Susan Brain

Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis.

Authors:

João de Sousa Valente Khadija M Alawi Patrik Keringer Sabah Bharde Faseeha Ayaz Nurjahan Saleque Xenia Kodji Dibesh Thapa Fulye Argunhan Susan D Brain

Osteoarthr Cartil Open 2020 Dec;2(4):100119

Section of Vascular Biology and Inflammation, School of Cardiovascular Medicine and Sciences, BHF Cardiovascular Centre of Research Excellence, King's College London, Franklin-Wilkins Building, London, SE1 9NH, UK.

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December 2020

The Antimicrobial Cathelicidin CRAMP Augments Platelet Activation during Psoriasis in Mice.

Authors:

Maryam F Salamah Thomas M Vallance Xenia Kodji Divyashree Ravishankar Harry F Williams Susan D Brain Sakthivel Vaiyapuri

Biomolecules 2020 09 2;10(9). Epub 2020 Sep 2.

School of Pharmacy, University of Reading, Reading RG6 6UB, UK.

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September 2020

Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome.

Authors:

Elizabeth A Evans Sophie R Sayers Xenia Kodji Yue Xia Mahum Shaikh Alizah Rizvi James Frame Susan D Brain Michael P Philpott Rosalind F Hannen Paul W Caton

Mol Metab 2020 11 26;41:101047. Epub 2020 Jun 26.

Department of Diabetes, School of Life Course Sciences, King's College London, UK. Electronic address:

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November 2020

Disruption of the Sensory System Affects Sterile Cutaneous Inflammation In Vivo.

Authors:

Federica La Russa Douglas M Lopes Carl Hobbs Fulye Argunhan Susan Brain Stuart Bevan David L H Bennett Stephen B McMahon

J Invest Dermatol 2019 09 8;139(9):1936-1945.e3. Epub 2019 Apr 8.

Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

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September 2019

CGRP Discovery and Timeline.

Authors:

Kate Arkless Fulye Argunhan Susan D Brain

Handb Exp Pharmacol 2019 ;255:1-12

Section of Vascular Biology & Inflammation, School of Cardiovascular Medicine & Sciences, BHF Centre for Cardiovascular Sciences, King's College London, London, UK.

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September 2019

The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation.

Authors:

Maryam F Salamah Divyashree Ravishankar Xenia Kodji Leonardo A Moraes Harry F Williams Thomas M Vallance Dina A Albadawi Rajendran Vaiyapuri Kim Watson Jonathan M Gibbins Susan D Brain Mauro Perretti Sakthivel Vaiyapuri

Blood Adv 2018 11;2(21):2973-2985

School of Pharmacy, University of Reading, Reading, United Kingdom.

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November 2018

The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects.

Authors:

Zizheng Kee Xenia Kodji Susan D Brain

Front Physiol 2018 19;9:1249. Epub 2018 Sep 19.

Section of Vascular Biology & Inflammation, BHF Centre for Cardiovascular Research, School of Cardiovascular Medicine and Sciences, King's College London, London, United Kingdom.

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September 2018

Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.

Authors:

Xenia Kodji Kate L Arkless Zizheng Kee Simon J Cleary Aisah A Aubdool Elizabeth Evans Paul Caton Simon C Pitchford Susan D Brain

FASEB J 2019 02 11;33(2):1578-1594. Epub 2018 Sep 11.

British Heart Foundation (BHF) Cardiovascular Centre of Research Excellence, Vascular Biology and Inflammation Section, King's College London, London, United Kingdom.

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February 2019

Transient Receptor Potential Canonical Channels 4 and 5 Mediate -Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice.

Authors:

Domingos M S Pereira Saulo J F Mendes Khadija Alawi Pratish Thakore Aisah Aubdool Nágila C F Sousa João F R da Silva José A Castro Ione C P Pereira Luís C N Silva Marcos A G Grisotto Valério Monteiro-Neto Soraia K P Costa Robson da Costa João B Calixto Susan D Brain Elizabeth S Fernandes

Oxid Med Cell Longev 2018 10;2018:4904696. Epub 2018 Jun 10.

Programa de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.

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October 2018

Association of Raynaud's phenomenon with a polymorphism in the NOS1 gene.

Authors:

Sabrina Munir Maxim B Freidin Susan Brain Frances M K Williams

PLoS One 2018 26;13(4):e0196279. Epub 2018 Apr 26.

Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.

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August 2018

A historical perspective on the role of sensory nerves in neurogenic inflammation.

Authors:

João Sousa-Valente Susan D Brain

Semin Immunopathol 2018 05 3;40(3):229-236. Epub 2018 Apr 3.

Vascular Biology and Inflammation Section, Cardiovascular School of Medicine and Science, British Heart Foundation Centre of Excellence, King's College London, Franklin-Wilkins Building, London, SE1 9NH, UK.

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May 2018

Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing.

Authors:

Pratish Thakore Susan D Brain David J Beech

Nat Commun 2018 03 23;9(1):1245. Epub 2018 Mar 23.

Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.

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March 2018

TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice.

Authors:

Ágnes Kemény Xenia Kodji Szabina Horváth Rita Komlódi Éva Szőke Zoltán Sándor Anikó Perkecz Csaba Gyömörei György Sétáló Balázs Kelemen Tamás Bíró Balázs István Tóth Susan D Brain Erika Pintér Rolland Gyulai

J Invest Dermatol 2018 08 14;138(8):1774-1784. Epub 2018 Mar 14.

Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary. Electronic address:

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August 2018

Response by Aubdool et al to Letters Regarding Article, "A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure".

Authors:

Aisah A Aubdool Fulye Argunhan Pratish Thakore Susan D Brain

Circulation 2018 03;137(11):1201-1202

British Heart Foundation Cardiovascular Centre of Excellence, Cardiovascular School of Medicine and Research, King's College London, United Kingdom.

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March 2018

The role of perivascular adipose tissue-derived sensory nerves in influencing vascular regulation.

Authors:

Pratish Thakore Susan D Brain

Cardiovasc Res 2017 07;113(8):847-848

Vascular Biology & Inflammation Section, Cardiovascular Division, King's College London BHF Cardiovascular Centre of Research Excellence, London SE1?9NH, UK.

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July 2017

Tail-Cuff Technique and Its Influence on Central Blood Pressure in the Mouse.

Authors:

Elena Wilde Aisah A Aubdool Pratish Thakore Lineu Baldissera Khadija M Alawi Julie Keeble Manasi Nandi Susan D Brain

J Am Heart Assoc 2017 Jun 27;6(6). Epub 2017 Jun 27.

Vascular Biology and Inflammation Section, BHF Cardiovascular Centre of Research Excellence, Cardiovascular Division, King's College London, London, United Kingdom

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June 2017

Transient receptor potential canonical 5 channels plays an essential role in hepatic dyslipidemia associated with cholestasis.

Authors:

Khadija M Alawi David Tandio Jin Xu Pratish Thakore Georgia Papacleovoulou Elizabeth S Fernandes Cristina Legido-Quigley Catherine Williamson Susan D Brain

Sci Rep 2017 05 24;7(1):2338. Epub 2017 May 24.

BHF Cardiovascular Centre of Excellence and Centre of Integrative Biomedicine, Cardiovascular Division, King's College London, London, UK.

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May 2017

A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure.

Authors:

Aisah A Aubdool Pratish Thakore Fulye Argunhan Sarah-Jane Smillie Moritz Schnelle Salil Srivastava Khadija M Alawi Elena Wilde Jennifer Mitchell Keith Farrell-Dillon Daniel A Richards Giuseppe Maltese Richard C Siow Manasi Nandi James E Clark Ajay M Shah Anette Sams Susan D Brain

Circulation 2017 Jul 26;136(4):367-383. Epub 2017 Apr 26.

From Cardiovascular Division, BHF Centre of Research Excellence and Centre of Integrative Biomedicine, King's College London, United Kingdom (A.A.A., F.A., S.-J.S., S.S., K.M.A., E.W., J.M., K.F.-D., G.M., R.C.S., S.D.B.); Institute of Pharmaceutical Sciences, King's College London, United Kingdom (P.T., M.N.); Cardiovascular Division, BHF Centre of Research Excellence, James Black Centre, King's College London, United Kingdom (M.S., D.A.R., A.M.S.); Department of Cardiology and Pneumology, Medical Center Goettingen, Germany (M.S.); Cardiovascular Division, BHF Centre of Research Excellence, Rayne Institute, St Thomas' Hospital, King's College London, United Kingdom (J.E.C.); Novo Nordisk A/S, Diabetic Complications Biology, Novo Nordisk Park, Maaloev, Denmark (A.S.); and Department of Clinical Experimental Research, Glostrup Research Institute, Rigshospitalet, Denmark (A.S.).

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July 2017

Transient Receptor Potential Ankyrin 1 Channel Expression on Peripheral Blood Leukocytes from Rheumatoid Arthritic Patients and Correlation with Pain and Disability.

Authors:

Ione Pereira Saulo J F Mendes Domingos M S Pereira Thayanne F Muniz Valderlane L P Colares Cinara R A V Monteiro Mahiba M R de S Martins Marcos A G Grisotto Valério Monteiro-Neto Sílvio G Monteiro João B Calixto Susan D Brain Elizabeth S Fernandes

Front Pharmacol 2017 10;8:53. Epub 2017 Feb 10.

Programa de Pós-graduação, Universidade Ceuma, São Luís MA, Brazil.

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February 2017

Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.

Authors:

Jie Chen Angelika Varga Srikumaran Selvarajah Agnes Jenes Beatrix Dienes Joao Sousa-Valente Akos Kulik Gabor Veress Susan D Brain David Baker Laszlo Urban Ken Mackie Istvan Nagy

Sci Rep 2016 Sep 22;6:33307. Epub 2016 Sep 22.

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

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September 2016

Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release.

Authors:

Zsófia Hajna Éva Sághy Maja Payrits Aisah A Aubdool Éva Szőke Gábor Pozsgai István Z Bátai Lívia Nagy Dániel Filotás Zsuzsanna Helyes Susan D Brain Erika Pintér

J Mol Neurosci 2016 Oct 15;60(2):157-70. Epub 2016 Aug 15.

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.

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October 2016

TRPA1 activation leads to neurogenic vasodilatation: involvement of reactive oxygen nitrogen species in addition to CGRP and NO.

Authors:

Aisah A Aubdool Xenia Kodji Nayaab Abdul-Kader Richard Heads Elizabeth S Fernandes Stuart Bevan Susan D Brain

Br J Pharmacol 2016 08 21;173(15):2419-33. Epub 2016 Jun 21.

Cardiovascular Division, BHF Centre of Excellence, King's College London, London, UK.

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August 2016

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation.

Authors:

Khadija M Alawi Fiona A Russell Aisah A Aubdool Salil Srivastava Yanira Riffo-Vasquez Lineu Baldissera Pratish Thakore Nurjahan Saleque Elizabeth S Fernandes David A Walsh Susan D Brain

Ann Rheum Dis 2017 Jan 10;76(1):252-260. Epub 2016 May 10.

Cardiovascular Division, BHF Cardiovascular Centre of Excellence and Centre of Integrative Biomedicine, King's College London, London, UK.

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January 2017

Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner.

Authors:

Elizabeth S Fernandes Fiona A Russell Khadija M Alawi Claire Sand Lihuan Liang Robin Salamon Jennifer V Bodkin Aisah A Aubdool Matthew Arno Clive Gentry Sarah-Jane Smillie Stuart Bevan Julie E Keeble Marzia Malcangio Susan D Brain

Arthritis Res Ther 2016 Jan 11;18. Epub 2016 Jan 11.

Centre for Cardiovascular Excellence, Waterloo Campus, King's College London, Franklin-Wilkins Building, 150 Stamford St, London, SE1 9NH, UK.

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January 2016

The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature.

Authors:

Khadija M Alawi Aisah A Aubdool Lihuan Liang Elena Wilde Abhinav Vepa Maria-Paraskevi Psefteli Susan D Brain Julie E Keeble

FASEB J 2015 Oct 1;29(10):4285-98. Epub 2015 Jul 1.

*Institute of Pharmaceutical Science and British Heart Foundation Cardiovascular Centre of Excellence and Centre of Integrative Biomedicine, Cardiovascular Division, King's College London, London, United Kingdom

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October 2015

Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension.

Authors:

Jennifer V Bodkin Pratish Thakore Aisah A Aubdool Lihuan Liang Elizabeth S Fernandes Manasi Nandi Domenico Spina James E Clark Philip I Aaronson Michael J Shattock Susan D Brain

Pharmacol Res Perspect 2014 Aug 23;2(4):e00052. Epub 2014 Jun 23.

Cardiovascular Division, BHF Centre of Excellence and Centre of Integrative Biomedicine, School of Medicine, King's College London London, SE1 9NH, U.K.

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August 2014