.CAPR-13-0181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497590PMC
February 2014

Glucose promotes breast cancer aggression and reduces metformin efficacy.

Cell Cycle 2013 Dec 3;12(24):3759-69. Epub 2013 Oct 3.

Department of Pathology; University of Colorado; Anschutz Medical Campus; Aurora, CO USA.

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http://dx.doi.org/10.4161/cc.26641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905068PMC
December 2013

Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer.

Breast Cancer Res Treat 2013 Apr 22;138(2):549-59. Epub 2013 Feb 22.

Young Women's Breast Cancer Translational Program, University of Colorado Cancer Center, University of Colorado Denver Anschutz Medical Campus, 12801 East 17th Avenue MS 8117, RM 8112, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/s10549-013-2437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608871PMC
April 2013

Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures.

Breast Cancer Res Treat 2012 Sep 24;135(2):415-32. Epub 2012 Jul 24.

Department of Medicine, Division of Medical Oncology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1007/s10549-012-2164-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818141PMC
September 2012

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

Cell Cycle 2012 Jan 15;11(2):367-76. Epub 2012 Jan 15.

Department of Pathology, University of Colorado Denver, Denver, CO, USA.

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http://dx.doi.org/10.4161/cc.11.2.18813DOI Listing
January 2012

Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

Cell Cycle 2011 Sep 1;10(17):2959-66. Epub 2011 Sep 1.

Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.4161/cc.10.17.16359DOI Listing
September 2011

Downregulation of miR-342 is associated with tamoxifen resistant breast tumors.

Mol Cancer 2010 Dec 20;9:317. Epub 2010 Dec 20.

Department of Pathology, University of Colorado Denver, School of Medicine, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1186/1476-4598-9-317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024251PMC
December 2010

Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation.

Carcinogenesis 2010 Apr 12;31(4):695-702. Epub 2010 Jan 12.

Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/carcin/bgq007DOI Listing
April 2010

Subcellular localization of the HER4 intracellular domain, 4ICD, identifies distinct prognostic outcomes for breast cancer patients.

Am J Pathol 2009 Nov 1;175(5):1802-9. Epub 2009 Oct 1.

Department of Pathology, University of Colorado Denver, Aurora, USA.

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http://dx.doi.org/10.2353/ajpath.2009.090204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774046PMC
November 2009

Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling.

Mol Cancer Res 2009 Nov 27;7(11):1882-92. Epub 2009 Oct 27.

Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-08
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http://dx.doi.org/10.1158/1541-7786.MCR-08-0509DOI Listing
November 2009

Metformin induces unique biological and molecular responses in triple negative breast cancer cells.

Cell Cycle 2009 Jul 21;8(13):2031-40. Epub 2009 Jul 21.

Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.4161/cc.8.13.8814DOI Listing
July 2009

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro.

Cell Cycle 2009 Mar 26;8(6):909-15. Epub 2009 Mar 26.

Department of Pathology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.4161/cc.8.6.7933DOI Listing
March 2009

Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells.

Int J Cancer 2007 May;120(9):1874-82

Department of Pathology and College of Medicine, University of Colorado at Denver and Health Sciences Center (UCDHSC), Aurora, CO, USA.

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http://dx.doi.org/10.1002/ijc.22423DOI Listing
May 2007

Caspase-3 mediated feedback activation of apical caspases in doxorubicin and TNF-alpha induced apoptosis.

Apoptosis 2006 Nov;11(11):1987-97

Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1007/s10495-006-0084-yDOI Listing
November 2006

Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.

Breast Cancer Res 2005 6;7(5):R708-18. Epub 2005 Jul 6.

Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center (OUHSC), Oklahoma City, OK, USA.

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http://dx.doi.org/10.1186/bcr1281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242139PMC
February 2006

Reconstitution of caspase-3 sensitizes MCF-7 breast cancer cells to radiation therapy.

Int J Oncol 2005 Jun;26(6):1675-80

Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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June 2005

Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention.

Cancer Res 2005 Feb;65(3):879-86

Department of Pathology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, Oklahoma City, OK 73104, USA.

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February 2005

Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients.

J Clin Oncol 2005 Feb;23(6):1152-60

Department of Internal Medicine, Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1200/JCO.2005.09.055DOI Listing
February 2005

Perinucleolar compartment prevalence has an independent prognostic value for breast cancer.

Cancer Res 2005 Jan;65(1):246-53

Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA.

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January 2005

Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice.

Comp Med 2004 Jun;54(3):280-7

Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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June 2004

Hormonal and dietary modulation of mammary carcinogenesis in mouse mammary tumor virus-c-erbB-2 transgenic mice.

Cancer Res 2003 May;63(10):2425-33

Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma 73140, USA.

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May 2003

Characterization and chromosomal instability of novel derived cell lines from a wt-erbB-2 transgenic mouse model.

Carcinogenesis 2003 Apr;24(4):659-64

Department of Pathology, Northwestern University School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1093/carcin/bgg001DOI Listing
April 2003

Age-associated biomarker profiles of human breast cancer.

Int J Biochem Cell Biol 2002 Nov;34(11):1318-30

Stiftung Tumorbank Basel and Department of Research, University Clinics, Basel, Switzerland.

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http://dx.doi.org/10.1016/s1357-2725(02)00052-3DOI Listing
November 2002