Susan A Fiscus

Susan A Fiscus

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Susan A Fiscus

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Maternal and Breastmilk Viral Load: Impacts of Adherence on Peripartum HIV Infections Averted-The Breastfeeding, Antiretrovirals, and Nutrition Study.

J Acquir Immune Defic Syndr 2016 Dec;73(5):572-580

*Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC; †Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC; ‡Currently, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA; §Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC; ‖Division of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Parktown, South Africa; ¶UNC Project, University of North Carolina, Lilongwe, Malawi; #Department of Microbiology and Immunology, School of Medicine, Center for AIDS Research, University of North Carolina, Chapel Hill, NC; **Division of Global Women's Health, Department of Obstetrics & Gynecology, Institute for Global Health and Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC; and ††Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA.

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http://dx.doi.org/10.1097/QAI.0000000000001145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141681PMC
December 2016

Fixed-dose combination emtricitabine/tenofovir/efavirenz initiated during acute HIV infection; 96-week efficacy and durability.

AIDS 2016 11;30(18):2815-2822

aDepartment of Medicine, UNC Institute for Global Health & Infectious Diseases bDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill cDepartment of Medicine, Division of Infectious Diseases dDepartment of Surgery eDuke Human Vaccine Institute, Duke University, Durham fLaboratory Corporation of America, Burlington, North Carolina gDepartment of Clinical Medicine, University of San Diego, San Diego, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101138PMC
November 2016

Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention.

N Engl J Med 2016 11;375(18):1726-1737

From the Department of Pathology, Johns Hopkins University School of Medicine (M.G.F.), and the Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (T.E.T.), Baltimore, and the Division of AIDS, National Institute of Allergy and Infectious Diseases (D.G., K.L.K., R. Browning, L.P.), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (G.K.S.), National Institutes of Health, Bethesda - all in Maryland; the Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston (M.Q., T.F., D.E.S.); the Retrovirology Core Laboratory, University of North Carolina School of Medicine, Chapel Hill (S.A.F., A.J.L.), and FHI 360, Durham (A.S.C.) - both in North Carolina; the UCLA Center for Clinical AIDS Research and Education, Los Angeles (J.S.C.); St. Jude Children's Research Hospital, Memphis, TN (P.M.F.); the Department of Obstetrics and Gynecology, College of Health Sciences, University of Zimbabwe, Harare (T.C.); Anova Health Institute (J.M.), Perinatal HIV Research Unit, University of the Witwatersrand, Faculty of Health Sciences (A.V.), and Empilweni Services and Research Unit (R.S.), Johannesburg, School of Public Health and Family Medicine, University of Cape Town (J.M.), and the Department of Obstetrics and Gynaecology, Stellenbosch University (G.B.T.), Cape Town, and the Centre for the AIDS Programme of Research in South Africa-Umlazi Clinical Research Site (D.M.) and Durban Paediatric HIV (R. Bobat), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban - all in South Africa; the University of North Carolina Project, Kamuzu Central Hospital-Tidziwe Center, Lilongwe, Malawi (F.E.M.); Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda (M.O.); the Department of Obstetrics and Gynecology, B.J. Medical College, Pune, India (R. Bhosale); the Centre for Infectious Disease Research in Zambia, Lusaka, Zambia (B.H.C.); Kilimanjaro Christian Medical Center-Duke University Collaboration, Moshi, Tanzania (P.M.); Frontier Science and Technology Research Foundation, Amherst, NY (M.B.); and the Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC (L.M.M.).

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http://dx.doi.org/10.1056/NEJMoa1511691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214343PMC
November 2016

Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells.

Antimicrob Agents Chemother 2015 Oct 3;59(10):6395-401. Epub 2015 Aug 3.

School of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/AAC.01148-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576057PMC
October 2015

Comparison of the Gen-Probe Aptima HIV-1 and Abbott HIV-1 qualitative assays with the Roche Amplicor HIV-1 DNA assay for early infant diagnosis using dried blood spots.

J Clin Virol 2014 Aug 2;60(4):418-21. Epub 2014 Jun 2.

UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.jcv.2014.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077672PMC
August 2014

Cross-platform analysis of HIV-1 RNA data generated by a multicenter assay validation study with wide geographic representation.

J Clin Microbiol 2012 Aug 12;50(8):2737-47. Epub 2012 Jun 12.

Rush Medical College, Department of Immunology and Microbiology, Chicago, Illinois, USA.

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http://dx.doi.org/10.1128/JCM.00578-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421531PMC
August 2012

Virologic determinants of breast milk transmission of HIV-1.

Adv Exp Med Biol 2012 ;743:69-80

Departments of Microbiology & Immunology and Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill, CB# 7290, Chapel Hill, NC 27599-7290, USA.

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http://dx.doi.org/10.1007/978-1-4614-2251-8_5DOI Listing
June 2012

Acute HIV infection among pregnant women in Malawi.

Diagn Microbiol Infect Dis 2010 Apr;66(4):356-60

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7030, USA.

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http://dx.doi.org/10.1016/j.diagmicrobio.2009.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864613PMC
April 2010

Nevirapine resistance in human immunodeficiency virus type 1-positive infants determined using dried blood spots stored for up to six years at room temperature.

J Clin Microbiol 2009 Apr 18;47(4):1209-11. Epub 2009 Feb 18.

Department of Microbiology and Immunology, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1128/JCM.00254-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668311PMC
April 2009

Diagnosis of human immunodeficiency virus type 1 infection in infants by use of dried blood spots and an ultrasensitive p24 antigen assay.

J Clin Microbiol 2009 Feb 10;47(2):459-62. Epub 2008 Dec 10.

Department Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7290, USA.

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http://dx.doi.org/10.1128/JCM.01181-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643698PMC
February 2009

Qualitative human immunodeficiency virus RNA analysis of dried blood spots for diagnosis of infections in infants.

J Clin Microbiol 2009 Jan 12;47(1):220-2. Epub 2008 Nov 12.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 11-141 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/JCM.01521-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2620881PMC
January 2009

Comparison of two rapid human immunodeficiency virus (HIV) assays, Determine HIV-1/2 and OraQuick Advance Rapid HIV-1/2, for detection of recent HIV seroconversion.

J Clin Microbiol 2008 Oct 6;46(10):3482-3. Epub 2008 Aug 6.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.

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http://dx.doi.org/10.1128/JCM.00665-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566129PMC
October 2008

Optimizing screening for acute human immunodeficiency virus infection with pooled nucleic acid amplification tests.

J Clin Microbiol 2008 May 19;46(5):1785-92. Epub 2008 Mar 19.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://jcm.asm.org/cgi/doi/10.1128/JCM.00787-07
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http://dx.doi.org/10.1128/JCM.00787-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395100PMC
May 2008

The pharmacokinetics and viral activity of tenofovir in the male genital tract.

J Acquir Immune Defic Syndr 2008 Mar;47(3):329-33

Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill , NC 27599-7360, USA.

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http://dx.doi.org/10.1097/QAI.0b013e3181632cc3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726724PMC
March 2008

Ultrasensitive p24 antigen assay for diagnosis of perinatal human immunodeficiency virus type 1 infection.

J Clin Microbiol 2007 Jul 2;45(7):2274-7. Epub 2007 May 2.

University of North Carolina at Chapel Hill, Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JCM.00813-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933021PMC
July 2007

Late postnatal transmission of HIV-1 and associated factors.

J Infect Dis 2007 Jul 24;196(1):10-4. Epub 2007 May 24.

Department of Epidemiology, Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1086/518511DOI Listing
July 2007

Rapid, real-time detection of acute HIV infection in patients in Africa.

J Infect Dis 2007 Feb 22;195(3):416-24. Epub 2006 Dec 22.

Department of Microbiology and Immunology, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC 27599-7290, USA.

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http://dx.doi.org/10.1086/510755DOI Listing
February 2007

HIV-1 viral load assays for resource-limited settings.

PLoS Med 2006 Oct;3(10):e417

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.0030417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592347PMC
October 2006

The impact of breastfeeding on the health of HIV-positive mothers and their children in sub-Saharan Africa.

Bull World Health Organ 2006 Jul;84(7):546-54

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627383PMC
http://dx.doi.org/10.2471/blt.05.027664DOI Listing
July 2006

Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women.

J Infect Dis 2006 Jun 20;193(11):1512-5. Epub 2006 Apr 20.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1086/503810DOI Listing
June 2006

Distinct mechanisms of T cell reconstitution can be identified by estimating thymic volume in adult HIV-1 disease.

J Infect Dis 2005 Nov 29;192(9):1577-87. Epub 2005 Sep 29.

Division of Infectious Diseases, MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109-1998, USA.

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http://dx.doi.org/10.1086/466527DOI Listing
November 2005

Quantitation of HIV-1 viral RNA in blood plasma and genital secretions.

Authors:
Susan A Fiscus

Methods Mol Biol 2005 ;304:201-13

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1385/1-59259-907-9:201DOI Listing
September 2005

Affordable, abbreviated roche monitor assay for quantification of human immunodeficiency virus type 1 RNA in plasma.

J Clin Microbiol 2005 Aug;43(8):4200-2

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JCM.43.8.4200-4202.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234002PMC
August 2005

Gender differences in perinatal HIV acquisition among African infants.

Pediatrics 2005 Feb;115(2):e167-72

Infectious Diseases Program, Department of Epidemiology, Bloomberg School of Public Health, MBBS, Room E7138, 615 N Wolfe St, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1542/peds.2004-1590DOI Listing
February 2005

Evaluation of an ultrasensitive p24 antigen assay as a potential alternative to human immunodeficiency virus type 1 RNA viral load assay in resource-limited settings.

J Clin Microbiol 2005 Jan;43(1):506-8

Global AIDS Program, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mail Stop A-12, Atlanta, GA 30333, USA.

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http://dx.doi.org/10.1128/JCM.43.1.506-508.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC540096PMC
January 2005

HIV-1 populations in blood and breast milk are similar.

Virology 2004 Dec;330(1):295-303

UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.virol.2004.09.004DOI Listing
December 2004

Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women.

J Acquir Immune Defic Syndr 2004 Dec;37(5):1577-80

Schools of Medicine, University of North Carolina, Chapel Hill 27599-7360, USA.

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http://dx.doi.org/10.1097/00126334-200412150-00008DOI Listing
December 2004

Weighted phenotypic susceptibility scores are predictive of the HIV-1 RNA response in protease inhibitor-experienced HIV-1-infected subjects.

J Infect Dis 2004 Sep 23;190(5):886-93. Epub 2004 Jul 23.

University of North Carolina Center for AIDS Research, University of North Carolina, Chapel Hill 27599, USA.

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http://dx.doi.org/10.1086/422692DOI Listing
September 2004

The pharmacokinetics, safety, and initial virologic response of a triple-protease inhibitor salvage regimen containing amprenavir, saquinavir, and ritonavir.

J Acquir Immune Defic Syndr 2004 Aug;36(4):921-8

Schools of Pharmacy and Medicine, University of North Carolina Center for AIDS Research, University of North Carolina at Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1097/00126334-200408010-00005DOI Listing
August 2004

Frequent detection of acute primary HIV infection in men in Malawi.

AIDS 2004 Feb;18(3):517-24

Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1097/00002030-200402200-00019DOI Listing
February 2004

Human immunodeficiency virus type 1 RNA in breast-milk components.

J Infect Dis 2003 Oct 1;188(8):1209-12. Epub 2003 Oct 1.

Center for Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599-7030, USA.

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http://dx.doi.org/10.1086/378414DOI Listing
October 2003

Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men.

J Infect Dis 2002 Nov 7;186(9):1339-43. Epub 2002 Oct 7.

School of Pharmacy, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1086/344311DOI Listing
November 2002

Effects of formulation and dosing strategy on amprenavir concentrations in the seminal plasma of human immunodeficiency virus type 1-infected men.

Clin Infect Dis 2002 Sep 23;35(6):760-2. Epub 2002 Aug 23.

School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1086/342389DOI Listing
September 2002

The pharmacokinetics of amprenavir, zidovudine, and lamivudine in the genital tracts of men infected with human immunodeficiency virus type 1 (AIDS clinical trials group study 850).

J Infect Dis 2002 Jul 26;186(2):198-204. Epub 2002 Jun 26.

Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1086/341209DOI Listing
July 2002

Trends in interventions to reduce perinatal human immunodeficiency virus type 1 transmission in North Carolina.

Pediatr Infect Dis J 2002 Jul;21(7):664-8

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599-7140, USA.

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http://dx.doi.org/10.1097/00006454-200207000-00012DOI Listing
July 2002

Addition of cyclophosphamide to antiretroviral therapy does not diminish the cellular reservoir in HIV-infected persons.

AIDS Res Hum Retroviruses 2002 May;18(8):535-43

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1089/088922202753747888DOI Listing
May 2002