Surinder K Batra

Surinder K Batra

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Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models.

J Surg Res 2019 Oct 9;242:145-150. Epub 2019 May 9.

Department of Surgery, University of California San Diego, La Jolla, California; Moores Cancer Center, University of California San Diego, La Jolla, California; Department of Surgery, VA San Diego Healthcare System, San Diego, California. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.04.048DOI Listing
October 2019

Combination Therapies and Drug Delivery Platforms in Combating Pancreatic Cancer.

J Pharmacol Exp Ther 2019 Sep 22;370(3):682-694. Epub 2019 Feb 22.

Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy (F.L., X.X., T.K.B.), and Department of Biochemistry and Molecular Biology (S.K.B.), University of Nebraska Medical Center, Omaha, Nebraska

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http://dx.doi.org/10.1124/jpet.118.255786DOI Listing
September 2019

PTTG1: a Unique Regulator of Stem/Cancer Stem Cells in the Ovary and Ovarian Cancer.

Stem Cell Rev Rep 2019 Sep 3. Epub 2019 Sep 3.

Department of Physiology, University of Louisville, 505 South Hancock Street, Clinical and Translational Research Building, Room 322, Louisville, KY, 40202, USA.

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http://dx.doi.org/10.1007/s12015-019-09911-5DOI Listing
September 2019

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Authors:
Channabasavaiah B Gurumurthy Aidan R O'Brien Rolen M Quadros John Adams Pilar Alcaide Shinya Ayabe Johnathan Ballard Surinder K Batra Marie-Claude Beauchamp Kathleen A Becker Guillaume Bernas David Brough Francisco Carrillo-Salinas Wesley Chan Hanying Chen Ruby Dawson Victoria DeMambro Jinke D'Hont Katharine M Dibb James D Eudy Lin Gan Jing Gao Amy Gonzales Anyonya R Guntur Huiping Guo Donald W Harms Anne Harrington Kathryn E Hentges Neil Humphreys Shiho Imai Hideshi Ishii Mizuho Iwama Eric Jonasch Michelle Karolak Bernard Keavney Nay-Chi Khin Masamitsu Konno Yuko Kotani Yayoi Kunihiro Imayavaramban Lakshmanan Catherine Larochelle Catherine B Lawrence Lin Li Volkhard Lindner Xian-De Liu Gloria Lopez-Castejon Andrew Loudon Jenna Lowe Loydie A Jerome-Majewska Taiji Matsusaka Hiromi Miura Yoshiki Miyasaka Benjamin Morpurgo Katherine Motyl Yo-Ichi Nabeshima Koji Nakade Toshiaki Nakashiba Kenichi Nakashima Yuichi Obata Sanae Ogiwara Mariette Ouellet Leif Oxburgh Sandra Piltz Ilka Pinz Moorthy P Ponnusamy David Ray Ronald J Redder Clifford J Rosen Nikki Ross Mark T Ruhe Larisa Ryzhova Ane M Salvador Sabrina Shameen Alam Radislav Sedlacek Karan Sharma Chad Smith Katrien Staes Lora Starrs Fumihiro Sugiyama Satoru Takahashi Tomohiro Tanaka Andrew W Trafford Yoshihiro Uno Leen Vanhoutte Frederique Vanrockeghem Brandon J Willis Christian S Wright Yuko Yamauchi Xin Yi Kazuto Yoshimi Xuesong Zhang Yu Zhang Masato Ohtsuka Satyabrata Das Daniel J Garry Tino Hochepied Paul Thomas Jan Parker-Thornburg Antony D Adamson Atsushi Yoshiki Jean-Francois Schmouth Andrei Golovko William R Thompson K C Kent Lloyd Joshua A Wood Mitra Cowan Tomoji Mashimo Seiya Mizuno Hao Zhu Petr Kasparek Lucy Liaw Joseph M Miano Gaetan Burgio

Genome Biol 2019 08 26;20(1):171. Epub 2019 Aug 26.

Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, the Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1186/s13059-019-1776-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709553PMC
August 2019

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIP.

Cancer Cell Int 2019 22;19:189. Epub 2019 Jul 22.

1Gastrointestinal Oncology Program, Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612 USA.

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http://dx.doi.org/10.1186/s12935-019-0876-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647259PMC
July 2019

Cancer-associated mucins: role in immune modulation and metastasis.

Cancer Metastasis Rev 2019 Jun;38(1-2):223-236

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.

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http://dx.doi.org/10.1007/s10555-018-09775-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614013PMC
June 2019

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer.

EBioMedicine 2019 Apr 5;42:375-385. Epub 2019 Apr 5.

Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491718PMC
April 2019

Immunometabolic Alterations by HPV Infection: New Dimensions to Head and Neck Cancer Disparity.

J Natl Cancer Inst 2019 Mar;111(3):233-244

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1093/jnci/djy207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410958PMC
March 2019

MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention.

Semin Cancer Biol 2019 02 2;54:63-71. Epub 2017 Dec 2.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute for Research in Cancer and Allied Diseases and Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984665PMC
February 2019

Unraveling the journey of cancer stem cells from origin to metastasis.

Biochim Biophys Acta Rev Cancer 2019 01 9;1871(1):50-63. Epub 2018 Nov 9.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0304419X183011
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http://dx.doi.org/10.1016/j.bbcan.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347501PMC
January 2019

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer.

J Control Release 2019 Jan 18;294:237-246. Epub 2018 Dec 18.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.12.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379902PMC
January 2019

Systems Biology Approach to Identify Novel Genomic Determinants for Pancreatic Cancer Pathogenesis.

Sci Rep 2019 Jan 15;9(1):123. Epub 2019 Jan 15.

BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-018-36328-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333820PMC
January 2019

Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.

J Exp Clin Cancer Res 2018 Dec 19;37(1):319. Epub 2018 Dec 19.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
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http://dx.doi.org/10.1186/s13046-018-0963-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299603PMC
December 2018

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice.

Gastroenterology 2018 11 4;155(5):1608-1624. Epub 2018 Aug 4.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183483
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http://dx.doi.org/10.1053/j.gastro.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219903PMC
November 2018

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells.

BMC Cancer 2018 Nov 22;18(1):1157. Epub 2018 Nov 22.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.

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http://dx.doi.org/10.1186/s12885-018-5074-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251200PMC
November 2018

PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective.

Semin Cancer Biol 2018 10 28;52(Pt 2):53-65. Epub 2017 Nov 28.

Department of Biochemistry and Molecular Biology and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972043PMC
October 2018

Concise Review: Current Status of Three-Dimensional Organoids as Preclinical Models.

Stem Cells 2018 09 29;36(9):1329-1340. Epub 2018 Jul 29.

Department of Biochemistry and Molecular Biology, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1002/stem.2852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158106PMC
September 2018

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.

Gastroenterology 2018 09 2;155(3):892-908.e6. Epub 2018 Jun 2.

Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183457
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http://dx.doi.org/10.1053/j.gastro.2018.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120776PMC
September 2018

A Comparative Analysis of Survival and Funding Discrepancies in Cancers with High Mortality.

Ann Surg 2018 Sep 4. Epub 2018 Sep 4.

Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1097/SLA.0000000000003042DOI Listing
September 2018

Hunting for transcription factors: STAT3 decoy in non-small cell lung cancer.

Transl Lung Cancer Res 2018 Sep;7(Suppl 3):S254-S257

Division of Oncology-Hematology, Department of Internal Medicine, VA Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.21037/tlcr.2018.09.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193924PMC
September 2018

Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway.

Biochim Biophys Acta Mol Basis Dis 2018 Aug 16;1864(8):2538-2549. Epub 2018 May 16.

Department of Biochemistry and Molecular Biology, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, NE-68198, USA; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, NE-68198, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183017
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http://dx.doi.org/10.1016/j.bbadis.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047753PMC
August 2018

MUC16 as a novel target for cancer therapy.

Expert Opin Ther Targets 2018 08 26;22(8):675-686. Epub 2018 Jul 26.

a Department of Biochemistry and Molecular Biology , University of Nebraska Medical Center , Omaha , NE , USA.

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http://dx.doi.org/10.1080/14728222.2018.1498845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300140PMC
August 2018

Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis.

Neoplasia 2018 08 6;20(8):813-825. Epub 2018 Jul 6.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037882PMC
August 2018

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors.

J Ovarian Res 2018 Aug 18;11(1):69. Epub 2018 Aug 18.

Department of Physiology, University of Louisville, 505 South Hancock Street, CTRB, Room 322, Louisville, 40202, KY, USA.

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http://dx.doi.org/10.1186/s13048-018-0439-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098829PMC
August 2018

p66Shc regulates migration of castration-resistant prostate cancer cells.

Cell Signal 2018 06 17;46:1-14. Epub 2018 Feb 17.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, United States; Section of Urology, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, United States; College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882563PMC
June 2018

Ramifications of secreted mucin MUC5AC in malignant journey: a holistic view.

Carcinogenesis 2018 05;39(5):633-651

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1093/carcin/bgy019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932566PMC
May 2018

Advanced pancreatic cancer: a meta-analysis of clinical trials over thirty years.

Oncotarget 2018 Apr 10;9(27):19396-19405. Epub 2018 Apr 10.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.18632/oncotarget.25036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922405PMC
April 2018

Natural products: a hope for glioblastoma patients.

Oncotarget 2018 Apr 24;9(31):22194-22219. Epub 2018 Apr 24.

Eppley Institute for Research in Cancer and Allied Diseases and Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

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http://dx.doi.org/10.18632/oncotarget.25175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955138PMC
April 2018

Emerging Roles of Electrospun Nanofibers in Cancer Research.

Adv Healthc Mater 2018 03 6;7(6):e1701024. Epub 2017 Dec 6.

Department of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

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http://dx.doi.org/10.1002/adhm.201701024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867260PMC
March 2018

Emerging trends in the immunotherapy of pancreatic cancer.

Cancer Lett 2018 03 12;417:35-46. Epub 2017 Dec 12.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA; Nanovaccine Institute, Ames, IA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801196PMC
March 2018

Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis.

PLoS One 2018 22;13(2):e0191696. Epub 2018 Feb 22.

Department of Biochemistry and Molecular Biology, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191696PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823380PMC
March 2018

PD2/PAF1 at the Crossroads of the Cancer Network.

Cancer Res 2018 01 8;78(2):313-319. Epub 2018 Jan 8.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-2175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771812PMC
January 2018

Ovarian Cancer Stem Cells: Unraveling a Germline Connection.

Stem Cells Dev 2017 12 28;26(24):1781-1803. Epub 2017 Nov 28.

1 Department of Physiology, University of Louisville , Louisville, Kentucky.

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http://dx.doi.org/10.1089/scd.2017.0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725638PMC
December 2017

Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis.

Biochemistry 2017 11 19;56(46):6083-6086. Epub 2017 Oct 19.

Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine , Carbondale, Illinois 62901, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00865DOI Listing
November 2017

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy.

Front Immunol 2017 10;8:1228. Epub 2017 Oct 10.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641316PMC
October 2017

Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells.

Oncotarget 2017 Oct 20;8(48):83754-83767. Epub 2017 Jul 20.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.18632/oncotarget.19410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663552PMC
October 2017

Biological determinants of radioresistance and their remediation in pancreatic cancer.

Biochim Biophys Acta Rev Cancer 2017 Aug 27;1868(1):69-92. Epub 2017 Feb 27.

Department of Biochemistry and Molecular Biology, Omaha, NE, United States; Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE, United States; Fred & Pamela Buffett Cancer Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548591PMC
August 2017

Genetic variants of mucins: unexplored conundrum.

Carcinogenesis 2017 07;38(7):671-679

Department of Biochemistry and Molecular Biology.

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http://dx.doi.org/10.1093/carcin/bgw120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862316PMC
July 2017

MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma.

Expert Opin Ther Targets 2017 07 29;21(7):657-669. Epub 2017 May 29.

a Department of Biochemistry and Molecular Biology , University of Nebraska Medical Center , Omaha , NE , USA.

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https://www.tandfonline.com/doi/full/10.1080/14728222.2017.1
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http://dx.doi.org/10.1080/14728222.2017.1323880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706649PMC
July 2017

Immunohistochemical expression of mucin antigens in gallbladder adenocarcinoma: MUC1-positive and MUC2-negative expression Is associated with vessel invasion and shortened survival.

Histol Histopathol 2017 Jun 27;32(6):585-596. Epub 2016 Sep 27.

Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

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http://dx.doi.org/10.14670/HH-11-824DOI Listing
June 2017

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer.

Genes Cancer 2017 Mar;8(3-4):517-527

Department of Pathology, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Sakuragoaka, Japan.

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http://dx.doi.org/10.18632/genesandcancer.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489649PMC
March 2017

Surface-Enhanced Raman Scattering-Based Immunoassay Technologies for Detection of Disease Biomarkers.

Biosensors (Basel) 2017 Jan 12;7(1). Epub 2017 Jan 12.

Department of Physics University of Nebraska at Omaha 6001 Dodge Street, Omaha, NE 68182, USA.

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http://dx.doi.org/10.3390/bios7010007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371780PMC
January 2017

Statin derivatives as therapeutic agents for castration-resistant prostate cancer.

Cancer Lett 2016 12 26;383(1):94-105. Epub 2016 Sep 26.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Section of Urology, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA; College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086260PMC
http://dx.doi.org/10.1016/j.canlet.2016.09.008DOI Listing
December 2016

Interleukin-22 Connects Smoking and Pancreatic Fibrosis During Chronic Pancreatitis.

Gastroenterology 2016 12 27;151(6):1067-1070. Epub 2016 Oct 27.

Department of Biochemistry and Molecular Biology and Eppley Institute for Research in Cancer and Allied Diseases and Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085163528
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http://dx.doi.org/10.1053/j.gastro.2016.10.033DOI Listing
December 2016

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis.

Biomaterials 2016 09 27;101:108-120. Epub 2016 May 27.

Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198.

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http://dx.doi.org/10.1016/j.biomaterials.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921319PMC
September 2016

Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer.

Mol Oncol 2016 08 29;10(7):1063-77. Epub 2016 Apr 29.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, United States; Buffett Cancer Center, Omaha, NE 68198, United States; Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198, United States; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2016.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972654PMC
August 2016

Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation.

Br J Cancer 2016 06 17;114(12):1376-86. Epub 2016 May 17.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

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http://dx.doi.org/10.1038/bjc.2016.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984453PMC
June 2016

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.

Cancer Lett 2016 May 16;374(2):304-14. Epub 2016 Feb 16.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881851PMC
May 2016

FAK and paxillin, two potential targets in pancreatic cancer.

Oncotarget 2016 May;7(21):31586-601

Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA.

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http://www.oncotarget.com/fulltext/8040
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http://dx.doi.org/10.18632/oncotarget.8040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058780PMC
May 2016

Novel Imidazopyridine Derivatives Possess Anti-Tumor Effect on Human Castration-Resistant Prostate Cancer Cells.

PLoS One 2015 29;10(6):e0131811. Epub 2015 Jun 29.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America; Section of Urology, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, United States of America; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America; College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, 807, ROC.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131811PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487901PMC
April 2016

Mucins and Wnt/β-catenin signaling in gastrointestinal cancers: an unholy nexus.

Carcinogenesis 2016 Mar 13;37(3):223-32. Epub 2016 Jan 13.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA, Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA

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http://dx.doi.org/10.1093/carcin/bgw005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014091PMC
March 2016

The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma.

Mol Oncol 2016 Feb 19;10(2):224-39. Epub 2015 Oct 19.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198-5870, USA; Eppley Institute for Research in Cancer and Allied Diseases, UNMC, Omaha, NE 68198-5950, USA; Fred and Pamela Buffett Cancer Center, UNMC, Omaha, NE 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740200PMC
February 2016

CXCR2 signaling regulates KRAS(G¹²D)-induced autocrine growth of pancreatic cancer.

Oncotarget 2016 Feb;7(6):7280-96

Department of Pathology and Microbiology, 985900 Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.18632/oncotarget.6906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872785PMC
February 2016

Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology.

Cancer Res 2016 Jan 11;76(2):418-28. Epub 2015 Nov 11.

Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska. Buffett Cancer Center, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, Nebraska.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-15-1488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715955PMC
January 2016

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95.

Oncotarget 2016 Jan;7(4):4399-413

Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.18632/oncotarget.6749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826214PMC
January 2016

Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.

Biochim Biophys Acta 2015 Dec 28;1856(2):211-25. Epub 2015 Aug 28.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663118PMC
December 2015

Advances in miRNA-Mediated Mucin Regulation.

Curr Pharmacol Rep 2015 Dec 15;1(6):355-364. Epub 2015 Jan 15.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1007/s40495-014-0010-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113945PMC
December 2015

ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells.

Cell Signal 2015 Nov 6;27(11):2261-71. Epub 2015 Aug 6.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA; Department of Surgery/Urology, University of Nebraska Medical Center, Omaha, NE, USA; College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565757PMC
November 2015

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model.

Oncotarget 2015 Nov;6(37):40295-309

Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.18632/oncotarget.5641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741896PMC
November 2015

Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy.

Cancer Res 2015 Nov 2;75(22):4669-74. Epub 2015 Nov 2.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska. Department of Pathology, University of Nebraska Medical Center, Omaha, Nebraska. Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651718PMC
November 2015

Significance of microRNA-based biomarkers for pancreatic cancer.

Ann Transl Med 2015 Oct;3(18):277

1 Departments of Biochemistry and Molecular Biology; 2 Fred and Pamela Buffett Cancer Center; 3 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-5870, USA.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.10.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630543PMC
October 2015

MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.

Oncotarget 2015 Aug;6(22):19118-31

The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662479PMC
http://dx.doi.org/10.18632/oncotarget.4078DOI Listing
August 2015

Mucin expression in endoscopic ultrasound-guided fine-needle aspiration specimens is a useful prognostic factor in pancreatic ductal adenocarcinoma.

Pancreas 2015 Jul;44(5):728-34

From the *Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences; †National Sanatorium Hoshizuka-Keiaien, Kanoya; ‡Department of Digestive and Lifestyle Diseases, §Department of Radiology, ∥Department of Epidemiology and Preventive Medicine, ¶Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; and #Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1097/MPA.0000000000000362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464972PMC
July 2015

Early detection of sporadic pancreatic cancer: summative review.

Pancreas 2015 Jul;44(5):693-712

From the *Department of Medicine, Mayo Clinic, Rochester, MN; †Department of Biomedical Engineering, University of Virginia, Charlottesville, VA; Departments of ‡Biochemistry and Molecular Biology, §Pathology and Microbiology, and ∥Surgery, Fred & Pamela Buffett Cancer Center, University of Nebraska, Omaha, NE; ¶Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD; #Division of Gastroenterology, University of Washington, Seattle, WA; **Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD; ††Sawgrass Leadership Institute, Ponte Vedra Beach, FL; ‡‡Department of Surgery, University of Utah, Salt Lake City, UT; §§Department of Radiology, Stanford University School of Medicine, Stanford; ∥∥Department of Medicine, David Geffen School of Medicine, and ¶¶General Surgery, University of California Los Angeles, Los Angeles, CA; ##Kenner Family Research Fund; ***Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; †††Department of Internal Medicine, University of Greifswald, Greifswald, Germany; ‡‡‡Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX; §§§Department of Health Sciences Research, Mayo Clinic, Rochester, MN; ∥∥∥Gastroenterology Division, Department of Internal Medicine and Comprehensive Cancer Center, and ¶¶¶Department of Surgery, School of Medicine, University of Michigan, Ann Arbor, MI; ###Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD; ****Departments of Surgery and Oncology, Kyushu University, Fukuoka, Japan; ††††Department of Medicine, Eastern Virginia Medical School, Norfolk, VA; and ‡‡‡‡Division of Oral Biology and Medicine, CLA School of Dentistry, Jonnson Comprehensive Cancer Center, University of California Los Angeles, L

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http://dx.doi.org/10.1097/MPA.0000000000000368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467589PMC
July 2015

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.

Nat Cell Biol 2015 Jun 18;17(6):816-26. Epub 2015 May 18.

1] Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, New York 10021, USA [2] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769922PMC
June 2015

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments.

Sci Rep 2015 Jun 5;5:9759. Epub 2015 Jun 5.

1] Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA [2] Department of Pathology, University of Nebraska Medical Center, Omaha, NE 68198, USA [3] Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1038/srep09759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456727PMC
June 2015