Publications by authors named "Susan Aja"

46Publications

Loss of CTRP4 alters adiposity and food intake behaviors in obese mice.

Am J Physiol Endocrinol Metab 2020 Oct 5. Epub 2020 Oct 5.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00448.2020DOI Listing
October 2020

Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice.

World J Diabetes 2020 Apr;11(4):126-136

Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4239/wjd.v11.i4.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156300PMC
April 2020

Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice.

Glia 2020 Oct 16;68(10):1987-2000. Epub 2020 Mar 16.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.23817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423758PMC
October 2020

MeCP2 Deficiency Disrupts Kainate-Induced Presynaptic Plasticity in the Mossy Fiber Projections in the Hippocampus.

Front Cell Neurosci 2019 3;13:286. Epub 2019 Jul 3.

Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Córdoba, Argentina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2019.00286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619486PMC
July 2019

DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders.

Transl Psychiatry 2018 04 12;8(1):76. Epub 2018 Apr 12.

Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41398-018-0123-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895599PMC
April 2018

Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality.

Cell Rep 2016 Feb 4;14(6):1308-1316. Epub 2016 Feb 4.

Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758873PMC
February 2016

D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway.

Biochem Biophys Res Commun 2016 Feb 21;470(4):818-23. Epub 2016 Jan 21.

Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea; Neurometabolomics Research Center, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2016.01.115DOI Listing
February 2016

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet.

Arch Biochem Biophys 2016 Feb 14;591:57-65. Epub 2015 Dec 14.

Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2015.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747866PMC
February 2016

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.

Mol Cell Biol 2015 Jun 23;35(11):1979-91. Epub 2015 Mar 23.

Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Baltimore Veterans Administration Medical Center, Baltimore, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01343-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420919PMC
June 2015

Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation.

PLoS One 2014 26;9(12):e115642. Epub 2014 Dec 26.

Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Brain Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277346PMC
August 2015

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice.

PLoS One 2014 9;9(10):e109527. Epub 2014 Oct 9.

The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America; Department of Brain Sciences, DGIST, Daegu, South Korea.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109527PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192301PMC
December 2015

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice.

Front Neurosci 2014 13;8:157. Epub 2014 Jun 13.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Institute for Cell Engineering, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Department of Ophthalmology, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Center for High-Throughput Biology, Johns Hopkins University School of Medicine Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fnins.2014.00
Publisher Site
http://dx.doi.org/10.3389/fnins.2014.00157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056383PMC
July 2014

Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice.

Am J Physiol Endocrinol Metab 2014 Apr 28;306(7):E779-90. Epub 2014 Jan 28.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00593.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962615PMC
April 2014

CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction.

Am J Physiol Regul Integr Comp Physiol 2013 Sep 10;305(5):R522-33. Epub 2013 Jul 10.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00110.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763026PMC
September 2013

CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism.

Am J Physiol Gastrointest Liver Physiol 2013 Aug 6;305(3):G214-24. Epub 2013 Jun 6.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpgi.00102.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742855PMC
August 2013

Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite.

Am J Physiol Regul Integr Comp Physiol 2013 Jun 10;304(12):R1085-95. Epub 2013 Apr 10.

Department of Physiology and Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00368.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680792PMC
June 2013

Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α.

PLoS One 2012 1;7(10):e46562. Epub 2012 Oct 1.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046562PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462192PMC
February 2013

The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal.

Mol Neurobiol 2012 Oct 7;46(2):332-48. Epub 2012 Jun 7.

Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-012-8283-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469761PMC
October 2012

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.

Nat Neurosci 2012 Mar 25;15(5):700-2. Epub 2012 Mar 25.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.3079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380241PMC
March 2012

CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition.

J Biol Chem 2012 Jan 15;287(2):1576-87. Epub 2011 Nov 15.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.278333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256898PMC
January 2012

Physiological oxygen level is critical for modeling neuronal metabolism in vitro.

J Neurosci Res 2012 Feb 17;90(2):422-34. Epub 2011 Oct 17.

Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jnr.22765DOI Listing
February 2012

Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity.

Cell Metab 2011 May;13(5):573-83

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2011.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093161PMC
May 2011

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.

Proc Natl Acad Sci U S A 2010 Sep 26;107(37):16320-4. Epub 2010 Jul 26.

Department of Pathology, Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1002176107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941284PMC
September 2010

AMPK in the brain: its roles in energy balance and neuroprotection.

J Neurochem 2009 May;109 Suppl 1:17-23

Department of Neuroscience, The Center for Metabolism and Obesity Research (CMOR), The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2009.05916.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925428PMC
May 2009

Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats.

Am J Physiol Regul Integr Comp Physiol 2008 Sep 30;295(3):R799-805. Epub 2008 Jul 30.

Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.90381.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536853PMC
September 2008

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro.

J Neurosci Methods 2008 Jan 7;167(2):292-301. Epub 2007 Sep 7.

Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2007.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257477PMC
January 2008

Leptin modulation of peripheral controls of meal size.

Physiol Behav 2006 Nov 2;89(4):511-6. Epub 2006 Jun 2.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave., Baltimore, MD 21205, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2006.04.020DOI Listing
November 2006

Serotonin-3 receptors in gastric mechanisms of cholecystokinin-induced satiety.

Authors:
Susan Aja

Am J Physiol Regul Integr Comp Physiol 2006 Jul 11;291(1):R112-4. Epub 2006 May 11.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00159.2006DOI Listing
July 2006

Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats.

Am J Physiol Regul Integr Comp Physiol 2006 Jul 16;291(1):R148-54. Epub 2006 Feb 16.

Department of Psychiatry and Behavioural Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00041.2006DOI Listing
July 2006

Recent advances in obesity: adiposity signaling and fat metabolism in energy homeostasis.

Adv Psychosom Med 2006 ;27:1-23

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Md., USA.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/90959
Publisher Site
http://dx.doi.org/10.1159/000090959DOI Listing
April 2006

Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression.

Peptides 2006 Jan 8;27(1):157-64. Epub 2005 Sep 8.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.peptides.2005.07.003DOI Listing
January 2006

Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei.

Neuroreport 2004 Apr;15(5):925-9

Departments of Neuroscience and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00001756-200404090-00038DOI Listing
April 2004

C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase.

J Biol Chem 2004 May 17;279(19):19970-6. Epub 2004 Mar 17.

Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M402165200
Publisher Site
http://dx.doi.org/10.1074/jbc.M402165200DOI Listing
May 2004